根据医用回旋加速器的物理要求,确定了医用回旋高频腔的具体结构设计方案。在加速电压较高、空间有限的情况下提升高频腔的品质因数,结构设计为1/2波长线的竖腔。为避免腔体在实际工作中由发热变形引起频率漂移,本次设计中采用微调环调...根据医用回旋加速器的物理要求,确定了医用回旋高频腔的具体结构设计方案。在加速电压较高、空间有限的情况下提升高频腔的品质因数,结构设计为1/2波长线的竖腔。为避免腔体在实际工作中由发热变形引起频率漂移,本次设计中采用微调环调谐结构来保证频率稳定度的要求。本文利用Microwave Studio CST程序对腔体的电磁场分布、品质因数Q_0、表面电流分布、耦合电容、微调环进行了详细的分析与仿真计算。与实际测量值进行对比,两者比较吻合,并对产生的误差进行了分析讨论。展开更多
Co-55 (t1/2=17.53 h) was produced by 150 μA irradiation of a natural nickel target using 15 MeV protons. It was separated from the irradiated target material by two ion exchange chromatography steps with a radiochemi...Co-55 (t1/2=17.53 h) was produced by 150 μA irradiation of a natural nickel target using 15 MeV protons. It was separated from the irradiated target material by two ion exchange chromatography steps with a radiochemical yield of >95% and was used for the preparation of [55Co]vancomycin ([55Co]VAN). Optimization studies were per- formed using Co-57 due to its longer half-life. Cobalt-57 (t1/2=271.79 d) was produced by irradiation of a natural nickel target with 150 μA current of 22 MeV protons. The 57Co was separated from the irradiated target material using a no-carrier-added method with a radiochemical yield of >97%. Both products were controlled for radionuclide and chemical purity. The solutions of [55Co]VAN were prepared (radiochemical yield>80%) starting with 55Co acetate and vancomycin at room temperature after 30 min. A precise solid phrase extraction (SPE) method was developed using Si Sep-Pak in order to purify/reconstitute the final formulation for animal studies. [55Co]VAN showed a radiochemical purity of more than 99%. The resultant specific activity was about 1.15 TBq/mmol. It is proved that the tracer is stable in the final product and in presence of human serum at 37°C up to 24 h. Biodistribution study of [55Co]VAN in normal rats was undertaken for up to 72 h.展开更多
文摘根据医用回旋加速器的物理要求,确定了医用回旋高频腔的具体结构设计方案。在加速电压较高、空间有限的情况下提升高频腔的品质因数,结构设计为1/2波长线的竖腔。为避免腔体在实际工作中由发热变形引起频率漂移,本次设计中采用微调环调谐结构来保证频率稳定度的要求。本文利用Microwave Studio CST程序对腔体的电磁场分布、品质因数Q_0、表面电流分布、耦合电容、微调环进行了详细的分析与仿真计算。与实际测量值进行对比,两者比较吻合,并对产生的误差进行了分析讨论。
基金Supported partly by IAEA/IAEO research grant for cyclotron production of Co-57.
文摘Co-55 (t1/2=17.53 h) was produced by 150 μA irradiation of a natural nickel target using 15 MeV protons. It was separated from the irradiated target material by two ion exchange chromatography steps with a radiochemical yield of >95% and was used for the preparation of [55Co]vancomycin ([55Co]VAN). Optimization studies were per- formed using Co-57 due to its longer half-life. Cobalt-57 (t1/2=271.79 d) was produced by irradiation of a natural nickel target with 150 μA current of 22 MeV protons. The 57Co was separated from the irradiated target material using a no-carrier-added method with a radiochemical yield of >97%. Both products were controlled for radionuclide and chemical purity. The solutions of [55Co]VAN were prepared (radiochemical yield>80%) starting with 55Co acetate and vancomycin at room temperature after 30 min. A precise solid phrase extraction (SPE) method was developed using Si Sep-Pak in order to purify/reconstitute the final formulation for animal studies. [55Co]VAN showed a radiochemical purity of more than 99%. The resultant specific activity was about 1.15 TBq/mmol. It is proved that the tracer is stable in the final product and in presence of human serum at 37°C up to 24 h. Biodistribution study of [55Co]VAN in normal rats was undertaken for up to 72 h.
