In this paper,large deviations principle(LDP)and moderate deviations principle(MDP)of record numbers in random walks are studied under certain conditions.The results show that the rate functions of LDP and MDP are dif...In this paper,large deviations principle(LDP)and moderate deviations principle(MDP)of record numbers in random walks are studied under certain conditions.The results show that the rate functions of LDP and MDP are different from those of weak record numbers,which are interesting complements of the conclusions by Li and Yao[1].展开更多
Isoperimetric type inequalities for integral geometric invariants of random lines in the Euclidean space are shown.Entropy inequalities of probability densities on the affine Grassmann manifold of lines are given.
The physical layer key generation technique provides an efficient method,which utilizes the natural dynamics of wireless channel.However,there are some extremely challenging security scenarios such as static or quasi-...The physical layer key generation technique provides an efficient method,which utilizes the natural dynamics of wireless channel.However,there are some extremely challenging security scenarios such as static or quasi-static environment,which lead to the low randomness of generated keys.Meanwhile,the coefficients of the static channel may be dropped into the guard space and discarded by the quantization approach,which causes low key generation rate.To tackle these issues,we propose a random coefficient-moving product based wireless key generation scheme(RCMP-WKG),where new random resources with remarkable fluctuations can be obtained by applying random coefficient and by moving product on the legitimate nodes.Furthermore,appropriate quantization approaches are used to increase the key generation rate.Moreover,the security of our proposed scheme is evaluated by analyzing different attacks and the eavesdropper’s mean square error(MSE).The simulation results reveal that the proposed scheme can achieve better performances in key capacity,key inconsistency rate(KIR)and key generation rate(KGR)compared with the prior works in static environment.Besides,the proposed scheme can deteriorate the MSE performance of the eavesdropper and improve the key generation performance of legitimate nodes by controlling the length of the moving product.展开更多
BACKGROUND:This study aims to explore the causal relationship of body weight,body mass index(BMI),and waist circumference (WC) with the risk of cardiac arrest (CA) using two-sample Mendelian randomization (MR).METHODS...BACKGROUND:This study aims to explore the causal relationship of body weight,body mass index(BMI),and waist circumference (WC) with the risk of cardiac arrest (CA) using two-sample Mendelian randomization (MR).METHODS:Data were summarized using genome-wide association studies (GWAS).Twosample MR analyses were performed using the inverse variance weighting (IVW) method,the weighted median method,and the MR-Egger analysis.Heterogeneity test and sensitivity analysis were performed using Cochran’s Q test and the leave-one-out method,respectively.The Steiger test was used to detect reverse causality.Bayesian model-averaged MR was used to identify the most influential risk factors.RESULTS:A total of 13 GWAS data were collected for BMI,body weight and WC.IVW analyses showed a positive correlation of body weight,BMI,and WC with CA (all OR>1 and P<0.05),with MR-Egger and weighted median methods confirming the IVW findings.No horizontal pleiotropy or heterogeneity was observed.Sensitivity analysis indicated that no single nucleotide polymorphism(SNP) caused significant changes in overall causality.Bayesian model-averaged MR was also used to rank causality based on marginal inclusion probability (MIP),and the corresponding modelaveraged causal estimate (MACE) were confirmed,which indicated that WC (GWAS ID:ukb-b-9405)was the highest-ranked risk factor (MIP=0.119,MACE=0.011);its posterior probability was 0.057.A total of 14 sex-specific GWAS data on weight,BMI,and WC were analyzed in relationship with CA,and the MR results showed no significant effects of sex-specific factors.CONCLUSION:Body weight,BMI,and WC are causally associated with an increased risk of CA,with WC identified as the most important risk factor.展开更多
The successful application of perimeter control of urban traffic system strongly depends on the macroscopic fundamental diagram of the targeted region.Despite intensive studies on the partitioning of urban road networ...The successful application of perimeter control of urban traffic system strongly depends on the macroscopic fundamental diagram of the targeted region.Despite intensive studies on the partitioning of urban road networks,the dynamic partitioning of urban regions reflecting the propagation of congestion remains an open question.This paper proposes to partition the network into homogeneous sub-regions based on random walk algorithm.Starting from selected random walkers,the road network is partitioned from the early morning when congestion emerges.A modified Akaike information criterion is defined to find the optimal number of partitions.Region boundary adjustment algorithms are adopted to optimize the partitioning results to further ensure the correlation of partitions.The traffic data of Melbourne city are used to verify the effectiveness of the proposed partitioning method.展开更多
Background:Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes.The effect on markers of health and disease,such as offspring telomere length...Background:Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes.The effect on markers of health and disease,such as offspring telomere length(TL)and mitochondrial DNA content(mtDNAc)is unknown.Objectives:We assessed the efficacy of maternal multiple micronutrient(MMN)-fortified balanced-energy protein(BEP)and iron-folic acid(IFA)supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome.Design:We conducted a randomized controlled trial in rural Burkina Faso,among pregnant females(15-40 years old)enrolled at<21 weeks of gestation.Mothers received either MMN-fortified BEP and IFA(intervention)or IFA only(control)throughout pregnancy.Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants,respectively.Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction.Linear regression models were fitted to assess TL and mtDNAc differences across trial arms.Results:We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL[β=-0.010(95%CI:-0.057,0.036);P=0.662]or mtDNAc[β=0.065(95%CI:-0.203,0.073);P=0.354],as compared to an IFA tablet alone.These findings were confirmed(P>0.05)by adjusting the regression models for potential prognostic factors of study outcomes at enrollment.Exploratory analyses indicated higher,but non-significantly different mtDNAc among children born either small-for-gestational age,low birthweight,or preterm.Conclusion:Newborns from mothers who received daily nutritional supplements across gestation did not have different relative TL or mtDNAc.展开更多
Real-time intelligent lithology identification while drilling is vital to realizing downhole closed-loop drilling. The complex and changeable geological environment in the drilling makes lithology identification face ...Real-time intelligent lithology identification while drilling is vital to realizing downhole closed-loop drilling. The complex and changeable geological environment in the drilling makes lithology identification face many challenges. This paper studies the problems of difficult feature information extraction,low precision of thin-layer identification and limited applicability of the model in intelligent lithologic identification. The author tries to improve the comprehensive performance of the lithology identification model from three aspects: data feature extraction, class balance, and model design. A new real-time intelligent lithology identification model of dynamic felling strategy weighted random forest algorithm(DFW-RF) is proposed. According to the feature selection results, gamma ray and 2 MHz phase resistivity are the logging while drilling(LWD) parameters that significantly influence lithology identification. The comprehensive performance of the DFW-RF lithology identification model has been verified in the application of 3 wells in different areas. By comparing the prediction results of five typical lithology identification algorithms, the DFW-RF model has a higher lithology identification accuracy rate and F1 score. This model improves the identification accuracy of thin-layer lithology and is effective and feasible in different geological environments. The DFW-RF model plays a truly efficient role in the realtime intelligent identification of lithologic information in closed-loop drilling and has greater applicability, which is worthy of being widely used in logging interpretation.展开更多
Deconvolution is a commonly employed technique for enhancing image quality in optical imaging methods.Unfortu-nately,its application in optical coherence tomography(OCT)is often hindered by sensitivity to noise,which ...Deconvolution is a commonly employed technique for enhancing image quality in optical imaging methods.Unfortu-nately,its application in optical coherence tomography(OCT)is often hindered by sensitivity to noise,which leads to ad-ditive ringing artifacts.These artifacts considerably degrade the quality of deconvolved images,thereby limiting its effect-iveness in OCT imaging.In this study,we propose a framework that integrates numerical random phase masks into the deconvolution process,effectively eliminating these artifacts and enhancing image clarity.The optimized joint operation of an iterative Richardson-Lucy deconvolution and numerical synthesis of random phase masks(RPM),termed as De-conv-RPM,enables a 2.5-fold reduction in full width at half-maximum(FWHM).We demonstrate that the Deconv-RPM method significantly enhances image clarity,allowing for the discernment of previously unresolved cellular-level details in nonkeratinized epithelial cells ex vivo and moving blood cells in vivo.展开更多
Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on su...Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation(MR)analysis to estimate the causal effect of educational attainment on suicide attempts,utilising genome-wide association study summary statistics from the Integrative Psychiatric Research(iPSYCH;6024 cases and 44240 controls)and FinnGen(8978 cases and 368299 controls).We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated effect.Results In the combined analysis of iPSYCH and FinnGen,each standard deviation(SD)decrease in genetically predicted educational attainment(equating to 3.4 years of education)was associated with a 105%higher risk of suicide attempts(odds ratio(OR):2.05;95%confidence interval(Cl):1.81 to 2.31).0f the 42 risk factors analysed,the two-step MR identified five factors that mediated the association between educational attainment and suicide attempts.The respective proportions of mediation were 47%(95%Cl:29%to 66%)for smoking behaviour,36%(95%Cl:0%to 84%)for chronic pain,49%(95%Cl:36%to 61%)for depression,35%(95%Cl:12%to 59%)for anxiety and 26%(95%Cl:18%to 34%)for insomnia.Multivariable MR implicated these five mediators collectively,accounting for 68%(95%Cl:40%to 96%)of the total effect.Conclusions This study identified smoking,chronic pain and mental disorders as primary intervention targets for attenuating suicide risk attributable to lower educational levels in the European population.展开更多
Background Observational studies highlight the association between gut microbiota(GM)composition and depression;however,evidence for the causal relationship between GM and specific depressive symptoms remains lacking....Background Observational studies highlight the association between gut microbiota(GM)composition and depression;however,evidence for the causal relationship between GM and specific depressive symptoms remains lacking.Aims We aimed to evaluate the causal relationship between GM and specific depressive symptoms as well as the mediating role of body mass index(BMI).Methods We performed a two-sample Mendelian randomisation(MR)analysis using genetic variants associated with GM and specific depressive symptoms from genome-wide association studies.The mediating role of BMI was subsequently explored using mediation analysis via two-step MR.Results MR evidence suggested the Bifidobacterium genus(β=0.03;95%CI-0.05 to-0.02;p<0.001 andβ=0.03;95%CI-0.05 to-0.02;p<0.001)and Actinobacteria phylum(β=-0.04;95%CI-0.06 to-0.02;p<0.001 andβ=-0.03;95%CI-0.05 to-0.03;p=0.001)had protective effects on both anhedonia and depressed mood.The Actinobacteria phylum also had protective effects on appetite changes(β=-0.04;95%CI-0.06 to-0.01;p=0.005),while the FamilyⅪhad an antiprotective effect(β=0.03;95%CI 0.01 to 0.04;p<0.001).The Bifidobacteriaceae family(β=-0.01;95%CI-0.02 to-0.01;p=0.001)and Actinobacteria phylum(β=-0.02;95%CI-0.03 to-0.01;p=0.001)showed protective effects against suicidality.The two-step MR analysis revealed that BMl also acted as a mediating moderator between the Actinobacteria phylum and appetite changes(mediated proportion,34.42%)and that BMI partially mediated the effect of the Bifidobacterium genus(14.14%and 8.05%)and Actinobacteria phylum(13.10%and 8.31%)on both anhedonia and depressed mood.Conclusions These findings suggest a potential therapeutic effect of Actinobacteria and Bifidobacterium on both depression and obesity.Further studies are required to translate these findings into clinical practice.展开更多
This paper investigates the low earth orbit(LEO)satellite-enabled coded compressed sensing(CCS)unsourced random access(URA)in orthogonal frequency division multiple access(OFDMA)framework,where a massive uniform plana...This paper investigates the low earth orbit(LEO)satellite-enabled coded compressed sensing(CCS)unsourced random access(URA)in orthogonal frequency division multiple access(OFDMA)framework,where a massive uniform planar array(UPA)is equipped on the satellite.In LEO satellite communications,unavoidable timing and frequency offsets cause phase shifts in the transmitted signals,substantially diminishing the decoding performance of current terrestrial CCS URA receiver.To cope with this issue,we expand the inner codebook with predefined timing and frequency offsets and formulate the inner decoding as a tractable compressed sensing(CS)problem.Additionally,we leverage the inherent sparsity of the UPA-equipped LEO satellite angular domain channels,thereby enabling the outer decoder to support more active devices.Furthermore,the outputs of the outer decoder are used to reduce the search space of the inner decoder,which cuts down the computational complexity and accelerates the convergence of the inner decoding.Simulation results verify the effectiveness of the proposed scheme.展开更多
Let{Z_(n)}_(n)≥0 be a critical or subcritical d-dimensional branching random walk started from a Poisson random measure whose intensity measure is the Lebesugue measure on R^(d).Denote by R_(n):=sup{u>0:Z_(n)({x∈...Let{Z_(n)}_(n)≥0 be a critical or subcritical d-dimensional branching random walk started from a Poisson random measure whose intensity measure is the Lebesugue measure on R^(d).Denote by R_(n):=sup{u>0:Z_(n)({x∈R^(d):∣x∣<u})=0}the radius of the largest empty ball centered at the origin of Z_(n).In this work,we prove that after suitable renormalization,Rn converges in law to some non-degenerate distribution as n→∞.Furthermore,our work shows that the renormalization scales depend on the offspring law and the dimension of the branching random walk.This completes the results of Révész[13]for the critical binary branching Wiener process.展开更多
Objective To investigate the causal relationships between plasma metabolites and osteoporosis via Mendelian randomization(MR) analysis.Methods Bidirectional MR was used to analyze pooled data from different genome-wid...Objective To investigate the causal relationships between plasma metabolites and osteoporosis via Mendelian randomization(MR) analysis.Methods Bidirectional MR was used to analyze pooled data from different genome-wide association studies(GWAS). The causal effect of plasma metabolites on osteoporosis was estimated using the inverse variance weighted method, intersections of statistically significant metabolites obtained from different sources of osteoporosis-related GWAS aggregated data was determined, and then sensitivity analysis was performed on these metabolites. Heterogeneity between single nucleotide polymorphisms was evaluated by Cochran's Q test. Horizontal pleiotropy was assessed through the application of the MR-Egger intercept method and the MRPRESSO method. The causal effect of osteoporosis on plasma metabolites was also evaluated using the inverse variance weighted method. Additionally, pathway analysis was conducted to identify potential metabolic pathways involved in the regulation of osteoporosis.Results Primary analysis and sensitivity analysis showed that 77 and 61 plasma metabolites had a causal relationship with osteoporosis from the GWAS data in the GCST90038656 and GCST90044600 datasets, respectively. Five common metabolites were identified via intersection. X-13684 levels and the glucose-to-maltose ratio were negatively associated with osteoporosis, whereas glycoursodeoxycholate levels and arachidoylcarnitine(C20) levels were positively associated with osteoporosis(all P < 0.05). The relationship between X-11299 levels and osteoporosis showed contradictory results(all P < 0.05). Pathway analysis indicated that glycine, serine, and threonine metabolism, valine, leucine, and isoleucine biosynthesis, galactose metabolism, arginine biosynthesis, and starch and sucrose metabolism pathways were participated in the development of osteoporosis.Conclusion We found a causal relationship between plasma metabolites and osteoporosis. These results offer novel perspectives with important implications for targeted metabolite-focused interventions in the management of osteoporosis.展开更多
In this paper,we mainly discuss a discrete estimation of the average differential entropy for a continuous time-stationary ergodic space-time random field.By estimating the probability value of a time-stationary rando...In this paper,we mainly discuss a discrete estimation of the average differential entropy for a continuous time-stationary ergodic space-time random field.By estimating the probability value of a time-stationary random field in a small range,we give an entropy estimation and obtain the average entropy estimation formula in a certain bounded space region.It can be proven that the estimation of the average differential entropy converges to the theoretical value with a probability of 1.In addition,we also conducted numerical experiments for different parameters to verify the convergence result obtained in the theoretical proofs.展开更多
Optical memory effect-based speckle-correlated technology has been developed for reconstructing hidden objectsfrom disordered speckle patterns,achieving imaging through scattering layers.However,the lighting efficienc...Optical memory effect-based speckle-correlated technology has been developed for reconstructing hidden objectsfrom disordered speckle patterns,achieving imaging through scattering layers.However,the lighting efficiency and fieldof view of existing speckle-correlated imaging systems are limited.Here,a near-infrared low spatial coherence fiberrandom laser illumination method is proposed to address the above limitations.Through the utilization of random Rayleighscattering within dispersion-shifted fibers to provide feedback,coupled with stimulated Raman scattering for amplification,a near-infrared fiber random laser exhibiting a high spectral density and extremely low spatial coherence is generated.Based on the designed fiber random laser,speckle-correlated imaging through scattering layers is achieved,with highlighting efficiency and a large imaging field of view.This work improves the performance of speckle-correlated imagingand enriches the research on imaging through scattering medium.展开更多
There are numerous terminals in the satellite Internet of Things(IoT).To save cost and reduce power consumption,the system needs terminals to catch the characteristics of low power consumption and light control.The re...There are numerous terminals in the satellite Internet of Things(IoT).To save cost and reduce power consumption,the system needs terminals to catch the characteristics of low power consumption and light control.The regular random access(RA)protocols may generate large amounts of collisions,which degrade the system throughout severally.The near-far effect and power control technologies are not applicable in capture effect to obtain power difference,resulting in the collisions that cannot be separated.In fact,the optimal design at the receiving end can also realize the condition of packet power domain separation,but there are few relevant researches.In this paper,an auxiliary beamforming scheme is proposed for power domain signal separation.It adds an auxiliary reception beam based on the conventional beam,utilizing the correlation of packets in time-frequency domain between the main and auxiliary beam to complete signal separation.The roll-off belt of auxiliary beam is used to create the carrier-to-noise ratio(CNR)difference.This paper uses the genetic algorithm to optimize the auxiliary beam direction.Simulation results show that the proposed scheme outperforms slotted ALOHA(SA)in terms of system throughput per-formance and without bringing terminals additional control burden.展开更多
Mental disorders seriously affect people’s health and social stability.This Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin C(VC)or 25-hydroxyvitamin D...Mental disorders seriously affect people’s health and social stability.This Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin C(VC)or 25-hydroxyvitamin D(25(OH)D)levels and mental disorders.The data used for the MR analysis were derived from the summary genome-wide association studies(GWAS)database for VC and 25(OH)D and from the Finn Gen consortium for fourteen mental disorders.Based on the inverse variance weighted(IVW)method,we found a potential causal association between circulating VC and anxiety disorders(IVW:OR=1.139,95%CI:1.023-1.269,P=0.018).However,no causal association was found between VC or 25(OH)D and other mental disorders(P>0.05).In the reverse MR analysis,individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating VC(P=0.012),while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D(P=0.012).However,the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders.In addition,there was no causal association between circulating VC and 25(OH)D(P>0.05).Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.展开更多
The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte C...The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte Carlo simulation(MCS), so-called refined stochastic finite element method to investigate the random vibration of functionally graded material(FGM) plates subjected to the moving load.The advantage of the proposed method is to use r-FSDT to improve the accuracy of classical FSDT, satisfy the stress-free condition at the plate boundaries, and combine with MCS to analyze the vibration of the FGM plate when the parameter inputs are random quantities following a normal distribution. The obtained results show that the distribution characteristics of the vibration response of the FGM plate depend on the standard deviation of the input parameters and the velocity of the moving load.Furthermore, the numerical results in this study are expected to contribute to improving the understanding of FGM plates subjected to moving loads with uncertain input parameters.展开更多
In this paper,we investigate the complete convergence and complete moment conver-gence for weighted sums of arrays of rowwise asymptotically negatively associated(ANA)random variables,without assuming identical distri...In this paper,we investigate the complete convergence and complete moment conver-gence for weighted sums of arrays of rowwise asymptotically negatively associated(ANA)random variables,without assuming identical distribution.The obtained results not only extend those of An and Yuan[1]and Shen et al.[2]to the case of ANA random variables,but also partially improve them.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.11671145)the Science and Technology Commission of Shanghai Municipality(Grant No.18dz2271000).
文摘In this paper,large deviations principle(LDP)and moderate deviations principle(MDP)of record numbers in random walks are studied under certain conditions.The results show that the rate functions of LDP and MDP are different from those of weak record numbers,which are interesting complements of the conclusions by Li and Yao[1].
文摘Isoperimetric type inequalities for integral geometric invariants of random lines in the Euclidean space are shown.Entropy inequalities of probability densities on the affine Grassmann manifold of lines are given.
基金supported in part by the National Natural Science Foundation of China(Numbers 62171445,62471477 and 62201592).
文摘The physical layer key generation technique provides an efficient method,which utilizes the natural dynamics of wireless channel.However,there are some extremely challenging security scenarios such as static or quasi-static environment,which lead to the low randomness of generated keys.Meanwhile,the coefficients of the static channel may be dropped into the guard space and discarded by the quantization approach,which causes low key generation rate.To tackle these issues,we propose a random coefficient-moving product based wireless key generation scheme(RCMP-WKG),where new random resources with remarkable fluctuations can be obtained by applying random coefficient and by moving product on the legitimate nodes.Furthermore,appropriate quantization approaches are used to increase the key generation rate.Moreover,the security of our proposed scheme is evaluated by analyzing different attacks and the eavesdropper’s mean square error(MSE).The simulation results reveal that the proposed scheme can achieve better performances in key capacity,key inconsistency rate(KIR)and key generation rate(KGR)compared with the prior works in static environment.Besides,the proposed scheme can deteriorate the MSE performance of the eavesdropper and improve the key generation performance of legitimate nodes by controlling the length of the moving product.
基金This study is supported by the National Natural Science Foundation of China (No. 82072127)。
文摘BACKGROUND:This study aims to explore the causal relationship of body weight,body mass index(BMI),and waist circumference (WC) with the risk of cardiac arrest (CA) using two-sample Mendelian randomization (MR).METHODS:Data were summarized using genome-wide association studies (GWAS).Twosample MR analyses were performed using the inverse variance weighting (IVW) method,the weighted median method,and the MR-Egger analysis.Heterogeneity test and sensitivity analysis were performed using Cochran’s Q test and the leave-one-out method,respectively.The Steiger test was used to detect reverse causality.Bayesian model-averaged MR was used to identify the most influential risk factors.RESULTS:A total of 13 GWAS data were collected for BMI,body weight and WC.IVW analyses showed a positive correlation of body weight,BMI,and WC with CA (all OR>1 and P<0.05),with MR-Egger and weighted median methods confirming the IVW findings.No horizontal pleiotropy or heterogeneity was observed.Sensitivity analysis indicated that no single nucleotide polymorphism(SNP) caused significant changes in overall causality.Bayesian model-averaged MR was also used to rank causality based on marginal inclusion probability (MIP),and the corresponding modelaveraged causal estimate (MACE) were confirmed,which indicated that WC (GWAS ID:ukb-b-9405)was the highest-ranked risk factor (MIP=0.119,MACE=0.011);its posterior probability was 0.057.A total of 14 sex-specific GWAS data on weight,BMI,and WC were analyzed in relationship with CA,and the MR results showed no significant effects of sex-specific factors.CONCLUSION:Body weight,BMI,and WC are causally associated with an increased risk of CA,with WC identified as the most important risk factor.
基金Project supported by the National Natural Science Foundation of China(Grant No.12072340)the Chinese Scholarship Council and the Australia Research Council through a linkage project fund。
文摘The successful application of perimeter control of urban traffic system strongly depends on the macroscopic fundamental diagram of the targeted region.Despite intensive studies on the partitioning of urban road networks,the dynamic partitioning of urban regions reflecting the propagation of congestion remains an open question.This paper proposes to partition the network into homogeneous sub-regions based on random walk algorithm.Starting from selected random walkers,the road network is partitioned from the early morning when congestion emerges.A modified Akaike information criterion is defined to find the optimal number of partitions.Region boundary adjustment algorithms are adopted to optimize the partitioning results to further ensure the correlation of partitions.The traffic data of Melbourne city are used to verify the effectiveness of the proposed partitioning method.
基金supported by the Bill&Melinda Gates Foundation(OPP1175213)supported by the Research Foundation Flanders(12X9620N and 12X9623N)the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(946192,HUMYCO)。
文摘Background:Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes.The effect on markers of health and disease,such as offspring telomere length(TL)and mitochondrial DNA content(mtDNAc)is unknown.Objectives:We assessed the efficacy of maternal multiple micronutrient(MMN)-fortified balanced-energy protein(BEP)and iron-folic acid(IFA)supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome.Design:We conducted a randomized controlled trial in rural Burkina Faso,among pregnant females(15-40 years old)enrolled at<21 weeks of gestation.Mothers received either MMN-fortified BEP and IFA(intervention)or IFA only(control)throughout pregnancy.Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants,respectively.Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction.Linear regression models were fitted to assess TL and mtDNAc differences across trial arms.Results:We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL[β=-0.010(95%CI:-0.057,0.036);P=0.662]or mtDNAc[β=0.065(95%CI:-0.203,0.073);P=0.354],as compared to an IFA tablet alone.These findings were confirmed(P>0.05)by adjusting the regression models for potential prognostic factors of study outcomes at enrollment.Exploratory analyses indicated higher,but non-significantly different mtDNAc among children born either small-for-gestational age,low birthweight,or preterm.Conclusion:Newborns from mothers who received daily nutritional supplements across gestation did not have different relative TL or mtDNAc.
基金financially supported by the National Natural Science Foundation of China(No.52174001)the National Natural Science Foundation of China(No.52004064)+1 种基金the Hainan Province Science and Technology Special Fund “Research on Real-time Intelligent Sensing Technology for Closed-loop Drilling of Oil and Gas Reservoirs in Deepwater Drilling”(ZDYF2023GXJS012)Heilongjiang Provincial Government and Daqing Oilfield's first batch of the scientific and technological key project “Research on the Construction Technology of Gulong Shale Oil Big Data Analysis System”(DQYT-2022-JS-750)。
文摘Real-time intelligent lithology identification while drilling is vital to realizing downhole closed-loop drilling. The complex and changeable geological environment in the drilling makes lithology identification face many challenges. This paper studies the problems of difficult feature information extraction,low precision of thin-layer identification and limited applicability of the model in intelligent lithologic identification. The author tries to improve the comprehensive performance of the lithology identification model from three aspects: data feature extraction, class balance, and model design. A new real-time intelligent lithology identification model of dynamic felling strategy weighted random forest algorithm(DFW-RF) is proposed. According to the feature selection results, gamma ray and 2 MHz phase resistivity are the logging while drilling(LWD) parameters that significantly influence lithology identification. The comprehensive performance of the DFW-RF lithology identification model has been verified in the application of 3 wells in different areas. By comparing the prediction results of five typical lithology identification algorithms, the DFW-RF model has a higher lithology identification accuracy rate and F1 score. This model improves the identification accuracy of thin-layer lithology and is effective and feasible in different geological environments. The DFW-RF model plays a truly efficient role in the realtime intelligent identification of lithologic information in closed-loop drilling and has greater applicability, which is worthy of being widely used in logging interpretation.
基金supported by the Guangdong Natural Science Fund General Program (2023A1515011289)Singapore Ministry of Health's National Medical Research Council under its Open Fund Individual Research Grant (MOH-OFIRG19may-0009)+2 种基金Ministry of Education Singapore under its Academic Research Fund Tier 1 (RG35/22)Academic Research Funding Tier 2 (MOE-T2EP30120-0001)China-Singapore International Joint Research Institute (203-A022001).
文摘Deconvolution is a commonly employed technique for enhancing image quality in optical imaging methods.Unfortu-nately,its application in optical coherence tomography(OCT)is often hindered by sensitivity to noise,which leads to ad-ditive ringing artifacts.These artifacts considerably degrade the quality of deconvolved images,thereby limiting its effect-iveness in OCT imaging.In this study,we propose a framework that integrates numerical random phase masks into the deconvolution process,effectively eliminating these artifacts and enhancing image clarity.The optimized joint operation of an iterative Richardson-Lucy deconvolution and numerical synthesis of random phase masks(RPM),termed as De-conv-RPM,enables a 2.5-fold reduction in full width at half-maximum(FWHM).We demonstrate that the Deconv-RPM method significantly enhances image clarity,allowing for the discernment of previously unresolved cellular-level details in nonkeratinized epithelial cells ex vivo and moving blood cells in vivo.
基金the Key Discipline of Zhejang Province in Public Health and Preventative Medicine(First Class,Category A)at the Hangzhou Medical College,China.
文摘Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation(MR)analysis to estimate the causal effect of educational attainment on suicide attempts,utilising genome-wide association study summary statistics from the Integrative Psychiatric Research(iPSYCH;6024 cases and 44240 controls)and FinnGen(8978 cases and 368299 controls).We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated effect.Results In the combined analysis of iPSYCH and FinnGen,each standard deviation(SD)decrease in genetically predicted educational attainment(equating to 3.4 years of education)was associated with a 105%higher risk of suicide attempts(odds ratio(OR):2.05;95%confidence interval(Cl):1.81 to 2.31).0f the 42 risk factors analysed,the two-step MR identified five factors that mediated the association between educational attainment and suicide attempts.The respective proportions of mediation were 47%(95%Cl:29%to 66%)for smoking behaviour,36%(95%Cl:0%to 84%)for chronic pain,49%(95%Cl:36%to 61%)for depression,35%(95%Cl:12%to 59%)for anxiety and 26%(95%Cl:18%to 34%)for insomnia.Multivariable MR implicated these five mediators collectively,accounting for 68%(95%Cl:40%to 96%)of the total effect.Conclusions This study identified smoking,chronic pain and mental disorders as primary intervention targets for attenuating suicide risk attributable to lower educational levels in the European population.
基金supported by the National Natural Science Foundation of China(grant number:81801345)Tianjin Key Medical Discipline(Specialty)Construction Project(grant number:TJYXZDXK-033A).
文摘Background Observational studies highlight the association between gut microbiota(GM)composition and depression;however,evidence for the causal relationship between GM and specific depressive symptoms remains lacking.Aims We aimed to evaluate the causal relationship between GM and specific depressive symptoms as well as the mediating role of body mass index(BMI).Methods We performed a two-sample Mendelian randomisation(MR)analysis using genetic variants associated with GM and specific depressive symptoms from genome-wide association studies.The mediating role of BMI was subsequently explored using mediation analysis via two-step MR.Results MR evidence suggested the Bifidobacterium genus(β=0.03;95%CI-0.05 to-0.02;p<0.001 andβ=0.03;95%CI-0.05 to-0.02;p<0.001)and Actinobacteria phylum(β=-0.04;95%CI-0.06 to-0.02;p<0.001 andβ=-0.03;95%CI-0.05 to-0.03;p=0.001)had protective effects on both anhedonia and depressed mood.The Actinobacteria phylum also had protective effects on appetite changes(β=-0.04;95%CI-0.06 to-0.01;p=0.005),while the FamilyⅪhad an antiprotective effect(β=0.03;95%CI 0.01 to 0.04;p<0.001).The Bifidobacteriaceae family(β=-0.01;95%CI-0.02 to-0.01;p=0.001)and Actinobacteria phylum(β=-0.02;95%CI-0.03 to-0.01;p=0.001)showed protective effects against suicidality.The two-step MR analysis revealed that BMl also acted as a mediating moderator between the Actinobacteria phylum and appetite changes(mediated proportion,34.42%)and that BMI partially mediated the effect of the Bifidobacterium genus(14.14%and 8.05%)and Actinobacteria phylum(13.10%and 8.31%)on both anhedonia and depressed mood.Conclusions These findings suggest a potential therapeutic effect of Actinobacteria and Bifidobacterium on both depression and obesity.Further studies are required to translate these findings into clinical practice.
基金supported by the National Key R&D Program of China under Grant 2023YFB2904703the National Natural Science Foundation of China under Grant 62341110,62371122 and 62322104+1 种基金the Jiangsu Province Basic Research Project under Grant BK20192002the Fundamental Research Funds for the Central Universities under Grant 2242022k30005 and 2242023K5003。
文摘This paper investigates the low earth orbit(LEO)satellite-enabled coded compressed sensing(CCS)unsourced random access(URA)in orthogonal frequency division multiple access(OFDMA)framework,where a massive uniform planar array(UPA)is equipped on the satellite.In LEO satellite communications,unavoidable timing and frequency offsets cause phase shifts in the transmitted signals,substantially diminishing the decoding performance of current terrestrial CCS URA receiver.To cope with this issue,we expand the inner codebook with predefined timing and frequency offsets and formulate the inner decoding as a tractable compressed sensing(CS)problem.Additionally,we leverage the inherent sparsity of the UPA-equipped LEO satellite angular domain channels,thereby enabling the outer decoder to support more active devices.Furthermore,the outputs of the outer decoder are used to reduce the search space of the inner decoder,which cuts down the computational complexity and accelerates the convergence of the inner decoding.Simulation results verify the effectiveness of the proposed scheme.
基金supported by the National Key R&D Program of China(2022YFA1006102).
文摘Let{Z_(n)}_(n)≥0 be a critical or subcritical d-dimensional branching random walk started from a Poisson random measure whose intensity measure is the Lebesugue measure on R^(d).Denote by R_(n):=sup{u>0:Z_(n)({x∈R^(d):∣x∣<u})=0}the radius of the largest empty ball centered at the origin of Z_(n).In this work,we prove that after suitable renormalization,Rn converges in law to some non-degenerate distribution as n→∞.Furthermore,our work shows that the renormalization scales depend on the offspring law and the dimension of the branching random walk.This completes the results of Révész[13]for the critical binary branching Wiener process.
文摘Objective To investigate the causal relationships between plasma metabolites and osteoporosis via Mendelian randomization(MR) analysis.Methods Bidirectional MR was used to analyze pooled data from different genome-wide association studies(GWAS). The causal effect of plasma metabolites on osteoporosis was estimated using the inverse variance weighted method, intersections of statistically significant metabolites obtained from different sources of osteoporosis-related GWAS aggregated data was determined, and then sensitivity analysis was performed on these metabolites. Heterogeneity between single nucleotide polymorphisms was evaluated by Cochran's Q test. Horizontal pleiotropy was assessed through the application of the MR-Egger intercept method and the MRPRESSO method. The causal effect of osteoporosis on plasma metabolites was also evaluated using the inverse variance weighted method. Additionally, pathway analysis was conducted to identify potential metabolic pathways involved in the regulation of osteoporosis.Results Primary analysis and sensitivity analysis showed that 77 and 61 plasma metabolites had a causal relationship with osteoporosis from the GWAS data in the GCST90038656 and GCST90044600 datasets, respectively. Five common metabolites were identified via intersection. X-13684 levels and the glucose-to-maltose ratio were negatively associated with osteoporosis, whereas glycoursodeoxycholate levels and arachidoylcarnitine(C20) levels were positively associated with osteoporosis(all P < 0.05). The relationship between X-11299 levels and osteoporosis showed contradictory results(all P < 0.05). Pathway analysis indicated that glycine, serine, and threonine metabolism, valine, leucine, and isoleucine biosynthesis, galactose metabolism, arginine biosynthesis, and starch and sucrose metabolism pathways were participated in the development of osteoporosis.Conclusion We found a causal relationship between plasma metabolites and osteoporosis. These results offer novel perspectives with important implications for targeted metabolite-focused interventions in the management of osteoporosis.
基金supported by the Shenzhen sustainable development project:KCXFZ 20201221173013036 and the National Natural Science Foundation of China(91746107).
文摘In this paper,we mainly discuss a discrete estimation of the average differential entropy for a continuous time-stationary ergodic space-time random field.By estimating the probability value of a time-stationary random field in a small range,we give an entropy estimation and obtain the average entropy estimation formula in a certain bounded space region.It can be proven that the estimation of the average differential entropy converges to the theoretical value with a probability of 1.In addition,we also conducted numerical experiments for different parameters to verify the convergence result obtained in the theoretical proofs.
基金supported by the National Natural Science Foundation of China(Grant Nos.62375040 and 11974071)the Sichuan Science and Technology Program(Grant Nos.2022ZYD0108 and 2023JDRC0030).
文摘Optical memory effect-based speckle-correlated technology has been developed for reconstructing hidden objectsfrom disordered speckle patterns,achieving imaging through scattering layers.However,the lighting efficiency and fieldof view of existing speckle-correlated imaging systems are limited.Here,a near-infrared low spatial coherence fiberrandom laser illumination method is proposed to address the above limitations.Through the utilization of random Rayleighscattering within dispersion-shifted fibers to provide feedback,coupled with stimulated Raman scattering for amplification,a near-infrared fiber random laser exhibiting a high spectral density and extremely low spatial coherence is generated.Based on the designed fiber random laser,speckle-correlated imaging through scattering layers is achieved,with highlighting efficiency and a large imaging field of view.This work improves the performance of speckle-correlated imagingand enriches the research on imaging through scattering medium.
基金supported by the National Science Foundation of China(No.U21A20450)Natural Science Foundation of Jiangsu Province Major Project(No.BK20192002)+1 种基金National Natural Science Foundation of China(No.61971440)National Natural Science Foundation of China(No.62271266).
文摘There are numerous terminals in the satellite Internet of Things(IoT).To save cost and reduce power consumption,the system needs terminals to catch the characteristics of low power consumption and light control.The regular random access(RA)protocols may generate large amounts of collisions,which degrade the system throughout severally.The near-far effect and power control technologies are not applicable in capture effect to obtain power difference,resulting in the collisions that cannot be separated.In fact,the optimal design at the receiving end can also realize the condition of packet power domain separation,but there are few relevant researches.In this paper,an auxiliary beamforming scheme is proposed for power domain signal separation.It adds an auxiliary reception beam based on the conventional beam,utilizing the correlation of packets in time-frequency domain between the main and auxiliary beam to complete signal separation.The roll-off belt of auxiliary beam is used to create the carrier-to-noise ratio(CNR)difference.This paper uses the genetic algorithm to optimize the auxiliary beam direction.Simulation results show that the proposed scheme outperforms slotted ALOHA(SA)in terms of system throughput per-formance and without bringing terminals additional control burden.
基金funded by the Nactional Natural Science Foundation of China(81872618)。
文摘Mental disorders seriously affect people’s health and social stability.This Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin C(VC)or 25-hydroxyvitamin D(25(OH)D)levels and mental disorders.The data used for the MR analysis were derived from the summary genome-wide association studies(GWAS)database for VC and 25(OH)D and from the Finn Gen consortium for fourteen mental disorders.Based on the inverse variance weighted(IVW)method,we found a potential causal association between circulating VC and anxiety disorders(IVW:OR=1.139,95%CI:1.023-1.269,P=0.018).However,no causal association was found between VC or 25(OH)D and other mental disorders(P>0.05).In the reverse MR analysis,individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating VC(P=0.012),while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D(P=0.012).However,the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders.In addition,there was no causal association between circulating VC and 25(OH)D(P>0.05).Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.
文摘The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte Carlo simulation(MCS), so-called refined stochastic finite element method to investigate the random vibration of functionally graded material(FGM) plates subjected to the moving load.The advantage of the proposed method is to use r-FSDT to improve the accuracy of classical FSDT, satisfy the stress-free condition at the plate boundaries, and combine with MCS to analyze the vibration of the FGM plate when the parameter inputs are random quantities following a normal distribution. The obtained results show that the distribution characteristics of the vibration response of the FGM plate depend on the standard deviation of the input parameters and the velocity of the moving load.Furthermore, the numerical results in this study are expected to contribute to improving the understanding of FGM plates subjected to moving loads with uncertain input parameters.
基金National Natural Science Foundation of China (Grant Nos.12061028, 71871046)Support Program of the Guangxi China Science Foundation (Grant No.2018GXNSFAA281011)。
文摘In this paper,we investigate the complete convergence and complete moment conver-gence for weighted sums of arrays of rowwise asymptotically negatively associated(ANA)random variables,without assuming identical distribution.The obtained results not only extend those of An and Yuan[1]and Shen et al.[2]to the case of ANA random variables,but also partially improve them.
