Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer.Circulating tumor cells(CTCs)play a pivotal role in cancer metastasis.However,the content...Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer.Circulating tumor cells(CTCs)play a pivotal role in cancer metastasis.However,the content of CTCs in peripheral blood is minimal,so the detection of CTCs in real samples is extremely challenging.Therefore,efficient enrichment and early detection of CTCs are essential to achieve timely diagnosis of diseases.In this work,we constructed an innovative and sensitive single-nanoparticle collision electrochemistry(SNCE)biosensor for the detection of MCF-7 cells(human breast cancer cells)by immunomagnetic separation technique and liposome signal amplification strategy.Liposomes embedded with platinum nanoparticles(Pt NPs)were used as signal probes,and homemade gold ultramicroelectrodes(Au UME)were used as the working electrodes.The effective collision between Pt NPs and UME would produce distinguishable step-type current.MCF-7 cells were accurately quantified according to the relationship between cell concentration and collision frequency(the number of step-type currents generated per unit time),realizing highly sensitive and specific detection of MCF-7 cells.The SNCE biosensor has a linear range of 10 cells·mL^(-1)to 10^(5) cells·mL^(-1)with a detection limit as low as 5 cells·mL^(-1).In addition,the successful detection of MCF-7 cells in complex samples showed that the SNCE biosensors have great potential for patient sample detection.展开更多
The formation control of multiple unmanned aerial vehicles(multi-UAVs)has always been a research hotspot.Based on the straight line trajectory,a multi-UAVs target point assignment algorithm based on the assignment pro...The formation control of multiple unmanned aerial vehicles(multi-UAVs)has always been a research hotspot.Based on the straight line trajectory,a multi-UAVs target point assignment algorithm based on the assignment probability is proposed to achieve the shortest overall formation path of multi-UAVs with low complexity and reduce the energy consumption.In order to avoid the collision between UAVs in the formation process,the concept of safety ball is introduced,and the collision detection based on continuous motion of two time slots and the lane occupation detection after motion is proposed to avoid collision between UAVs.Based on the idea of game theory,a method of UAV motion form setting based on the maximization of interests is proposed,including the maximization of self-interest and the maximization of formation interest is proposed,so that multi-UAVs can complete the formation task quickly and reasonably with the linear trajectory assigned in advance.Finally,through simulation verification,the multi-UAVs target assignment algorithm based on the assignment probability proposed in this paper can effectively reduce the total path length,and the UAV motion selection method based on the maximization interests can effectively complete the task formation.展开更多
Using function one direction S-rough sets （function one direction singular rough sets）, f-law and F- law and the concept of law distance and the concept of system law collided by F-law are given. Using these concept...Using function one direction S-rough sets （function one direction singular rough sets）, f-law and F- law and the concept of law distance and the concept of system law collided by F-law are given. Using these concepts, state characteristic presented by system law collided by F-law and recognition of these states characteristic and recognition criterion and applications are given. Function one direction S-rough sets is one of basic forms of function S-rough sets （function singular rough sets）. Function one direction S-rough sets is importance theory and is a method in studying system law collision.展开更多
The Alpine zone of Central Pamir is elongated in sublatitudinal direction between the Hercynians of Northern Pamir and the Cimmerians of Southern Pamir south of the Vanch\|Akbaital thrust. Its western continuation is ...The Alpine zone of Central Pamir is elongated in sublatitudinal direction between the Hercynians of Northern Pamir and the Cimmerians of Southern Pamir south of the Vanch\|Akbaital thrust. Its western continuation is overthrusted by the Herat fault and its eastern continuation is cut by the Karakoram strike\|slip fault.. The Central Pamir is a mainly S\|vergent (at the southern part N\|vergent) Alpine nappe stack then folding in antiform. It comprises deposits from Vendian to Neogene which have a thickness of 10km. Paleozoic and Mesozoic tectonic activity was poorly displaied in its limits. Rifting took place in Early and probably Upper Paleozoic. Pre\|Upper Cretaceous unconformity is known only in southern (autochthonous) part of the Zone as a result of closing of Bangong\|Nu Jiang ocean. In northern (allochthonous) part of the zone the sequence of Mesozoic and Paleogene rocks has no unconformities. Alpine endogenous processes were developed very intensively. They implied nappes and imbricate structures, linear folding, different igneous activity, zonal metamorphism. Slices of pyroxenites and gabbroids occured. Calc\|alkaline lavas and tuffs constitutes the major part of Paleocene to Miocene sequence (andesites\|ryolites\|in Paleogene, alkaline basalts in Oligocene—Miocene). Oligocene—Miocene zonal metamorphic belt of the intermediate type of high pressure including series of granitegneiss domes can be traced along the Central Pamir. Cores of domes include migmatites and remobilized bodies of the Early Paleozoic gneissic granites. The decompression took place at a later stage and rocks were overprinted by the andalusite\|sillimanite type metamorphism.. Syenite and leucogranite bodies, pegmatite and aplite veins were emplaced.展开更多
The failure mechanism of a cylindrical shell cut into fragments by circumferential detonation collision was experimentally and numerically investigated.A self-designed detonation wave regulator was used to control the...The failure mechanism of a cylindrical shell cut into fragments by circumferential detonation collision was experimentally and numerically investigated.A self-designed detonation wave regulator was used to control the detonation and cut the shell.It was found that the self-designed regulator controlled the fragment shape.The macrostructure and micro-characteristics of fragments revealed that shear fracture was a prior mechanism,the shell fractured not only at the position of detonation collision,but the crack also penetrated the shell at the first contact position of the Chapmen-Jouguet(C-J)wave.The effects of groove number and outer layer thickness on the fracture behavior were tested by simulations.When the thickness of the outer layer was 5e18 mm,it has little effect on fragmentation of the shell,and shells all fractured at similar positions.The increase of the groove number reduced the fracture possibility of the first contact position of the C-J wave.When the groove number reached 7 with a 10 mm outer layer(1/4 model),the fracture only occurred at the position of detonation collision and the fragment width rebounded.展开更多
This paper proposes a novel collision post structure designed to improve the crashworthiness of subway cab cars.The structure provides two innovative features:1)a simpler connection between the post and the car roof,w...This paper proposes a novel collision post structure designed to improve the crashworthiness of subway cab cars.The structure provides two innovative features:1)a simpler connection between the post and the car roof,which gives a more reasonable load transfer path to reduce the stress concentration at the joint;and 2)a stiffness induction design that provides an ideal deformation model to protect the safe space of the cab cars.The novel collision post structure was evaluated with finite element analysis,and a prototype cab car was mechanically tested.The results demonstrate that the deformation response was stable and agreed well with the expected ideal mode.The maximum load was 874.17 kN and the responses remained well above the elastic design load of 334 kN as required by the design specification.In addition,there was no significant tearing failure during the whole test process.Therefore,the novel collision post structure proposed has met the requirements specified in new standard to improve the crashworthiness of subway cab cars.Finally,the energy absorption efficiency and light weight design highlights were also summarized and discussed.展开更多
Using dual function one direction S-rough sets, this article gives the f-law, the F-law, law distance and the concept of system law collided by the F-law. The characteristics presented by the system law collided by th...Using dual function one direction S-rough sets, this article gives the f-law, the F-law, law distance and the concept of system law collided by the F-law. The characteristics presented by the system law collided by the F-law, the recognition of these characteristics and recognition criterion are also proposed. The dual function one direction S-rough sets is one of the basic forms of function S-rough sets. Its basic theory and application in the study of system law collision are reviewed.展开更多
Despite of modern navigation devices, there are problems in navigation of vessels in waterways due to the geographical structures, disturbances in water, dynamic nature, and heavily environmental influenced sea traffi...Despite of modern navigation devices, there are problems in navigation of vessels in waterways due to the geographical structures, disturbances in water, dynamic nature, and heavily environmental influenced sea traffic. Even though all vessels are equipped with modern navigation devices, the accidents are reported caused by various reasons and mainly by human factor according to investigation. We propose an effective and efficient composition collision risk calculation method for finding the collision probability and avoiding the collision between ships in possible collision situations. The proposed composition collision risk calculation method at ship's position using combination of fuzzy and fuzzy comprehensive evaluation methods. The algorithm is straightforward to implement and is shown to be effective in automatic ship handling for ships involved in complex navigation situations. Experiments are carried out with indigenous data and the results show the effectiveness of the proposed approach.展开更多
Head disk collision models of 'coefficient-of-restitution' are widely used in the head disk interface simulation. A new head disk collision model called 'critical velocity model' has been developed. Nu...Head disk collision models of 'coefficient-of-restitution' are widely used in the head disk interface simulation. A new head disk collision model called 'critical velocity model' has been developed. Numerical simulation of dynamics of a typical Winchester-type slider is presented under the influence of head disk collisions due to disk surface defects such as localize asperities. Two kinds of head disk collision models have been compared and analysed. The results show that the critical velocity is a very important parameter which affects the dynamics of the slider.展开更多
Let P=(po, p1,..., pn-1 ) and Q=(qo,q1..., qm-1) be two arbitrary convex polygonsin plane. In this paper, the author studies the problems of how to quickly determine their possiblecollision range and movable range. In...Let P=(po, p1,..., pn-1 ) and Q=(qo,q1..., qm-1) be two arbitrary convex polygonsin plane. In this paper, the author studies the problems of how to quickly determine their possiblecollision range and movable range. In the paper, a new sufficient and necessary condition for decidingpossible collision is proposed,and the basic characters of the oblique supporting lines are investigated,and on these grounds the problem to determine the possible collision range is transformed into thatof searching the supporting points on the sets of convex polygon vertexs. Using the strategy ofsearching simultaneously the sets of vertexes of P and Q, the author constructs the fast algorithmfor finding the supporting points, the time-complexity of which is O(log2(m + n)). Based on theseresults, the algorithms to quickly determine the range are given, which possess the time-complexityof O(log2(m+n)).展开更多
The collision process of a flying bird and the aircraft windshield was simulated by using movable cellular automata ( MCA) method to improve the structure design of aircrafts. The simulation results show that the whol...The collision process of a flying bird and the aircraft windshield was simulated by using movable cellular automata ( MCA) method to improve the structure design of aircrafts. The simulation results show that the whole strike process is performed in 4. 8 ms,the critical strike velocity for an aeronautic glass windshield is 360 km/h,the windshield vibrates and deforms in the collision,and after absorbing the kinetic energy,its temperature increases. The simulation results coincide with the experiment data better. It is clear that MCA method has more advantages than the usual methods of continuum mechanics.展开更多
The plutonic rocks of the westernmost part of the Sirwa massif belong to the Ediacaran post-collisional magmatic chain of the Anti-Atlas.The geochemistry of major and trace elements attests that the fractional crystal...The plutonic rocks of the westernmost part of the Sirwa massif belong to the Ediacaran post-collisional magmatic chain of the Anti-Atlas.The geochemistry of major and trace elements attests that the fractional crystallization cannot account for the variations between the granitoids and the associated MME.They represent two contemporaneous but independent magmatic tendencies.However,Sr and Nd configur data argue for a similar and juvenile material展开更多
基金supported by the National Natural Science Foundation of China(Nos.22274037,22376055 and 21904032)the Natural Science Foundation of Hubei Province(2022CFB383)。
文摘Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer.Circulating tumor cells(CTCs)play a pivotal role in cancer metastasis.However,the content of CTCs in peripheral blood is minimal,so the detection of CTCs in real samples is extremely challenging.Therefore,efficient enrichment and early detection of CTCs are essential to achieve timely diagnosis of diseases.In this work,we constructed an innovative and sensitive single-nanoparticle collision electrochemistry(SNCE)biosensor for the detection of MCF-7 cells(human breast cancer cells)by immunomagnetic separation technique and liposome signal amplification strategy.Liposomes embedded with platinum nanoparticles(Pt NPs)were used as signal probes,and homemade gold ultramicroelectrodes(Au UME)were used as the working electrodes.The effective collision between Pt NPs and UME would produce distinguishable step-type current.MCF-7 cells were accurately quantified according to the relationship between cell concentration and collision frequency(the number of step-type currents generated per unit time),realizing highly sensitive and specific detection of MCF-7 cells.The SNCE biosensor has a linear range of 10 cells·mL^(-1)to 10^(5) cells·mL^(-1)with a detection limit as low as 5 cells·mL^(-1).In addition,the successful detection of MCF-7 cells in complex samples showed that the SNCE biosensors have great potential for patient sample detection.
基金supported by the Basic Scientific Research Business Expenses of Central Universities(3072022QBZ0806)。
文摘The formation control of multiple unmanned aerial vehicles(multi-UAVs)has always been a research hotspot.Based on the straight line trajectory,a multi-UAVs target point assignment algorithm based on the assignment probability is proposed to achieve the shortest overall formation path of multi-UAVs with low complexity and reduce the energy consumption.In order to avoid the collision between UAVs in the formation process,the concept of safety ball is introduced,and the collision detection based on continuous motion of two time slots and the lane occupation detection after motion is proposed to avoid collision between UAVs.Based on the idea of game theory,a method of UAV motion form setting based on the maximization of interests is proposed,including the maximization of self-interest and the maximization of formation interest is proposed,so that multi-UAVs can complete the formation task quickly and reasonably with the linear trajectory assigned in advance.Finally,through simulation verification,the multi-UAVs target assignment algorithm based on the assignment probability proposed in this paper can effectively reduce the total path length,and the UAV motion selection method based on the maximization interests can effectively complete the task formation.
基金the Natural Science Foundation of Shandong Province of China (Y2004A04)the Natural Science Foundation of Fujian Province of China (Z0511049).
文摘Using function one direction S-rough sets （function one direction singular rough sets）, f-law and F- law and the concept of law distance and the concept of system law collided by F-law are given. Using these concepts, state characteristic presented by system law collided by F-law and recognition of these states characteristic and recognition criterion and applications are given. Function one direction S-rough sets is one of basic forms of function S-rough sets （function singular rough sets）. Function one direction S-rough sets is importance theory and is a method in studying system law collision.
文摘The Alpine zone of Central Pamir is elongated in sublatitudinal direction between the Hercynians of Northern Pamir and the Cimmerians of Southern Pamir south of the Vanch\|Akbaital thrust. Its western continuation is overthrusted by the Herat fault and its eastern continuation is cut by the Karakoram strike\|slip fault.. The Central Pamir is a mainly S\|vergent (at the southern part N\|vergent) Alpine nappe stack then folding in antiform. It comprises deposits from Vendian to Neogene which have a thickness of 10km. Paleozoic and Mesozoic tectonic activity was poorly displaied in its limits. Rifting took place in Early and probably Upper Paleozoic. Pre\|Upper Cretaceous unconformity is known only in southern (autochthonous) part of the Zone as a result of closing of Bangong\|Nu Jiang ocean. In northern (allochthonous) part of the zone the sequence of Mesozoic and Paleogene rocks has no unconformities. Alpine endogenous processes were developed very intensively. They implied nappes and imbricate structures, linear folding, different igneous activity, zonal metamorphism. Slices of pyroxenites and gabbroids occured. Calc\|alkaline lavas and tuffs constitutes the major part of Paleocene to Miocene sequence (andesites\|ryolites\|in Paleogene, alkaline basalts in Oligocene—Miocene). Oligocene—Miocene zonal metamorphic belt of the intermediate type of high pressure including series of granitegneiss domes can be traced along the Central Pamir. Cores of domes include migmatites and remobilized bodies of the Early Paleozoic gneissic granites. The decompression took place at a later stage and rocks were overprinted by the andalusite\|sillimanite type metamorphism.. Syenite and leucogranite bodies, pegmatite and aplite veins were emplaced.
基金the National Natural Science Foundation of China No.11972018the Defense Pre-Research Joint Foundation of Chinese Ordnance Industry No.6141B012858.
文摘The failure mechanism of a cylindrical shell cut into fragments by circumferential detonation collision was experimentally and numerically investigated.A self-designed detonation wave regulator was used to control the detonation and cut the shell.It was found that the self-designed regulator controlled the fragment shape.The macrostructure and micro-characteristics of fragments revealed that shear fracture was a prior mechanism,the shell fractured not only at the position of detonation collision,but the crack also penetrated the shell at the first contact position of the Chapmen-Jouguet(C-J)wave.The effects of groove number and outer layer thickness on the fracture behavior were tested by simulations.When the thickness of the outer layer was 5e18 mm,it has little effect on fragmentation of the shell,and shells all fractured at similar positions.The increase of the groove number reduced the fracture possibility of the first contact position of the C-J wave.When the groove number reached 7 with a 10 mm outer layer(1/4 model),the fracture only occurred at the position of detonation collision and the fragment width rebounded.
基金Project(2016YFB1200505-016)supported by the National Key Research and Development Program of ChinaProject(51675537)supported by the National Natural Science Foundation of ChinaProject(2018zzts161)supported by the Independent Exploration and Innovation Project of Central South University,China。
文摘This paper proposes a novel collision post structure designed to improve the crashworthiness of subway cab cars.The structure provides two innovative features:1)a simpler connection between the post and the car roof,which gives a more reasonable load transfer path to reduce the stress concentration at the joint;and 2)a stiffness induction design that provides an ideal deformation model to protect the safe space of the cab cars.The novel collision post structure was evaluated with finite element analysis,and a prototype cab car was mechanically tested.The results demonstrate that the deformation response was stable and agreed well with the expected ideal mode.The maximum load was 874.17 kN and the responses remained well above the elastic design load of 334 kN as required by the design specification.In addition,there was no significant tearing failure during the whole test process.Therefore,the novel collision post structure proposed has met the requirements specified in new standard to improve the crashworthiness of subway cab cars.Finally,the energy absorption efficiency and light weight design highlights were also summarized and discussed.
基金Natural Science Foundation of Shandong Province of China (Y2004A04)Education Hall Foundation of Fujian Education Official of China(JA04268).
文摘Using dual function one direction S-rough sets, this article gives the f-law, the F-law, law distance and the concept of system law collided by the F-law. The characteristics presented by the system law collided by the F-law, the recognition of these characteristics and recognition criterion are also proposed. The dual function one direction S-rough sets is one of the basic forms of function S-rough sets. Its basic theory and application in the study of system law collision are reviewed.
基金supported by ETRI through Maritime Safety & Maritime Traffic Management R&D Program of the MOF/KIMST (2009403, Development of Next Generation VTS for Maritime Safety)supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MEST) (No. 2011-0015009)
文摘Despite of modern navigation devices, there are problems in navigation of vessels in waterways due to the geographical structures, disturbances in water, dynamic nature, and heavily environmental influenced sea traffic. Even though all vessels are equipped with modern navigation devices, the accidents are reported caused by various reasons and mainly by human factor according to investigation. We propose an effective and efficient composition collision risk calculation method for finding the collision probability and avoiding the collision between ships in possible collision situations. The proposed composition collision risk calculation method at ship's position using combination of fuzzy and fuzzy comprehensive evaluation methods. The algorithm is straightforward to implement and is shown to be effective in automatic ship handling for ships involved in complex navigation situations. Experiments are carried out with indigenous data and the results show the effectiveness of the proposed approach.
文摘Head disk collision models of 'coefficient-of-restitution' are widely used in the head disk interface simulation. A new head disk collision model called 'critical velocity model' has been developed. Numerical simulation of dynamics of a typical Winchester-type slider is presented under the influence of head disk collisions due to disk surface defects such as localize asperities. Two kinds of head disk collision models have been compared and analysed. The results show that the critical velocity is a very important parameter which affects the dynamics of the slider.
文摘Let P=(po, p1,..., pn-1 ) and Q=(qo,q1..., qm-1) be two arbitrary convex polygonsin plane. In this paper, the author studies the problems of how to quickly determine their possiblecollision range and movable range. In the paper, a new sufficient and necessary condition for decidingpossible collision is proposed,and the basic characters of the oblique supporting lines are investigated,and on these grounds the problem to determine the possible collision range is transformed into thatof searching the supporting points on the sets of convex polygon vertexs. Using the strategy ofsearching simultaneously the sets of vertexes of P and Q, the author constructs the fast algorithmfor finding the supporting points, the time-complexity of which is O(log2(m + n)). Based on theseresults, the algorithms to quickly determine the range are given, which possess the time-complexityof O(log2(m+n)).
文摘The collision process of a flying bird and the aircraft windshield was simulated by using movable cellular automata ( MCA) method to improve the structure design of aircrafts. The simulation results show that the whole strike process is performed in 4. 8 ms,the critical strike velocity for an aeronautic glass windshield is 360 km/h,the windshield vibrates and deforms in the collision,and after absorbing the kinetic energy,its temperature increases. The simulation results coincide with the experiment data better. It is clear that MCA method has more advantages than the usual methods of continuum mechanics.
文摘The plutonic rocks of the westernmost part of the Sirwa massif belong to the Ediacaran post-collisional magmatic chain of the Anti-Atlas.The geochemistry of major and trace elements attests that the fractional crystallization cannot account for the variations between the granitoids and the associated MME.They represent two contemporaneous but independent magmatic tendencies.However,Sr and Nd configur data argue for a similar and juvenile material
