1 Journal of Yunnan Agricultural University(Natural science edition)is sponsored byYunnan Agricultural University,and is a com-prehensive scientific periodical publication inChina and abroad.The main report aspectsare...1 Journal of Yunnan Agricultural University(Natural science edition)is sponsored byYunnan Agricultural University,and is a com-prehensive scientific periodical publication inChina and abroad.The main report aspectsare research thesis,research report,researchbulletin and summary of subject progress thatinvolves basic research as well as applicationand development research of agriculture,biolo-gy and related subjects,etc.展开更多
Mendelian randomization(MR)is widely used in causal mediation analysis to control unmeasured confounding effects,which is valid under some strong assumptions.It is thus of great interest to assess the impact of violat...Mendelian randomization(MR)is widely used in causal mediation analysis to control unmeasured confounding effects,which is valid under some strong assumptions.It is thus of great interest to assess the impact of violations of these MR assumptions through sensitivity analysis.Sensitivity analyses have been conducted for simple MR-based causal average effect analyses,but they are not available for MR-based mediation analysis studies,and we aim to fill this gap in this paper.We propose to use two sensitivity parameters to quantify the effect due to the deviation of the IV assumptions.With these two sensitivity parameters,we derive consistent indirect causal effect estimators and establish their asymptotic propersties.Our theoretical results can be used in MR-based mediation analysis to study the impact of violations of MR as-sumptions.The finite sample performance of the proposed method is illustrated through simulation studies,sensitivity ana-lysis,and application to a real genome-wide association study.展开更多
In this review, the theorelical study on D-physics is summarized including D-(?) mixing, D meson decays, diquark contributions to D-physics, 1/Nc expansion, final state interactions and some discussions about BEPC and...In this review, the theorelical study on D-physics is summarized including D-(?) mixing, D meson decays, diquark contributions to D-physics, 1/Nc expansion, final state interactions and some discussions about BEPC and BES.展开更多
文摘1 Journal of Yunnan Agricultural University(Natural science edition)is sponsored byYunnan Agricultural University,and is a com-prehensive scientific periodical publication inChina and abroad.The main report aspectsare research thesis,research report,researchbulletin and summary of subject progress thatinvolves basic research as well as applicationand development research of agriculture,biolo-gy and related subjects,etc.
基金This work was supported by the National Natural Science Foundation of China(12171451,72091212).
文摘Mendelian randomization(MR)is widely used in causal mediation analysis to control unmeasured confounding effects,which is valid under some strong assumptions.It is thus of great interest to assess the impact of violations of these MR assumptions through sensitivity analysis.Sensitivity analyses have been conducted for simple MR-based causal average effect analyses,but they are not available for MR-based mediation analysis studies,and we aim to fill this gap in this paper.We propose to use two sensitivity parameters to quantify the effect due to the deviation of the IV assumptions.With these two sensitivity parameters,we derive consistent indirect causal effect estimators and establish their asymptotic propersties.Our theoretical results can be used in MR-based mediation analysis to study the impact of violations of MR as-sumptions.The finite sample performance of the proposed method is illustrated through simulation studies,sensitivity ana-lysis,and application to a real genome-wide association study.
文摘In this review, the theorelical study on D-physics is summarized including D-(?) mixing, D meson decays, diquark contributions to D-physics, 1/Nc expansion, final state interactions and some discussions about BEPC and BES.
