Rock bursts are spontaneous, violent fracture of rock that can occur in deep mines, and the likelihood of rock bursts occurring increases as depth of the mine increases. Rock bursts are also affected by the compressiv...Rock bursts are spontaneous, violent fracture of rock that can occur in deep mines, and the likelihood of rock bursts occurring increases as depth of the mine increases. Rock bursts are also affected by the compressive strength, tensile strength, tangential strength, elastic energy index, etc. of rock, and the relationship between these factors and rock bursts in deep mines is difficult to analyze from quantitative point. Typical rock burst instances as a sample set were collected, and membership function was introduced to process the discrete values of these factors with the discrete factors as condition attributes and rock burst situations as decision attributes. Dominance-based rough set theory was used to generate preference rules of rock burst, and eventually rock burst laws analysis in deep mines with preference relation was taken. The results show that this model for rock burst laws analysis in deep mines is more reasonable and feasible, and the prediction results are more scientific.展开更多
OBJECTIVE Lychee seed,a famous traditional Chinese medicine,recently were reported to improve the learning and memory abilities in mice.However,it is still unclear whether lychee seed saponins(LSS)can improve the cogn...OBJECTIVE Lychee seed,a famous traditional Chinese medicine,recently were reported to improve the learning and memory abilities in mice.However,it is still unclear whether lychee seed saponins(LSS)can improve the cognitive function and associated mechanisms.METHODS In present studies,we established the Alzheimer disease(AD)model by injecting Aβ25-35 into the lateral ventricle of rats.Then the spatial learning and memory abilities of LSS-treated rats were evaluated with the Morris water maze,meanwhile the protein expressions of AKT,GSK3β and Tau in the hippocampal neuron were analyzed by immunohistochemistry and Western blotting.RESULTS The results showed LSS can improve the cognitive functions of AD rats through shortening the escape latency,increasing the number across the platform,platform quadrant dwell time and the percentage of the total distance run platform quadrant.The protein expression of AKT was significantly up-regulated and that of GSK3β and Tau were decreased remarkably in the hippocampal CA1 area.CONCLUSION Our study is the first to show that LSS significantly improve the cognitive function and prevent hippocampal neuronal injury of the rats with AD by activation of the PI3K/AKT/GSK3βsignaling pathway,suggesting LSS may be developed into the nutrient supplement for the treatment of AD.展开更多
目的利用静息态功能MRI探讨δ-连环蛋白(catenin)不同表达状态的乳腺癌患者采用蒽环联合环磷酰胺(anthracyclines cyclophosphamide,AC)化疗方案2个周期后的脑认知功能改变。材料与方法前瞻性收集66例经病理证实乳腺癌并首次进行标准化...目的利用静息态功能MRI探讨δ-连环蛋白(catenin)不同表达状态的乳腺癌患者采用蒽环联合环磷酰胺(anthracyclines cyclophosphamide,AC)化疗方案2个周期后的脑认知功能改变。材料与方法前瞻性收集66例经病理证实乳腺癌并首次进行标准化化疗患者,根据组织血清δ-catenin水平,分为δ-catenin高表达组31例和低表达组35例,同时收集健康对照(healthy control,HC)组36例。所有受试者在化疗前及2个化疗周期后进行神经心理学评分并行脑静息态功能MRI、3D-T1加权成像,分析脑静息态功能MRI指标,包括低频振幅(amplitude of low frequency fluctuation,ALFF)值、分数低频振幅(fractional amplitude of low frequency fluctuation,fALFF)值、局部一致性(regional homogeneity,ReHo)值,并对患者化疗前后神经心理学评分以及脑静息态功能MRI指标进行对比分析。结果化疗前δ-catenin高表达组人表皮生长因子受体2(human epidermal growth factor receptor 2,HER-2)显著高于低表达组,差异有统计学意义(P<0.05)。乳腺癌患者化疗前后神经心理学评分显示,δ-catenin高表达组患者化疗后癌症治疗认知功能评估(Functional Assessment of Cancer Therapy-Cognitive,FACT-Cog)总分、感知认知能力(Perceived Cognitive Abilities,PCA)、简易智力状态检查评分(Mini Mental State Examination,MMSE)、蒙特利尔认知评估评分(Montreal Cognitive Assessment,MOCA)、数字符号转化测验(Digital Symbol Substitution Test,DSST)以及中文听觉词语学习测验(Auditory Verbal Learning Test,AVLT)、数字连线实验B(Line-B)评分较化疗前差异有统计学意义,而低表达组只有AVLT-长时记忆(AVLT-long)评分差异有统计学意义(P均<0.05)。与化疗前相比,化疗2周期后部分脑区ALFF及ReHo值改变差异有统计学意义(P<0.05)。δ-catenin低表达组患者化疗后右侧前扣带和旁扣带脑回ALFF值下降,而δ-catenin高表达组右侧小脑半球4-5区、双侧脑岛、左侧舌回化疗后ALFF值下降。ReHo指标中,δ-catenin低表达组患者化疗后左侧眶部额下回ReHo值下降;而δ-catenin高表达组则左侧缘上回、左侧三角部额下回ReHo值下降(P均<0.05)。结论δ-catenin高表达进一步加重化疗对乳腺癌患者脑认知功能的损伤,主要涉及执行认知功能调控等相关脑区。展开更多
目的:旨在评估帕金森病(Parkinson’s disease,PD)患者的肺功能状况,探讨PD患者肺功能与运动症状的关系。方法:纳入PD患者104例,采用便携式肺功能仪进行肺功能评估,根据肺功能结果,将患者分为伴有通气功能障碍组(37例)和不伴有通气功能...目的:旨在评估帕金森病(Parkinson’s disease,PD)患者的肺功能状况,探讨PD患者肺功能与运动症状的关系。方法:纳入PD患者104例,采用便携式肺功能仪进行肺功能评估,根据肺功能结果,将患者分为伴有通气功能障碍组(37例)和不伴有通气功能障碍组(67例),比较2组的临床资料,采用单因素分析及多因素logistic回归模型探讨肺功能异常的相关因素,采用Spearman相关性分析探讨肺功能参数与运动症状的关系。结果:2组患者的运动迟缓评分和姿势步态评分比较差异有统计学意义(P<0.05);logistic回归分析显示,肺通气功能障碍与姿势步态评分之间呈正相关(回归系数β=0.171,95%CI=1.015~1.386,P=0.032)。不同分期PD患者的用力肺活量占预计值(forced vital capacity as percentage of predicted value,FVC%)(t=2.143,P=0.034)、第1秒用力呼气容积占预计值(forced expiratory volume in 1 second as percentage of predicted value,FEV1%)(t=2.118,P=0.037)、呼气峰值流速占预计值(peak expiratory flow as percentage of predicted value,PEF%)(t=2.002,P=0.048)、最大呼气压占预计值(maximal expiratory pressure as percentage of predicted value,MEP%)(t=2.412,P=0.018)、最大吸气压占预计值(maximal expiratory pressure as percentage of predicted value,MIP%)(t=2.119,P=0.036)差异有统计学意义。结论:PD患者的肺功能较预期值偏低,伴有肺通气功能障碍的发生率为35.58%,主要表现为限制性通气功能障碍,PD患者肺功能与运动症状存在关联。展开更多
基金Project(2011AA060407) supported by the National High Technology Research and Development Program of China
文摘Rock bursts are spontaneous, violent fracture of rock that can occur in deep mines, and the likelihood of rock bursts occurring increases as depth of the mine increases. Rock bursts are also affected by the compressive strength, tensile strength, tangential strength, elastic energy index, etc. of rock, and the relationship between these factors and rock bursts in deep mines is difficult to analyze from quantitative point. Typical rock burst instances as a sample set were collected, and membership function was introduced to process the discrete values of these factors with the discrete factors as condition attributes and rock burst situations as decision attributes. Dominance-based rough set theory was used to generate preference rules of rock burst, and eventually rock burst laws analysis in deep mines with preference relation was taken. The results show that this model for rock burst laws analysis in deep mines is more reasonable and feasible, and the prediction results are more scientific.
基金supported by Science and Technology Planning Project of Sichuan Province(2008SZ0050,14JC0798)Educational Commission of Sichuan Province(10ZA035,15ZA0155)+1 种基金Science and Technology Program of Luzhou(2015-S-43,2016LZXNYD-T03)Key Development Program of Southwest Medical University(2010ZD-010)
文摘OBJECTIVE Lychee seed,a famous traditional Chinese medicine,recently were reported to improve the learning and memory abilities in mice.However,it is still unclear whether lychee seed saponins(LSS)can improve the cognitive function and associated mechanisms.METHODS In present studies,we established the Alzheimer disease(AD)model by injecting Aβ25-35 into the lateral ventricle of rats.Then the spatial learning and memory abilities of LSS-treated rats were evaluated with the Morris water maze,meanwhile the protein expressions of AKT,GSK3β and Tau in the hippocampal neuron were analyzed by immunohistochemistry and Western blotting.RESULTS The results showed LSS can improve the cognitive functions of AD rats through shortening the escape latency,increasing the number across the platform,platform quadrant dwell time and the percentage of the total distance run platform quadrant.The protein expression of AKT was significantly up-regulated and that of GSK3β and Tau were decreased remarkably in the hippocampal CA1 area.CONCLUSION Our study is the first to show that LSS significantly improve the cognitive function and prevent hippocampal neuronal injury of the rats with AD by activation of the PI3K/AKT/GSK3βsignaling pathway,suggesting LSS may be developed into the nutrient supplement for the treatment of AD.
文摘目的利用静息态功能MRI探讨δ-连环蛋白(catenin)不同表达状态的乳腺癌患者采用蒽环联合环磷酰胺(anthracyclines cyclophosphamide,AC)化疗方案2个周期后的脑认知功能改变。材料与方法前瞻性收集66例经病理证实乳腺癌并首次进行标准化化疗患者,根据组织血清δ-catenin水平,分为δ-catenin高表达组31例和低表达组35例,同时收集健康对照(healthy control,HC)组36例。所有受试者在化疗前及2个化疗周期后进行神经心理学评分并行脑静息态功能MRI、3D-T1加权成像,分析脑静息态功能MRI指标,包括低频振幅(amplitude of low frequency fluctuation,ALFF)值、分数低频振幅(fractional amplitude of low frequency fluctuation,fALFF)值、局部一致性(regional homogeneity,ReHo)值,并对患者化疗前后神经心理学评分以及脑静息态功能MRI指标进行对比分析。结果化疗前δ-catenin高表达组人表皮生长因子受体2(human epidermal growth factor receptor 2,HER-2)显著高于低表达组,差异有统计学意义(P<0.05)。乳腺癌患者化疗前后神经心理学评分显示,δ-catenin高表达组患者化疗后癌症治疗认知功能评估(Functional Assessment of Cancer Therapy-Cognitive,FACT-Cog)总分、感知认知能力(Perceived Cognitive Abilities,PCA)、简易智力状态检查评分(Mini Mental State Examination,MMSE)、蒙特利尔认知评估评分(Montreal Cognitive Assessment,MOCA)、数字符号转化测验(Digital Symbol Substitution Test,DSST)以及中文听觉词语学习测验(Auditory Verbal Learning Test,AVLT)、数字连线实验B(Line-B)评分较化疗前差异有统计学意义,而低表达组只有AVLT-长时记忆(AVLT-long)评分差异有统计学意义(P均<0.05)。与化疗前相比,化疗2周期后部分脑区ALFF及ReHo值改变差异有统计学意义(P<0.05)。δ-catenin低表达组患者化疗后右侧前扣带和旁扣带脑回ALFF值下降,而δ-catenin高表达组右侧小脑半球4-5区、双侧脑岛、左侧舌回化疗后ALFF值下降。ReHo指标中,δ-catenin低表达组患者化疗后左侧眶部额下回ReHo值下降;而δ-catenin高表达组则左侧缘上回、左侧三角部额下回ReHo值下降(P均<0.05)。结论δ-catenin高表达进一步加重化疗对乳腺癌患者脑认知功能的损伤,主要涉及执行认知功能调控等相关脑区。
文摘目的:旨在评估帕金森病(Parkinson’s disease,PD)患者的肺功能状况,探讨PD患者肺功能与运动症状的关系。方法:纳入PD患者104例,采用便携式肺功能仪进行肺功能评估,根据肺功能结果,将患者分为伴有通气功能障碍组(37例)和不伴有通气功能障碍组(67例),比较2组的临床资料,采用单因素分析及多因素logistic回归模型探讨肺功能异常的相关因素,采用Spearman相关性分析探讨肺功能参数与运动症状的关系。结果:2组患者的运动迟缓评分和姿势步态评分比较差异有统计学意义(P<0.05);logistic回归分析显示,肺通气功能障碍与姿势步态评分之间呈正相关(回归系数β=0.171,95%CI=1.015~1.386,P=0.032)。不同分期PD患者的用力肺活量占预计值(forced vital capacity as percentage of predicted value,FVC%)(t=2.143,P=0.034)、第1秒用力呼气容积占预计值(forced expiratory volume in 1 second as percentage of predicted value,FEV1%)(t=2.118,P=0.037)、呼气峰值流速占预计值(peak expiratory flow as percentage of predicted value,PEF%)(t=2.002,P=0.048)、最大呼气压占预计值(maximal expiratory pressure as percentage of predicted value,MEP%)(t=2.412,P=0.018)、最大吸气压占预计值(maximal expiratory pressure as percentage of predicted value,MIP%)(t=2.119,P=0.036)差异有统计学意义。结论:PD患者的肺功能较预期值偏低,伴有肺通气功能障碍的发生率为35.58%,主要表现为限制性通气功能障碍,PD患者肺功能与运动症状存在关联。
