目的:观察黑地黄丸治疗肾性贫血(RA)患者促红素低反应性的临床疗效。方法:56例促红素低反应性患者随机分为治疗组(各28例),疗程8周。观察两组治疗前后红细胞数(RBC)、血红蛋白(Hb)、红细胞压积(HCT)、治疗前后肾功能、计算内生肌酐清除...目的:观察黑地黄丸治疗肾性贫血(RA)患者促红素低反应性的临床疗效。方法:56例促红素低反应性患者随机分为治疗组(各28例),疗程8周。观察两组治疗前后红细胞数(RBC)、血红蛋白(Hb)、红细胞压积(HCT)、治疗前后肾功能、计算内生肌酐清除率(CCr)、对RA的疗效、统计两组患者8周疗程人均重组人红细胞生成素(r Hu EPO)总用量及每周使用量,描绘r Hu EPO使用曲线图;计算促红素抵抗指数(ERI)并描绘ERI变化曲线图。结果:完成研究50例(治疗组26例,对照组24例);与对照组同期相比,治疗组RBC、Hb、HCT均高于对照组(P <0. 05);两组治疗后Cr、BUN、CCr组间比较差异均有统计学意义(P>0. 05);治疗组总有效率92. 31%,效果优于对照组(P <0. 01);治疗组人均使用r Hu EPO总量少于对照组(P <0. 01);r Hu EPO使用曲线图显示,治疗组r Hu EPO用量在前3周时呈上升趋势,3周后逐渐下降;在治疗的4~5周,治疗组ERI低于同期对照组(P <0. 05),在治疗的6~8 w,治疗组较对照组同期ERI明显下降(P <0. 01)。结论:中药黑地黄丸治疗促红素低反应性疗效确切,可改善贫血水平和肾功能,减少rh EPO用量,降低ERI,从而减轻促红素低反应性。展开更多
0141177 24小时肺的保存:猪模型中简单化的和常规威斯康星大学溶液的比较/Wright N C//Transplantation.-2000,69(7).-1261～1265 医科情0141178 稳定的肺移植受者中受损的呈现抗原的细胞功能有助于 T 细胞的低反应性/Knoop C//Transpla...0141177 24小时肺的保存:猪模型中简单化的和常规威斯康星大学溶液的比较/Wright N C//Transplantation.-2000,69(7).-1261～1265 医科情0141178 稳定的肺移植受者中受损的呈现抗原的细胞功能有助于 T 细胞的低反应性/Knoop C//Transplantation.-2000,69(7).-1332～1336展开更多
Objective: To build a cell model of LPS-induced hyper- and hypo-responsiveness in macrophage cells . Methods: Macrophage cell line RAW264. 7 was pre-cultured with or without 10 ng/ml LPS for 18 h, then challenged with...Objective: To build a cell model of LPS-induced hyper- and hypo-responsiveness in macrophage cells . Methods: Macrophage cell line RAW264. 7 was pre-cultured with or without 10 ng/ml LPS for 18 h, then challenged with lipopolysaccharide(LPS) , or MDP, Zymosan, PAF, FMLP, PMA for 24 h. The levels of TNF-α , IL-1 , IL-6, IL-10 , NO and O2-, were measured. Results: LI'S pretreatment markedly inhibited TNF-a NO and IL-6 production, but increased IL-1, IL-10 and O2- release to LPS challenge. LPS pretreatment also altered macrophage responsiveness to the other stimuli. Conclusion: LPS can induce hyper- and hypo-responsiveness simultaneously in the macrophage cell lines. Changes in macrophage responsiveness depend on stimuli and effectors which are measured.展开更多
In this paper, four kinds of polymethacrylates(PMAs) used as multifunctional additives were synthesized from quaternary C1—C14 methacrylate, among which sample 4 exhibited relatively better performance. According to ...In this paper, four kinds of polymethacrylates(PMAs) used as multifunctional additives were synthesized from quaternary C1—C14 methacrylate, among which sample 4 exhibited relatively better performance. According to the methacrylate ratio of sample 4, the optimized reaction conditions of PMA were explored by orthogonal experiments comprising 4 factors and 3 levels, and the optimized reaction conditions covered an initiator dosage of 0.8 %, a molecular weight regulator dosage of 0.4%, a reaction temperature of 95 ℃ and a reaction time of 8.5 h. When the optimized PMA samples were used to formulate the 75W/90 automotive gear base oil, they exhibited improved shear stability and good low temperature property. In comparison with foreign commercial polymethacrylate GP, the optimized PMA samples exhibited better thickening ability, similar shear stability and slightly weak low temperature property, with their performance being the same as GP's on the whole. The slight difference in the performance between the optimized PMA and GP was attributed to the difference of chain length of copolymers and the distribution of relative molecular mass between them.展开更多
文摘目的:观察黑地黄丸治疗肾性贫血(RA)患者促红素低反应性的临床疗效。方法:56例促红素低反应性患者随机分为治疗组(各28例),疗程8周。观察两组治疗前后红细胞数(RBC)、血红蛋白(Hb)、红细胞压积(HCT)、治疗前后肾功能、计算内生肌酐清除率(CCr)、对RA的疗效、统计两组患者8周疗程人均重组人红细胞生成素(r Hu EPO)总用量及每周使用量,描绘r Hu EPO使用曲线图;计算促红素抵抗指数(ERI)并描绘ERI变化曲线图。结果:完成研究50例(治疗组26例,对照组24例);与对照组同期相比,治疗组RBC、Hb、HCT均高于对照组(P <0. 05);两组治疗后Cr、BUN、CCr组间比较差异均有统计学意义(P>0. 05);治疗组总有效率92. 31%,效果优于对照组(P <0. 01);治疗组人均使用r Hu EPO总量少于对照组(P <0. 01);r Hu EPO使用曲线图显示,治疗组r Hu EPO用量在前3周时呈上升趋势,3周后逐渐下降;在治疗的4~5周,治疗组ERI低于同期对照组(P <0. 05),在治疗的6~8 w,治疗组较对照组同期ERI明显下降(P <0. 01)。结论:中药黑地黄丸治疗促红素低反应性疗效确切,可改善贫血水平和肾功能,减少rh EPO用量,降低ERI,从而减轻促红素低反应性。
文摘0141177 24小时肺的保存:猪模型中简单化的和常规威斯康星大学溶液的比较/Wright N C//Transplantation.-2000,69(7).-1261～1265 医科情0141178 稳定的肺移植受者中受损的呈现抗原的细胞功能有助于 T 细胞的低反应性/Knoop C//Transplantation.-2000,69(7).-1332～1336
基金Supported by National Natural Science Foundation of China (No.39730210)
文摘Objective: To build a cell model of LPS-induced hyper- and hypo-responsiveness in macrophage cells . Methods: Macrophage cell line RAW264. 7 was pre-cultured with or without 10 ng/ml LPS for 18 h, then challenged with lipopolysaccharide(LPS) , or MDP, Zymosan, PAF, FMLP, PMA for 24 h. The levels of TNF-α , IL-1 , IL-6, IL-10 , NO and O2-, were measured. Results: LI'S pretreatment markedly inhibited TNF-a NO and IL-6 production, but increased IL-1, IL-10 and O2- release to LPS challenge. LPS pretreatment also altered macrophage responsiveness to the other stimuli. Conclusion: LPS can induce hyper- and hypo-responsiveness simultaneously in the macrophage cell lines. Changes in macrophage responsiveness depend on stimuli and effectors which are measured.
文摘In this paper, four kinds of polymethacrylates(PMAs) used as multifunctional additives were synthesized from quaternary C1—C14 methacrylate, among which sample 4 exhibited relatively better performance. According to the methacrylate ratio of sample 4, the optimized reaction conditions of PMA were explored by orthogonal experiments comprising 4 factors and 3 levels, and the optimized reaction conditions covered an initiator dosage of 0.8 %, a molecular weight regulator dosage of 0.4%, a reaction temperature of 95 ℃ and a reaction time of 8.5 h. When the optimized PMA samples were used to formulate the 75W/90 automotive gear base oil, they exhibited improved shear stability and good low temperature property. In comparison with foreign commercial polymethacrylate GP, the optimized PMA samples exhibited better thickening ability, similar shear stability and slightly weak low temperature property, with their performance being the same as GP's on the whole. The slight difference in the performance between the optimized PMA and GP was attributed to the difference of chain length of copolymers and the distribution of relative molecular mass between them.
