目的探讨脊髓小脑性共济失调3型(spinocerebellar ataxia type 3,SCA3)无症状基因携带者与患者周围神经传导异常特征,寻找与SCA3疾病严重程度及病程相关的电生理指标。方法对确诊的20例无症状基因携带者(preclinical carriers of spinoc...目的探讨脊髓小脑性共济失调3型(spinocerebellar ataxia type 3,SCA3)无症状基因携带者与患者周围神经传导异常特征,寻找与SCA3疾病严重程度及病程相关的电生理指标。方法对确诊的20例无症状基因携带者(preclinical carriers of spinocerebellar ataxias type 3,PreSCA3)、39例SCA3患者及32名健康对照者进行周围神经传导(nerve conductive study,NCS)检测,比较各组间的神经传导异常,分析各电生理参数与共济失调等级量表(scale for the assessment and rating of ataxia,SARA)总分及病程的相关性。结果PreSCA3感觉神经传导异常发生率为20%,并且PreSCA3组尺神经、胫神经、腓肠神经SNAP波幅及尺神经MCV显著低于健康对照组(P<0.05)。SCA3患者NCS异常发生率为69.2%,以感觉神经传导异常为主(53.8%),主要表现为混合性损害(48.1%)。与健康对照组相比,SCA3患者所有检测神经SNAP波幅、SCV及腓总神经CMAP波幅、尺神经MCV显著降低(P<0.05)。此外,正中、尺、胫、腓总及腓肠神经SNAP波幅、SCV与SARA总分及病程呈负相关(P<0.05)。结论部分PreSCA3已存在周围神经损害,主要累及感觉神经。SCA3患者NCS检查异常率高,主要表现为混合性损害为主的感觉性周围神经病。SNAP波幅、SCV可能作为监测疾病发生发展的潜在生物学标记物。展开更多
Physiological parameters of people and enact assessment standard of indoor thermal environment that are appropriate to our national conditions were explored from the perspective of physiology. From December 2005 to Ja...Physiological parameters of people and enact assessment standard of indoor thermal environment that are appropriate to our national conditions were explored from the perspective of physiology. From December 2005 to January 2006, nerve conduction velocities and skin temperatures of 20 healthy students were tested with questionnaire investigation. The results show that the nerve conduction velocities as well as skin temperatures present an obvious decline trend in a continuous draught, and that the nerve conduction velocities and skin temperatures have a definite linear relationship. Draught velocity is an important factor in winter that affects body comfort, and the subjects are sensitive to air velocity.展开更多
文摘目的探讨脊髓小脑性共济失调3型(spinocerebellar ataxia type 3,SCA3)无症状基因携带者与患者周围神经传导异常特征,寻找与SCA3疾病严重程度及病程相关的电生理指标。方法对确诊的20例无症状基因携带者(preclinical carriers of spinocerebellar ataxias type 3,PreSCA3)、39例SCA3患者及32名健康对照者进行周围神经传导(nerve conductive study,NCS)检测,比较各组间的神经传导异常,分析各电生理参数与共济失调等级量表(scale for the assessment and rating of ataxia,SARA)总分及病程的相关性。结果PreSCA3感觉神经传导异常发生率为20%,并且PreSCA3组尺神经、胫神经、腓肠神经SNAP波幅及尺神经MCV显著低于健康对照组(P<0.05)。SCA3患者NCS异常发生率为69.2%,以感觉神经传导异常为主(53.8%),主要表现为混合性损害(48.1%)。与健康对照组相比,SCA3患者所有检测神经SNAP波幅、SCV及腓总神经CMAP波幅、尺神经MCV显著降低(P<0.05)。此外,正中、尺、胫、腓总及腓肠神经SNAP波幅、SCV与SARA总分及病程呈负相关(P<0.05)。结论部分PreSCA3已存在周围神经损害,主要累及感觉神经。SCA3患者NCS检查异常率高,主要表现为混合性损害为主的感觉性周围神经病。SNAP波幅、SCV可能作为监测疾病发生发展的潜在生物学标记物。
基金Project(CSTC 2004AA7008) supported by the State I mportant Project of the Science and Technology
文摘Physiological parameters of people and enact assessment standard of indoor thermal environment that are appropriate to our national conditions were explored from the perspective of physiology. From December 2005 to January 2006, nerve conduction velocities and skin temperatures of 20 healthy students were tested with questionnaire investigation. The results show that the nerve conduction velocities as well as skin temperatures present an obvious decline trend in a continuous draught, and that the nerve conduction velocities and skin temperatures have a definite linear relationship. Draught velocity is an important factor in winter that affects body comfort, and the subjects are sensitive to air velocity.
