Liver cancer,particularly hepatocellular carcinoma,remains a formidable challenge in medical research and requires a deeper understanding of its molecular underpinnings.In a fascinating recent study published in Milit...Liver cancer,particularly hepatocellular carcinoma,remains a formidable challenge in medical research and requires a deeper understanding of its molecular underpinnings.In a fascinating recent study published in Military Medical Research,Xiong et al.[1]revealed the complex roles of F-box and leucine-rich repeat 6(FBXL6)and Kirsten rat sarcoma(KRAS)^(G12D) in the pathogenesis of liver cancer.This research offers critical insights into how these proteins contribute to hepatocellular carcinoma development and progression,potentially paving the way for targeted therapeutic strategies.This commentary analyzes the key findings from this study and their broader implications in oncology.展开更多
The ^(12)C+^(12)C fusion is one of the most important reactions in modern nuclear astrophysics.The trend and magnitude of the reaction rate within the Gamow window strongly influence various astrophysical processes.Ho...The ^(12)C+^(12)C fusion is one of the most important reactions in modern nuclear astrophysics.The trend and magnitude of the reaction rate within the Gamow window strongly influence various astrophysical processes.However,direct measurement of this reaction is extremely difficult,which makes it necessary to develop indirect methods.In this study,the ^(23)Na+p reaction system was used to study the compound nucleus ^(24)Mg.We employed a thick-target inverse kinematics method combined with theγ-charged-particle coincidence technique to measure the proton andα exit channels of ^(24)Mg.Technical details of the ^(23)Na+p thick-target inverse kinematics experiment and analysis are presented herein.展开更多
基金supported by the National Natural Science Foundation of China(82271518,81971158,and 81671306)the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(JCRCFZ-2022-030)the Guiding Projects of Traditional Chinese Medicine in 2023–2024 by Hubei Provincial Administration of Traditional Chinese Medicine(ZY2023F038).
文摘Liver cancer,particularly hepatocellular carcinoma,remains a formidable challenge in medical research and requires a deeper understanding of its molecular underpinnings.In a fascinating recent study published in Military Medical Research,Xiong et al.[1]revealed the complex roles of F-box and leucine-rich repeat 6(FBXL6)and Kirsten rat sarcoma(KRAS)^(G12D) in the pathogenesis of liver cancer.This research offers critical insights into how these proteins contribute to hepatocellular carcinoma development and progression,potentially paving the way for targeted therapeutic strategies.This commentary analyzes the key findings from this study and their broader implications in oncology.
基金supported by the National Key Research and Development Project (No. 2022YFA1602301)the National Natural Science Foundation of China (Nos. U2267205, 12275361, 12125509, 12222514, 11961141003, and 12005304)+2 种基金the CAST Young Talent Support Planthe CNNC Science Fund for Talented Young Scholarsthe Continuous-Support Basic Scientific Research Project
文摘The ^(12)C+^(12)C fusion is one of the most important reactions in modern nuclear astrophysics.The trend and magnitude of the reaction rate within the Gamow window strongly influence various astrophysical processes.However,direct measurement of this reaction is extremely difficult,which makes it necessary to develop indirect methods.In this study,the ^(23)Na+p reaction system was used to study the compound nucleus ^(24)Mg.We employed a thick-target inverse kinematics method combined with theγ-charged-particle coincidence technique to measure the proton andα exit channels of ^(24)Mg.Technical details of the ^(23)Na+p thick-target inverse kinematics experiment and analysis are presented herein.
基金supported by the National Natural Science Foundation of China (50772107)National Key Basic Research Program of China (973)(2007CB210206)National High-Tech Research and Development Program of China (863) (2009AA05Z435)~~
基金The project was supported by the National Natural Science Foundation of China (50772107)National Key Basic Research Program of China (973)(2007CB210206)National High-Tech Research and Development Program of China (863) (2009AA05Z435)~~
文摘本文研究了HeLa细胞经过12C6+离子束辐照之后的DNA损伤效应,及辐照后p53激活的分子机制。运用中性单细胞电泳技术,检测了HeLa细胞经过4Gy 12C6+离子束辐照间隔0、3、6和12h之后DNA的损伤情况,及0.5、1、2和4Gy 12C6+离子束辐照后即时的DNA损伤情况。同时运用细胞生长实时监测仪监测了HeLa细胞在经过0、0.5和1Gy 12C6+离子束辐照之后的生长变化,并运用AO/EB双染检测了辐照细胞24h后的凋亡情况。另外,利用8mmol/L的咖啡因[抑制ATM(ataxia-telangiectasia,mutated)和ATR(ATM and Rad3-related kinase)]和20μmol/L的wortmannin[抑制ATM和DNA-PK(DNA-dependent protein kinase)]处理HeLa细胞后再进行1Gy 12C6+离子束辐照,通过westernblot检测p53的表达。结果显示,12C6+离子束辐照可造成HeLa细胞的DNA损伤,损伤随剂量升高而升高但随测定间隔时间降低,诱导HeLa细胞发生凋亡;而且辐照后p53表达升高。结果证明12C6+离子束辐照可造成HeLa细胞的DNA损伤并诱导损伤修复及凋亡等效应,损伤效应相关因子p53被激活,并且激活依赖于ATM。
