A new ruthenium polypyridine complex, [Ru(phen) 2(pMIP)] 2+(phen=1,10-phenanthroline, pMIP=2-(4-methylphenyl)imidazo phenanthroline), was synthesized and characterized by elementary analysis, MS and 1H NMR. Spectrosco...A new ruthenium polypyridine complex, [Ru(phen) 2(pMIP)] 2+(phen=1,10-phenanthroline, pMIP=2-(4-methylphenyl)imidazo phenanthroline), was synthesized and characterized by elementary analysis, MS and 1H NMR. Spectroscopic methods have been carried out on the interaction mechanism of the Ru (Ⅱ) complex with yeast tRNA systematically. The experimental results indicate that the complex binds to yeast tRNA with an intercalative mode possibly, and interacts with yeast tRNA enantioselectively. The experimental results also suggest that spectroscopic method is effective on studying the interaction mechanism of Ru (Ⅱ) complexes with RNA. Information obtained from the study is potentially useful in the design of new RNA-targeting drugs.展开更多
The coordination compound of [Pb（PNS）（NO3）Cl]·H2O was synthesized by using ligand PNS and lead nitrate.The molecular structure of [Pb（PNS）（NO3）Cl]·H2O was determined by using a single crystal diffrac...The coordination compound of [Pb（PNS）（NO3）Cl]·H2O was synthesized by using ligand PNS and lead nitrate.The molecular structure of [Pb（PNS）（NO3）Cl]·H2O was determined by using a single crystal diffraction analysis.The crystal belongs to triclinic with space group P1-.The unit cell parameters are as follows:a=0.7634（3）nm,b=0.7794（3）nm,c=1.0679（5）nm,d=102.087（13）°,β=91.605（13）°,（γ=91.605（10）°,V=0.6262（5）nm3,Z=2,Mr=2.582g/cm3）,μ=13.709mm-1,F（000）=452,R1=0.0355,wR2=0.0785 for the title complex.In [Pb（PNS）（NO3）Cl]·H2O,the Pb（Ⅱ） ion has a distorted square pyramided coordination geometry coordinated by two N and one O atoms from PNS,one Cl-ion and one 0 atom from nitrate ion.展开更多
The interaction of ruthenium polypyridyl complex with DNA has been studied by isothermal titration calorimetry (ITC). The results show that complex [Ru(phen)2PMIP]2+ {phen=1,10-phenanthroline, PMIP=2-(4-methylphenyl)i...The interaction of ruthenium polypyridyl complex with DNA has been studied by isothermal titration calorimetry (ITC). The results show that complex [Ru(phen)2PMIP]2+ {phen=1,10-phenanthroline, PMIP=2-(4-methylphenyl)imidazo1,10-phenanthroline} interacts with calf thymus DNA (CT DNA) in terms of a model for a single set of identical sites through intercalation. The results are in agreement with our previous observations from spectroscopic methods and viscosity measurements. In addition, the results further show that the driving force for DNA binding with the complex is mainly driven by the enthalpy changes, and the contribution from the entropy changes to this driving force is negligible.展开更多
基金supported by the National Natural Science Foundation of China(21073143)“Chunhui Project”from the Ministry of Education of China(Z2009-1-71002,Z2009-1-71006)+2 种基金Graduate Starting Seed Fund of Northwestern Polytechnical University(NPU),China(Z2015152)NPU Foundation for Graduate InnovationChina~~
文摘A new ruthenium polypyridine complex, [Ru(phen) 2(pMIP)] 2+(phen=1,10-phenanthroline, pMIP=2-(4-methylphenyl)imidazo phenanthroline), was synthesized and characterized by elementary analysis, MS and 1H NMR. Spectroscopic methods have been carried out on the interaction mechanism of the Ru (Ⅱ) complex with yeast tRNA systematically. The experimental results indicate that the complex binds to yeast tRNA with an intercalative mode possibly, and interacts with yeast tRNA enantioselectively. The experimental results also suggest that spectroscopic method is effective on studying the interaction mechanism of Ru (Ⅱ) complexes with RNA. Information obtained from the study is potentially useful in the design of new RNA-targeting drugs.
文摘The coordination compound of [Pb（PNS）（NO3）Cl]·H2O was synthesized by using ligand PNS and lead nitrate.The molecular structure of [Pb（PNS）（NO3）Cl]·H2O was determined by using a single crystal diffraction analysis.The crystal belongs to triclinic with space group P1-.The unit cell parameters are as follows:a=0.7634（3）nm,b=0.7794（3）nm,c=1.0679（5）nm,d=102.087（13）°,β=91.605（13）°,（γ=91.605（10）°,V=0.6262（5）nm3,Z=2,Mr=2.582g/cm3）,μ=13.709mm-1,F（000）=452,R1=0.0355,wR2=0.0785 for the title complex.In [Pb（PNS）（NO3）Cl]·H2O,the Pb（Ⅱ） ion has a distorted square pyramided coordination geometry coordinated by two N and one O atoms from PNS,one Cl-ion and one 0 atom from nitrate ion.
文摘The interaction of ruthenium polypyridyl complex with DNA has been studied by isothermal titration calorimetry (ITC). The results show that complex [Ru(phen)2PMIP]2+ {phen=1,10-phenanthroline, PMIP=2-(4-methylphenyl)imidazo1,10-phenanthroline} interacts with calf thymus DNA (CT DNA) in terms of a model for a single set of identical sites through intercalation. The results are in agreement with our previous observations from spectroscopic methods and viscosity measurements. In addition, the results further show that the driving force for DNA binding with the complex is mainly driven by the enthalpy changes, and the contribution from the entropy changes to this driving force is negligible.
