Cell-matrix interaction is the key for understanding the cell behaviors,especially the mechanosensitivity of cell adhesion,cell migration and differentiation,etc.Cells are constantly probing,pushing and pulling on the...Cell-matrix interaction is the key for understanding the cell behaviors,especially the mechanosensitivity of cell adhesion,cell migration and differentiation,etc.Cells are constantly probing,pushing and pulling on the surrounding extracellular matrix.These cell-generated forces drive cell migration and tissue morphogenesis,and maintain the intrinsic mechanical tone of tissues.Therefore,knowledge of the spatial and temporal nature of these forces are essential to understanding when and where mechanical events come to play in both physiological and pathological settings.However,because of the complexity of cell geometry and insufficient展开更多
基金supported by the National Natural Science Foundation of China through grant nos.11221202 and 11025208
文摘Cell-matrix interaction is the key for understanding the cell behaviors,especially the mechanosensitivity of cell adhesion,cell migration and differentiation,etc.Cells are constantly probing,pushing and pulling on the surrounding extracellular matrix.These cell-generated forces drive cell migration and tissue morphogenesis,and maintain the intrinsic mechanical tone of tissues.Therefore,knowledge of the spatial and temporal nature of these forces are essential to understanding when and where mechanical events come to play in both physiological and pathological settings.However,because of the complexity of cell geometry and insufficient
