The aim of this work is to develop a three-dimensional model of deep groove ball bearing to investigate the loaded stresses and central displacements of bearing rings. The equivalent stresses and central displacements...The aim of this work is to develop a three-dimensional model of deep groove ball bearing to investigate the loaded stresses and central displacements of bearing rings. The equivalent stresses and central displacements of bearing rings are obtained based on the simulated analysis. Moreover, several parameters, such as load magnitude, raceway groove curvature radius(RGCR), thicknesses of outer and inner rings, are varied to investigate their effects on the equivalent stresses and central displacements of bearing rings. Research results provide useful guidelines for determining the design parameters.展开更多
This study proposes an alternative calculation mode for stresses on the slip surface(SS).The calculation of the normal stress(NS)on the SS involves examining its composition and expanding its unknown using the Taylor ...This study proposes an alternative calculation mode for stresses on the slip surface(SS).The calculation of the normal stress(NS)on the SS involves examining its composition and expanding its unknown using the Taylor series.This expansion enables the reasonable construction of a function describing the NS on the SS.Additionally,by directly incorporating the nonlinear Generalized Hoke-Brown(GHB)strength criterion and utilizing the slope factor of safety(FOS)definition,a function of the shear stress on the SS is derived.This function considers the mutual feedback mechanism between the NS and strength parameters of the SS.The stress constraints conditions are then introduced at both ends of the SS based on the spatial stress relation of one point.Determining the slope FOS and stress solution for the SS involves considering the mechanical equilibrium conditions and the stress constraint conditions satisfied by the sliding body.The proposed approach successfully simulates the tension-shear stress zone near the slope top and provides an intuitive description of the concentration effect of compression-shear stress of the SS near the slope toe.Furthermore,compared to other methods,the present method demonstrates superior processing capabilities for the embedded nonlinear GHB strength criterion.展开更多
Recent advancements in additive manufacturing(AM)have revolutionized the design and production of complex engineering microstructures.Despite these advancements,their mathematical modeling and computational analysis r...Recent advancements in additive manufacturing(AM)have revolutionized the design and production of complex engineering microstructures.Despite these advancements,their mathematical modeling and computational analysis remain significant challenges.This research aims to develop an effective computational method for analyzing the free vibration of functionally graded(FG)microplates under high temperatures while resting on a Pasternak foundation(PF).This formulation leverages a new thirdorder shear deformation theory(new TSDT)for improved accuracy without requiring shear correction factors.Additionally,the modified couple stress theory(MCST)is incorporated to account for sizedependent effects in microplates.The PF is characterized by two parameters including spring stiffness(k_(w))and shear layer stiffness(k_(s)).To validate the proposed method,the results obtained are compared with those of the existing literature.Furthermore,numerical examples explore the influence of various factors on the high-temperature free vibration of FG microplates.These factors include the length scale parameter(l),geometric dimensions,material properties,and the presence of the elastic foundation.The findings significantly enhance our comprehension of the free vibration of FG microplates in high thermal environments.In addition,the findings significantly enhance our comprehension of the free vibration of FG microplates in high thermal environments.In addition,the results of this research will have great potential in military and defense applications such as components of submarines,fighter aircraft,and missiles.展开更多
The aims were to investigate the effect of salt stress on key enzyme activity of nitrogen metabolism and the concentration of nitrate nitrogen and ammonium nitrogen response to salt stress.Two rice cultivars,Mudanjian...The aims were to investigate the effect of salt stress on key enzyme activity of nitrogen metabolism and the concentration of nitrate nitrogen and ammonium nitrogen response to salt stress.Two rice cultivars,Mudanjiang 30(sensitive cultivar)and Longdao 5(salt-tolerant cultivar),were treated with different salt concentrations(CK 0%,S10.075%,S20.15%,S30.225%and S40.3%).The results showed that the activities of nitrate reductase(NR),glutamine synthase(GS),glutamate synthase(GOGAT)and glutamate dehydrogenase(GDH)in the functional leaves and roots of rice in cold region presented a single peak curve change and the peak occurred in the heading stage;compared with those of the CK,the activities of NR,GS and GOGAT of rice in cold region decreased,but the activity of GDH increased in the heading stage under salt stress.The variation for key enzyme activity of nitrogen metabolism was the highest under S4 treatment.The activities of NR,GS and GOGAT in the functional leaves significantly decreased compared with those in roots;the concentrations of nitrate nitrogen and ammonium nitrogen in the functional leaves and roots of rice in cold region presented a single peak curve change and the peak occurred in the heading stage;compared with that of the CK,the concentration of nitrate nitrogen decreased in leaves and roots,the concentration of ammonium nitrogen decreased and the concentration of ammonium nitrogen in roots increased under salt stress.The variations for the activities of NR,GS and GOGAT in the functional leaves and roots of Longdao 5 were less than those of Mudanjiang 30 under the same concentration of salt stress.展开更多
A generalized form of material gradation applicable to a more broad range of functionally graded materials(FGMs) was presented.With the material model,analytical expressions of crack tip higher order stress fields in ...A generalized form of material gradation applicable to a more broad range of functionally graded materials(FGMs) was presented.With the material model,analytical expressions of crack tip higher order stress fields in a series form for opening mode and shear mode cracks under quasi-static loading were developed through the approach of asymptotic analysis.Then,a numerical experiment was conducted to verify the accuracy of the developed expressions for representing crack tip stress fields and their validity in full field data analysis by using them to extract the stress intensity factors from the results of a finite element analysis by local collocation and then comparing the estimations with the existing solution.The expressions show that nonhomogeneity parameters are embedded in the angular functions associated with higher terms in a recursive manner and at least the first three terms in the expansions must be considered to explicitly account for material nonhomogeneity effects on crack tip stress fields in the case of FGMs.The numerical experiment further confirms that the addition of the nonhomogeneity specific terms in the expressions not only improves estimates of stress intensity factor,but also gives consistent estimates as the distance away from the crack tip increases.Hence,the analytical expressions are suitable for the representation of crack tip stress fields and the analysis of full field data.展开更多
Aim Leptin, a 16 ku hormone from the ob gene, has been identified as an important protein involved obesity. As a chronic metabolic disorder, Obesity is associated with a high risk of developing cardiovascular and meta...Aim Leptin, a 16 ku hormone from the ob gene, has been identified as an important protein involved obesity. As a chronic metabolic disorder, Obesity is associated with a high risk of developing cardiovascular and metabolic diseases, such as heart failure. The main aim of this paper is to probe the effects of leptin on contractile function of cardiomyocyte in adult rat. And the mechanism of the action involved of oxidative stress and autophagy were investigated. Methods Isolated adult rat cardiomyocytes were exposed to leptin （1, 10, and 100 nmol · L^-1） for 1 hour. The calcium transients and contraction in adult rat cardiomyocytes were recorded with SoftEdge MyoCam system. Using the corresponding agents such as apocynin, tempol and rapamycin, the underlying mecha- nism of leptin involved of oxidative stress and autophagy was determined. Werstern blot was employed to evaluate the expression of LC3B and Beclin-1. Results While perfusing the cardiomyocytes with leptin, peak shortening （PS） and maximal velocity of shortening/relengthening （ ± dL/dtmax） of cell shortening were markedly decreased, and prolonged time to 50% relengthening （TR50%）. As well as, baseline （bl） , peak and time to 50% baseline （TB50%） of calcium transient were markedly depressed. Leptin attenuated autophagy as evidenced by decreased LC3-Ⅱ and Beclin-1. All of the abnormalities were significantly attenuated by apocynin, tempol or rapamyein. Conclusion Leptin has depressing effects on intracellular free calcium and myocardial systolic function. Apocy-nin, tempol or rapamycin could block the effects of leptin. The mechanism involved oxidative stress and autophagy.展开更多
基金the National Natural Science Foundation of China (No. 51605354)the Fundamental Research Funds for the Central Universities (WUT: 2015IVA021)+1 种基金the Innovative Research Team Development Program of Ministry of Education of China (No. IRT13087)the High-end Talent Leading Program of Hubei Province (No. 201286)
文摘The aim of this work is to develop a three-dimensional model of deep groove ball bearing to investigate the loaded stresses and central displacements of bearing rings. The equivalent stresses and central displacements of bearing rings are obtained based on the simulated analysis. Moreover, several parameters, such as load magnitude, raceway groove curvature radius(RGCR), thicknesses of outer and inner rings, are varied to investigate their effects on the equivalent stresses and central displacements of bearing rings. Research results provide useful guidelines for determining the design parameters.
基金Project(52278380)supported by the National Natural Science Foundation of ChinaProject(2023JJ30670)supported by the National Science Foundation of and Technology Major Project of Hunan Province,China。
文摘This study proposes an alternative calculation mode for stresses on the slip surface(SS).The calculation of the normal stress(NS)on the SS involves examining its composition and expanding its unknown using the Taylor series.This expansion enables the reasonable construction of a function describing the NS on the SS.Additionally,by directly incorporating the nonlinear Generalized Hoke-Brown(GHB)strength criterion and utilizing the slope factor of safety(FOS)definition,a function of the shear stress on the SS is derived.This function considers the mutual feedback mechanism between the NS and strength parameters of the SS.The stress constraints conditions are then introduced at both ends of the SS based on the spatial stress relation of one point.Determining the slope FOS and stress solution for the SS involves considering the mechanical equilibrium conditions and the stress constraint conditions satisfied by the sliding body.The proposed approach successfully simulates the tension-shear stress zone near the slope top and provides an intuitive description of the concentration effect of compression-shear stress of the SS near the slope toe.Furthermore,compared to other methods,the present method demonstrates superior processing capabilities for the embedded nonlinear GHB strength criterion.
文摘Recent advancements in additive manufacturing(AM)have revolutionized the design and production of complex engineering microstructures.Despite these advancements,their mathematical modeling and computational analysis remain significant challenges.This research aims to develop an effective computational method for analyzing the free vibration of functionally graded(FG)microplates under high temperatures while resting on a Pasternak foundation(PF).This formulation leverages a new thirdorder shear deformation theory(new TSDT)for improved accuracy without requiring shear correction factors.Additionally,the modified couple stress theory(MCST)is incorporated to account for sizedependent effects in microplates.The PF is characterized by two parameters including spring stiffness(k_(w))and shear layer stiffness(k_(s)).To validate the proposed method,the results obtained are compared with those of the existing literature.Furthermore,numerical examples explore the influence of various factors on the high-temperature free vibration of FG microplates.These factors include the length scale parameter(l),geometric dimensions,material properties,and the presence of the elastic foundation.The findings significantly enhance our comprehension of the free vibration of FG microplates in high thermal environments.In addition,the findings significantly enhance our comprehension of the free vibration of FG microplates in high thermal environments.In addition,the results of this research will have great potential in military and defense applications such as components of submarines,fighter aircraft,and missiles.
基金Supported by the National Key R&D Program of China(2016YFD0300104)。
文摘The aims were to investigate the effect of salt stress on key enzyme activity of nitrogen metabolism and the concentration of nitrate nitrogen and ammonium nitrogen response to salt stress.Two rice cultivars,Mudanjiang 30(sensitive cultivar)and Longdao 5(salt-tolerant cultivar),were treated with different salt concentrations(CK 0%,S10.075%,S20.15%,S30.225%and S40.3%).The results showed that the activities of nitrate reductase(NR),glutamine synthase(GS),glutamate synthase(GOGAT)and glutamate dehydrogenase(GDH)in the functional leaves and roots of rice in cold region presented a single peak curve change and the peak occurred in the heading stage;compared with those of the CK,the activities of NR,GS and GOGAT of rice in cold region decreased,but the activity of GDH increased in the heading stage under salt stress.The variation for key enzyme activity of nitrogen metabolism was the highest under S4 treatment.The activities of NR,GS and GOGAT in the functional leaves significantly decreased compared with those in roots;the concentrations of nitrate nitrogen and ammonium nitrogen in the functional leaves and roots of rice in cold region presented a single peak curve change and the peak occurred in the heading stage;compared with that of the CK,the concentration of nitrate nitrogen decreased in leaves and roots,the concentration of ammonium nitrogen decreased and the concentration of ammonium nitrogen in roots increased under salt stress.The variations for the activities of NR,GS and GOGAT in the functional leaves and roots of Longdao 5 were less than those of Mudanjiang 30 under the same concentration of salt stress.
基金Project(20080431344) supported by Postdoctoral Science Foundation of ChinaProject(51021001) supported by the National Natural Science Foundation of China
文摘A generalized form of material gradation applicable to a more broad range of functionally graded materials(FGMs) was presented.With the material model,analytical expressions of crack tip higher order stress fields in a series form for opening mode and shear mode cracks under quasi-static loading were developed through the approach of asymptotic analysis.Then,a numerical experiment was conducted to verify the accuracy of the developed expressions for representing crack tip stress fields and their validity in full field data analysis by using them to extract the stress intensity factors from the results of a finite element analysis by local collocation and then comparing the estimations with the existing solution.The expressions show that nonhomogeneity parameters are embedded in the angular functions associated with higher terms in a recursive manner and at least the first three terms in the expansions must be considered to explicitly account for material nonhomogeneity effects on crack tip stress fields in the case of FGMs.The numerical experiment further confirms that the addition of the nonhomogeneity specific terms in the expressions not only improves estimates of stress intensity factor,but also gives consistent estimates as the distance away from the crack tip increases.Hence,the analytical expressions are suitable for the representation of crack tip stress fields and the analysis of full field data.
文摘Aim Leptin, a 16 ku hormone from the ob gene, has been identified as an important protein involved obesity. As a chronic metabolic disorder, Obesity is associated with a high risk of developing cardiovascular and metabolic diseases, such as heart failure. The main aim of this paper is to probe the effects of leptin on contractile function of cardiomyocyte in adult rat. And the mechanism of the action involved of oxidative stress and autophagy were investigated. Methods Isolated adult rat cardiomyocytes were exposed to leptin （1, 10, and 100 nmol · L^-1） for 1 hour. The calcium transients and contraction in adult rat cardiomyocytes were recorded with SoftEdge MyoCam system. Using the corresponding agents such as apocynin, tempol and rapamycin, the underlying mecha- nism of leptin involved of oxidative stress and autophagy was determined. Werstern blot was employed to evaluate the expression of LC3B and Beclin-1. Results While perfusing the cardiomyocytes with leptin, peak shortening （PS） and maximal velocity of shortening/relengthening （ ± dL/dtmax） of cell shortening were markedly decreased, and prolonged time to 50% relengthening （TR50%）. As well as, baseline （bl） , peak and time to 50% baseline （TB50%） of calcium transient were markedly depressed. Leptin attenuated autophagy as evidenced by decreased LC3-Ⅱ and Beclin-1. All of the abnormalities were significantly attenuated by apocynin, tempol or rapamyein. Conclusion Leptin has depressing effects on intracellular free calcium and myocardial systolic function. Apocy-nin, tempol or rapamycin could block the effects of leptin. The mechanism involved oxidative stress and autophagy.
