Single-entity collisional electrochemistry(SECE)is a branch of single-entity electrochemistry.It can directly characterize entities/particles with single particle resolution through random collisions between particles...Single-entity collisional electrochemistry(SECE)is a branch of single-entity electrochemistry.It can directly characterize entities/particles with single particle resolution through random collisions between particles and electrodes in a solution,and obtain rich physicochemical information,thus becoming one of the frontiers of electroanalytical chemistry in the past two decades.Interestingly,the(micro/nanoscale)sensing electrodes have evolved from a polarizable liquid/liquid(mercury/liquid)interface to a solid/liquid interface and then to a liquid/liquid interface(i.e.,an interface between twoimmiscible electrolyte solutions,ITIES),as if they have completed a cycle(but in fact they have not).ITIES has become the latest sensing electrode in the booming SECE due to its polarizability(up to 1.1 V at the water/a,a,a-trifluorotoluene interface)and high reproducibility.The four measurement modes(direct electrolysis,mediated electrolysis,current blockade,and charge displacement)developed in the realm of SECE at solid/liquid interfaces have also been fully realized at the miniature ITIES.This article will discuss these four modes at the ITIES from the perspectives of basic concepts,operating mechanisms,and latest developments(e.g.,discovery of ionosomes,blockade effect of Faradaic ion transfer,etc.),and look forward to the future development and direction of this emerging field.展开更多
Objective Allocryptopine （ALL） is an effective alkaloid of Corydalis decumbens （Thunb.） Pers. Papaveraceae and has proved to be an- ti-arrhythmic. The purpose of our study is to investigate the effects of ALL on t...Objective Allocryptopine （ALL） is an effective alkaloid of Corydalis decumbens （Thunb.） Pers. Papaveraceae and has proved to be an- ti-arrhythmic. The purpose of our study is to investigate the effects of ALL on transmural repolarizing ionic ingredients of outward potassium current （Ito） and slow delayed rectifier potassium current （IKs）. Methods The monophasic action potential （MAP） technique was used to record the MAP duration of the epicardium （Epi）, myocardium （M） and endocardium （Endo） of the rabbit heart and the whole cell patch clamp was used to record/to and IKs in cardiomyocytes of Epi, M and Endo layers that were isolated from rabbit ventricles. Results The effects of ALL on MAP of Epi, M and Endo layers were disequilibrium. ALL could effectively reduce the transmural dispersion of repolarization （TDR） in rabbit transmural ventricular wall. ALL decreased the current densities of/to and IKs in a voltage and concentration dependent way and narrowed the repolarizing differences among three layers. The analysis of gating kinetics showed ALL accelerated the channel activation ofIto in M layers and partly inhibit the channel openings of/to in Epi, M and Endo cells. On the other hand, ALL mainly slowed channel deactivation of IKs channel in Epi and Endo layers without affecting its activation. Conclusions Our study gives partially explanation about the mechanisms of tmnsmural inhibition of/to and IKs channels by ALL in rabbit myocardium. These findings provide novel perspective regarding the anti-arrhythmogenesis application of ALL in clinical settings.展开更多
The way of neutral point to earth via full compensation arc suppression coil can solve the problem of residual current compensation in coal mine power network effectively. Based on the analysis on the grounding curren...The way of neutral point to earth via full compensation arc suppression coil can solve the problem of residual current compensation in coal mine power network effectively. Based on the analysis on the grounding current detection results of Xieqiao coal mine, the conclusion that harmonic component of grounding current is dominated by higher harmonics with complex harmonic sources in coal mine power network system was obtained. The influences of harmonic source type and fault point position on harmonic voltage and harmonic current were analyzed theoretically. The influences of earthed fault feeder detection result and the estimation errors of parameters to earth on residual current compensation were analyzed. A new thought of residual current prediction and the selections of model method and control method were proposed on this basis. The simulation results prove that harmonic amplitudes of zero sequence voltage and zero sequence current are determined by harmonic source type as well as fault point position in coal mine power network, and also prove that zero sequence voltage detection can avoid the unstable problem of coal mine power network system caused by undercompensation of capacitive current. Finally, the experimental device of full compensation arc suppression coil is introduced.展开更多
It is important for the safety of transmission system to accurately calculate single-phase earth fault current distribution.Features of double sided elimination method were illustrated.Quantitative calculation of sing...It is important for the safety of transmission system to accurately calculate single-phase earth fault current distribution.Features of double sided elimination method were illustrated.Quantitative calculation of single-phase earth fault current distribution and case verification were accomplished by using the loop method.Influences of some factors,such as single-phase earth fault location and ground resistance of poles,on short-circuit current distribution were discussed.Results show that:1) results of the loop method conform to those of double sided elimination method;2) the fault location hardly influences macro-distribution of short-circuit current.However,current near fault location is evidently influenced;and 3) the short-circuit current distribution is not so sensitive to the ground resistance of poles.展开更多
基金supported by the National Natural Science Foundation of China(No.21904143).
文摘Single-entity collisional electrochemistry(SECE)is a branch of single-entity electrochemistry.It can directly characterize entities/particles with single particle resolution through random collisions between particles and electrodes in a solution,and obtain rich physicochemical information,thus becoming one of the frontiers of electroanalytical chemistry in the past two decades.Interestingly,the(micro/nanoscale)sensing electrodes have evolved from a polarizable liquid/liquid(mercury/liquid)interface to a solid/liquid interface and then to a liquid/liquid interface(i.e.,an interface between twoimmiscible electrolyte solutions,ITIES),as if they have completed a cycle(but in fact they have not).ITIES has become the latest sensing electrode in the booming SECE due to its polarizability(up to 1.1 V at the water/a,a,a-trifluorotoluene interface)and high reproducibility.The four measurement modes(direct electrolysis,mediated electrolysis,current blockade,and charge displacement)developed in the realm of SECE at solid/liquid interfaces have also been fully realized at the miniature ITIES.This article will discuss these four modes at the ITIES from the perspectives of basic concepts,operating mechanisms,and latest developments(e.g.,discovery of ionosomes,blockade effect of Faradaic ion transfer,etc.),and look forward to the future development and direction of this emerging field.
文摘Objective Allocryptopine （ALL） is an effective alkaloid of Corydalis decumbens （Thunb.） Pers. Papaveraceae and has proved to be an- ti-arrhythmic. The purpose of our study is to investigate the effects of ALL on transmural repolarizing ionic ingredients of outward potassium current （Ito） and slow delayed rectifier potassium current （IKs）. Methods The monophasic action potential （MAP） technique was used to record the MAP duration of the epicardium （Epi）, myocardium （M） and endocardium （Endo） of the rabbit heart and the whole cell patch clamp was used to record/to and IKs in cardiomyocytes of Epi, M and Endo layers that were isolated from rabbit ventricles. Results The effects of ALL on MAP of Epi, M and Endo layers were disequilibrium. ALL could effectively reduce the transmural dispersion of repolarization （TDR） in rabbit transmural ventricular wall. ALL decreased the current densities of/to and IKs in a voltage and concentration dependent way and narrowed the repolarizing differences among three layers. The analysis of gating kinetics showed ALL accelerated the channel activation ofIto in M layers and partly inhibit the channel openings of/to in Epi, M and Endo cells. On the other hand, ALL mainly slowed channel deactivation of IKs channel in Epi and Endo layers without affecting its activation. Conclusions Our study gives partially explanation about the mechanisms of tmnsmural inhibition of/to and IKs channels by ALL in rabbit myocardium. These findings provide novel perspective regarding the anti-arrhythmogenesis application of ALL in clinical settings.
基金The financial support from the National Natural Science Foundation of China (No. 51107143)
文摘The way of neutral point to earth via full compensation arc suppression coil can solve the problem of residual current compensation in coal mine power network effectively. Based on the analysis on the grounding current detection results of Xieqiao coal mine, the conclusion that harmonic component of grounding current is dominated by higher harmonics with complex harmonic sources in coal mine power network system was obtained. The influences of harmonic source type and fault point position on harmonic voltage and harmonic current were analyzed theoretically. The influences of earthed fault feeder detection result and the estimation errors of parameters to earth on residual current compensation were analyzed. A new thought of residual current prediction and the selections of model method and control method were proposed on this basis. The simulation results prove that harmonic amplitudes of zero sequence voltage and zero sequence current are determined by harmonic source type as well as fault point position in coal mine power network, and also prove that zero sequence voltage detection can avoid the unstable problem of coal mine power network system caused by undercompensation of capacitive current. Finally, the experimental device of full compensation arc suppression coil is introduced.
文摘It is important for the safety of transmission system to accurately calculate single-phase earth fault current distribution.Features of double sided elimination method were illustrated.Quantitative calculation of single-phase earth fault current distribution and case verification were accomplished by using the loop method.Influences of some factors,such as single-phase earth fault location and ground resistance of poles,on short-circuit current distribution were discussed.Results show that:1) results of the loop method conform to those of double sided elimination method;2) the fault location hardly influences macro-distribution of short-circuit current.However,current near fault location is evidently influenced;and 3) the short-circuit current distribution is not so sensitive to the ground resistance of poles.
