Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to asse...Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to assess this complex toxicity endpoint and will be valuable for screening emerging pollutants as well as for m anaging new chemicals in China.Currently,there are few published DART prediction models in China,but many related research and development projects are in progress.In 2013,WU et al.published an expert rule-based DART decision tree(DT).This DT relies on known chemical structures linked to DART to forecast DART potential of a given chemical.Within this procedure,an accurate DART data interpretation is the foundation of building and expanding the DT.This paper excerpted case studies demonstrating DART data curation and interpretation of four chemicals(including 8-hydroxyquinoline,3,5,6-trichloro-2-pyridinol,thiacloprid,and imidacloprid)to expand the existing DART DT.Chemicals were first selected from the database of Solid Waste and Chemicals Management Center,Ministry of Ecology and Environment(MEESCC)in China.The structures of these 4 chemicals were analyzed and preliminarily grouped by chemists based on core structural features,functional groups,receptor binding property,metabolism,and possible mode of actions.Then,the DART conclusion was derived by collecting chemical information,searching,integrating,and interpreting DART data by the toxicologists.Finally,these chemicals were classified into either an existing category or a new category via integrating their chemical features,DART conclusions,and biological properties.The results showed that 8-hydroxyquinoline impacted estrous cyclicity,s exual organ weights,and embryonal development,and 3,5,6-trichloro-2-pyridinol caused central nervous system(CNS)malformations,which were added to an existing subcategory 8e(aromatic compounds with multi-halogen and nitro groups)of the DT.Thiacloprid caused dystocia and fetal skeletal malformation,and imidacloprid disrupted the endocrine system and male fertility.They both contain 2-chloro-5-methylpyridine substituted imidazolidine c yclic ring,which were expected to create a new category of neonicotinoids.The current work delineates a t ransparent process of curating toxicological data for the purpose of DART data interpretation.In the presence of sufficient related structures and DART data,the DT can be expanded by iteratively adding chemicals within the a pplicable domain of each category or subcategory.This DT can potentially serve as a tool for screening emerging pollutants and assessing new chemicals in China.展开更多
Assessing the vulnerability of a platform is crucial in its design.In fact,the results obtained from vulnerability analyses provide valuable information,leading to precise design choices or corrective solutions that e...Assessing the vulnerability of a platform is crucial in its design.In fact,the results obtained from vulnerability analyses provide valuable information,leading to precise design choices or corrective solutions that enhance the platform's chances of surviving different scenarios.Such scenarios can involve various types of threats that can affect the platform's survivability.Among such,blast waves impacting the platform's structure represent critical conditions that have not yet been studied in detail.That is,frameworks for vulnerability assessment that can deal with blast loading have not been presented yet.In this context,this work presents a fast-running engineering tool that can quantify the risk that a structure fails when it is subjected to blast loading from the detonation of high explosive-driven threats detonating at various distances from the structure itself.The tool has been implemented in an in-house software that calculates vulnerability to various impacting objects,and its capabilities have been shown through a simplified,yet realistic,case study.The novelty of this research lies in the development of an integrated computational environment capable of calculating the platform's vulnerability to blast waves,without the need for running expensive finite element simulations.In fact,the proposed tool is fully based on analytical models integrated with a probabilistic approach for vulnerability calculation.展开更多
Efficient tool condition monitoring techniques help to realize intelligent management of tool life and reduce tool usage costs.In this paper,the influence of different wear degrees of ball-end milling cutters on the t...Efficient tool condition monitoring techniques help to realize intelligent management of tool life and reduce tool usage costs.In this paper,the influence of different wear degrees of ball-end milling cutters on the texture shape of machining tool marks is investigated,and a method is proposed for predicting the wear state(including the position and degree of tool wear)of ball-end milling cutters based on entropy measurement of tool mark texture images.Firstly,data samples are prepared through wear experiments,and the change law of the tool mark texture shape with the tool wear state is analyzed.Then,a two-dimensional sample entropy algorithm is developed to quantify the texture morphology.Finally,the processing parameters and tool attitude are integrated into the prediction process to predict the wear value and wear position of the ball end milling cutter.After testing,the correlation between the predicted value and the standard value of the proposed tool condition monitoring method reaches 95.32%,and the accuracy reaches 82.73%,indicating that the proposed method meets the requirement of tool condition monitoring.展开更多
To solve the scheduling problem of dual-armed cluster tools for wafer fabrications with residency time and reentrant constraints,a heuristic scheduling algorithm was developed.Firstly,on the basis of formulating sched...To solve the scheduling problem of dual-armed cluster tools for wafer fabrications with residency time and reentrant constraints,a heuristic scheduling algorithm was developed.Firstly,on the basis of formulating scheduling problems domain of dual-armed cluster tools,a non-integer programming model was set up with a minimizing objective function of the makespan.Combining characteristics of residency time and reentrant constraints,a scheduling algorithm of searching the optimal operation path of dual-armed transport module was presented under many kinds of robotic scheduling paths for dual-armed cluster tools.Finally,the experiments were designed to evaluate the proposed algorithm.The results show that the proposed algorithm is feasible and efficient for obtaining an optimal scheduling solution of dual-armed cluster tools with residency time and reentrant constraints.展开更多
The Mahalanobis distance features proposed by P.C.Mahalanobis, an Indian statistician, can be used in an automatic on-line cutting tool condition monitoring process based on digital image processing. In this paper, a ...The Mahalanobis distance features proposed by P.C.Mahalanobis, an Indian statistician, can be used in an automatic on-line cutting tool condition monitoring process based on digital image processing. In this paper, a new method of obtaining Mahalanobis distance features from a tool image is proposed. The key of calculating Mahalanobis distance is appropriately dividing the object into several component sets. Firstly, a technique is proposed that can automatically divide the component groups for calculating Mahalanobis distance based on the gray level of wearing or breakage regions in a tool image. The wearing region can be divided into high gray level component group and the tool-blade into low one. Then, the relation between Mahalanobis distance features of component groups and tool conditions is investigated. The results indicate that the high brightness region on the flank surface of the turning tool will change with its abrasion change and if the tool is heavily abraded, the area of high brightness will increase apparently. The Mahalanobis distance features of high gray level component group are related with wearing state of tool and low gray level component group correlated with breakage of tool. The experimental results show that the abrasion of the tool’s flank surface affected the Mahalanobis distances of high brightness component of the tool and the pixels of high brightness component set. Compared with the changes of them, we found that the Mahalanobis distance of high brightness component of the tool was more sensitive to the abrasion of cutting tool than the area of high brightness component set of the tool. Here we found that the relative changing rate of the area of high brightness component set was not quite obvious and it was ranging from 2% to 15%, while the relative changing rate of the Mahalanobis distance in table 1 ranges from 13.9% to 47%. It is 3 times higher than the changing rate of the area.展开更多
To improve the productivity of cluster tools in semiconductor fabrications,on the basis of stating scheduling problems,a try and error-based scheduling algorithm was proposed with residency time constraints and an obj...To improve the productivity of cluster tools in semiconductor fabrications,on the basis of stating scheduling problems,a try and error-based scheduling algorithm was proposed with residency time constraints and an objective of minimizing Makespan for the wafer jobs in cluster tools.Firstly,mathematical formulations of scheduling problems were presented by using assumptions and definitions of a scheduling domain.Resource conflicts were analyzed in the built scheduling model,and policies to solve resource conflicts were built.A scheduling algorithm was developed.Finally,the performances of the proposed algorithm were evaluated and compared with those of other methods by simulations.Experiment results indicate that the proposed algorithm is effective and practical in solving the scheduling problem of the cluster tools.展开更多
A new problem that classical statistical methods are incapable of solving is reliability modeling and assessment when multiple numerical control machine tools(NCMTs) reveal zero failures after a reliability test. Thus...A new problem that classical statistical methods are incapable of solving is reliability modeling and assessment when multiple numerical control machine tools(NCMTs) reveal zero failures after a reliability test. Thus, the zero-failure data form and corresponding Bayesian model are developed to solve the zero-failure problem of NCMTs, for which no previous suitable statistical model has been developed. An expert-judgment process that incorporates prior information is presented to solve the difficulty in obtaining reliable prior distributions of Weibull parameters. The equations for the posterior distribution of the parameter vector and the Markov chain Monte Carlo(MCMC) algorithm are derived to solve the difficulty of calculating high-dimensional integration and to obtain parameter estimators. The proposed method is applied to a real case; a corresponding programming code and trick are developed to implement an MCMC simulation in Win BUGS, and a mean time between failures(MTBF) of 1057.9 h is obtained. Given its ability to combine expert judgment, prior information, and data, the proposed reliability modeling and assessment method under the zero failure of NCMTs is validated.展开更多
文摘Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to assess this complex toxicity endpoint and will be valuable for screening emerging pollutants as well as for m anaging new chemicals in China.Currently,there are few published DART prediction models in China,but many related research and development projects are in progress.In 2013,WU et al.published an expert rule-based DART decision tree(DT).This DT relies on known chemical structures linked to DART to forecast DART potential of a given chemical.Within this procedure,an accurate DART data interpretation is the foundation of building and expanding the DT.This paper excerpted case studies demonstrating DART data curation and interpretation of four chemicals(including 8-hydroxyquinoline,3,5,6-trichloro-2-pyridinol,thiacloprid,and imidacloprid)to expand the existing DART DT.Chemicals were first selected from the database of Solid Waste and Chemicals Management Center,Ministry of Ecology and Environment(MEESCC)in China.The structures of these 4 chemicals were analyzed and preliminarily grouped by chemists based on core structural features,functional groups,receptor binding property,metabolism,and possible mode of actions.Then,the DART conclusion was derived by collecting chemical information,searching,integrating,and interpreting DART data by the toxicologists.Finally,these chemicals were classified into either an existing category or a new category via integrating their chemical features,DART conclusions,and biological properties.The results showed that 8-hydroxyquinoline impacted estrous cyclicity,s exual organ weights,and embryonal development,and 3,5,6-trichloro-2-pyridinol caused central nervous system(CNS)malformations,which were added to an existing subcategory 8e(aromatic compounds with multi-halogen and nitro groups)of the DT.Thiacloprid caused dystocia and fetal skeletal malformation,and imidacloprid disrupted the endocrine system and male fertility.They both contain 2-chloro-5-methylpyridine substituted imidazolidine c yclic ring,which were expected to create a new category of neonicotinoids.The current work delineates a t ransparent process of curating toxicological data for the purpose of DART data interpretation.In the presence of sufficient related structures and DART data,the DT can be expanded by iteratively adding chemicals within the a pplicable domain of each category or subcategory.This DT can potentially serve as a tool for screening emerging pollutants and assessing new chemicals in China.
文摘Assessing the vulnerability of a platform is crucial in its design.In fact,the results obtained from vulnerability analyses provide valuable information,leading to precise design choices or corrective solutions that enhance the platform's chances of surviving different scenarios.Such scenarios can involve various types of threats that can affect the platform's survivability.Among such,blast waves impacting the platform's structure represent critical conditions that have not yet been studied in detail.That is,frameworks for vulnerability assessment that can deal with blast loading have not been presented yet.In this context,this work presents a fast-running engineering tool that can quantify the risk that a structure fails when it is subjected to blast loading from the detonation of high explosive-driven threats detonating at various distances from the structure itself.The tool has been implemented in an in-house software that calculates vulnerability to various impacting objects,and its capabilities have been shown through a simplified,yet realistic,case study.The novelty of this research lies in the development of an integrated computational environment capable of calculating the platform's vulnerability to blast waves,without the need for running expensive finite element simulations.In fact,the proposed tool is fully based on analytical models integrated with a probabilistic approach for vulnerability calculation.
基金Project(51975169)supported by the National Natural Science Foundation of ChinaProject(LH2022E085)supported by the Natural Science Foundation of Heilongjiang Province,China。
文摘Efficient tool condition monitoring techniques help to realize intelligent management of tool life and reduce tool usage costs.In this paper,the influence of different wear degrees of ball-end milling cutters on the texture shape of machining tool marks is investigated,and a method is proposed for predicting the wear state(including the position and degree of tool wear)of ball-end milling cutters based on entropy measurement of tool mark texture images.Firstly,data samples are prepared through wear experiments,and the change law of the tool mark texture shape with the tool wear state is analyzed.Then,a two-dimensional sample entropy algorithm is developed to quantify the texture morphology.Finally,the processing parameters and tool attitude are integrated into the prediction process to predict the wear value and wear position of the ball end milling cutter.After testing,the correlation between the predicted value and the standard value of the proposed tool condition monitoring method reaches 95.32%,and the accuracy reaches 82.73%,indicating that the proposed method meets the requirement of tool condition monitoring.
基金Projects(7107111561273035)supported by the National Natural Science Foundation of China
文摘To solve the scheduling problem of dual-armed cluster tools for wafer fabrications with residency time and reentrant constraints,a heuristic scheduling algorithm was developed.Firstly,on the basis of formulating scheduling problems domain of dual-armed cluster tools,a non-integer programming model was set up with a minimizing objective function of the makespan.Combining characteristics of residency time and reentrant constraints,a scheduling algorithm of searching the optimal operation path of dual-armed transport module was presented under many kinds of robotic scheduling paths for dual-armed cluster tools.Finally,the experiments were designed to evaluate the proposed algorithm.The results show that the proposed algorithm is feasible and efficient for obtaining an optimal scheduling solution of dual-armed cluster tools with residency time and reentrant constraints.
文摘The Mahalanobis distance features proposed by P.C.Mahalanobis, an Indian statistician, can be used in an automatic on-line cutting tool condition monitoring process based on digital image processing. In this paper, a new method of obtaining Mahalanobis distance features from a tool image is proposed. The key of calculating Mahalanobis distance is appropriately dividing the object into several component sets. Firstly, a technique is proposed that can automatically divide the component groups for calculating Mahalanobis distance based on the gray level of wearing or breakage regions in a tool image. The wearing region can be divided into high gray level component group and the tool-blade into low one. Then, the relation between Mahalanobis distance features of component groups and tool conditions is investigated. The results indicate that the high brightness region on the flank surface of the turning tool will change with its abrasion change and if the tool is heavily abraded, the area of high brightness will increase apparently. The Mahalanobis distance features of high gray level component group are related with wearing state of tool and low gray level component group correlated with breakage of tool. The experimental results show that the abrasion of the tool’s flank surface affected the Mahalanobis distances of high brightness component of the tool and the pixels of high brightness component set. Compared with the changes of them, we found that the Mahalanobis distance of high brightness component of the tool was more sensitive to the abrasion of cutting tool than the area of high brightness component set of the tool. Here we found that the relative changing rate of the area of high brightness component set was not quite obvious and it was ranging from 2% to 15%, while the relative changing rate of the Mahalanobis distance in table 1 ranges from 13.9% to 47%. It is 3 times higher than the changing rate of the area.
基金Projects(71071115,60574054) supported by the National Natural Science Foundation of China
文摘To improve the productivity of cluster tools in semiconductor fabrications,on the basis of stating scheduling problems,a try and error-based scheduling algorithm was proposed with residency time constraints and an objective of minimizing Makespan for the wafer jobs in cluster tools.Firstly,mathematical formulations of scheduling problems were presented by using assumptions and definitions of a scheduling domain.Resource conflicts were analyzed in the built scheduling model,and policies to solve resource conflicts were built.A scheduling algorithm was developed.Finally,the performances of the proposed algorithm were evaluated and compared with those of other methods by simulations.Experiment results indicate that the proposed algorithm is effective and practical in solving the scheduling problem of the cluster tools.
基金Project(2014ZX04014-011)supported by State Key Science&Technology Program of ChinaProject([2016]414)supported by the 13th Five-year Program of Education Department of Jilin Province,China
文摘A new problem that classical statistical methods are incapable of solving is reliability modeling and assessment when multiple numerical control machine tools(NCMTs) reveal zero failures after a reliability test. Thus, the zero-failure data form and corresponding Bayesian model are developed to solve the zero-failure problem of NCMTs, for which no previous suitable statistical model has been developed. An expert-judgment process that incorporates prior information is presented to solve the difficulty in obtaining reliable prior distributions of Weibull parameters. The equations for the posterior distribution of the parameter vector and the Markov chain Monte Carlo(MCMC) algorithm are derived to solve the difficulty of calculating high-dimensional integration and to obtain parameter estimators. The proposed method is applied to a real case; a corresponding programming code and trick are developed to implement an MCMC simulation in Win BUGS, and a mean time between failures(MTBF) of 1057.9 h is obtained. Given its ability to combine expert judgment, prior information, and data, the proposed reliability modeling and assessment method under the zero failure of NCMTs is validated.
