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Self-adaptive PID controller of microwave drying rotary device tuning on-line by genetic algorithms 被引量:6
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作者 杨彪 梁贵安 +5 位作者 彭金辉 郭胜惠 李玮 张世敏 李英伟 白松 《Journal of Central South University》 SCIE EI CAS 2013年第10期2685-2692,共8页
The control design, based on self-adaptive PID with genetic algorithms(GA) tuning on-line was investigated, for the temperature control of industrial microwave drying rotary device with the multi-layer(IMDRDWM) and wi... The control design, based on self-adaptive PID with genetic algorithms(GA) tuning on-line was investigated, for the temperature control of industrial microwave drying rotary device with the multi-layer(IMDRDWM) and with multivariable nonlinear interaction of microwave and materials. The conventional PID control strategy incorporated with optimization GA was put forward to maintain the optimum drying temperature in order to keep the moisture content below 1%, whose adaptation ability included the cost function of optimization GA according to the output change. Simulations on five different industrial process models and practical temperature process control system for selenium-enriched slag drying intensively by using IMDRDWM were carried out systematically, indicating the reliability and effectiveness of control design. The parameters of proposed control design are all on-line implemented without iterative predictive calculations, and the closed-loop system stability is guaranteed, which makes the developed scheme simpler in its synthesis and application, providing the practical guidelines for the control implementation and the parameter design. 展开更多
关键词 industrial microwave DRYING ROTARY device self-adaptive PID controller genetic algorithm ON-LINE tuning SELENIUM-ENRICHED SLAG
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Shift control method for the local time at descendi ngnode based on sun-synchronous orbit satellite 被引量:5
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作者 Yang Yong'an Feng Zuren +1 位作者 Sun Linyan Tan Wei 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第1期141-145,共5页
This article analyzes the shift factors of the descending node local time for sun-synchronous satellites and proposes a shift control method to keep the local time shift within an allowance range. It is found that the... This article analyzes the shift factors of the descending node local time for sun-synchronous satellites and proposes a shift control method to keep the local time shift within an allowance range. It is found that the satellite orbit design and the orbit injection deviation are the causes for the initial shift velocity, whereas the atmospheric drag and the sun gravitational perturbation produce the shift acceleration. To deal with these shift factors, a shift control method is put forward, through such methods as orbit variation design, orbit altitude, and inclination keeping control. The simulation experiment and practical application have proved the effectiveness of this control method. 展开更多
关键词 space engineering sun-synchronous orbit satellite local time of descending node drift control method.
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Stiffness-damping matching method of an ECAS system based on LQG control 被引量:9
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作者 陈一锴 何杰 +2 位作者 M.KING 陈无畏 张卫华 《Journal of Central South University》 SCIE EI CAS 2014年第1期439-446,共8页
A novel method of matching stiffness and continuous variable damping of an ECAS(electronically controlled air suspension) based on LQG(linear quadratic Gaussian) control was proposed to simultaneously improve the road... A novel method of matching stiffness and continuous variable damping of an ECAS(electronically controlled air suspension) based on LQG(linear quadratic Gaussian) control was proposed to simultaneously improve the road-friendliness and ride comfort of a two-axle school bus.Taking account of the suspension nonlinearities and target-height-dependent variation in suspension characteristics,a stiffness model of the ECAS mounted on the drive axle of the bus was developed based on thermodynamics and the key parameters were obtained through field tests.By determining the proper range of the target height for the ECAS of the fully-loaded bus based on the design requirements of vehicle body bounce frequency,the control algorithm of the target suspension height(i.e.,stiffness) was derived according to driving speed and road roughness.Taking account of the nonlinearities of a continuous variable semi-active damper,the damping force was obtained through the subtraction of the air spring force from the optimum integrated suspension force,which was calculated based on LQG control.Finally,a GA(genetic algorithm)-based matching method between stepped variable damping and stiffness was employed as a benchmark to evaluate the effectiveness of the LQG-based matching method.Simulation results indicate that compared with the GA-based matching method,both dynamic tire force and vehicle body vertical acceleration responses are markedly reduced around the vehicle body bounce frequency employing the LQG-based matching method,with peak values of the dynamic tire force PSD(power spectral density) decreased by 73.6%,60.8% and 71.9% in the three cases,and corresponding reduction are 71.3%,59.4% and 68.2% for the vehicle body vertical acceleration.A strong robustness to variation of driving speed and road roughness is also observed for the LQG-based matching method. 展开更多
关键词 matching method electronically controlled air suspension linear quadratic Gaussian genetic algorithm
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Combined indirect and direct method for adaptive fuzzy output feedback control of nonlinear system 被引量:2
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作者 Ding Quanxin Chen Haitong +1 位作者 Jiang Changsheng Chen Zongji 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2007年第1期120-124,共5页
A novel control method for a general class of nonlinear systems using fuzzy logic systems (FLSs) is presertted. Indirect and direct methods are combined to design the adaptive fuzzy output feedback controller and a ... A novel control method for a general class of nonlinear systems using fuzzy logic systems (FLSs) is presertted. Indirect and direct methods are combined to design the adaptive fuzzy output feedback controller and a high-gain observer is used to estimate the derivatives of the system output. The closed-loop system is proven to be semiglobally uniformly ultimately bounded. In addition, it is shown that if the approximation accuracy of the fuzzy logic system is high enough and the observer gain is chosen sufficiently large, an arbitrarily small tracking error can be achieved. Simulation results verify the effectiveness of the newly designed scheme and the theoretical discussion. 展开更多
关键词 Nonlinear control systems Non-affine Combined indirect and direct method Adaptive fuzzy controller High-gain observer (HGO)
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A novel PID controller tuning method based on optimization technique 被引量:5
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作者 梁昔明 李山春 HASSAN A B 《Journal of Central South University》 SCIE EI CAS 2010年第5期1036-1042,共7页
An approach for parameter estimation of proportional-integral-derivative(PID) control system using a new nonlinear programming(NLP) algorithm was proposed.SQP/IIPM algorithm is a sequential quadratic programming(SQP) ... An approach for parameter estimation of proportional-integral-derivative(PID) control system using a new nonlinear programming(NLP) algorithm was proposed.SQP/IIPM algorithm is a sequential quadratic programming(SQP) based algorithm that derives its search directions by solving quadratic programming(QP) subproblems via an infeasible interior point method(IIPM) and evaluates step length adaptively via a simple line search and/or a quadratic search algorithm depending on the termination of the IIPM solver.The task of tuning PI/PID parameters for the first-and second-order systems was modeled as constrained NLP problem. SQP/IIPM algorithm was applied to determining the optimum parameters for the PI/PID control systems.To assess the performance of the proposed method,a Matlab simulation of PID controller tuning was conducted to compare the proposed SQP/IIPM algorithm with the gain and phase margin(GPM) method and Ziegler-Nichols(ZN) method.The results reveal that,for both step and impulse response tests,the PI/PID controller using SQP/IIPM optimization algorithm consistently reduce rise time,settling-time and remarkably lower overshoot compared to GPM and ZN methods,and the proposed method improves the robustness and effectiveness of numerical optimization of PID control systems. 展开更多
关键词 PID controller optimization infeasible interior point method sequential quadratic programming SIMULATION
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Input-to-state stability of Euler-Maruyama method for stochastic delay control systems 被引量:2
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作者 Shifang Kuang Feiqi Deng Yunjian Peng 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2013年第2期309-317,共9页
This paper develops the mean-square exponential input-to-state stability(exp-ISS) of the Euler-Maruyama(EM) method for stochastic delay control systems(SDCSs).The definition of mean-square exp-ISS of numerical m... This paper develops the mean-square exponential input-to-state stability(exp-ISS) of the Euler-Maruyama(EM) method for stochastic delay control systems(SDCSs).The definition of mean-square exp-ISS of numerical methods is established.The conditions of the exact and EM method for an SDCS with the property of mean-square exp-ISS are obtained without involving control Lyapunov functions or functional.Under the global Lipschitz coefficients and mean-square continuous measurable inputs,it is proved that the mean-square exp-ISS of an SDCS holds if and only if that of the EM method is preserved for a sufficiently small step size.The proposed results are evaluated by using numerical experiments to show their effectiveness. 展开更多
关键词 Euler-Maruyama(EM) method exponential inputto-state stability(exp-ISS) numerical solution stochastic delay control system(SDCS) time delay
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Continuity control method of cutter posture vector for efficient five-axis machining 被引量:1
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作者 HWANG Jong-dae KIM Sang-myung +1 位作者 JUNG Hyun-chul JUNG Yoon-gyo 《Journal of Central South University》 SCIE EI CAS 2011年第6期1969-1975,共7页
During five-axis machining of impeller, the excessive local interference avoidance leads to inconsistency of cutter posture, low quality of machined surface and increase of processing time. Therefore, in order to impr... During five-axis machining of impeller, the excessive local interference avoidance leads to inconsistency of cutter posture, low quality of machined surface and increase of processing time. Therefore, in order to improve the efficiency of five-axis machining of impellers, it is necessary to minimize the cutter posture changes and create a continuous tool path while avoiding interference. By using an MC-space algorithm for interference avoidance, an MB-spline algorithm for continuous control was intended to create a five-axis machining tool path with excellent surface quality and economic feasibility. A five-axis cutting experiment was performed to verify the effectiveness of the continuity control. The result shows that the surface shape with continuous method is greatly improved, and the surface roughness is generally favorable. Consequently, the effectiveness of the suggested method is verified by identifying the improvement of efficiency of five-axis machining of an impeller in aspects of surface quality and machining time. 展开更多
关键词 five-axis control machining CONFIGURATION-SPACE B-SPLINE continuity control method IMPELLER interference
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STATE SPACE METHODS FOR DECENTRALIZED H_∞ CONTROL
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作者 Wu Min Gut Weihua Chen Ning(Department of Automatic Control Engineering, Central South University of Technology, Changsha, 410083, China) 《Journal of Central South University》 SCIE EI CAS 1994年第1期91-96,共6页
This paper presents state space methods for decentralized Hoe control, which contain two respects: a parametrization approach and an iterative algorithm. For large scale systems with N subsystems, decentralized Hoe c... This paper presents state space methods for decentralized Hoe control, which contain two respects: a parametrization approach and an iterative algorithm. For large scale systems with N subsystems, decentralized Hoe con trollers can be derived by a parametrization result for centralized Her: controllers and designed by an iterative algorithm with structured constraint to the controllers. 展开更多
关键词 DECENTRALIZED control STATE SPACE method H_∞ control
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Research on Controlled Volume Operation Method of Large-scale Water Transfer Canal
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作者 DING Zhiliang WANG Changde +1 位作者 XU Duo XIAO Hua 《Journal of Northeast Agricultural University(English Edition)》 CAS 2011年第3期47-59,共13页
The controlled volume method of operation is especially suitable for large-scale water delivery canal system with complex operation requirements. An operating simulation model based on the storage volume control metho... The controlled volume method of operation is especially suitable for large-scale water delivery canal system with complex operation requirements. An operating simulation model based on the storage volume control method for multi-reach canal system in series was established. In allusion to the deficiency of existing controlled volume algorithm, the improved controlled volume algorithm of the whole canal pools was proposed, and the simulation results indicated that the storage volume and water level of each canal pool could be accurately controlled after the improved algorithm had been adopted. However, for some typical discharge demand operating conditions, if the previously mentioned algorithm was adopted, then it certainly would cause some unnecessary gate adjustments, and consequently the disturbed canal pools would be increased. Therefore, the idea of controlled volume operation method of continuous canal pools was proposed, and corresponding algorithm was designed. Through simulating practical project, the results indicated that the new controlled volume algorithm proposed for typical operating conditions could comparatively and obviously reduce the number of regulated check gates and disturb canal pools for some typical discharge demand operating conditions, thus the control efficiency of canal system could be improved. 展开更多
关键词 canal operation controlled volume method of operation control algorithm SIMULATION
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A Chebyshev-Gauss Pseudospectral Method for Solving Optimal Control Problems 被引量:7
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作者 TANG Xiao-Jun WEI Jian-Li CHEN Kai 《自动化学报》 EI CSCD 北大核心 2015年第10期1778-1787,共10页
关键词 最优控制问题 切比雪夫 高斯点 伪谱法 拉格朗日插值 非线性规划问题 数值稳定性 求解
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Some Equivalence Transform Methods for Simulating Models in Control Systems
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作者 Degui, Liu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1993年第4期32-42,共11页
In this paper two classes of equivalence transform methods for solving ordinary differential equations are proposed. One class of method is the equivalence integral transform method for special differential algebraic ... In this paper two classes of equivalence transform methods for solving ordinary differential equations are proposed. One class of method is the equivalence integral transform method for special differential algebraic problems. The advantage of this class of method is such that the amount of work calculating one integration with parameters becomes that of two interpolations, when the system of nonlinear equations is solved on the right hand side function. The other class of method is the equivalence substitution method for avoiding calculating derivative on the right hand side function. In order to avoid calculation derivatives, two equivalence substitution methods are proposed here. The application instances of some special effect of the equivalence substitution methods are given. 展开更多
关键词 ALGEBRA Calculations Computer simulation control systems Differential equations Integration Interpolation Mathematical models Mathematical transformations Nonlinear equations Numerical methods
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Compensated methods for networked control system with packet drops based on compressed sensing
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作者 FAN Ruifeng YIN Xunhe +1 位作者 LIU Zhenfei LAM Hak Keung 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第6期1539-1556,共18页
Due to unreliable and bandwidth-limited characteristics of communication link in networked control systems,the realtime compensated methods for single-output systems and multioutput systems are proposed in this paper ... Due to unreliable and bandwidth-limited characteristics of communication link in networked control systems,the realtime compensated methods for single-output systems and multioutput systems are proposed in this paper based on the compressed sensing(CS)theory and sliding window technique,by which the estimates of dropping data packets in the feedback channel are obtained and the performance degradation induced by packet drops is reduced.Specifically,in order to reduce the cumulative error caused by the algorithm,the compensated estimates for single-output systems are corrected via the regularization term;considering the process of single-packet transmission,a new sequential CS framework of sensor data streams is introduced to effectively compensate the dropping packet on single-channel of multi-output systems;in presence of the medium access constraints on multi-channel,the communication sequence for scheduling is coupled to the algorithm and the estimates of the multiple sensors for multi-output systems are obtained via the regularization term.Simulation results illustrate that the proposed methods perform well and receive satisfactory performance. 展开更多
关键词 networked control systems packet drop compensated method compressed sensing(CS)
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Mean-square Exponential Input-to-state Stability of Euler-Maruyama Method Applied to Stochastic Control Systems 被引量:4
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作者 ZHU Qiao HU Guang-Da ZENG Li 《自动化学报》 EI CSCD 北大核心 2010年第3期406-411,共6页
关键词 均方指数 收敛性 连续随机函数 控制方法
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模块化多电平矩阵换流器的等值阻抗模型解析分析 被引量:1
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作者 魏杰 何佳伟 +2 位作者 李斌 周博昊 戴魏 《电力自动化设备》 北大核心 2025年第1期147-155,共9页
模块化多电平矩阵换流器(M3C)的阻抗建模是柔性低频输电系统稳定性分析和故障特性分析的关键理论基础。介绍了M3C的拓扑结构、数学模型与控制策略。在此基础上,分析了计及M3C拓扑结构特点、dq坐标变换过程和双dq分解控制的扰动电流-桥... 模块化多电平矩阵换流器(M3C)的阻抗建模是柔性低频输电系统稳定性分析和故障特性分析的关键理论基础。介绍了M3C的拓扑结构、数学模型与控制策略。在此基础上,分析了计及M3C拓扑结构特点、dq坐标变换过程和双dq分解控制的扰动电流-桥臂电压-扰动电压传递响应特性,推导了M3C等值阻抗特性与频率的关系,建立了可用固定电阻与随频率变化电抗串联表示的M3C等值阻抗数学模型。在PSCAD/EMTDC仿真平台上利用扫频法对等值阻抗理论分析的准确性进行验证,并讨论了系统控制参数、运行功率、一次参数等不同因素对M3C阻抗频率特性的影响。 展开更多
关键词 模块化多电平矩阵换流器 双dq分解控制 控制响应 等值阻抗 扫频法
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煤矿深部巷道大变形分步联合控制研究 被引量:1
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作者 李培涛 刘泉声 +2 位作者 朱元广 高峰 范利丹 《岩土力学》 北大核心 2025年第2期591-612,共22页
深部巷道大变形已成为深部煤炭安全高效开采的关键制约因素。为实现深部软弱围岩稳定性控制,提出了基于深部巷道大变形演化过程的分步联合支护方案及其理论分析模型。结果表明,深部软弱围岩呈破裂碎胀变形-损伤扩容变形-连续变形的分布... 深部巷道大变形已成为深部煤炭安全高效开采的关键制约因素。为实现深部软弱围岩稳定性控制,提出了基于深部巷道大变形演化过程的分步联合支护方案及其理论分析模型。结果表明,深部软弱围岩呈破裂碎胀变形-损伤扩容变形-连续变形的分布特征。分步联合支护后,围岩极限承载力随锚杆和锚索等效支护力增大呈线性增大趋势,但随注浆修复系数呈指数增大趋势。锚杆和锚索支护设计时应以极限承载力所需的注浆修复系数等于1.0时的等效支护力临界条件为基准。深浅孔注浆支护时须同时考虑注浆修复系数和围岩破裂区半径。不同支护措施的协同支护参数可由破裂修复区围岩极限承载平衡条件确定。数值模拟和工程应用分析表明,分步联合支护可实现深部软弱围岩碎胀大变形控制,具有较高的工程推广应用价值。 展开更多
关键词 深部软弱围岩 大变形 分步联合支护 承载平衡 协同控制
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基于改进粒子群算法的光伏逆变器控制参数辨识 被引量:3
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作者 罗建 孙越 江丽娟 《河南理工大学学报(自然科学版)》 CAS 北大核心 2025年第1期124-133,共10页
精准的光伏并网逆变器模型是研究大规模光伏接入下电力系统故障特性的重要工具。目的为了解决现有光伏逆变器仿真模型与实际工作中的光伏逆变器特性相差较大的问题,方法提出采用参数辨识的方法构建逆变器的辨识模型。以重庆云阳某1 MW... 精准的光伏并网逆变器模型是研究大规模光伏接入下电力系统故障特性的重要工具。目的为了解决现有光伏逆变器仿真模型与实际工作中的光伏逆变器特性相差较大的问题,方法提出采用参数辨识的方法构建逆变器的辨识模型。以重庆云阳某1 MW光伏电站为实际参照模型,首先根据实际工作情况将逆变器的工作区间划分为3个阶段,利用数学扰动法分别对3个阶段中的待辨识参数划分灵敏度高低等级,并由此提出不同阶段不同灵敏度参数分步辨识策略;其次,分阶段采集实际光伏电站工作数据,对该数据进行分析处理,获得各待辨识参数的初始取值范围,设计同步辨识参数实验作为参照;最后提出改进的混沌遗传粒子群优化算法(chaos genetic algorithm of particle swarm optimization,CGAPSO)作为辨识算法,分步分工作阶段辨识相关参数,通过对比参数的同步辨识结果,验证所提方法的优越性,并将辨识结果代入仿真模型。结果结果表明,低灵敏度参数的同步辨识结果误差远超过可接受范围,而CGAPSO分步辨识出的相关参数误差皆在1.1%以下,精度远高于同步辨识结果。结论基于改进粒子群算法构建的辨识模型输出数据与实际逆变器工作数据契合度高,可准确反映逆变器实际工作特性。 展开更多
关键词 光伏并网逆变器 逆变器控制策略 参数辨识 数学扰动法 改进粒子群优化算法
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一种高精度的柱温箱控制系统设计
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作者 闫丹 苏淑靖 +2 位作者 吴梦香 郭杨盛 亢叶飞 《中国测试》 北大核心 2025年第5期117-122,共6页
针对柱温箱温度控制的非线性、时变问题,设计一种高精度温度控制系统。控制系统软件上以温度偏差作为决策变量,较大温度偏差采用改进Bang-Bang温控策略,中等温度偏差采用模糊温控策略,微小温差采用模糊PID温控策略,硬件上以Cortex-M3内... 针对柱温箱温度控制的非线性、时变问题,设计一种高精度温度控制系统。控制系统软件上以温度偏差作为决策变量,较大温度偏差采用改进Bang-Bang温控策略,中等温度偏差采用模糊温控策略,微小温差采用模糊PID温控策略,硬件上以Cortex-M3内核处理器为核心,结合温度采集电路以及温度控制电路。实验结果表明:温度稳态精度达到了预期设计目标,设定温度为40.00℃时,稳态误差在0.04℃以内,同时具有良好的抗干扰能力。 展开更多
关键词 柱温箱温控 复合温度控制方法 改进Bang-Bang控制 模糊控制 PID控制
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轴流涡轮可控涡设计中动叶进、出口速度环量控制方式研究
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作者 管继伟 郭魁俊 《汽轮机技术》 北大核心 2025年第3期161-169,共9页
根据完全径向平衡方程,决定轴流涡轮叶片排间隙中径向压力梯度的是以下3项:流体微团的圆周分速引起的加速度、子午分速引起的加速度的径向分量以及沿子午流线方向的加速度的径向分量。结合完全径向平衡方程的求解考察了9种典型的动叶进... 根据完全径向平衡方程,决定轴流涡轮叶片排间隙中径向压力梯度的是以下3项:流体微团的圆周分速引起的加速度、子午分速引起的加速度的径向分量以及沿子午流线方向的加速度的径向分量。结合完全径向平衡方程的求解考察了9种典型的动叶进、出口速度环量控制方式对轴流涡轮反动度和级后参数沿径向分布的影响,对于不同的速度环量控制方式所对应的上述3项、级后的子午速度和静压进行了定量对比和分析。结果表明:沿径向增大的动叶进、出口速度环量有利于子午流线在静、动叶间隙中形成负曲率,从而抑制反动度的径向梯度。级后子午速度和静压的径向分布主要由轮周功的径向分布决定。当轮周功沿径向均匀分布时,级后静压的径向均匀性在所有的轮周功分布方式中居中,级后子午速度的径向均匀性最好,积分余速损失处于较低的水平。综合评价反动度、级后气动参数的径向均匀性以及积分余速损失,在可控涡设计中推荐采用动叶进、出口速度环量沿径向增大且轮周功沿径向均匀分布的速度环量控制方式。 展开更多
关键词 反动度 可控涡设计 速度环量控制方式 积分余速损失
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水压条件下黏弹性材料动态力学参数的宽带测试与分析
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作者 刘哲 张子璇 +1 位作者 张杰 侯宏 《船舶力学》 北大核心 2025年第8期1271-1276,共6页
结合共振法与基于直达波提取的波速法,实现水中加压条件下黏弹性材料连续宽频范围的动态力学参数测试。搭建可实现水下加压的压力舱测试系统,以短时宽带脉冲作为测试激励信号,利用激光测振仪采集细棒激振端与自由端的纵向振动速度信号... 结合共振法与基于直达波提取的波速法,实现水中加压条件下黏弹性材料连续宽频范围的动态力学参数测试。搭建可实现水下加压的压力舱测试系统,以短时宽带脉冲作为测试激励信号,利用激光测振仪采集细棒激振端与自由端的纵向振动速度信号。一方面以共振法计算共振频率处的力学参数,另一方面提取直达波信号,以波速法计算宽频范围的力学参数,二者测试结果吻合良好,验证了本方法的有效性。本文测试方法适用于水下加压条件,有效测试频带范围宽,测试效率高。 展开更多
关键词 水下加压 动态力学参数测试 直达波提取 共振法
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国家人体生物监测项目中化学污染物靶向定量分析的实验室质量控制策略
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作者 杨艳伟 张续 +14 位作者 林潇 孙琦 付慧 陆一夫 邱天 张卓娜 谢琳娜 张海婧 张淼 胡小键 曲英莉 赵峰 吕跃斌 朱英 施小明 《色谱》 北大核心 2025年第6期559-570,共12页
国家人体生物监测项目于2016年正式启动,该项目的目标是通过对我国人群进行现场流行病学调查,并监测人体生物样本中的环境污染物,来获取具有代表性的环境污染物在普通人群中的暴露负荷数据,为政府制定环境污染防控政策和采取相应干预措... 国家人体生物监测项目于2016年正式启动,该项目的目标是通过对我国人群进行现场流行病学调查,并监测人体生物样本中的环境污染物,来获取具有代表性的环境污染物在普通人群中的暴露负荷数据,为政府制定环境污染防控政策和采取相应干预措施提供重要的科学依据。为了获取人群生物样本中准确且可比的化学污染物数据,在国家人体生物监测项目的框架下,实验室从分析方法、实验空白到检测过程,对化学污染物的靶向定量分析实施了多维度的质量控制措施。项目的质量控制程序分为两个阶段进行:(1)检测前阶段中生物监测分析方法的验证、空白的筛查与控制;(2)检测阶段中大规模样本分析过程的质量控制。应用于国家人体生物监测项目的分析方法均需经过验证程序,以全面评估方法的性能,验证的重点包括方法检出限和方法定量限、基质效应、稳定性及残留与稀释。所有监测指标均需通过空白筛查程序,以识别、消除或降低实验中的空白干扰,确保每批次的空白测定结果均低于方法检出限。实验室采用内部质量控制与外部质量控制相结合的方式,具体措施主要包括:(1)10类监测指标的方法验证及检测过程均使用包括美国国家标准与技术研究院(NIST)、欧洲标准局(ERM)及中国标准物质中心在内生产的生物基质标准物质,以确保方法的准确性及溯源性;(2)15类监测指标使用商品质控样和内部质控样,以评价测试过程的稳定性;(3)9类共60项监测指标参与德国外部质量评估计划(G-EQUAS),并取得了满意的结果;(4)15类监测指标使用盲样。多维度的质量控制措施为生成高质量的生物监测数据提供了专业支撑。 展开更多
关键词 国家人体生物监测项目 质量控制 方法验证 实验空白 综述
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