Aortic stenosis （AS） is a common valvular heart disease in the Western populations, with an estimated overall prevalence of 3% in adults over 75 years. To understand its patho-biological processes represents a prior...Aortic stenosis （AS） is a common valvular heart disease in the Western populations, with an estimated overall prevalence of 3% in adults over 75 years. To understand its patho-biological processes represents a priority. In elderly patients, AS usually involves trileaflet valves and is referred to as degenerative calcific processes. Scientific evidence suggests the involvement of an active ＂atherosclerosis-like＂ pathogenesis in the initiation phase of degenerative AS. To the contrary, the progression could be driven by different forces （such as mechanical stress, genetic factors and interaction between inflammation and calcification）. The improved understanding presents potentially new therapeutic targets for preventing and inhibiting the development and progression of the disease. Furthermore, in clinical practice the management of AS patients implies the evaluation of generalized atherosclerotic manifestations （i.e., in the coronary and carotid arteries） even for prognostic reasons. In counselling elderly patients, the risk stratification should address individual frailty beyond the generic risk scores. In these regard, the co-morbidities, and in particular those linked to the global atherosclerotic burden, should be carefully investigated in order to define the risk/benefit ratio for invasive treatment strategies. We present a detailed overview of insights in pathogenesis of AS with possible practical implications.展开更多
The low-cost,self-configuration capability and "plug-and-play" feature of Ethernet establishes its dominant position in the local area networks(LAN).However,it is hard to extend to large scale because of the...The low-cost,self-configuration capability and "plug-and-play" feature of Ethernet establishes its dominant position in the local area networks(LAN).However,it is hard to extend to large scale because of the legacy broadcast-based service discovery mechanism.Therefore,to solve this problem,a new split network architecture named Software-Defined Networking(SDN) is introduced in this paper,and a novel floodless service discovery mechanism(FSDM)for SDN is designed.For the FSDM,the widespread broadcast messages for Dynamic Host Configuration Protocol(DHCP) and Address Resolution Protocol(ARP) are considered especially,respectively.Then the DHCP relay and ARP proxy are proposed to handle DHCP broadcast messages and ARP broadcast messages,respectively.The proposed FSDM in this paper can eliminate flooding completely,reserve the autoconfiguration characteristics.Particularly,there is no need to change the existing hardware,software and protocols of hosts for the proposed scheme.Finally,the simulation results are demonstrated to show that our proposed model allows redundant links existed in network and has the property of scalability,which can significantly reduce network traffic in data plane and control traffic in control plane,and decrease the overhead of control plane.展开更多
文摘Aortic stenosis （AS） is a common valvular heart disease in the Western populations, with an estimated overall prevalence of 3% in adults over 75 years. To understand its patho-biological processes represents a priority. In elderly patients, AS usually involves trileaflet valves and is referred to as degenerative calcific processes. Scientific evidence suggests the involvement of an active ＂atherosclerosis-like＂ pathogenesis in the initiation phase of degenerative AS. To the contrary, the progression could be driven by different forces （such as mechanical stress, genetic factors and interaction between inflammation and calcification）. The improved understanding presents potentially new therapeutic targets for preventing and inhibiting the development and progression of the disease. Furthermore, in clinical practice the management of AS patients implies the evaluation of generalized atherosclerotic manifestations （i.e., in the coronary and carotid arteries） even for prognostic reasons. In counselling elderly patients, the risk stratification should address individual frailty beyond the generic risk scores. In these regard, the co-morbidities, and in particular those linked to the global atherosclerotic burden, should be carefully investigated in order to define the risk/benefit ratio for invasive treatment strategies. We present a detailed overview of insights in pathogenesis of AS with possible practical implications.
基金supported by the National Basic Research Program(973)of China(No.2012CB315801)the National Natural Science Fund(No.61302089,61300184)the fundamental research funds for the Central Universities(No.2013RC0113)
文摘The low-cost,self-configuration capability and "plug-and-play" feature of Ethernet establishes its dominant position in the local area networks(LAN).However,it is hard to extend to large scale because of the legacy broadcast-based service discovery mechanism.Therefore,to solve this problem,a new split network architecture named Software-Defined Networking(SDN) is introduced in this paper,and a novel floodless service discovery mechanism(FSDM)for SDN is designed.For the FSDM,the widespread broadcast messages for Dynamic Host Configuration Protocol(DHCP) and Address Resolution Protocol(ARP) are considered especially,respectively.Then the DHCP relay and ARP proxy are proposed to handle DHCP broadcast messages and ARP broadcast messages,respectively.The proposed FSDM in this paper can eliminate flooding completely,reserve the autoconfiguration characteristics.Particularly,there is no need to change the existing hardware,software and protocols of hosts for the proposed scheme.Finally,the simulation results are demonstrated to show that our proposed model allows redundant links existed in network and has the property of scalability,which can significantly reduce network traffic in data plane and control traffic in control plane,and decrease the overhead of control plane.
