Sections of 30 cases of human cirrhosis were stained with rabbit anti-insulin-likegrowth factor Ⅱ(IGF Ⅱ)by double PAP method.By the serological examination 15 patientsshowed HBV infection and sections of 14 eases we...Sections of 30 cases of human cirrhosis were stained with rabbit anti-insulin-likegrowth factor Ⅱ(IGF Ⅱ)by double PAP method.By the serological examination 15 patientsshowed HBV infection and sections of 14 eases were HBsAg postively with a total rate of 67％(20 cases).The IGF Ⅱ was positive in the cytoplasm of all the liver and ductular cells.Binucle-ated,polypoid liver cells and the peripheral cells of the lobules or nodules were distinctly posi-tive,The liver cells which were strongly positive were a kind of thin polygonal cells with asmall oval or a round deeply stained nucleus in each.They might exist sporadically in the lob-ules or in the marginal portion of a nodule.These liver cells are quite different from the so-called oval cells which are derived from the proliferating ductules and are generally believed tobe responsible for the pathogensis of hepatoma.展开更多
目的观察拉贝洛尔、硝苯地平联合硫酸镁治疗妊娠高血压的效果及对胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、胰岛素样生长因子-Ⅱ(IGF-Ⅱ)、胰岛素样生长因子结合蛋白-1(IGFBP-1)的影响。方法选取2018年11月至2020年11月福建省立医院南院妇产科收治...目的观察拉贝洛尔、硝苯地平联合硫酸镁治疗妊娠高血压的效果及对胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、胰岛素样生长因子-Ⅱ(IGF-Ⅱ)、胰岛素样生长因子结合蛋白-1(IGFBP-1)的影响。方法选取2018年11月至2020年11月福建省立医院南院妇产科收治的127例妊娠高血压患者,按照随机数表法分为对照组(n=63)和研究组(n=64),对照组使用硝苯地平+硫酸镁治疗,研究组使用拉贝洛尔+硫酸镁治疗,4周后比较两组的血压指标和生化指标,分娩后比较两组的胰岛素样生长因子水平、顺产率、不良结局发生率。结果研究组患者的收缩压(SBP)、舒张压(DBP)低于对照组,差异有统计学意义(P<0.05)。研究组患者的24 h尿蛋白水平(24 h rUprV)、B型钠尿肽(BNP)低于对照组,差异有统计学意义(P<0.05)。研究组产妇的IGF-Ⅰ、IGF-Ⅱ水平高于对照组,IGFBP-1低于对照组,差异有统计学意义(P<0.05)。研究组产妇的顺产率高于对照组,两组的分级数据比较,差异有统计学意义(P<0.05)。研究组的不良结局总发生率低于对照组,差异有统计学意义(P<0.05)。结论拉贝洛尔联合硫酸镁治疗妊娠高血压,有利于降低血压水平,调节胰岛素样生长因子,改善生化指标和妊娠结局,具有更好的临床治疗效果。展开更多
To investigate the effects of early nutritional intervention on the serum insulin-like growth factor-1 (IGF1),insulin-like growth factor binding protein 3 (IGFBP3), intestinal development, and catch-up growth of intra...To investigate the effects of early nutritional intervention on the serum insulin-like growth factor-1 (IGF1),insulin-like growth factor binding protein 3 (IGFBP3), intestinal development, and catch-up growth of intrauterine growth retardation (IUGR) rats by giving the IUGR new born rats different protein level diet. Methods IUGR rat model was built by starvation of pregnant female rats. Twenty-four IUGR pups and 8 normal pups were divided randomly into 4 groups: normal control group (C group); IUGR control group(S group), IUGR low-protein diet group (SL group), and IUGR high-protein diet group (SH group). Detected the serum IGF1, IGFBP3, body weight, body length, intestinal weight length, intestinal villi height (VH), crypt depth (CD), villi absorbing area (VSA), mucous thickness (MT), and disaccharidase at the 4th week. Results (1) The SH group showed the fastest catch-up growth, serum IGF1, IGFBP3, VH, and VSA were significantly higher than those of normal control group and IUGR control group. The intestinal weight and length, and the activities of lactase and saccharase of the SH group also reached the normal control group level. (2) The SL group kept on small size, the serum IGF1, IGFBP3, and most of intestinal histological indexes were all significantly lower than other groups. (3) IGF-1, IGFBP3 were positively correlated to intestinal VH, VSA, saccharase, body weight and length. Conclusions The serum IGF1 was a sensitive index to the catch-up growth. The early nutritional intervention of high-protein diet after birth is helpful for the catch-up growth of IUGR through promoting the intestinal development and the ab-sorption of nutrition展开更多
基金Supported by the National Natural Science Foundation of China,No.3880376
文摘Sections of 30 cases of human cirrhosis were stained with rabbit anti-insulin-likegrowth factor Ⅱ(IGF Ⅱ)by double PAP method.By the serological examination 15 patientsshowed HBV infection and sections of 14 eases were HBsAg postively with a total rate of 67％(20 cases).The IGF Ⅱ was positive in the cytoplasm of all the liver and ductular cells.Binucle-ated,polypoid liver cells and the peripheral cells of the lobules or nodules were distinctly posi-tive,The liver cells which were strongly positive were a kind of thin polygonal cells with asmall oval or a round deeply stained nucleus in each.They might exist sporadically in the lob-ules or in the marginal portion of a nodule.These liver cells are quite different from the so-called oval cells which are derived from the proliferating ductules and are generally believed tobe responsible for the pathogensis of hepatoma.
文摘目的观察拉贝洛尔、硝苯地平联合硫酸镁治疗妊娠高血压的效果及对胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、胰岛素样生长因子-Ⅱ(IGF-Ⅱ)、胰岛素样生长因子结合蛋白-1(IGFBP-1)的影响。方法选取2018年11月至2020年11月福建省立医院南院妇产科收治的127例妊娠高血压患者,按照随机数表法分为对照组(n=63)和研究组(n=64),对照组使用硝苯地平+硫酸镁治疗,研究组使用拉贝洛尔+硫酸镁治疗,4周后比较两组的血压指标和生化指标,分娩后比较两组的胰岛素样生长因子水平、顺产率、不良结局发生率。结果研究组患者的收缩压(SBP)、舒张压(DBP)低于对照组,差异有统计学意义(P<0.05)。研究组患者的24 h尿蛋白水平(24 h rUprV)、B型钠尿肽(BNP)低于对照组,差异有统计学意义(P<0.05)。研究组产妇的IGF-Ⅰ、IGF-Ⅱ水平高于对照组,IGFBP-1低于对照组,差异有统计学意义(P<0.05)。研究组产妇的顺产率高于对照组,两组的分级数据比较,差异有统计学意义(P<0.05)。研究组的不良结局总发生率低于对照组,差异有统计学意义(P<0.05)。结论拉贝洛尔联合硫酸镁治疗妊娠高血压,有利于降低血压水平,调节胰岛素样生长因子,改善生化指标和妊娠结局,具有更好的临床治疗效果。
文摘To investigate the effects of early nutritional intervention on the serum insulin-like growth factor-1 (IGF1),insulin-like growth factor binding protein 3 (IGFBP3), intestinal development, and catch-up growth of intrauterine growth retardation (IUGR) rats by giving the IUGR new born rats different protein level diet. Methods IUGR rat model was built by starvation of pregnant female rats. Twenty-four IUGR pups and 8 normal pups were divided randomly into 4 groups: normal control group (C group); IUGR control group(S group), IUGR low-protein diet group (SL group), and IUGR high-protein diet group (SH group). Detected the serum IGF1, IGFBP3, body weight, body length, intestinal weight length, intestinal villi height (VH), crypt depth (CD), villi absorbing area (VSA), mucous thickness (MT), and disaccharidase at the 4th week. Results (1) The SH group showed the fastest catch-up growth, serum IGF1, IGFBP3, VH, and VSA were significantly higher than those of normal control group and IUGR control group. The intestinal weight and length, and the activities of lactase and saccharase of the SH group also reached the normal control group level. (2) The SL group kept on small size, the serum IGF1, IGFBP3, and most of intestinal histological indexes were all significantly lower than other groups. (3) IGF-1, IGFBP3 were positively correlated to intestinal VH, VSA, saccharase, body weight and length. Conclusions The serum IGF1 was a sensitive index to the catch-up growth. The early nutritional intervention of high-protein diet after birth is helpful for the catch-up growth of IUGR through promoting the intestinal development and the ab-sorption of nutrition
