Expert systems (ESs) are being increasingly applied to the fault diagnosis of engines. Based on the idea of ES template (EST), an object-oriented rule-type EST is emphatically studied on such aspects as the object-ori...Expert systems (ESs) are being increasingly applied to the fault diagnosis of engines. Based on the idea of ES template (EST), an object-oriented rule-type EST is emphatically studied on such aspects as the object-oriented knowledge representation, the heuristic inference engine with an improved depth-first search (DFS) and the graphical user interface. A diagnositic ES instance for debris on magnetic chip detectors (MCDs) is then created with the EST. The spot running shows that the rule-type EST enhances the abilities of knowledge representation and heuristic inference, and breaks a new way for the rapid construction and implementation of ES.展开更多
The noninfarcted myocardium underwent significant electrophysiological remodelling as part of the healed myocardial infarction remodelling. This study aimed at investigating the effects of nervous growth factor （NGF...The noninfarcted myocardium underwent significant electrophysiological remodelling as part of the healed myocardial infarction remodelling. This study aimed at investigating the effects of nervous growth factor （NGF） on delayed afterdepolarizations （DADs） and triggered activity （TA） of the noninfarcted myocardium in the myocardial infarcted rabbit model. Rabbits with the left anterior descending coronary artery occlusion were prepared and recovered for 8 weeks （HMI group, n=9）. Other rabbits with myocardial infarction were infused NGF to the left stellate ganglion （HMI＋NGF group, 400 U/day for 8 weeks, n=8）. Myocytes were isolated from regions of the noninfarcted left ventricular free wall. Action potentials and ion currents were recorded with whole-cell patch clamp. The results showed that more DADs and TA events of HMI＋NGF myocytes than that of HMI and Ctrl group. Iti and ICa-L of NGF＋HMI myocytes were increased significantly compared with HMI and Ctrl cells, which contributed to DADs-related triggered arrhythmia. Comparing with HM1 and Ctrl myocytes, significant prolongations of APD50 and APD90 in HMI＋NGF myocytes were found. The results indicated the electrophysiological change of HMI myocytes with NGF infusion. It suggested that more events of DADs and TA in HMI myocytes with NGF treatment. The underlying mechanism may be involved in the increase of Iti and ICa-L.展开更多
文摘Expert systems (ESs) are being increasingly applied to the fault diagnosis of engines. Based on the idea of ES template (EST), an object-oriented rule-type EST is emphatically studied on such aspects as the object-oriented knowledge representation, the heuristic inference engine with an improved depth-first search (DFS) and the graphical user interface. A diagnositic ES instance for debris on magnetic chip detectors (MCDs) is then created with the EST. The spot running shows that the rule-type EST enhances the abilities of knowledge representation and heuristic inference, and breaks a new way for the rapid construction and implementation of ES.
基金Supported by the General Program of National Natural Science of China(30770901)
文摘The noninfarcted myocardium underwent significant electrophysiological remodelling as part of the healed myocardial infarction remodelling. This study aimed at investigating the effects of nervous growth factor （NGF） on delayed afterdepolarizations （DADs） and triggered activity （TA） of the noninfarcted myocardium in the myocardial infarcted rabbit model. Rabbits with the left anterior descending coronary artery occlusion were prepared and recovered for 8 weeks （HMI group, n=9）. Other rabbits with myocardial infarction were infused NGF to the left stellate ganglion （HMI＋NGF group, 400 U/day for 8 weeks, n=8）. Myocytes were isolated from regions of the noninfarcted left ventricular free wall. Action potentials and ion currents were recorded with whole-cell patch clamp. The results showed that more DADs and TA events of HMI＋NGF myocytes than that of HMI and Ctrl group. Iti and ICa-L of NGF＋HMI myocytes were increased significantly compared with HMI and Ctrl cells, which contributed to DADs-related triggered arrhythmia. Comparing with HM1 and Ctrl myocytes, significant prolongations of APD50 and APD90 in HMI＋NGF myocytes were found. The results indicated the electrophysiological change of HMI myocytes with NGF infusion. It suggested that more events of DADs and TA in HMI myocytes with NGF treatment. The underlying mechanism may be involved in the increase of Iti and ICa-L.
