As a typical sedimentary soft rock,mudstone has the characteristics of being easily softened and disintegrated under the effect of wetting and drying(WD).The first cycle of WD plays an important role in the entire WD ...As a typical sedimentary soft rock,mudstone has the characteristics of being easily softened and disintegrated under the effect of wetting and drying(WD).The first cycle of WD plays an important role in the entire WD cycles.X-ray micro-computed tomography(micro-CT)was used as a non-destructive tool to quantitatively analyze microstructural changes of the mudstone due to the first cycle of WD.The test results show that WD leads to an increase of pore volume and pore connectivity in the mudstone.The porosity and fractal dimension of each slice of mudstone not only increase in value,but also in fluctuation amplitude.The pattern of variation in the frequency distribution of the equivalent radii of connected,isolated pores and pore throats in mudstone under WD effect satisfies the Gaussian distribution.Under the effect of WD,pores and pore throats with relatively small sizes increase the most.The sphericity of the pores in mudstones is positively correlated with the pore radius.The WD effect transforms the originally angular and flat pores into round and regular pores.This paper can provide a reference for the study of the deterioration and catastrophic mechanisms of mudstone under wetting and drying cycles.展开更多
As a negative electrode material for lithium-ion batteries,silicon monoxide(SiO)suffers from dramatic volume changes during cycling,causing excessive stress within the electrode and resulting in electrode deformation ...As a negative electrode material for lithium-ion batteries,silicon monoxide(SiO)suffers from dramatic volume changes during cycling,causing excessive stress within the electrode and resulting in electrode deformation and fragmentation.This ultimately leads to a decrease in cell capacity.The trends of volume expansion and capacity change of the SiO/graphite(SiO/C)composite electrode during cycling were investigated via in situ expansion monitoring.First,a series of expansion test schemes were designed,and the linear relationship between negative electrode expansion and cell capacity degradation was quantitatively analyzed.Then,the effects of different initial pressures on the long-term cycling performance of the cell were evaluated.Finally,the mechanism of their effects was analyzed by scanning electron microscope.The results show that after 50 cycles,the cell capacity decreases from 2.556 mAh to 1.689 mAh,with a capacity retention ratio(CRR)of only 66.08%.A linear relationship between the capacity retention ratio and thickness expansion was found.Electrochemical measurements and scanning electron microscope images demonstrate that intense stress inhibits the lithiation of the negative electrode and that the electrode is more susceptible to irreversible damage during cycling.Overall,these results reveal the relationship between the cycling performance of SiO and the internal pressure of the electrode from a macroscopic point of view,which provides some reference for the application of SiO/C composite electrodes in lithium-ion batteries.展开更多
Lithium nickel oxide(Li_(2)NiO_(2)),as a sacrificial cathode prelithiation additive,has been used to compensate for the lithium loss for improving the lifespan of lithium-ion batteries(LIBs).However,high-cost Li_(2)Ni...Lithium nickel oxide(Li_(2)NiO_(2)),as a sacrificial cathode prelithiation additive,has been used to compensate for the lithium loss for improving the lifespan of lithium-ion batteries(LIBs).However,high-cost Li_(2)NiO_(2)suffers from inferior delithiation kinetics during the first cycle.Herein,we investigated the effects of the cost-effective copper substituted Li_(2)Ni_(1-x)Cu_(x)O_(2)(x=0,0.2,0.3,0.5,0.7)synthesized by a high-temperature solid-phase method on the structure,morphology,electrochemical performance of graphite‖LiFePO_(4)battery.The X-ray diffraction(XRD)refinement result demonstrated that Cu substitution strategy could be favorable for eliminating the NiO_(x)impurity phase and weakening Li-O bond.Analysis on density of states(DOS)indicates that Cu substitution is good for enhancing the electronic conductivity,as well as reducing the delithi-ation voltage polarization confirmed by electrochemical characterizations.Therefore,the optimal Li_(2)Ni_(0.7)Cu_(0.3)O_(2)delivered a high delithiation capacity of 437 mAh·g^(-1),around 8%above that of the pristine Li_(2)NiO_(2).Furthermore,a graphite‖LiFePO_(4)pouch cell with a nominal capacity of 3000 mAh demonstrated a notably improved reversible capacity,energy density and cycle life through introducing 2 wt%Li_(2)Ni_(0.7)Cu_(0.3)O_(2)additive,delivering a 6.2 mAh·g^(-1)higher initial discharge capacity and achieving around 5%improvement in capacity retentnion at 0.5P over 1000 cycles.Additionally,the post-mortem analyses testified that the Li_(2)Ni_(0.7)Cu_(0.3)O_(2)additive could suppress solid electrolyte interphase(SEI)decomposition and homogenize the Li distribution,which benefits to stabilizing interface between graphite and electrolyte,and alleviating dendritic Li plating.In conclusion,the Li_(2)Ni_(0.7)Cu_(0.3)O_(2)additive may offer advantages such as lower cost,lower delithiation voltage and higher prelithiation capacity compared with Li_(2)NiO_(2),making it a promising candidate of cathode prelithiation additive for next-generation LIBs.展开更多
It is quite complex to evaluate the mechanism of action for antitumor drugs on cancer cells.Studies have pointed out that there is an unique advantage of Fourier transform infrared spectrum to obtain a fingerprint of ...It is quite complex to evaluate the mechanism of action for antitumor drugs on cancer cells.Studies have pointed out that there is an unique advantage of Fourier transform infrared spectrum to obtain a fingerprint of all molecules present in the cells when cancer cells were exposed to anti-cancer drugs.Trichostatin A(TSA) is a most potent reversible inhibitor of mammalian histone deacetylases.It can inhibit cancer cell growth in vitro and in vivo.In the present study,HeLa cells were exposed to 0,50,100,200,300 and 400 nmol·L-1 TSA,and FTIR spectra were applied to evaluate the effect of TSA on cancer cells.Results show that there is some significant relationship between the changes in FTIR absorption and cell cycle arresting.On the other hand,this investigation shows that the concentration of TSA had to be more than 200 nmol·L-1 in order to ensure A1 080 cm-1/A1 540 cm-1≥1 for inhibiting cell proliferation.展开更多
Crystalline@amorphous NiCo_(2)S_(4)@MoS_(2)(v-NCS@MS)nanostructures were designed and constructed via an ethylene glycol-induced strategy with hydrothermal synthesis and solvothermal method,which simultaneously realiz...Crystalline@amorphous NiCo_(2)S_(4)@MoS_(2)(v-NCS@MS)nanostructures were designed and constructed via an ethylene glycol-induced strategy with hydrothermal synthesis and solvothermal method,which simultaneously realized the defect regulation of crystal NiCo_(2)S_(4) in the core.Taking advantage of the flexible protection of an amor-phous shell and the high capacity of a conductive core with defects,the v-NCS@MS electrode exhibited high specif-ic capacity(1034 mAh·g^(-1) at 1 A·g^(-1))and outstanding rate capability.Moreover,a hybrid supercapacitor was assembled with v-NCS@MS as cathode and activated carbon(AC)as anode,which can achieve remarkably high specific energy of 111 Wh·kg^(-1) at a specific power of 219 W·kg^(-1) and outstanding capacity retention of 80.5%after 15000 cycling at different current densities.展开更多
The effect of freeze-thaw(F-T)cycles on the mechanical behaviors and internal mechanism of rock mass is a critical research topic.In permafrost or seasonally frozen regions,F-T cycles have adverse effects on the mecha...The effect of freeze-thaw(F-T)cycles on the mechanical behaviors and internal mechanism of rock mass is a critical research topic.In permafrost or seasonally frozen regions,F-T cycles have adverse effects on the mechanical properties of rock mass,leading to many serious disasters in mining and geotechnical operations.In this paper,uniaxial compression tests are carried out on cyan sandstone after different F-T cycles.The failure modes and damage evolution of cyan sandstone under F-T cycles are studied.In addition,from the perspective of fracture and pore volume,the calculation equations of rock strain under frost heaving pressure and F-T cycles are established and verified with the corresponding laboratory tests.Subsequently,based on the classical damage theory,the F-T damage variables of cyan sandstone under different F-T cycles are calculated,and the meso-damage calculation model of cyan sandstone under F-T-loading coupling conditions is derived.Furthermore,through the discrete element numerical simulation software(PFC^(3D)),the microscopic damage evolution process of cyan sandstone under uniaxial compression after F-T cycles is studied,including the change of microcracks number,distribution of microcracks,and the acoustic emission(AE)count.The goal of this study is to investigate the damage evolution mechanism of rock from the mesoscopic and microscopic aspects,which has certain guiding value for accurately understanding the damage characteristics of rock in cold regions.展开更多
Organic Rankine cycle(ORC) is applicable for the heat-work conversion. Whereas, there also exist a lot issues that influence the efficiency and the cost of the system. In this work, eleven pure working fluids(as categ...Organic Rankine cycle(ORC) is applicable for the heat-work conversion. Whereas, there also exist a lot issues that influence the efficiency and the cost of the system. In this work, eleven pure working fluids(as categorized into alkanes, and fluorinated alkanes) are investigated based on the first and second law of thermodynamics. The major objective is to obtain the most suitable working fluid for the latent heat source. The results show that the working fluid is an important factor of the system performance. The heat absorption of the working fluid in the evaporator is inversely proportional to the evaporating temperature, but the thermal and exergetic efficiencies are just the opposite. RC318 has the highest net power output and the lowest outlet temperature of the heat source, but its global warming potential(GWP) value is too high. The cyclohexane shows the highest thermal efficiency among the fluids investigated. Moreover, the figure of merit(FOM) of the isobutane is higher than that of other working fluids. Overall, the cyclohexane shows that the optimal comprehensive performance is more feasible for medium grade heat source in engineering applications.展开更多
A simplified dual-pressure ammonia-water absorption power cycle(DPAPC-a) using low grade energy resources is presented and analyzed.This cycle uses turbine exhaust heat to distill the basic solution for desorption.The...A simplified dual-pressure ammonia-water absorption power cycle(DPAPC-a) using low grade energy resources is presented and analyzed.This cycle uses turbine exhaust heat to distill the basic solution for desorption.The structure of the cycle is simple which comprises evaporator,turbine,regenerator(desorber),absorber,pump and throttle valves for both diluted solution and vapor.And it is of high efficiency,because the working medium has large temperature difference in evaporation and small temperature difference in absorptive condensation,which can match the sensible exothermal heat resource and the cooling water simultaneously.Orthogonal calculation was made to investigate the influence of the working concentration,the basic concentration and the circulation multiple on the cycle performance,with 85-110 ℃ heat resource and 20-32 ℃ cooling water.An optimum scheme was given in the condition of 110 ℃ sensitive heat resource and 20 ℃ cooling water,with the working concentration of 0.6,basic concentration of 0.385,and circulation multiple of 5.The thermal efficiency and the power recovery efficiency are 8.06 % and 6.66%,respectively.The power recovery efficiency of the DPAPC-a is 28.8% higher than that of the steam Rankine cycle(SRC) and 12.7% higher than that of ORC(R134a) under the optimized situation.展开更多
心脏磁共振成像(cardiac magnetic resonance,CMR)过程中患者误动、异常幅度的呼吸运动、心律失常会造成CMR图像质量下降,为解决现有的CMR图像增强网络需要人为制作配对数据,且图像增强后部分组织纹理细节丢失的问题,提出了基于空频域...心脏磁共振成像(cardiac magnetic resonance,CMR)过程中患者误动、异常幅度的呼吸运动、心律失常会造成CMR图像质量下降,为解决现有的CMR图像增强网络需要人为制作配对数据,且图像增强后部分组织纹理细节丢失的问题,提出了基于空频域特征学习的循环一致性生成对抗网络(cycle-consistent generative adversavial network based on spatial-frequency domain feature learning,SFFL-CycleGAN).研究结果表明,该网络无须人为制作配对数据集,增强后的CMR图像组织纹理细节丰富,在结构相似度(structural similarity,SSIM)和峰值信噪比(peak signal to noise ratio,PSNR)等方面均优于现有的配对训练网络以及原始的CycleGAN网络,图像增强效果好,有效助力病情诊断.展开更多
In order to improve the efficiency of a geothermal power plant, oil wells in the high water cut stage were used as geothermal wells, thereby improving the recovery ratio and economic benefit. A new function that refle...In order to improve the efficiency of a geothermal power plant, oil wells in the high water cut stage were used as geothermal wells, thereby improving the recovery ratio and economic benefit. A new function that reflects both the technical and economic performances was put forward and used as the objective function. An organic Rankine cycle (ORC) was analyzed through the energetic and exergetic analyses, and the reasons for low efficiency were pinpointed. Results indicate that geothermal water directly transferring heat to the working fluid reduces energy dissipation and increases cycle efficiencies. The net power output with an internal heat exchanger (IHE) is averagely 5.3% higher than that without an IHE. R601a and R601 can be used to replace R123 for geothermal water below 110℃. Moreover, the modified ORC dramatically outperforms the actual one.展开更多
Organic Rankine cycle(ORC)is widely used for the low grade geothermal power generation.However,a large amount of irreversible loss results in poor technical and economic performance due to its poor matching between th...Organic Rankine cycle(ORC)is widely used for the low grade geothermal power generation.However,a large amount of irreversible loss results in poor technical and economic performance due to its poor matching between the heat source/sink and the working medium in the condenser and the evaporator.The condensing temperature,cooling water temperature difference and pinch point temperature difference are often fixed according to engineering experience.In order to optimize the ORC system comprehensively,the coupling effect of evaporation and condensation process was proposed in this paper.Based on the laws of thermodynamics,the energy analysis,exergy analysis and entropy analysis were adopted to investigate the ORC performance including net output power,thermal efficiency,exergy efficiency,thermal conductivity,irreversible loss,etc.,using geothermal water at a temperature of 120℃as the heat source and isobutane as the working fluid.The results show that there exists a pair of optimal evaporating temperature and condensing temperatures to maximize the system performance.The net power output and the system comprehensive performance achieve their highest values at the same evaporating temperature,but the system comprehensive performance corresponds to a lower condensing temperature than the net power output.展开更多
Oxy fuel combustion and conventional cycle(currently working cycle) in Kazeroon plant are modeled using commercial thermodynamic modeling software. Economic evaluation of the two models regarding the resources of tran...Oxy fuel combustion and conventional cycle(currently working cycle) in Kazeroon plant are modeled using commercial thermodynamic modeling software. Economic evaluation of the two models regarding the resources of transport and injection of carbon dioxide into oil fields at Gachsaran for enhanced oil recovery in the various oil price indices is conducted and indices net present value(NPV) and internal rate of return on investment(IRR) are calculated. The results of the two models reveal that gross efficiency of the oxy fuel cycle is more than reference cycle(62% compared to 49.03%), but the net efficiency is less(41.85% compared to 47.92%) because of the high-energy consumption of the components, particularly air separation unit(ASU) in the oxy fuel cycle. In this model, pure carbon dioxide with pressure of 20×105 Pa and purity of 96.84% was captured. NOX emissions also decrease by 4289.7 tons per year due to separation of nitrogen in ASU. In this model, none of the components of oxy fuel cycle is a major engineering challenge. With increasing oil price, economic justification of oxy fuel combustion model increases. With the price of oil at $ 80 per barrel in mind and $ 31 per ton fines for emissions of carbon dioxide in the atmosphere, IRR is the same for both models.展开更多
The experimental tests of tensile for lead-flee solder Sn-3.5Ag were performed for the general work temperatures range from 11 to 90 ℃ and strain rate range from 5 × 10^-5 to 2 × 10^-2s^-1, and its stress--...The experimental tests of tensile for lead-flee solder Sn-3.5Ag were performed for the general work temperatures range from 11 to 90 ℃ and strain rate range from 5 × 10^-5 to 2 × 10^-2s^-1, and its stress--strain curves were compared to those of solder Sn-37Pb. The parameters in Anand model for solder Sn-3.5Ag were fitted based on experimental data and nonlinear fitting method, and its validity was checked by means of experimental data. Furthermore, the Anand model was used in the FEM analysis to evaluate solder joint thermal cycle reliability. The results show that solder Sn-3.5Ag has a better creep resistance than solder Sn-37Pb. The maximum stress is located at the upper right comer of the outmost solder joint from the symmetric center, and thermal fatigue life is predicted to be 3.796 × 10^4 cycles under the calculated conditions.展开更多
The life cycle of CIMS (Computer Integrated Manufacturing System) includes four phases:requirement analyzing, designing, implementation and running. For reducing the risk of investment and achieving better economic re...The life cycle of CIMS (Computer Integrated Manufacturing System) includes four phases:requirement analyzing, designing, implementation and running. For reducing the risk of investment and achieving better economic results the simulation technique is needed in the above four phases of CIMS life cycle. Under the support of China 863/CIMS plan a series of simulation projects are established. Some of them are finished with succeed and have been used in application. In this paper four simulation projects are introduced.(1) The Integrated Manufacturing Simulation Software (IMSS). It is an integrated platform, based on the discrete event simulation principle. It can be used to analyze and design CIMS, especially FMS; and evaluate the daily production plan.(2) The Advanced Hierarchical Control System Emulator (AHCSE), a software system, based on the finite state machine principle. It can be used to analyze and design of CIMS hicrarchical control system, and check expanded system performance before expanding.(3) The Factory Scheduling Environment (FASE), a software system based on the discrete event simulation principle and artificial intelligence technology. It can be used for shop floor scheduling. (4) The Machining Process Simulator (MPS). It can simulate the machining process of machining center by computer. It can check the correctness of NC code (including interference and confliction) and replace the real machining center to support the simulation environment for shop floor scheduling and controlling. There are three companies and universities joining in these four projects, they are: Tsinghua University,Huazhong University of Technology, Beliing Institute of Computer Application and Simulation.展开更多
A comparison on subcritical and transcritical organic Rankine cycle（ORC） system with a heat source of 110 ℃ geothermal water was presented. The net power output, thermal and exergy efficiencies and the products of ...A comparison on subcritical and transcritical organic Rankine cycle（ORC） system with a heat source of 110 ℃ geothermal water was presented. The net power output, thermal and exergy efficiencies and the products of the heat transfer coefficient（U） and the total heat exchange area（A）（UA values） were calculated for parametric optimization. Nine candidate working fluids were investigated and compared. Under the given conditions, transcritical systems have higher net power outputs than subcritical ones. The highest net power output of transcritical systems is 18.63 k W obtained by R218, and that of subcritical systems is 13.57 k W obtained by R600 a. Moreover, with the increase of evaporating pressure, the thermal and exergy efficiencies of transcritical systems increase at first and then decrease, but the efficiencies of subcritical ones increase. As a result, the efficiencies of transcritical systems cannot always outperform those of the subcritical ones. However, the subcritical systems have lower minimum UA values and lower expansion ratios than the transcritical ones at the maximum net power output. In addition, the transcritical cycles have higher expansion ratios than the subcritical ones at their maximum net power output.展开更多
There have been a number of applications of satellite altimetry to seasonal and interannual sea level variability in the South China Sea. However, these applications usually exclude shallow waters along the coast, wit...There have been a number of applications of satellite altimetry to seasonal and interannual sea level variability in the South China Sea. However, these applications usually exclude shallow waters along the coast, with one of the concerns being large aliased tide-correction error. In this study the authors analyzed 14 years of merged satellite altimeter data to obtain the amplitude and phase of the semi-annual cycle and to examine the variation at the K1 alias frequency (close to the semi-annual frequency). The results indicate that the amplitude of the semi-annual cycle ranges from 3-7 cm, substantial compared with that of the annual cycle; while the amplitude at the K1 alias frequency (error of the K1 tidal correction) is essentially 1 cm only. Altimeter-derived semi-annual cycle is in good agreement with that from independent tide-gauge observations, pointing to the competent ability of satellite altimetry in observing semi-annual sea level variations in the South China Sea.展开更多
Background and Objective Lung cancer is the rst killer of human being in the whole world. Recently, although many treatment strategies have been developed, the anti-cancer effects
基金Project(41877240)supported by the National Natural Science Foundation of China。
文摘As a typical sedimentary soft rock,mudstone has the characteristics of being easily softened and disintegrated under the effect of wetting and drying(WD).The first cycle of WD plays an important role in the entire WD cycles.X-ray micro-computed tomography(micro-CT)was used as a non-destructive tool to quantitatively analyze microstructural changes of the mudstone due to the first cycle of WD.The test results show that WD leads to an increase of pore volume and pore connectivity in the mudstone.The porosity and fractal dimension of each slice of mudstone not only increase in value,but also in fluctuation amplitude.The pattern of variation in the frequency distribution of the equivalent radii of connected,isolated pores and pore throats in mudstone under WD effect satisfies the Gaussian distribution.Under the effect of WD,pores and pore throats with relatively small sizes increase the most.The sphericity of the pores in mudstones is positively correlated with the pore radius.The WD effect transforms the originally angular and flat pores into round and regular pores.This paper can provide a reference for the study of the deterioration and catastrophic mechanisms of mudstone under wetting and drying cycles.
基金supported by the Fundamental Research Funds for the Central Universities(WK2090000055)Anhui Provincial Natural Science Foundation of China(2308085QG231).
文摘As a negative electrode material for lithium-ion batteries,silicon monoxide(SiO)suffers from dramatic volume changes during cycling,causing excessive stress within the electrode and resulting in electrode deformation and fragmentation.This ultimately leads to a decrease in cell capacity.The trends of volume expansion and capacity change of the SiO/graphite(SiO/C)composite electrode during cycling were investigated via in situ expansion monitoring.First,a series of expansion test schemes were designed,and the linear relationship between negative electrode expansion and cell capacity degradation was quantitatively analyzed.Then,the effects of different initial pressures on the long-term cycling performance of the cell were evaluated.Finally,the mechanism of their effects was analyzed by scanning electron microscope.The results show that after 50 cycles,the cell capacity decreases from 2.556 mAh to 1.689 mAh,with a capacity retention ratio(CRR)of only 66.08%.A linear relationship between the capacity retention ratio and thickness expansion was found.Electrochemical measurements and scanning electron microscope images demonstrate that intense stress inhibits the lithiation of the negative electrode and that the electrode is more susceptible to irreversible damage during cycling.Overall,these results reveal the relationship between the cycling performance of SiO and the internal pressure of the electrode from a macroscopic point of view,which provides some reference for the application of SiO/C composite electrodes in lithium-ion batteries.
基金supported by the Significant Science and Technology Project in Xiamen(Future Industry Field)(Grant No.3502Z20231057).
文摘Lithium nickel oxide(Li_(2)NiO_(2)),as a sacrificial cathode prelithiation additive,has been used to compensate for the lithium loss for improving the lifespan of lithium-ion batteries(LIBs).However,high-cost Li_(2)NiO_(2)suffers from inferior delithiation kinetics during the first cycle.Herein,we investigated the effects of the cost-effective copper substituted Li_(2)Ni_(1-x)Cu_(x)O_(2)(x=0,0.2,0.3,0.5,0.7)synthesized by a high-temperature solid-phase method on the structure,morphology,electrochemical performance of graphite‖LiFePO_(4)battery.The X-ray diffraction(XRD)refinement result demonstrated that Cu substitution strategy could be favorable for eliminating the NiO_(x)impurity phase and weakening Li-O bond.Analysis on density of states(DOS)indicates that Cu substitution is good for enhancing the electronic conductivity,as well as reducing the delithi-ation voltage polarization confirmed by electrochemical characterizations.Therefore,the optimal Li_(2)Ni_(0.7)Cu_(0.3)O_(2)delivered a high delithiation capacity of 437 mAh·g^(-1),around 8%above that of the pristine Li_(2)NiO_(2).Furthermore,a graphite‖LiFePO_(4)pouch cell with a nominal capacity of 3000 mAh demonstrated a notably improved reversible capacity,energy density and cycle life through introducing 2 wt%Li_(2)Ni_(0.7)Cu_(0.3)O_(2)additive,delivering a 6.2 mAh·g^(-1)higher initial discharge capacity and achieving around 5%improvement in capacity retentnion at 0.5P over 1000 cycles.Additionally,the post-mortem analyses testified that the Li_(2)Ni_(0.7)Cu_(0.3)O_(2)additive could suppress solid electrolyte interphase(SEI)decomposition and homogenize the Li distribution,which benefits to stabilizing interface between graphite and electrolyte,and alleviating dendritic Li plating.In conclusion,the Li_(2)Ni_(0.7)Cu_(0.3)O_(2)additive may offer advantages such as lower cost,lower delithiation voltage and higher prelithiation capacity compared with Li_(2)NiO_(2),making it a promising candidate of cathode prelithiation additive for next-generation LIBs.
基金This research work was supported by the National Natural Science Funds of China(30800204)
文摘It is quite complex to evaluate the mechanism of action for antitumor drugs on cancer cells.Studies have pointed out that there is an unique advantage of Fourier transform infrared spectrum to obtain a fingerprint of all molecules present in the cells when cancer cells were exposed to anti-cancer drugs.Trichostatin A(TSA) is a most potent reversible inhibitor of mammalian histone deacetylases.It can inhibit cancer cell growth in vitro and in vivo.In the present study,HeLa cells were exposed to 0,50,100,200,300 and 400 nmol·L-1 TSA,and FTIR spectra were applied to evaluate the effect of TSA on cancer cells.Results show that there is some significant relationship between the changes in FTIR absorption and cell cycle arresting.On the other hand,this investigation shows that the concentration of TSA had to be more than 200 nmol·L-1 in order to ensure A1 080 cm-1/A1 540 cm-1≥1 for inhibiting cell proliferation.
文摘Crystalline@amorphous NiCo_(2)S_(4)@MoS_(2)(v-NCS@MS)nanostructures were designed and constructed via an ethylene glycol-induced strategy with hydrothermal synthesis and solvothermal method,which simultaneously realized the defect regulation of crystal NiCo_(2)S_(4) in the core.Taking advantage of the flexible protection of an amor-phous shell and the high capacity of a conductive core with defects,the v-NCS@MS electrode exhibited high specif-ic capacity(1034 mAh·g^(-1) at 1 A·g^(-1))and outstanding rate capability.Moreover,a hybrid supercapacitor was assembled with v-NCS@MS as cathode and activated carbon(AC)as anode,which can achieve remarkably high specific energy of 111 Wh·kg^(-1) at a specific power of 219 W·kg^(-1) and outstanding capacity retention of 80.5%after 15000 cycling at different current densities.
基金Projects(52474167,52104109)supported by the National Natural Science Foundation of ChinaProject(2022JJ40602)supported by the Natural Science Foundation of Hunan Province,China。
文摘The effect of freeze-thaw(F-T)cycles on the mechanical behaviors and internal mechanism of rock mass is a critical research topic.In permafrost or seasonally frozen regions,F-T cycles have adverse effects on the mechanical properties of rock mass,leading to many serious disasters in mining and geotechnical operations.In this paper,uniaxial compression tests are carried out on cyan sandstone after different F-T cycles.The failure modes and damage evolution of cyan sandstone under F-T cycles are studied.In addition,from the perspective of fracture and pore volume,the calculation equations of rock strain under frost heaving pressure and F-T cycles are established and verified with the corresponding laboratory tests.Subsequently,based on the classical damage theory,the F-T damage variables of cyan sandstone under different F-T cycles are calculated,and the meso-damage calculation model of cyan sandstone under F-T-loading coupling conditions is derived.Furthermore,through the discrete element numerical simulation software(PFC^(3D)),the microscopic damage evolution process of cyan sandstone under uniaxial compression after F-T cycles is studied,including the change of microcracks number,distribution of microcracks,and the acoustic emission(AE)count.The goal of this study is to investigate the damage evolution mechanism of rock from the mesoscopic and microscopic aspects,which has certain guiding value for accurately understanding the damage characteristics of rock in cold regions.
基金Project(51406130) supported by the National Natural Science Foundation of China
文摘Organic Rankine cycle(ORC) is applicable for the heat-work conversion. Whereas, there also exist a lot issues that influence the efficiency and the cost of the system. In this work, eleven pure working fluids(as categorized into alkanes, and fluorinated alkanes) are investigated based on the first and second law of thermodynamics. The major objective is to obtain the most suitable working fluid for the latent heat source. The results show that the working fluid is an important factor of the system performance. The heat absorption of the working fluid in the evaporator is inversely proportional to the evaporating temperature, but the thermal and exergetic efficiencies are just the opposite. RC318 has the highest net power output and the lowest outlet temperature of the heat source, but its global warming potential(GWP) value is too high. The cyclohexane shows the highest thermal efficiency among the fluids investigated. Moreover, the figure of merit(FOM) of the isobutane is higher than that of other working fluids. Overall, the cyclohexane shows that the optimal comprehensive performance is more feasible for medium grade heat source in engineering applications.
基金Project(50976022) supported by the National Natural Science Foundation of ChinaProject(BY2011155) supported by Science and Technology Innovation and Transformation of Achievements of Special Fund of Jiangsu Province, China
文摘A simplified dual-pressure ammonia-water absorption power cycle(DPAPC-a) using low grade energy resources is presented and analyzed.This cycle uses turbine exhaust heat to distill the basic solution for desorption.The structure of the cycle is simple which comprises evaporator,turbine,regenerator(desorber),absorber,pump and throttle valves for both diluted solution and vapor.And it is of high efficiency,because the working medium has large temperature difference in evaporation and small temperature difference in absorptive condensation,which can match the sensible exothermal heat resource and the cooling water simultaneously.Orthogonal calculation was made to investigate the influence of the working concentration,the basic concentration and the circulation multiple on the cycle performance,with 85-110 ℃ heat resource and 20-32 ℃ cooling water.An optimum scheme was given in the condition of 110 ℃ sensitive heat resource and 20 ℃ cooling water,with the working concentration of 0.6,basic concentration of 0.385,and circulation multiple of 5.The thermal efficiency and the power recovery efficiency are 8.06 % and 6.66%,respectively.The power recovery efficiency of the DPAPC-a is 28.8% higher than that of the steam Rankine cycle(SRC) and 12.7% higher than that of ORC(R134a) under the optimized situation.
文摘心脏磁共振成像(cardiac magnetic resonance,CMR)过程中患者误动、异常幅度的呼吸运动、心律失常会造成CMR图像质量下降,为解决现有的CMR图像增强网络需要人为制作配对数据,且图像增强后部分组织纹理细节丢失的问题,提出了基于空频域特征学习的循环一致性生成对抗网络(cycle-consistent generative adversavial network based on spatial-frequency domain feature learning,SFFL-CycleGAN).研究结果表明,该网络无须人为制作配对数据集,增强后的CMR图像组织纹理细节丰富,在结构相似度(structural similarity,SSIM)和峰值信噪比(peak signal to noise ratio,PSNR)等方面均优于现有的配对训练网络以及原始的CycleGAN网络,图像增强效果好,有效助力病情诊断.
基金Project(2012AA052804) supported by the National High Technology Research and Development Program of China
文摘In order to improve the efficiency of a geothermal power plant, oil wells in the high water cut stage were used as geothermal wells, thereby improving the recovery ratio and economic benefit. A new function that reflects both the technical and economic performances was put forward and used as the objective function. An organic Rankine cycle (ORC) was analyzed through the energetic and exergetic analyses, and the reasons for low efficiency were pinpointed. Results indicate that geothermal water directly transferring heat to the working fluid reduces energy dissipation and increases cycle efficiencies. The net power output with an internal heat exchanger (IHE) is averagely 5.3% higher than that without an IHE. R601a and R601 can be used to replace R123 for geothermal water below 110℃. Moreover, the modified ORC dramatically outperforms the actual one.
基金Project(2018YFB1501805)supported by the National Key Research and Development Program of ChinaProject(51406130)supported by the National Natural Science Foundation of ChinaProject(201604-504)supported by the Key Laboratory of Efficient Utilization of Low and Medium Grade Energy(Tianjin University),China
文摘Organic Rankine cycle(ORC)is widely used for the low grade geothermal power generation.However,a large amount of irreversible loss results in poor technical and economic performance due to its poor matching between the heat source/sink and the working medium in the condenser and the evaporator.The condensing temperature,cooling water temperature difference and pinch point temperature difference are often fixed according to engineering experience.In order to optimize the ORC system comprehensively,the coupling effect of evaporation and condensation process was proposed in this paper.Based on the laws of thermodynamics,the energy analysis,exergy analysis and entropy analysis were adopted to investigate the ORC performance including net output power,thermal efficiency,exergy efficiency,thermal conductivity,irreversible loss,etc.,using geothermal water at a temperature of 120℃as the heat source and isobutane as the working fluid.The results show that there exists a pair of optimal evaporating temperature and condensing temperatures to maximize the system performance.The net power output and the system comprehensive performance achieve their highest values at the same evaporating temperature,but the system comprehensive performance corresponds to a lower condensing temperature than the net power output.
文摘Oxy fuel combustion and conventional cycle(currently working cycle) in Kazeroon plant are modeled using commercial thermodynamic modeling software. Economic evaluation of the two models regarding the resources of transport and injection of carbon dioxide into oil fields at Gachsaran for enhanced oil recovery in the various oil price indices is conducted and indices net present value(NPV) and internal rate of return on investment(IRR) are calculated. The results of the two models reveal that gross efficiency of the oxy fuel cycle is more than reference cycle(62% compared to 49.03%), but the net efficiency is less(41.85% compared to 47.92%) because of the high-energy consumption of the components, particularly air separation unit(ASU) in the oxy fuel cycle. In this model, pure carbon dioxide with pressure of 20×105 Pa and purity of 96.84% was captured. NOX emissions also decrease by 4289.7 tons per year due to separation of nitrogen in ASU. In this model, none of the components of oxy fuel cycle is a major engineering challenge. With increasing oil price, economic justification of oxy fuel combustion model increases. With the price of oil at $ 80 per barrel in mind and $ 31 per ton fines for emissions of carbon dioxide in the atmosphere, IRR is the same for both models.
基金Project(50376076) supported by the National Natural Science Foundation of China
文摘The experimental tests of tensile for lead-flee solder Sn-3.5Ag were performed for the general work temperatures range from 11 to 90 ℃ and strain rate range from 5 × 10^-5 to 2 × 10^-2s^-1, and its stress--strain curves were compared to those of solder Sn-37Pb. The parameters in Anand model for solder Sn-3.5Ag were fitted based on experimental data and nonlinear fitting method, and its validity was checked by means of experimental data. Furthermore, the Anand model was used in the FEM analysis to evaluate solder joint thermal cycle reliability. The results show that solder Sn-3.5Ag has a better creep resistance than solder Sn-37Pb. The maximum stress is located at the upper right comer of the outmost solder joint from the symmetric center, and thermal fatigue life is predicted to be 3.796 × 10^4 cycles under the calculated conditions.
文摘The life cycle of CIMS (Computer Integrated Manufacturing System) includes four phases:requirement analyzing, designing, implementation and running. For reducing the risk of investment and achieving better economic results the simulation technique is needed in the above four phases of CIMS life cycle. Under the support of China 863/CIMS plan a series of simulation projects are established. Some of them are finished with succeed and have been used in application. In this paper four simulation projects are introduced.(1) The Integrated Manufacturing Simulation Software (IMSS). It is an integrated platform, based on the discrete event simulation principle. It can be used to analyze and design CIMS, especially FMS; and evaluate the daily production plan.(2) The Advanced Hierarchical Control System Emulator (AHCSE), a software system, based on the finite state machine principle. It can be used to analyze and design of CIMS hicrarchical control system, and check expanded system performance before expanding.(3) The Factory Scheduling Environment (FASE), a software system based on the discrete event simulation principle and artificial intelligence technology. It can be used for shop floor scheduling. (4) The Machining Process Simulator (MPS). It can simulate the machining process of machining center by computer. It can check the correctness of NC code (including interference and confliction) and replace the real machining center to support the simulation environment for shop floor scheduling and controlling. There are three companies and universities joining in these four projects, they are: Tsinghua University,Huazhong University of Technology, Beliing Institute of Computer Application and Simulation.
基金Project(2012AA053001) supported by the National High Technology Research and Development Program of China
文摘A comparison on subcritical and transcritical organic Rankine cycle（ORC） system with a heat source of 110 ℃ geothermal water was presented. The net power output, thermal and exergy efficiencies and the products of the heat transfer coefficient（U） and the total heat exchange area（A）（UA values） were calculated for parametric optimization. Nine candidate working fluids were investigated and compared. Under the given conditions, transcritical systems have higher net power outputs than subcritical ones. The highest net power output of transcritical systems is 18.63 k W obtained by R218, and that of subcritical systems is 13.57 k W obtained by R600 a. Moreover, with the increase of evaporating pressure, the thermal and exergy efficiencies of transcritical systems increase at first and then decrease, but the efficiencies of subcritical ones increase. As a result, the efficiencies of transcritical systems cannot always outperform those of the subcritical ones. However, the subcritical systems have lower minimum UA values and lower expansion ratios than the transcritical ones at the maximum net power output. In addition, the transcritical cycles have higher expansion ratios than the subcritical ones at their maximum net power output.
基金Canadian Space Agency Government Research Initiative ProgramNASA Ocean Surface Topography Science Team Program
文摘There have been a number of applications of satellite altimetry to seasonal and interannual sea level variability in the South China Sea. However, these applications usually exclude shallow waters along the coast, with one of the concerns being large aliased tide-correction error. In this study the authors analyzed 14 years of merged satellite altimeter data to obtain the amplitude and phase of the semi-annual cycle and to examine the variation at the K1 alias frequency (close to the semi-annual frequency). The results indicate that the amplitude of the semi-annual cycle ranges from 3-7 cm, substantial compared with that of the annual cycle; while the amplitude at the K1 alias frequency (error of the K1 tidal correction) is essentially 1 cm only. Altimeter-derived semi-annual cycle is in good agreement with that from independent tide-gauge observations, pointing to the competent ability of satellite altimetry in observing semi-annual sea level variations in the South China Sea.
基金supported by a grant from the key project of the National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30430300)National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30670922)INTERNATION Scienc and Techniquie COOPRATION PROGRAM OF CHINA (ISCP) (to Qinghua ZHOU)(No.2006DFB32330)
文摘Background and Objective Lung cancer is the rst killer of human being in the whole world. Recently, although many treatment strategies have been developed, the anti-cancer effects
