Background Obstructive sleep apnea （OSA） is a common disease in patients with acute coronary syndrome （ACS） and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients...Background Obstructive sleep apnea （OSA） is a common disease in patients with acute coronary syndrome （ACS） and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients in previous study were treated with bare metal stents and the sample sizes were relatively low. The goal of this study was to evaluate the influence of OSA on the severity and prognosis of patients admitted for ACS. Methods In this prospective cohort study, we enrolled patients with ACS who were hospitalized for coronary angiogram/percutaneous coronary intervention and undergone polysomnography. We divided the patients into two groups： moderate to severe OSA group [apnea-hypopnea index （AHI） 〉 15 events/h] and control group （AHI ≤ 15 events/h）. They were followed up for up 32 months. Then, we compared the ACS severity and long-term major adverse cardiovascular events （MACE） in patients with different severity of OSA. Results Five hundred and twenty nine patients were included in the final analysis, with 76% of them being men and an average age of 59 ＋ 10 years. The overall mean AHI is 29 ± 19 events/h, 70.5% of them （373/529） being with moderate to severe OSA and 29.5% （156/529） assign into control group. Compared with controls, patients with moderate or severe OSA exhibited a higher prevalence of hypertension as well as higher body mass index, SYNTAX score, Epworth score and length of hospitalization. With a median follow-up duration of 30 months, accumulative rate of MACE was also higher in patients with moderate or severe OSA than that in the control group （8.6% vs. 3.2%, P = 0.028）. After adjusting for baseline confounders by cox regression model, moderate to severe OSA was an independent risk factor of long-term MACE （P = 0.047, HR = 1.618, 95% CI： 1.069-3.869）. Conclusions The results of this study demonstrate that moderate or severe OSA is correlated with disease severity and associated with worse long-term prognosis in ACS patients. The results raising the possibility that early diagnose and interventions of OSA could improve long-term outcomes in ACS patients.展开更多
Energy efficiency(EE) of cellular networks has attracted considerable attention recently. However, EE of relay-assisted cellular networks where the macro base stations(MBSs) are equipped with the multi-antenna has not...Energy efficiency(EE) of cellular networks has attracted considerable attention recently. However, EE of relay-assisted cellular networks where the macro base stations(MBSs) are equipped with the multi-antenna has not been thoroughly addressed. This paper considered the downlink transmission of multi-antenna relay-assisted cellular networks, meanwhile, a strategic sleep scheme was used in relay stations(RSs), which dynamically adjusted the RS working mode according to whether the number of users serviced by the relay exceeds a given threshold. A geometric model was built to derive the coverage probability and mean achievable rate from the MBSs to user(UE), the MBS to RS, the RS to UE links and analyze the system EE. It is shown that the energy efficiency of cellular network with strategic sleep RS is slightly higher than that of cellular network with non-sleeping strategy. Furthermore, the MBS equipped with multi-antenna has better impact on energy efficiency and spectral efficiency than the MBS with single antenna.展开更多
文摘Background Obstructive sleep apnea （OSA） is a common disease in patients with acute coronary syndrome （ACS） and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients in previous study were treated with bare metal stents and the sample sizes were relatively low. The goal of this study was to evaluate the influence of OSA on the severity and prognosis of patients admitted for ACS. Methods In this prospective cohort study, we enrolled patients with ACS who were hospitalized for coronary angiogram/percutaneous coronary intervention and undergone polysomnography. We divided the patients into two groups： moderate to severe OSA group [apnea-hypopnea index （AHI） 〉 15 events/h] and control group （AHI ≤ 15 events/h）. They were followed up for up 32 months. Then, we compared the ACS severity and long-term major adverse cardiovascular events （MACE） in patients with different severity of OSA. Results Five hundred and twenty nine patients were included in the final analysis, with 76% of them being men and an average age of 59 ＋ 10 years. The overall mean AHI is 29 ± 19 events/h, 70.5% of them （373/529） being with moderate to severe OSA and 29.5% （156/529） assign into control group. Compared with controls, patients with moderate or severe OSA exhibited a higher prevalence of hypertension as well as higher body mass index, SYNTAX score, Epworth score and length of hospitalization. With a median follow-up duration of 30 months, accumulative rate of MACE was also higher in patients with moderate or severe OSA than that in the control group （8.6% vs. 3.2%, P = 0.028）. After adjusting for baseline confounders by cox regression model, moderate to severe OSA was an independent risk factor of long-term MACE （P = 0.047, HR = 1.618, 95% CI： 1.069-3.869）. Conclusions The results of this study demonstrate that moderate or severe OSA is correlated with disease severity and associated with worse long-term prognosis in ACS patients. The results raising the possibility that early diagnose and interventions of OSA could improve long-term outcomes in ACS patients.
基金partly supported by the National Natural Science Foundation of China (Grant No. 61371112, No.61701221 )the Jiangsu Natural Science Foundation (No. BK20160781)+2 种基金Jiangsu Higher Education Institutions Natural Science Foundation (No. 16KJB510013, 16KJB510038)the Research Innovation Project for College Graduates of Jiangsu Province (No. KYLX16_0662)the Natural Science Foundation of Nantong University Xinglin College (No. 2016K116)
文摘Energy efficiency(EE) of cellular networks has attracted considerable attention recently. However, EE of relay-assisted cellular networks where the macro base stations(MBSs) are equipped with the multi-antenna has not been thoroughly addressed. This paper considered the downlink transmission of multi-antenna relay-assisted cellular networks, meanwhile, a strategic sleep scheme was used in relay stations(RSs), which dynamically adjusted the RS working mode according to whether the number of users serviced by the relay exceeds a given threshold. A geometric model was built to derive the coverage probability and mean achievable rate from the MBSs to user(UE), the MBS to RS, the RS to UE links and analyze the system EE. It is shown that the energy efficiency of cellular network with strategic sleep RS is slightly higher than that of cellular network with non-sleeping strategy. Furthermore, the MBS equipped with multi-antenna has better impact on energy efficiency and spectral efficiency than the MBS with single antenna.
