Microspheres containing an antimetabolite drug 5-Fluorouracil were prepared from (poly(lactic) acide)(PLA) or poly(lactic acid)-polyethylene glycol(PLA-PEG) as the carrier by using a water-in-oil-in-water emulsion sol...Microspheres containing an antimetabolite drug 5-Fluorouracil were prepared from (poly(lactic) acide)(PLA) or poly(lactic acid)-polyethylene glycol(PLA-PEG) as the carrier by using a water-in-oil-in-water emulsion solvent evaporation technique. The conditions of the microspheres preparation such as polymer concentration in organic solvent, relative molecular weight of PLA-PEG and PLA/PEG mass ratio were discussed. The surface morphology and the size of the microspheres were observed by SEM. The drug content of microspheres was examined by TGA and the drug release in vitro was evaluated. According to the results, the drug content increased with the nano-silica used. The highest drug content in this study was 39.9%. The drug-release kinetics satisfied the requirements of controlled drug-release.展开更多
The ordered two dimensional arrays of uniform copolymer microspheres had been fabricated on a substrate by the liquid capillary meniscus attraction force method. Thin aluminium film was deposited on the latex monolaye...The ordered two dimensional arrays of uniform copolymer microspheres had been fabricated on a substrate by the liquid capillary meniscus attraction force method. Thin aluminium film was deposited on the latex monolayer through vacuum evaporation. After ultrasonic etching and dissolving of polymer spheres a surface with features remained. Different patterings of net, islands and separate spots can be obtained by controlling the ultrasonic treatment time. The interaction among the metal, microspheres and the substrate as well as its effect on the micropatternings has been discussed.展开更多
文摘Microspheres containing an antimetabolite drug 5-Fluorouracil were prepared from (poly(lactic) acide)(PLA) or poly(lactic acid)-polyethylene glycol(PLA-PEG) as the carrier by using a water-in-oil-in-water emulsion solvent evaporation technique. The conditions of the microspheres preparation such as polymer concentration in organic solvent, relative molecular weight of PLA-PEG and PLA/PEG mass ratio were discussed. The surface morphology and the size of the microspheres were observed by SEM. The drug content of microspheres was examined by TGA and the drug release in vitro was evaluated. According to the results, the drug content increased with the nano-silica used. The highest drug content in this study was 39.9%. The drug-release kinetics satisfied the requirements of controlled drug-release.
文摘The ordered two dimensional arrays of uniform copolymer microspheres had been fabricated on a substrate by the liquid capillary meniscus attraction force method. Thin aluminium film was deposited on the latex monolayer through vacuum evaporation. After ultrasonic etching and dissolving of polymer spheres a surface with features remained. Different patterings of net, islands and separate spots can be obtained by controlling the ultrasonic treatment time. The interaction among the metal, microspheres and the substrate as well as its effect on the micropatternings has been discussed.
