In this paper,a series of Co(Ⅲ)complexes of N,N’-bis-(2-chloroethyl)amine(BCA) were synthesized and characterized by H-NMR and IR spectra.Cyclic voltammtry studies showed that variation of the alkyl group in the aux...In this paper,a series of Co(Ⅲ)complexes of N,N’-bis-(2-chloroethyl)amine(BCA) were synthesized and characterized by H-NMR and IR spectra.Cyclic voltammtry studies showed that variation of the alkyl group in the auxiliary ligands alters the reduction potentials of the complexes,and linear sweep voltammtry studies demonstrated that one electron reduction to the CO(Ⅱ)complexes may cause the release of axial ligand (BCA).In the end the complexes were evaluated for their hypoxia-slective cytotoxicity against S562 cells in vitro,two of them showed stated selectivity.展开更多
文摘In this paper,a series of Co(Ⅲ)complexes of N,N’-bis-(2-chloroethyl)amine(BCA) were synthesized and characterized by H-NMR and IR spectra.Cyclic voltammtry studies showed that variation of the alkyl group in the auxiliary ligands alters the reduction potentials of the complexes,and linear sweep voltammtry studies demonstrated that one electron reduction to the CO(Ⅱ)complexes may cause the release of axial ligand (BCA).In the end the complexes were evaluated for their hypoxia-slective cytotoxicity against S562 cells in vitro,two of them showed stated selectivity.
