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Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges
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作者 Shuai Zhong Lirou Su +4 位作者 Mingkun Xu Desmond Loke Bin Yu Yishu Zhang Rong Zhao 《Nano-Micro Letters》 SCIE EI CAS 2025年第3期168-216,共49页
Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power consumption.To fully leverage its advantage... Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power consumption.To fully leverage its advantages,convertingthe external analog signals to spikes is an essential prerequisite.Conventionalapproaches including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area costs.Recent efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory system.They can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory systems.This review summarizesand benchmarks the recent progress of artificial sensory neurons.It starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial sensoryneurons.Furthermore,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also provided.Finally,we highlight the challenges and perspectives for the future development of artificial sensory neurons. 展开更多
关键词 Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing
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A fractional-order improved FitzHugh–Nagumo neuron model
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作者 Pushpendra Kumar Vedat Suat Erturk 《Chinese Physics B》 2025年第1期519-528,共10页
We propose a fractional-order improved Fitz Hugh–Nagumo(FHN)neuron model in terms of a generalized Caputo fractional derivative.Following the existence of a unique solution for the proposed model,we derive the numeri... We propose a fractional-order improved Fitz Hugh–Nagumo(FHN)neuron model in terms of a generalized Caputo fractional derivative.Following the existence of a unique solution for the proposed model,we derive the numerical solution using a recently proposed L1 predictor–corrector method.The given method is based on the L1-type discretization algorithm and the spline interpolation scheme.We perform the error and stability analyses for the given method.We perform graphical simulations demonstrating that the proposed FHN neuron model generates rich electrical activities of periodic spiking patterns,chaotic patterns,and quasi-periodic patterns.The motivation behind proposing a fractional-order improved FHN neuron model is that such a system can provide a more nuanced description of the process with better understanding and simulation of the neuronal responses by incorporating memory effects and non-local dynamics,which are inherent to many biological systems. 展开更多
关键词 FitzHugh-Nagumo neuron model generalized Caputo fractional derivative L1 predictor-corrector method STABILITY error estimation
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Dynamical behaviors in discrete memristor-coupled small-world neuronal networks
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作者 鲁婕妤 谢小华 +3 位作者 卢亚平 吴亚联 李春来 马铭磷 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第4期729-734,共6页
The brain is a complex network system in which a large number of neurons are widely connected to each other and transmit signals to each other.The memory characteristic of memristors makes them suitable for simulating... The brain is a complex network system in which a large number of neurons are widely connected to each other and transmit signals to each other.The memory characteristic of memristors makes them suitable for simulating neuronal synapses with plasticity.In this paper,a memristor is used to simulate a synapse,a discrete small-world neuronal network is constructed based on Rulkov neurons and its dynamical behavior is explored.We explore the influence of system parameters on the dynamical behaviors of the discrete small-world network,and the system shows a variety of firing patterns such as spiking firing and triangular burst firing when the neuronal parameterαis changed.The results of a numerical simulation based on Matlab show that the network topology can affect the synchronous firing behavior of the neuronal network,and the higher the reconnection probability and number of the nearest neurons,the more significant the synchronization state of the neurons.In addition,by increasing the coupling strength of memristor synapses,synchronization performance is promoted.The results of this paper can boost research into complex neuronal networks coupled with memristor synapses and further promote the development of neuroscience. 展开更多
关键词 small-world networks Rulkov neurons MEMRISTOR SYNCHRONIZATION
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Synchronization and firing mode transition of two neurons in a bilateral auditory system driven by a high–low frequency signal
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作者 Charles Omotomide Apata 唐浥瑞 +2 位作者 周祎凡 蒋龙 裴启明 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期722-735,共14页
The FitzHugh–Nagumo neuron circuit integrates a piezoelectric ceramic to form a piezoelectric sensing neuron,which can capture external sound signals and simulate the auditory neuron system.Two piezoelectric sensing ... The FitzHugh–Nagumo neuron circuit integrates a piezoelectric ceramic to form a piezoelectric sensing neuron,which can capture external sound signals and simulate the auditory neuron system.Two piezoelectric sensing neurons are coupled by a parallel circuit consisting of a Josephson junction and a linear resistor,and a binaural auditory system is established.Considering the non-singleness of external sound sources,the high–low frequency signal is used as the input signal to study the firing mode transition and synchronization of this system.It is found that the angular frequency of the high–low frequency signal is a key factor in determining whether the dynamic behaviors of two coupled neurons are synchronous.When they are in synchronization at a specific angular frequency,the changes in physical parameters of the input signal and the coupling strength between them will not destroy their synchronization.In addition,the firing mode of two coupled auditory neurons in synchronization is affected by the characteristic parameters of the high–low frequency signal rather than the coupling strength.The asynchronous dynamic behavior and variations in firing modes will harm the auditory system.These findings could help determine the causes of hearing loss and devise functional assistive devices for patients. 展开更多
关键词 piezoelectric ceramic Josephson junction auditory neuron SYNCHRONIZATION
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Fractional-order heterogeneous memristive Rulkov neuronal network and its medical image watermarking application
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作者 丁大为 牛炎 +4 位作者 张红伟 杨宗立 王金 王威 王谋媛 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期306-314,共9页
This article proposes a novel fractional heterogeneous neural network by coupling a Rulkov neuron with a Hopfield neural network(FRHNN),utilizing memristors for emulating neural synapses.The study firstly demonstrates... This article proposes a novel fractional heterogeneous neural network by coupling a Rulkov neuron with a Hopfield neural network(FRHNN),utilizing memristors for emulating neural synapses.The study firstly demonstrates the coexistence of multiple firing patterns through phase diagrams,Lyapunov exponents(LEs),and bifurcation diagrams.Secondly,the parameter related firing behaviors are described through two-parameter bifurcation diagrams.Subsequently,local attraction basins reveal multi-stability phenomena related to initial values.Moreover,the proposed model is implemented on a microcomputer-based ARM platform,and the experimental results correspond to the numerical simulations.Finally,the article explores the application of digital watermarking for medical images,illustrating its features of excellent imperceptibility,extensive key space,and robustness against attacks including noise and cropping. 展开更多
关键词 fractional order MEMRISTORS Rulkov neuron medical image watermarking
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Dynamics and synchronization in a memristor-coupled discrete heterogeneous neuron network considering noise
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作者 晏询 李志军 李春来 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期537-544,共8页
Research on discrete memristor-based neural networks has received much attention.However,current research mainly focuses on memristor–based discrete homogeneous neuron networks,while memristor-coupled discrete hetero... Research on discrete memristor-based neural networks has received much attention.However,current research mainly focuses on memristor–based discrete homogeneous neuron networks,while memristor-coupled discrete heterogeneous neuron networks are rarely reported.In this study,a new four-stable discrete locally active memristor is proposed and its nonvolatile and locally active properties are verified by its power-off plot and DC V–I diagram.Based on two-dimensional(2D)discrete Izhikevich neuron and 2D discrete Chialvo neuron,a heterogeneous discrete neuron network is constructed by using the proposed discrete memristor as a coupling synapse connecting the two heterogeneous neurons.Considering the coupling strength as the control parameter,chaotic firing,periodic firing,and hyperchaotic firing patterns are revealed.In particular,multiple coexisting firing patterns are observed,which are induced by different initial values of the memristor.Phase synchronization between the two heterogeneous neurons is discussed and it is found that they can achieve perfect synchronous at large coupling strength.Furthermore,the effect of Gaussian white noise on synchronization behaviors is also explored.We demonstrate that the presence of noise not only leads to the transition of firing patterns,but also achieves the phase synchronization between two heterogeneous neurons under low coupling strength. 展开更多
关键词 heterogeneous neuron network discrete memristor coexisting attractors SYNCHRONIZATION noise
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Memristors-coupled neuron models with multiple firing patterns and homogeneous and heterogeneous multistability
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作者 Xuan Wang Santo Banerjee +1 位作者 Yinghong Cao Jun Mou 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第10期176-189,共14页
Memristors are extensively used to estimate the external electromagnetic stimulation and synapses for neurons.In this paper,two distinct scenarios,i.e.,an ideal memristor serves as external electromagnetic stimulation... Memristors are extensively used to estimate the external electromagnetic stimulation and synapses for neurons.In this paper,two distinct scenarios,i.e.,an ideal memristor serves as external electromagnetic stimulation and a locally active memristor serves as a synapse,are formulated to investigate the impact of a memristor on a two-dimensional Hindmarsh-Rose neuron model.Numerical simulations show that the neuronal models in different scenarios have multiple burst firing patterns.The introduction of the memristor makes the neuronal model exhibit complex dynamical behaviors.Finally,the simulation circuit and DSP hardware implementation results validate the physical mechanism,as well as the reliability of the biological neuron model. 展开更多
关键词 MEMRISTOR MULTISTABILITY Hamilton energy firing pattern neuron model hardware implementation
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One memristor–one electrolyte-gated transistor-based high energy-efficient dropout neuronal units
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作者 李亚霖 时凯璐 +4 位作者 朱一新 方晓 崔航源 万青 万昌锦 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期569-573,共5页
Artificial neural networks(ANN) have been extensively researched due to their significant energy-saving benefits.Hardware implementations of ANN with dropout function would be able to avoid the overfitting problem. Th... Artificial neural networks(ANN) have been extensively researched due to their significant energy-saving benefits.Hardware implementations of ANN with dropout function would be able to avoid the overfitting problem. This letter reports a dropout neuronal unit(1R1T-DNU) based on one memristor–one electrolyte-gated transistor with an ultralow energy consumption of 25 p J/spike. A dropout neural network is constructed based on such a device and has been verified by MNIST dataset, demonstrating high recognition accuracies(> 90%) within a large range of dropout probabilities up to40%. The running time can be reduced by increasing dropout probability without a significant loss in accuracy. Our results indicate the great potential of introducing such 1R1T-DNUs in full-hardware neural networks to enhance energy efficiency and to solve the overfitting problem. 展开更多
关键词 dropout neuronal unit synaptic transistors MEMRISTOR artificial neural network
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Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing
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作者 严浩然 颜家琦 +1 位作者 俞连春 邵玉峰 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期758-763,共6页
The Hodgkin–Huxley model assumes independent ion channel activation,although mutual interactions are common in biological systems.This raises the problem why neurons would favor independent over cooperative channel a... The Hodgkin–Huxley model assumes independent ion channel activation,although mutual interactions are common in biological systems.This raises the problem why neurons would favor independent over cooperative channel activation.In this study,we evaluate how cooperative activation of sodium channels affects the neuron’s information processing and energy consumption.Simulations of the stochastic Hodgkin–Huxley model with cooperative activation of sodium channels show that,while cooperative activation enhances neuronal information processing capacity,it greatly increases the neuron’s energy consumption.As a result,cooperative activation of sodium channel degrades the energy efficiency for neuronal information processing.This discovery improves our understanding of the design principles for neural systems,and may provide insights into future designs of the neuromorphic computing devices as well as systematic understanding of pathological mechanisms for neural diseases. 展开更多
关键词 energy efficiency ion channel noise action potential generation neuronal dynamics
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安寐丹对冠心病合并抑郁症小鼠海马药效学及机制研究
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作者 孔俊虹 陈弦 +2 位作者 殷建峰 沙晨曦 龚楚桥 《南京中医药大学学报》 北大核心 2025年第1期86-94,共9页
目的探讨安寐丹对冠心病合并抑郁症小鼠海马的药效学及相关机制的影响。方法通过建立冠心病模型合并慢性不可预知温和应激法(CUMS)的抑郁症模型,将小鼠随机分为空白组、模型组、安寐丹低剂量组(1.5 g·kg^(-1))、安寐丹高剂量组(3 g... 目的探讨安寐丹对冠心病合并抑郁症小鼠海马的药效学及相关机制的影响。方法通过建立冠心病模型合并慢性不可预知温和应激法(CUMS)的抑郁症模型,将小鼠随机分为空白组、模型组、安寐丹低剂量组(1.5 g·kg^(-1))、安寐丹高剂量组(3 g·kg^(-1))以及阿伐他汀组(阿托伐他汀钙片,0.3 g·kg^(-1))。采用蔗糖偏好实验、旷场实验、强迫游泳实验评估小鼠行为学变化;qPCR和ELISA法检测海马组织白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)mRNA表达水平和含量;尼氏染色观察海马体CA1、CA3、DG区神经元及尼氏体变化;Western blot法检测组织关键蛋白表达。结果与空白组相比,模型组小鼠蔗糖偏好率降低(P<0.01),强迫游泳静止不动时间延长(P<0.01),旷场实验中的运动距离变化不明显;总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显升高(P<0.01),高密度脂蛋白胆固醇(HDL-C)水平降低明显(P<0.01);IL-1β、IL-6和TNF-αmRNA表达水平和含量明显升高(P<0.01);海马组织谷氨酸受体1(GluR1)、突触后密度蛋白-95(PSD-95)、脑源性神经营养因子(BDNF)和磷酸化的钙调蛋白质依赖的激酶(p-CaMKⅡ)表达均减少(P<0.01);细胞骨架活性调节蛋白(Arc)表达增加(P<0.01);模型组细胞结构不规则并出现不同程度损伤,尼氏体减少或消失,细胞膜破裂。与模型组相比,安寐丹各剂量组小鼠的蔗糖偏好率显著增加(P<0.01),强迫游泳实验中的不动时间显著降低(P<0.01),安寐丹各剂量组和阿伐他汀组小鼠TC、TG、LDL-C水平降低(P<0.01),HDL-C水平升高(P<0.01);IL-1β、IL-6、TNF-α含量和mRNA水平降低(P<0.01);安寐丹各剂量组海马组织GluR1、PSD-95、BDNF、p-CaMKⅡ表达均增加(P<0.05,P<0.01),Arc表达降低(P<0.01)。安寐丹组及阿伐他汀组细胞形态结构改善,尼氏体不同程度增多,细胞膜较完整。结论安寐丹有效改善冠心病合并抑郁症小鼠的血脂四项和其抑郁样行为,通过抑制促炎因子,提高神经营养因子的表达,有效改善神经元突触相关蛋白表达,降低对神经元的损伤,从而有效地防止了冠心病与抑郁共病现象的加剧。 展开更多
关键词 抑郁症 安寐丹 冠心病 细胞骨架活性调节蛋白 突触后密度蛋白-95 神经元损伤
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Application of single neuron adaptive PID controller during the process of timber drying 被引量:4
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作者 张冬妍 刘亚秋 曹军 《Journal of Forestry Research》 SCIE CAS CSCD 2003年第3期244-248,共5页
The paper presents a method of using single neuron adaptive PID control for adjusting system or servo system to implement timber drying process control, which combines the thought of parameter adaptive PID control and... The paper presents a method of using single neuron adaptive PID control for adjusting system or servo system to implement timber drying process control, which combines the thought of parameter adaptive PID control and the character of neural network on exactly describing nonlinear and uncertainty dynamic process organically. The method implements functions of adaptive and self-learning by adjusting weighting parameters. Adaptive neural network can make some output trail given hoping value to decouple in static state. The simulation result indicates the validity, veracity and robustness of the method used in the timber drying process 展开更多
关键词 Process control Timber drying Single neuron Adaptive control PID control
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FAULT-TOLERANT INTEGRATED NAVIGATION SYSTEM BASED ON NEURONS 被引量:1
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作者 马昕 袁信 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 1998年第2期4-7,共4页
In this paper, the multisensor data fusion technique of a fault tolerant integrated navigation system is discussed. A neural approach for data fusion is proposed for multisensor integrated systems. The simulation res... In this paper, the multisensor data fusion technique of a fault tolerant integrated navigation system is discussed. A neural approach for data fusion is proposed for multisensor integrated systems. The simulation results show that this neural approach for data fusion is feasible. 展开更多
关键词 navigation system neuron data fusion fault tolerant
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7,8-DHF对糖尿病大鼠视网膜的保护作用及其机制
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作者 杨爱萍 郑新宝 +5 位作者 陈春峰 陈佳玉 夏静 李明芳 吴陆赟 赵永旺 《眼科新进展》 CAS 北大核心 2025年第1期5-9,共5页
目的探讨7,8-二羟基黄酮(7,8-DHF)对糖尿病大鼠视网膜的保护作用及其机制。方法取SPF级雄性SD大鼠18只,将大鼠随机分为正常组、模型组和实验组,每组6只。正常组采用普通饲料喂养,其余大鼠采用高脂乳剂连续灌胃2周建立糖尿病模型。实验... 目的探讨7,8-二羟基黄酮(7,8-DHF)对糖尿病大鼠视网膜的保护作用及其机制。方法取SPF级雄性SD大鼠18只,将大鼠随机分为正常组、模型组和实验组,每组6只。正常组采用普通饲料喂养,其余大鼠采用高脂乳剂连续灌胃2周建立糖尿病模型。实验组大鼠给予7,8-DHF(5 mg·kg^(-1))腹腔注射干预,正常组和模型组大鼠给予同等量生理盐水,各组大鼠每天干预1次,连续2周。观察各组大鼠造模前后体重与空腹血糖变化。2周后采用眼底照相和眼底荧光素血管造影(FFA)观察各组大鼠眼底视网膜变化。采用HE染色、CD31免疫荧光及TUNEL实验检测大鼠视网膜神经细胞变化及凋亡情况。结果干预2周后,与正常组相比,模型组和实验组大鼠体重均下降,空腹血糖均上升,差异均有统计学意义(均为P<0.05);与模型组相比,实验组大鼠体重上升,空腹血糖下降,差异均有统计学意义(P<0.05)。各组大鼠眼底照相和FFA检查均未发现糖尿病性视网膜病变眼底改变。HE染色结果显示,正常组和实验组大鼠视网膜结构完整,排列整齐,厚薄均匀,模型组大鼠视网膜层次尚清晰。与正常组及实验组相比,模型组大鼠视网膜内层厚度均变薄,差异均有统计学意义(均P<0.05)。CD31免疫荧光染色结果显示,各组大鼠CD31免疫荧光强度值大致相当,差异无统计学意义(均为P>0.05)。TUNEL实验结果显示,与正常组比较,模型组大鼠视网膜神经凋亡细胞数明显增加,差异有统计学意义(P<0.001);与模型组相比,实验组大鼠视网膜神经凋亡细胞数明显减少,差异有统计学意义(P<0.001)。结论糖尿病大鼠视网膜神经凋亡可能早于血管内皮细胞损伤。7,8-DHF可以改善糖尿病大鼠体重及降低血糖,保护DM大鼠视网膜神经细胞。 展开更多
关键词 7 8-二羟基黄酮 糖尿病大鼠 视网膜神经细胞 凋亡
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Neuron芯片TMPN3150与A/D芯片TLC0832的两种接口实现方法
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作者 崔春来 彭楚武 胡雁 《国外电子元器件》 2003年第8期21-24,共4页
根据神经元芯片TMPN3150的两种I/O模式 ,给出了该神经元芯片与A/D芯片TLC0832实现接口的两种不同方法 ,同时给出了硬件电路和软件程序 ,并对两种方法进行了比较。
关键词 neuron芯片 TMPN3150 A/D芯片 TLC0832 神经元芯片 接口
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基于细胞和果蝇模型的狗枣猕猴桃黄酮提取物抗炎和助眠功效研究
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作者 王乐琪 王萍 《食品科学技术学报》 北大核心 2025年第2期75-85,共11页
为评价狗枣猕猴桃果实黄酮提取物(Actinidia kolomikta fruit flavonoid extract,AFFE)抗炎、助眠的功效,以巨噬细胞RAW264.7炎症模型、小鼠海马神经元细胞HT22和黑腹雄蝇为实验对象,分析了AFFE对炎症介质、神经递质及睡眠时间的影响。... 为评价狗枣猕猴桃果实黄酮提取物(Actinidia kolomikta fruit flavonoid extract,AFFE)抗炎、助眠的功效,以巨噬细胞RAW264.7炎症模型、小鼠海马神经元细胞HT22和黑腹雄蝇为实验对象,分析了AFFE对炎症介质、神经递质及睡眠时间的影响。结果表明,对于脂多糖诱导的RAW264.7细胞,250μg/mL AFFE使得其NO、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白细胞介素-6(interleukin-6,IL-6)生成量分别减少62.71%、47.38%和65.53%,同时TNF-α和IL-6的mRNA表达极显著下调(P<0.01),AFFE表现出良好的抗炎活性。对于HT22细胞,250μg/mL AFFE能极显著提高神经递质γ-氨基丁酸(γ-aminobutyric acid,GABA)和5-羟色胺(5-hydroxytryptamine,5-HT)产生量(P<0.01),上调GABRA1、GABRA2、5-HT2A受体mRNA表达。在雄蝇睡眠剥夺模型中,雄蝇经质量分数10%AFFE培养基中培养后,全天睡眠时间延长11.58%,与空白对照组无显著性差异。经L C-MS分析,AFFE中共检测出33种活性成分,其中有14种黄酮类物质。研究结果表明,AFFE对神经递质GABA和5-HT生成增长率与炎症介质NO、TNF-α和IL-6分泌抑制率之间有正相关关系,AFFE的助眠作用与其黄酮类物质的抗炎能力有关。 展开更多
关键词 狗枣猕猴桃 抗炎 助眠 巨噬细胞 海马神经元细胞 黑腹雄蝇
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基于新型忆阻器的多端输入LIF神经元电路的设计
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作者 柯善武 金尧耀 +3 位作者 蒙嘉豪 吴鑫江 王今朝 叶葱 《微电子学与计算机》 2025年第2期86-92,共7页
由于传统的互补金属-氧化物-半导体(Complementary Metal Oxide Semiconductor,CMOS)神经元电路与生物学的契合性较差且电路复杂,提出了一种基于忆阻器的多端口输入的泄露-整合-激发(Leaky-Integrate-Fire,LIF)神经元电路。该电路由运... 由于传统的互补金属-氧化物-半导体(Complementary Metal Oxide Semiconductor,CMOS)神经元电路与生物学的契合性较差且电路复杂,提出了一种基于忆阻器的多端口输入的泄露-整合-激发(Leaky-Integrate-Fire,LIF)神经元电路。该电路由运放、逻辑门等器件以及忆阻器构成,主要分为信号叠加模块和神经元信号产生模块。通过施加多个双尖峰脉冲信号并调节输入信号的数量和频率,模拟了生物神经元受到的不同程度刺激。研究发现施加到神经元上信号的数量和频率达到一定的值,神经元电路才会输出电压信号,这与生物体中只有受到一定程度的刺激时才会做出反应的现象是一致的。进一步,调节该电路中神经元信号产生模块的阈值电压大小,研究发现输入相同的信号,只有当电路的阈值电压较低时,神经元电路才能输出电压信号,这与生物中不同部位受到相同的刺激,神经元兴奋程度越高,越容易做出反应的现象一致。由此,该文所提出的LIF神经元电路不仅解决了传统电路输入信号单一、输入信号波形与生物信号波形差异大等问题,而且能模拟生物神经元的兴奋程度,这为人工神经网络的设计提供理论依据。 展开更多
关键词 忆阻器 LIF神经元电路 多端输入 阈值电压 人工神经网络
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通调心肾针刺法结合温阳补肾灸治疗血管性痴呆的疗效及对认知功能的影响
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作者 李蔚然 杨琪琪 +2 位作者 周欣华 王克坡 李飞 《中国中医药信息杂志》 CAS 2025年第1期158-163,共6页
目的观察通调心肾针刺法结合温阳补肾灸治疗血管性痴呆(VD)的临床疗效及对事件相关电位P300、神经元特异性烯醇化酶(NSE)及乙酰胆碱酯酶(AChE)的影响。方法采用随机数字表法将60例VD患者分为针灸组和西药组各30例。2组均予调控血压、血... 目的观察通调心肾针刺法结合温阳补肾灸治疗血管性痴呆(VD)的临床疗效及对事件相关电位P300、神经元特异性烯醇化酶(NSE)及乙酰胆碱酯酶(AChE)的影响。方法采用随机数字表法将60例VD患者分为针灸组和西药组各30例。2组均予调控血压、血糖、血脂等西医基础治疗;西药组予盐酸多奈哌齐片,每次5mg,每日1次,口服;针灸组在西药组治疗基础上,予通调心肾针刺法结合温阳补肾灸,每日1次,每周6次;2组均连续治疗4周。于治疗前后当日评估2组患者简易智力状态检查量表(MMSE)、日常生活能力量表(ADL)评分,检测血清NSE、AChE浓度,测定事件相关电位P300,并判定MMSE和P300的异常检出率变化。监测2组安全性指标。结果与本组治疗前比较,2组MMSE评分、ADL评分均显著提高(P<0.05),针灸组P300潜伏期下降、P300波幅升高(P<0.05),2组NSE、AChE水平降低(P<0.05);与西药组比较,针灸组治疗后MMSE评分、ADL评分及P300波幅升高,P300潜伏期下降,NSE、AChE水平下降(P<0.05)。患者P300潜伏期异常检出率明显高于MMSE评分异常检出率(P<0.05);与本组治疗前比较,针灸组患者P300潜伏期异常率和MMSE评分异常率降低(P<0.05)。2组均未见明显不良反应。结论通调心肾针刺法结合温阳补肾灸能提高患者认知功能及改善日常生活能力,其机制可能与降低NSE及AChE水平有关,事件相关电位P300在判断VD及认知能力方面较MMSE更为敏感。 展开更多
关键词 通调心肾针刺法 温阳补肾灸 血管性痴呆 神经元特异性烯醇化酶 乙酰胆碱酯酶 事件相关电位P300
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n-3多不饱和磷脂酰丝氨酸对大鼠海马神经元细胞的抗凋亡作用研究
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作者 付万冬 杨艳 +1 位作者 周宇芳 廖妙飞 《食品安全质量检测学报》 2025年第2期246-253,共8页
目的研究n-3多不饱和磷脂酰丝氨酸对大鼠海马神经元细胞(rat hippocampal neurons cells,RHNC)抗凋亡能力的影响。方法以RHNC为对象,以乙酸佛波酯(phorbol 12-myristate 13-acetate,PMA)为诱导剂,建立凋亡模型。以二十二碳六烯酸(docosa... 目的研究n-3多不饱和磷脂酰丝氨酸对大鼠海马神经元细胞(rat hippocampal neurons cells,RHNC)抗凋亡能力的影响。方法以RHNC为对象,以乙酸佛波酯(phorbol 12-myristate 13-acetate,PMA)为诱导剂,建立凋亡模型。以二十二碳六烯酸(docosahexaenoic acid,DHA)/二十碳五烯酸(eicosapentaenoic acid,EPA)型磷脂酰丝氨酸(DHA/EPA-phosphatidylserine,DHA/EPA-PS)为保护剂,用吖啶橙染色后在激光共聚焦显微镜下观察细胞不同凋亡时期的形态。通过磷脂酰丝氨酸外翻实验(Annexin V-FITC/PI双染实验),在细胞水平研究以DHA/EPA-PS为代表的n-3多不饱和磷脂酰丝氨酸对RHNC的抗凋亡能力。结果在PMA质量浓度为10.0 mg/L、作用时间24 h条件下,建立RHNC凋亡模型。15.0 mg/L DHA/EPA-PS对RHNC的预保护效果最好,此时早期、中期凋亡细胞较少且无晚期凋亡细胞,凋亡率为11.46%±4.11%,细胞形态和核膜完整,突起不受PMA的影响。结论以DHA/EPA-PS为代表的n-3多不饱和磷脂酰丝氨酸对RHNC具有一定的抗凋亡作用。本研究可为磷脂酰丝氨酸的生物活性研究提供较好的数据支撑。 展开更多
关键词 n-3多不饱和磷脂酰丝氨 海马神经元细胞 抗凋亡
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A/D芯片TLC2543与Neuron芯片的接口应用
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作者 黄天戍 杨显娇 王志刚 《国外电子元器件》 2002年第6期12-14,共3页
介绍了lonworks技术中Neuron芯片的一种I/O应用模式和A/D芯片TLC2543的串行接口特性。
关键词 neuron芯片 串行接口 TLC2543 A/D转换器 数字信号传输 通信
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State-Incomplete Intelligent Dynamic Multipath Routing Algorithm in LEO Satellite Networks
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作者 Peng Liang Wang Xiaoxiang 《China Communications》 2025年第2期1-11,共11页
The low Earth orbit(LEO)satellite networks have outstanding advantages such as wide coverage area and not being limited by geographic environment,which can provide a broader range of communication services and has bec... The low Earth orbit(LEO)satellite networks have outstanding advantages such as wide coverage area and not being limited by geographic environment,which can provide a broader range of communication services and has become an essential supplement to the terrestrial network.However,the dynamic changes and uneven distribution of satellite network traffic inevitably bring challenges to multipath routing.Even worse,the harsh space environment often leads to incomplete collection of network state data for routing decision-making,which further complicates this challenge.To address this problem,this paper proposes a state-incomplete intelligent dynamic multipath routing algorithm(SIDMRA)to maximize network efficiency even with incomplete state data as input.Specifically,we model the multipath routing problem as a markov decision process(MDP)and then combine the deep deterministic policy gradient(DDPG)and the K shortest paths(KSP)algorithm to solve the optimal multipath routing policy.We use the temporal correlation of the satellite network state to fit the incomplete state data and then use the message passing neuron network(MPNN)for data enhancement.Simulation results show that the proposed algorithm outperforms baseline algorithms regarding average end-to-end delay and packet loss rate and performs stably under certain missing rates of state data. 展开更多
关键词 deep deterministic policy gradient LEO satellite network message passing neuron network multipath routing
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