A measurement system for the scattering characteristics of warhead fragments based on high-speed imaging systems offers advantages such as simple deployment,flexible maneuverability,and high spatiotemporal resolution,...A measurement system for the scattering characteristics of warhead fragments based on high-speed imaging systems offers advantages such as simple deployment,flexible maneuverability,and high spatiotemporal resolution,enabling the acquisition of full-process data of the fragment scattering process.However,mismatches between camera frame rates and target velocities can lead to long motion blur tails of high-speed fragment targets,resulting in low signal-to-noise ratios and rendering conventional detection algorithms ineffective in dynamic strong interference testing environments.In this study,we propose a detection framework centered on dynamic strong interference disturbance signal separation and suppression.We introduce a mixture Gaussian model constrained under a joint spatialtemporal-transform domain Dirichlet process,combined with total variation regularization to achieve disturbance signal suppression.Experimental results demonstrate that the proposed disturbance suppression method can be integrated with certain conventional motion target detection tasks,enabling adaptation to real-world data to a certain extent.Moreover,we provide a specific implementation of this process,which achieves a detection rate close to 100%with an approximate 0%false alarm rate in multiple sets of real target field test data.This research effectively advances the development of the field of damage parameter testing.展开更多
A joint resource allocation scheme concerned with the sensor subset,power and bandwidth for range-only target tracking in multiple-input multiple-output(MIMO)radar systems is proposed.By selecting an optimal subset of...A joint resource allocation scheme concerned with the sensor subset,power and bandwidth for range-only target tracking in multiple-input multiple-output(MIMO)radar systems is proposed.By selecting an optimal subset of sensors with the predetermined size and implementing the power allocation and bandwidth strategies among them,this algorithm can help achieving a better performance within the same resource constraints.Firstly,the Bayesian Cramer-Rao bound(BCRB)is derived from it.Secondly,a criterion for minimizing the BCRB at the target location among all targets tracking in a certain range is derived.Thirdly,the optimization problem involved with three variable vectors is formulated,which can be simplified by deriving the relationship between the optimal power allocation vector and the bandwidth allocation vector.Then,the simplified optimization problem is solved by the cyclic minimization algorithm incorporated with the sequential parametric convex approximation(SPCA)algorithm.Finally,the validity of the proposed method is demonstrated with simulation results.展开更多
Momordica antiviral protein 30 kD(MAP30)is a type I ribosome-inactivating protein(RIP)with antibacterial,anti-HIV and antitumor activities but lacks the ability to target tumor cells.To increase its tumor-targeting ab...Momordica antiviral protein 30 kD(MAP30)is a type I ribosome-inactivating protein(RIP)with antibacterial,anti-HIV and antitumor activities but lacks the ability to target tumor cells.To increase its tumor-targeting ability,the arginine-glycine-aspartic(RGD)peptide and the epidermal growth factor receptor interference(EGFRi)peptide were fused with MAP30,which was named ELRL-MAP30.The efficiency of targeted therapy for triple-negative breast cancer(TNBC)MDA-MB-231 cells,which lack the expression of estrogen receptor(ER),Progesterone receptor(PgR)and human epidermal growth factor receptor-2(HER2),is limited.In this study,we focus on exploring the effect and mechanism of ELRL-MAP30 on TNBC MDA-MB-231 cells.First,we discovered that ELRL-MAP30 significantly inhibited the migration and invasion of MDA-MB-231 cells and induced MDA-MB-231 cell apoptosis.Moreover,ELRL-MAP30 treatment resulted in a significant increase in Bax expression and a decrease in Bcl-2 expression.Furthermore,ELRL-MAP30 triggered apoptosis via the Fak/EGFR/Erk and Ilk/Akt signaling pathways.In addition,recombinant ELRL-MAP30 can inhibit chicken embryonic angiogenesis,and also inhibit the tube formation ability of human umbilical vein endothelial cells(HUVECs),indicating its potential therapeutic effects on tumor angiogenesis.Collectively,these results indicate that ELRL-MAP30 has significant tumor-targeting properties in MDA-MB-231 cancer cells and reveals potential therapeutic effects on angiogenesis.These findings indicate the potential role of ELRL-MAP30 in the targeted treatment of the TNBC cell line MDA-MB-231.展开更多
This paper proposes a distributed event-triggered control(ETC)framework to address cooperative target fencing challenges in UAV swarm.The proposed architecture eliminates the reliance on preset formation parameters wh...This paper proposes a distributed event-triggered control(ETC)framework to address cooperative target fencing challenges in UAV swarm.The proposed architecture eliminates the reliance on preset formation parameters while achieving multi-objective cooperative control for target fencing,network connectivity preservation,collision avoidance,and communication efficiency optimization.Firstly,a differential state observer is constructed to obtain the target's unmeasurable states.Secondly,leveraging swarm selforganization principles,a geometric-constraint-free distributed fencing controller is designed by integrating potential field methods with consensus theory.The controller dynamically adjusts inter-UAV distances via single potential function,enabling coordinated optimization of persistent network connectivity and collision-free motion during target fencing.Thirdly,a dual-threshold ETC mechanism based on velocity consensus deviation and fencing error is proposed,which can be triggered based on task features to dynamically adjust the communication frequency,significantly reduce the communication burden and exclude Zeno behavior.Theoretical analysis demonstrates the stability of closed-loop systems.Multi-scenario simulations show that the proposed method can achieve robust fencing under target maneuverability,partial UAV failures,and communication disturbances.展开更多
Compared with single-domain unmanned swarms,cross-domain unmanned swarms continue to face new challenges in terms of platform performance and constraints.In this paper,a joint unmanned swarm target assignment and miss...Compared with single-domain unmanned swarms,cross-domain unmanned swarms continue to face new challenges in terms of platform performance and constraints.In this paper,a joint unmanned swarm target assignment and mission trajectory planning method is proposed to meet the requirements of cross-domain unmanned swarm mission planning.Firstly,the different performances of cross-domain heterogeneous platforms and mission requirements of targets are characterised by using a collection of operational resources.Secondly,an algorithmic framework for joint target assignment and mission trajectory planning is proposed,in which the initial planning of the trajectory is performed in the target assignment phase,while the trajectory is further optimised afterwards.Next,the estimation of the distribution algorithms is combined with the genetic algorithm to solve the objective function.Finally,the algorithm is numerically simulated by specific cases.Simulation results indicate that the proposed algorithm can perform effective task assignment and trajectory planning for cross-domain unmanned swarms.Furthermore,the solution performance of the hybrid estimation of distribution algorithm(EDA)-genetic algorithm(GA)algorithm is better than that of GA and EDA.展开更多
The key challenge of the extended target probability hypothesis density (ET-PHD) filter is to reduce the computational complexity by using a subset to approximate the full set of partitions. In this paper, the influen...The key challenge of the extended target probability hypothesis density (ET-PHD) filter is to reduce the computational complexity by using a subset to approximate the full set of partitions. In this paper, the influence for the tracking results of different partitions is analyzed, and the form of the most informative partition is obtained. Then, a fast density peak-based clustering (FDPC) partitioning algorithm is applied to the measurement set partitioning. Since only one partition of the measurement set is used, the ET-PHD filter based on FDPC partitioning has lower computational complexity than the other ET-PHD filters. As FDPC partitioning is able to remove the spatially close clutter-generated measurements, the ET-PHD filter based on FDPC partitioning has good tracking performance in the scenario with more clutter-generated measurements. The simulation results show that the proposed algorithm can get the most informative partition and obviously reduce computational burden without losing tracking performance. As the number of clutter-generated measurements increased, the ET-PHD filter based on FDPC partitioning has better tracking performance than other ET-PHD filters. The FDPC algorithm will play an important role in the engineering realization of the multiple extended target tracking filter.展开更多
An experimental and finite element simulation investigation are conducted to study the deformation patterns of steel targets during the penetration process of tungsten alloy long rods,as well as the influence of stren...An experimental and finite element simulation investigation are conducted to study the deformation patterns of steel targets during the penetration process of tungsten alloy long rods,as well as the influence of strength of the target on the deformation patterns.The experimental results revealed slight mass loss in the first layer of the steel target during the transient entrance phase,with an extremely negligible loss in target mass during the quasi-steady penetration phase.The results of macro-analysis,micro-analysis and simulation show that the eroded target material migrated towards the periphery of the crater,causing an increase in the target's thickness,remained within the target,instead of flowing out of the crater.Therefore,the process of long rods penetrating the metal target is considered as a process of backward extrusion.By combining the backward extrusion theory with energy conservation,a penetration depth model for long rods penetrating a metal target,taking into account both the diameter of the crater and the friction coefficient between the rod and the target,has been established.Although the model is not yet perfect,it innovatively applies the principles of solid mechanics to the study of long rod penetration.Additionally,it takes into account the friction coefficient between the rod and the target during the penetration process.Therefore,this model provides a new research direction for future studies on long rod penetration.展开更多
In the existing impact time control guidance (ITCG) laws for moving-targets, the effects of time-varying velocity caused by aerodynamics and gravity cannot be effectively con-sidered. Therefore, an ITCG with field-of-...In the existing impact time control guidance (ITCG) laws for moving-targets, the effects of time-varying velocity caused by aerodynamics and gravity cannot be effectively con-sidered. Therefore, an ITCG with field-of-view (FOV) constraints based on biased proportional navigation guidance (PNG) is developed in this paper. The remaining flight time (time-to-go) estimation method is derived considering aerodynamic force and gravity. The number of differential equations is reduced and the integration step is increased by changing the integral variable, which makes it possible to obtain time-to-go through integration. An impact time controller with FOV constraints is proposed by analyzing the influence of the biased term on time-to-go and FOV constraint. Then, numerical simulations are performed to verify the correctness and superiority of the method.展开更多
文摘A measurement system for the scattering characteristics of warhead fragments based on high-speed imaging systems offers advantages such as simple deployment,flexible maneuverability,and high spatiotemporal resolution,enabling the acquisition of full-process data of the fragment scattering process.However,mismatches between camera frame rates and target velocities can lead to long motion blur tails of high-speed fragment targets,resulting in low signal-to-noise ratios and rendering conventional detection algorithms ineffective in dynamic strong interference testing environments.In this study,we propose a detection framework centered on dynamic strong interference disturbance signal separation and suppression.We introduce a mixture Gaussian model constrained under a joint spatialtemporal-transform domain Dirichlet process,combined with total variation regularization to achieve disturbance signal suppression.Experimental results demonstrate that the proposed disturbance suppression method can be integrated with certain conventional motion target detection tasks,enabling adaptation to real-world data to a certain extent.Moreover,we provide a specific implementation of this process,which achieves a detection rate close to 100%with an approximate 0%false alarm rate in multiple sets of real target field test data.This research effectively advances the development of the field of damage parameter testing.
基金supported by the National Natural Science Foundation of China(615015136140146941301481)
文摘A joint resource allocation scheme concerned with the sensor subset,power and bandwidth for range-only target tracking in multiple-input multiple-output(MIMO)radar systems is proposed.By selecting an optimal subset of sensors with the predetermined size and implementing the power allocation and bandwidth strategies among them,this algorithm can help achieving a better performance within the same resource constraints.Firstly,the Bayesian Cramer-Rao bound(BCRB)is derived from it.Secondly,a criterion for minimizing the BCRB at the target location among all targets tracking in a certain range is derived.Thirdly,the optimization problem involved with three variable vectors is formulated,which can be simplified by deriving the relationship between the optimal power allocation vector and the bandwidth allocation vector.Then,the simplified optimization problem is solved by the cyclic minimization algorithm incorporated with the sequential parametric convex approximation(SPCA)algorithm.Finally,the validity of the proposed method is demonstrated with simulation results.
文摘Momordica antiviral protein 30 kD(MAP30)is a type I ribosome-inactivating protein(RIP)with antibacterial,anti-HIV and antitumor activities but lacks the ability to target tumor cells.To increase its tumor-targeting ability,the arginine-glycine-aspartic(RGD)peptide and the epidermal growth factor receptor interference(EGFRi)peptide were fused with MAP30,which was named ELRL-MAP30.The efficiency of targeted therapy for triple-negative breast cancer(TNBC)MDA-MB-231 cells,which lack the expression of estrogen receptor(ER),Progesterone receptor(PgR)and human epidermal growth factor receptor-2(HER2),is limited.In this study,we focus on exploring the effect and mechanism of ELRL-MAP30 on TNBC MDA-MB-231 cells.First,we discovered that ELRL-MAP30 significantly inhibited the migration and invasion of MDA-MB-231 cells and induced MDA-MB-231 cell apoptosis.Moreover,ELRL-MAP30 treatment resulted in a significant increase in Bax expression and a decrease in Bcl-2 expression.Furthermore,ELRL-MAP30 triggered apoptosis via the Fak/EGFR/Erk and Ilk/Akt signaling pathways.In addition,recombinant ELRL-MAP30 can inhibit chicken embryonic angiogenesis,and also inhibit the tube formation ability of human umbilical vein endothelial cells(HUVECs),indicating its potential therapeutic effects on tumor angiogenesis.Collectively,these results indicate that ELRL-MAP30 has significant tumor-targeting properties in MDA-MB-231 cancer cells and reveals potential therapeutic effects on angiogenesis.These findings indicate the potential role of ELRL-MAP30 in the targeted treatment of the TNBC cell line MDA-MB-231.
文摘This paper proposes a distributed event-triggered control(ETC)framework to address cooperative target fencing challenges in UAV swarm.The proposed architecture eliminates the reliance on preset formation parameters while achieving multi-objective cooperative control for target fencing,network connectivity preservation,collision avoidance,and communication efficiency optimization.Firstly,a differential state observer is constructed to obtain the target's unmeasurable states.Secondly,leveraging swarm selforganization principles,a geometric-constraint-free distributed fencing controller is designed by integrating potential field methods with consensus theory.The controller dynamically adjusts inter-UAV distances via single potential function,enabling coordinated optimization of persistent network connectivity and collision-free motion during target fencing.Thirdly,a dual-threshold ETC mechanism based on velocity consensus deviation and fencing error is proposed,which can be triggered based on task features to dynamically adjust the communication frequency,significantly reduce the communication burden and exclude Zeno behavior.Theoretical analysis demonstrates the stability of closed-loop systems.Multi-scenario simulations show that the proposed method can achieve robust fencing under target maneuverability,partial UAV failures,and communication disturbances.
文摘Compared with single-domain unmanned swarms,cross-domain unmanned swarms continue to face new challenges in terms of platform performance and constraints.In this paper,a joint unmanned swarm target assignment and mission trajectory planning method is proposed to meet the requirements of cross-domain unmanned swarm mission planning.Firstly,the different performances of cross-domain heterogeneous platforms and mission requirements of targets are characterised by using a collection of operational resources.Secondly,an algorithmic framework for joint target assignment and mission trajectory planning is proposed,in which the initial planning of the trajectory is performed in the target assignment phase,while the trajectory is further optimised afterwards.Next,the estimation of the distribution algorithms is combined with the genetic algorithm to solve the objective function.Finally,the algorithm is numerically simulated by specific cases.Simulation results indicate that the proposed algorithm can perform effective task assignment and trajectory planning for cross-domain unmanned swarms.Furthermore,the solution performance of the hybrid estimation of distribution algorithm(EDA)-genetic algorithm(GA)algorithm is better than that of GA and EDA.
基金supported by the National Natural Science Foundation of China(61401475)
文摘The key challenge of the extended target probability hypothesis density (ET-PHD) filter is to reduce the computational complexity by using a subset to approximate the full set of partitions. In this paper, the influence for the tracking results of different partitions is analyzed, and the form of the most informative partition is obtained. Then, a fast density peak-based clustering (FDPC) partitioning algorithm is applied to the measurement set partitioning. Since only one partition of the measurement set is used, the ET-PHD filter based on FDPC partitioning has lower computational complexity than the other ET-PHD filters. As FDPC partitioning is able to remove the spatially close clutter-generated measurements, the ET-PHD filter based on FDPC partitioning has good tracking performance in the scenario with more clutter-generated measurements. The simulation results show that the proposed algorithm can get the most informative partition and obviously reduce computational burden without losing tracking performance. As the number of clutter-generated measurements increased, the ET-PHD filter based on FDPC partitioning has better tracking performance than other ET-PHD filters. The FDPC algorithm will play an important role in the engineering realization of the multiple extended target tracking filter.
基金supported by the National Natural Science Foundation of China(Grant Nos.12102201,U2341244).
文摘An experimental and finite element simulation investigation are conducted to study the deformation patterns of steel targets during the penetration process of tungsten alloy long rods,as well as the influence of strength of the target on the deformation patterns.The experimental results revealed slight mass loss in the first layer of the steel target during the transient entrance phase,with an extremely negligible loss in target mass during the quasi-steady penetration phase.The results of macro-analysis,micro-analysis and simulation show that the eroded target material migrated towards the periphery of the crater,causing an increase in the target's thickness,remained within the target,instead of flowing out of the crater.Therefore,the process of long rods penetrating the metal target is considered as a process of backward extrusion.By combining the backward extrusion theory with energy conservation,a penetration depth model for long rods penetrating a metal target,taking into account both the diameter of the crater and the friction coefficient between the rod and the target,has been established.Although the model is not yet perfect,it innovatively applies the principles of solid mechanics to the study of long rod penetration.Additionally,it takes into account the friction coefficient between the rod and the target during the penetration process.Therefore,this model provides a new research direction for future studies on long rod penetration.
基金supported by the National Natural Science Foundation of China(U21B2028).
文摘In the existing impact time control guidance (ITCG) laws for moving-targets, the effects of time-varying velocity caused by aerodynamics and gravity cannot be effectively con-sidered. Therefore, an ITCG with field-of-view (FOV) constraints based on biased proportional navigation guidance (PNG) is developed in this paper. The remaining flight time (time-to-go) estimation method is derived considering aerodynamic force and gravity. The number of differential equations is reduced and the integration step is increased by changing the integral variable, which makes it possible to obtain time-to-go through integration. An impact time controller with FOV constraints is proposed by analyzing the influence of the biased term on time-to-go and FOV constraint. Then, numerical simulations are performed to verify the correctness and superiority of the method.
