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Investigation of hydroxyl-terminated polybutadiene propellant breaking characteristics and mechanism impacted by submerged cavitation water jet 被引量:4
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作者 Wenjun Zhou Meng Zhao +3 位作者 Bo Liu Youzhi Ma Youzhi Zhang Xuanjun Wang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期559-572,共14页
A submerged cavitation water jet(SCWJ)is an effective method to recycle solid propellant from obsolete solid engines by the breaking method.Solid propellant's breaking modes and mechanical process under SCWJ impac... A submerged cavitation water jet(SCWJ)is an effective method to recycle solid propellant from obsolete solid engines by the breaking method.Solid propellant's breaking modes and mechanical process under SCWJ impact are unclear.This study aims to understand those impact breaking mechanisms.The hydroxyl-terminated polybutadiene(HTPB)propellant was chosen as the research material,and a self-designed test system was used to conduct impact tests at four different working pressures.The high-speed camera characterized crack propagation,and the DIC method calculated strain change during the impact process.Besides,micro and macro fracture morphologies were characterized by scanning electron microscope(SEM)and computed tomography(CT)scanning.The results reveal that the compressive strain concentration region locates right below the nozzle,and the shear strain region distributes symmetrically with the jet axis,which increases to 4% at first 16th ms,the compressive strain rises to 2% and 6% in the axial and transverse direction,respectively.The two tensile cracks formed first at the compression strain concentrate region,and there generate many shear cracks around the tensile cracks,and those shear cracks that develop and aggregate cause the cracks to become wider and cut through the tensile cracks,forming the tensile-shear cracks and the impact parts eventually fail.The HTPB propellant forms a breaking hole shaped conical after impact 10 s.The mass loss increases by 17 times at maximum,with the working pressure increasing by three times.Meanwhile,the damage value of the breaking hole remaining on the surface increases by 7.8 times while 2.9 times in the depth of the breaking hole.The breaking efficiency is closely affected by working pressures.The failure modes of HTPB impacted by SCWJ are classified as tensile crack-dominated and tensile-shear crack-dominated damage mechanisms. 展开更多
关键词 Submerged cavitation water jet hydroxyl-terminated polybutadiene propellant Breaking characteristics Failure modes
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Research advancements in phosphogypsum crystal modifiers
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作者 LI Yi-lin LI Sheng-long +4 位作者 ZHANG Ruo-qing JIANG Ji-zhou XIANG Kun Arramel ZOU Jing 《Journal of Central South University》 CSCD 2024年第11期4098-4119,共22页
The excessive demand for phosphorus-based fertilizers is contributing to the undesired byproduct of phosphogypsum(PG),typically found in large quantities in phosphoric acid industry.Without proper management,this indu... The excessive demand for phosphorus-based fertilizers is contributing to the undesired byproduct of phosphogypsum(PG),typically found in large quantities in phosphoric acid industry.Without proper management,this industrial waste poses a significant environmental pollution risk.Current technologies are struggle to effectively handle the volume of PG produced,but one promising solution is its conversion into hemihydrate gypsum(CaSO_(4)·0.5 H_(2)O,HH).HH can exist in two phases,α-HH andβ-HH,withα-hemihydrate gypsum(α-HH)being preferred for its complete crystal structure and lower water requirement for hydration.The morphology ofα-HH gypsum is crucial for its material applications,and controlling crystal morphology is possible through the use of suitable crystal modifiers.This review explores various aspects of crystal modifiers and highlights their role in the preparation ofα-HH from PG.It suggests that leveraging the interfacial properties of PG could lead to innovative applications.Additionally,the review outlines future directions for PG development and identifies challenges to be addressed in the next steps. 展开更多
关键词 PHOSPHOGYPSUM hemihydrate gypsum crystal modifiers
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Establishment of a field visualization detection method for multiplex recombinase polymerase amplification combined with CRISPR/Cas12a in genetically modified crops 被引量:1
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作者 YAN Jingying NI Liang +2 位作者 SHEN Xingyu LÜ Bingtao LI Yu 《浙江大学学报(农业与生命科学版)》 北大核心 2025年第3期391-401,共11页
With the approval of more and more genetically modified(GM)crops in our country,GM safety management has become more important.Transgenic detection is a major approach for transgenic safety management.Nevertheless,a c... With the approval of more and more genetically modified(GM)crops in our country,GM safety management has become more important.Transgenic detection is a major approach for transgenic safety management.Nevertheless,a convenient and visual technique with low equipment requirements and high sensitivity for the field detection of GM plants is still lacking.On the basis of the existing recombinase polymerase amplification(RPA)technique,we developed a multiplex RPA(multi-RPA)method that can simultaneously detect three transgenic elements,including the cauliflower mosaic virus 35S gene(CaMV35S)promoter,neomycin phosphotransferaseⅡgene(NptⅡ)and hygromycin B phosphotransferase gene(Hyg),thus improving the detection rate.Moreover,we coupled this multi-RPA technique with the CRISPR/Cas12a reporter system,which enabled the detection results to be clearly observed by naked eyes under ultraviolet(UV)light(254 nm;which could be achieved by a portable UV flashlight),therefore establishing a multi-RPA visual detection technique.Compared with the traditional test strip detection method,this multi-RPA-CRISPR/Cas12a technique has the higher specificity,higher sensitivity,wider application range and lower cost.Compared with other polymerase chain reaction(PCR)techniques,it also has the advantages of low equipment requirements and visualization,making it a potentially feasible method for the field detection of GM plants. 展开更多
关键词 genetically modified crop recombinase polymerase amplification CRISPR/Cas12a field detection
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Graphene Oxide on Rheological and Self-healing Properties of Modified Asphalt
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作者 LIU Qinbao ZHAO Yan +1 位作者 GAO Honggang YAN Luchun 《材料科学与工程学报》 北大核心 2025年第1期80-89,共10页
Graphene oxide nanomaterials are increasingly used in various fields due to their superior properties.In order to study the influence of graphene oxide additives on the performance of modified asphalt,in this study,gr... Graphene oxide nanomaterials are increasingly used in various fields due to their superior properties.In order to study the influence of graphene oxide additives on the performance of modified asphalt,in this study,graphene oxide modified asphalt was prepared and characteristics was studied including the high deformation resistance performance and the self-healing property of modified asphalt.Functional groups and morphology of graphene oxide modified asphalt were described by Fourier transform infrared spectroscopy.The high deformation resistance performance and self-healing effect of asphalt samples were obtained through dynamic slear rheometer(DSR)test.Results shows that graphene oxide dispersions improve the performance of asphalt relatively well compared to graphene oxide powder.There is no chemical reaction between graphene oxide and asphalt,but physical connection.The addition of graphene oxide improved the high deformation resistance of modified asphalt and expedited the self-healing ability of asphalt under fatigue load. 展开更多
关键词 Graphene Oxide modified asphalt Rheological property SELF-HEALING
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Deformations and extensions of modified λ-differential Lie-Yamaguti algebras
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作者 TENG Wen PAN Yuewei 《中山大学学报(自然科学版)(中英文)》 北大核心 2025年第4期115-127,共13页
The modifiedλ-differential Lie-Yamaguti algebras are considered,in which a modifiedλ-differential Lie-Yamaguti algebra consisting of a Lie-Yamaguti algebra and a modifiedλ-differential operator.First we introduce t... The modifiedλ-differential Lie-Yamaguti algebras are considered,in which a modifiedλ-differential Lie-Yamaguti algebra consisting of a Lie-Yamaguti algebra and a modifiedλ-differential operator.First we introduce the representation of modifiedλ-differential Lie-Yamaguti algebras.Furthermore,we establish the cohomology of a modifiedλ-differential Lie-Yamaguti algebra with coefficients in a representation.Finally,we investigate the one-parameter formal deformations and Abelian extensions of modifiedλ-differential Lie-Yamaguti algebras using the second cohomology group. 展开更多
关键词 Lie-Yamaguti algebra modifiedλ-differential operator representation and cohomology one-parameter formal deformation Abelian extension
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Toughening modification of cellulose acetate butyrate and using for CL-20-based polymer bonded explosives
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作者 Na Li Zhengzheng Zhang +5 位作者 Fengqin Shang Shaohua Jin Lijie Li Changgen Feng Jiaming Gao Yu Chen 《Defence Technology(防务技术)》 2025年第4期29-39,共11页
CAB is a binder commonly utilized in CL-20-based mixed explosives.Based on the requirements of CL-20-based polymer bonded explosives in formability,safety,and detonation energy,we explored a hightoughness and low dosa... CAB is a binder commonly utilized in CL-20-based mixed explosives.Based on the requirements of CL-20-based polymer bonded explosives in formability,safety,and detonation energy,we explored a hightoughness and low dosage CAB binder system.CAB was subjected to different toughening modifications and the effects of the modified CAB binders on the bonding and coating of CL-20 crystals,as well as the formability,safety,and mechanical properties of CL-20-based polymer bonded explosive molding powder(MP)were evaluated.The changes in glass transition temperature(Tg)and mechanical properties of the modified binders were investigated using the molecular dynamics simulation at first.A series of modified binders with different molecular weights were then synthesized and characterized by FTIR,1H NMR,^(13)C NMR and SEC.The T_(g) and cross-sectional morphologies of the binder membranes were determined by DSC and SEM.The tensile properties of the binder membranes with different molecular weights and their mixtures with the plasticizer were evaluated at different temperature.With the optimized modified binder,CL-20/CAB and CL-20/CAB-g-PCL-3 MPs with the same plasticizer ratio and Cl-20/CAB-g-PCL-3 MP with a lower plasticizer ratio and higher CL-20 content were prepared and evaluated for the bonding and coating effects,crystal form,mechanical sensitivity and specific heat capacity(C_(p))by SEM,XRD,sensitivity testing and DSC,respectively.Their compressive strengths and splitting tensile strengths were measured at different temperature using a universal testing machine.Our work has provided a high-toughness and low-dosage binder system for CL-20-based MPs and offers a novel strategy to improve the formability,safety,and energy of CL-20 based polymer bonded explosives. 展开更多
关键词 modified CAB binders CL-20-Based MPs FORMABILITY Safety Energy
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Early Intervention on the Properties of Steel Slag at High Temperature by Modifier Compound with Tailings: A Feasible Way for Comprehensive Utilization of Solid Wastes
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作者 LIAN Fang ZHANG Zuoshun +2 位作者 MA Laijun Bater Sayin LIAO Hongqiang 《矿物学报》 CAS CSCD 北大核心 2013年第S1期49-49,共1页
Steel slag, a by-product of the steel production industry reaches 10%–15% of crude steel output (Motz and Geiseler, 2001). Their main application lies in the field of building materials due to some containing cementi... Steel slag, a by-product of the steel production industry reaches 10%–15% of crude steel output (Motz and Geiseler, 2001). Their main application lies in the field of building materials due to some containing cementitious components, such as dicalcium silicate (C2S) and tricalcium silicate (C3S) (Waligora et al., 2010). However, blended cements with steelmaking slag show low early hydration activity, low compressive strength and bad durability because steel slag generates above 1600 ℃ with the tense and large grain size crystals, consisting of low content of C2S and C3S and high proportions of f-CaO and f-MgO compared with cement clinker. 展开更多
关键词 steel SLAG early INTERVENTION high temperature modifierS TAILINGS building materials
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Effects of Plasticizers,Antioxidants and Burning Rate Modifiers on Aging Performance of the HTPB/HMDI Composite Solid Propellant
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作者 Ahmed M Enew Ehab Abadir +1 位作者 Sahar Elmarsafy Karim K Elsharkawy 《含能材料》 EI CAS CSCD 北大核心 2019年第1期21-27,90,共8页
The effects of plasticizers,antioxidants and burning rate modifiers on the aging performance of the composite solid propellant based on hydroxyl-terminated polybutadiene(HTPB)/hexamethylene diisocyanate(HMDI)were expl... The effects of plasticizers,antioxidants and burning rate modifiers on the aging performance of the composite solid propellant based on hydroxyl-terminated polybutadiene(HTPB)/hexamethylene diisocyanate(HMDI)were explored by apply-ing an accelerated aging program for 90 day at 70 ℃. The HTPB propellant matrix with the diisooctyl sebacate(DOS)as plasti-cizers and diisooctyl azelate(DOZ), antioxidants as N,N ′-Diphenyl-p-phenylenediamine(AO) and 2,2′-methylenebis(4-methyl-6-tert-butylphenol)(cyanox 2246)and burning rate modifiers as barium ferrite(BF),copper chromites(CC)and fer-ric oxide(FO)were varied. Results show that sample(S1)which based on DOS decreases the stress value and increases the strain value which considered to be an excellent start for aging program. Sample(S3)containing AO presents the higher resis-tance to oxidation showing the better performance that reflects on increasing the shelf life of the composite solid propellant mo-tor. Sample(S5)which based on BF enhances the ballistic performance among over the other tested two samples. The accelerat-ed aging program allowed us to estimate the motor in-service lifetime. 展开更多
关键词 polybutadiene(HTPB)/hexamethylene diisocyanate(HMDI)composite solid PROPELLANT plasticizers ANTIOXIDANTS burning rate modifierS aging program
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Dispersion of ultrafine alumina in modifier solution ——the role of polar interfacial interaction
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作者 HU Yue hua 1,QIU Guan zhou 1,J.D.Miller 2 (1.Department of Mineral Engineering, Central South University, Changsha 410083, China 2.Department of Metallurgical Engineering, University of Utah, 412 WBB, Salt Lake City, UT 84112, USA) 《Journal of Central South University of Technology》 2001年第1期18-23,共6页
Dispersion of ultrafine alumina suspension is examined by using particle size analyzer. The zeta potential and contact angle measurements were used to discuss the electrokinetic behavior and surface wettability of alu... Dispersion of ultrafine alumina suspension is examined by using particle size analyzer. The zeta potential and contact angle measurements were used to discuss the electrokinetic behavior and surface wettability of alumina in modifier solution, and to calculate the electrostatic interaction forces and interfacial interaction forces between alumina particles. The aggregation of ultrafine alumina occurs near its PZC. Addition of modifier increases the zeta potential of alumina and its surface hydrophilicity, resulting in increase of electrostatic and hydration repulsion. It makes the suspension of ultrafine alumina completely dispersed. The average particle size of the suspension is decreased from 1.73 μm in absence of modifier to 0.8 μm in the presence of tripolyphosphate. According to polar interfacial interaction approach, the hydration forces responsible for the stability of alumina suspension in the presence of modifier have also been obtained. The extended DLVO theory is successful to describe the dispersion behavior of ultrafine alumina in modifier solution. 展开更多
关键词 DISPERSION ALUMINA modifier polar interfacial interaction extended DLVO theory
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Localization in modified polar representation: hybrid measurements and closed-form solution 被引量:1
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作者 CONG Xunchao SUN Yimao +2 位作者 YANG Yanbing ZHANG Lei CHEN Liangyin 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期575-588,共14页
Classical localization methods use Cartesian or Polar coordinates, which require a priori range information to determine whether to estimate position or to only find bearings. The modified polar representation (MPR) u... Classical localization methods use Cartesian or Polar coordinates, which require a priori range information to determine whether to estimate position or to only find bearings. The modified polar representation (MPR) unifies near-field and farfield models, alleviating the thresholding effect. Current localization methods in MPR based on the angle of arrival (AOA) and time difference of arrival (TDOA) measurements resort to semidefinite relaxation (SDR) and Gauss-Newton iteration, which are computationally complex and face the possible diverge problem. This paper formulates a pseudo linear equation between the measurements and the unknown MPR position,which leads to a closed-form solution for the hybrid TDOA-AOA localization problem, namely hybrid constrained optimization(HCO). HCO attains Cramér-Rao bound (CRB)-level accuracy for mild Gaussian noise. Compared with the existing closed-form solutions for the hybrid TDOA-AOA case, HCO provides comparable performance to the hybrid generalized trust region subproblem (HGTRS) solution and is better than the hybrid successive unconstrained minimization (HSUM) solution in large noise region. Its computational complexity is lower than that of HGTRS. Simulations validate the performance of HCO achieves the CRB that the maximum likelihood estimator (MLE) attains if the noise is small, but the MLE deviates from CRB earlier. 展开更多
关键词 LOCALIZATION modified polar representation time difference of arrival(TDOA) angle of arrival(AOA) closed-form solution
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Investigation of granite failure precursor under axial load using modified LSTM framework
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作者 WANG Ya-lei XU Jin-ming 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2930-2943,共14页
Granite is usually composed of quartz,biotite,feldspar,and cracks,and the variation characteristics of these components could reflect the deformation and failure process of rock well.Taking granite as an example,the v... Granite is usually composed of quartz,biotite,feldspar,and cracks,and the variation characteristics of these components could reflect the deformation and failure process of rock well.Taking granite as an example,the video camera was used to record the deformation and failure process of rock.The distribution of meso-components in video images was then identified.The meso-components of rock failure precursors were also discussed.Moreover,a modified LSTM(long short-term memory method)based on SSA(sparrow search algorithm)was proposed to estimate the change of meso-components of rock failure precursor.It shows that the initiation and expansion of cracks are mainly caused by feldspar and quartz fracture,and when the quartz and feldspar exit the stress framework,rock failure occurs;the second large increase of crack area and the second large decrease of quartz or feldspar area may be used as a precursor of rock failure;the precursor time of rock failure based on meso-scopic components is about 4 s earlier than that observed by the naked eye;the modified LSTM network has the strongest estimation ability for quartz area change,followed by feldspar and biotite,and has the worst estimation ability for cracks;when using the modified LSTM network to predict the precursors of rock instability and failure,quartz and feldspar could be given priority.The results presented herein may provide reference in the investigation of rock failure mechanism. 展开更多
关键词 GRANITE failure precursor axial load modified long short-term memory method
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Research Progress of Agricultural Genetically Modified Crop Safety Evaluation
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作者 Li Ran Liang Liang +4 位作者 Zhao Haibo Zhao Yujia Fan Peilei Liu Ran Zhao Yue 《Journal of Northeast Agricultural University(English Edition)》 CAS 2024年第3期74-84,共11页
The commercial cultivation of genetically modified(GM)crops has eased the global food crisis and brought considerable economic and social benefits to countries.Because of the potential safety problems,it is necessary ... The commercial cultivation of genetically modified(GM)crops has eased the global food crisis and brought considerable economic and social benefits to countries.Because of the potential safety problems,it is necessary to make clear the molecular genetic characteristics,edible safety,planting,processing,and other aspects of the safety evaluation of GM crops.The safety problems existing in the cultivation of GM crops,safety evaluation and detection of GM crops were introduced in this paper,which provided the basis for safety evaluation and effective supervision of GM crops and their products.Commercial cultivation and reasonable supervision based on safety evaluation have far-reaching significance for ensuring consumer safety,enhancing the credibility of the national political system and enhancing citizens'confidence in the safety of GM crop products for consumption. 展开更多
关键词 genetically modified(GM)crop safety evaluation BIOSAFETY environmental safety detection method
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酚酸基纳米金修饰电极检测食品中的亚硝酸盐和亚硫酸盐 被引量:2
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作者 陈林林 吴松遥 +5 位作者 郝熙 李伟 张铭 张海鹏 李昕彤 张娜 《食品工业科技》 CAS 北大核心 2025年第1期274-282,共9页
基于酚酸良好的还原性和无污染性建立酚酸基纳米金传感体系,以实现亚硝酸盐和亚硫酸盐的灵敏检测。采用不同酚酸还原氯金酸制备纳米金(Gold nanoparticles,AuNPs),通过紫外光谱和交流阻抗法获得还原效果最佳的酚酸为没食子酸(Gallic aci... 基于酚酸良好的还原性和无污染性建立酚酸基纳米金传感体系,以实现亚硝酸盐和亚硫酸盐的灵敏检测。采用不同酚酸还原氯金酸制备纳米金(Gold nanoparticles,AuNPs),通过紫外光谱和交流阻抗法获得还原效果最佳的酚酸为没食子酸(Gallic acid,GA)。利用电沉积法制备GA@AuNPs@Au电极,并由线性扫描伏安法(Linear scanning voltammetry,LSV)表征亚硝酸盐和亚硫酸盐的电化学行为。优化体系条件为:GA浓度1 mmol/L、孵育温度70℃、反应时间60 min、pH6.0磷酸盐缓冲溶液浓度0.15 mol/L。亚硝酸盐和亚硫酸盐浓度在0.001~7 mmol/L范围内与氧化峰电流分别呈良好的线性关系(R2>0.994),检出限分别为0.20μmol/L和0.24μmol/L(S/N=3)。该修饰电极的重现性和稳定性良好,可用于实际样品中亚硝酸盐和亚硫酸盐的同时测定。 展开更多
关键词 酚酸 纳米金 修饰电极 亚硝酸盐 亚硫酸盐
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纳米ZnO/TiO_(2)与SBS复配改性沥青性能研究 被引量:1
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作者 张映雪 丁秀婷 柳力 《化工新型材料》 北大核心 2025年第7期278-284,共7页
为了提高苯乙烯-丁二烯-苯乙烯共聚物(SBS)改性沥青的性能,使用纳米ZnO、纳米TiO_(2)与SBS改性沥青进行复合改性。通过对改性沥青进行三大指标、温度扫描以及低温蠕变试验,研究了其物理性能和流变性能,运用红外光谱仪和荧光显微镜进行... 为了提高苯乙烯-丁二烯-苯乙烯共聚物(SBS)改性沥青的性能,使用纳米ZnO、纳米TiO_(2)与SBS改性沥青进行复合改性。通过对改性沥青进行三大指标、温度扫描以及低温蠕变试验,研究了其物理性能和流变性能,运用红外光谱仪和荧光显微镜进行微观分析。结果表明:随着纳米ZnO和纳米TiO_(2)添加量的增加,纳米ZnO/TiO_(2)/SBS复配改性沥青的针入度减小、软化点增大,高温性能明显改善。此外,纳米ZnO/TiO_(2)/SBS复配改性沥青的复数剪切模量和车辙因子增加,相位角减小,表明其抗车辙性能得到提升。其中3%ZnO和4%TiO_(2)掺量的性能最佳。纳米ZnO/TiO_(2)/SBS复配改性沥青的延度随着纳米改性剂掺量的增加而减小,劲度模量增大,蠕变速率减小,低温性能略有下降。与基质沥青相比,SBS改性沥青中出现新的吸收峰,表明SBS对基质沥青的改性属于化学改性。而在纳米ZnO/TiO_(2)/SBS复配改性沥青中,并未出现新的吸收峰,表明纳米ZnO和TiO_(2)对SBS改性沥青的改性属于物理改性。 展开更多
关键词 道路工程 改性沥青 流变性能 荧光显微镜 红外光谱
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SBS/C5树脂复配改性沥青流变性能 被引量:1
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作者 马峰 王宇行 +2 位作者 史柯 傅珍 石天鑫 《应用化工》 北大核心 2025年第2期271-276,共6页
为改善透水沥青路面的使用性能,延长其使用寿命,以SK70#基质沥青、SBS改性剂和C5加氢树脂为原材料,利用高速剪切法制备SBS掺量为4%,6%,8%,10%,C5加氢树脂掺量为6%的改性沥青,通过温度扫描、多应力蠕变恢复、低温松弛等试验分析SBS/C5对... 为改善透水沥青路面的使用性能,延长其使用寿命,以SK70#基质沥青、SBS改性剂和C5加氢树脂为原材料,利用高速剪切法制备SBS掺量为4%,6%,8%,10%,C5加氢树脂掺量为6%的改性沥青,通过温度扫描、多应力蠕变恢复、低温松弛等试验分析SBS/C5对改性沥青高低温性能的改善效果,利用线性振幅扫描试验评价SBS/C5树脂复配改性沥青的疲劳特性。结果表明:SBS/C5树脂的掺入使得沥青稠度增加,相较于基质沥青,SBS/C5明显改善了沥青的温度敏感性、高温稳定性和低温抗裂性。短期老化会降低改性沥青的低温性能,且当SBS改性剂掺量为10%时,抗老化性能最佳。改性后沥青的疲劳性能有所增强,有效改善了沥青的抗变形能力,提升了沥青的疲劳寿命。综合改性沥青各项指标分析得出SBS最佳掺量为6.0%。 展开更多
关键词 道路工程 SBS/C5 改性沥青 流变性能 道路材料
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CAR-T细胞治疗的临床关键问题和对策 被引量:2
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作者 陈新峰 刘莎莎 张毅 《中国肿瘤生物治疗杂志》 北大核心 2025年第1期9-13,共5页
自2017年以来,已有12款嵌合抗原受体基因修饰T淋巴细胞(CAR-T细胞)产品相继被批准用于血液系统恶性肿瘤的治疗,包括复发性/难治性急性B淋巴细胞白血病、特定亚型B细胞淋巴瘤和多发性骨髓瘤。然而,CAR-T细胞疗法在应用过程中面临诸多挑战... 自2017年以来,已有12款嵌合抗原受体基因修饰T淋巴细胞(CAR-T细胞)产品相继被批准用于血液系统恶性肿瘤的治疗,包括复发性/难治性急性B淋巴细胞白血病、特定亚型B细胞淋巴瘤和多发性骨髓瘤。然而,CAR-T细胞疗法在应用过程中面临诸多挑战,如在治疗血液系统肿瘤中的抵抗、生产周期长、个体化/价格昂贵,在实体瘤中的肿瘤异质性强/抗原逃逸、浸润能力不足、免疫抑制微环境和反应性差等问题。随着肿瘤免疫学研究的深入和基因工程技术的发展,尝试了众多新策略来提升CAR-T细胞疗法的疗效和普适性。作者根据自身对该领域研究的认知,针对CAR-T细胞疗法的临床关键问题及其应对解决策略进行述评,为未来CAR-T细胞疗法的基础研究和临床转化提供重要思路。 展开更多
关键词 免疫治疗 嵌合抗原受体基因修饰T淋巴细胞 肿瘤微环境 实体瘤
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木质素磺酸钙对分散土水力-力学特性影响 被引量:1
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作者 张晓飞 李佳超 +2 位作者 陈新炜 邓红艳 周红波 《排灌机械工程学报》 北大核心 2025年第2期170-177,201,共9页
传统的土壤改性剂(如石灰、水泥、石膏和粉煤灰等)对土壤水力-力学特性有一定的改善,但对环境有一定的破坏作用.以一种生物环境友好型材料—木质素磺酸钙(以下简称木素)作为改性剂,开展了针孔试验、碎块试验、钠离子交换百分比试验、界... 传统的土壤改性剂(如石灰、水泥、石膏和粉煤灰等)对土壤水力-力学特性有一定的改善,但对环境有一定的破坏作用.以一种生物环境友好型材料—木质素磺酸钙(以下简称木素)作为改性剂,开展了针孔试验、碎块试验、钠离子交换百分比试验、界限含水率试验、无侧限抗压强度试验、直接剪切试验、渗透试验和核磁孔隙度试验,研究了木素掺量、干密度、含水率对天然分散土的分散性和水力-力学特性的影响.结果表明:木素掺量为3%和4%时,改性土样呈非分散性,且干密度越大,分散性越差;随着木素的掺入,土样的液限、塑限、塑性指数降低;木素掺量为2%,对土样的无侧限抗压强度、抗剪强度及渗透性改善效果最好,而木素掺量过大时,土样的水力-力学特性变差;T_(2)谱呈现双峰结构,随着木素掺量的增加,主峰逐渐向右移动,土样的小孔隙孔径变大,大孔径孔隙数量增多. 展开更多
关键词 分散性土 木质素磺酸钙 改性土 水力-力学特性 孔隙演化特征
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生物吸附剂改性栗蓬的制备及其对Cr(Ⅵ)吸附性能的研究 被引量:1
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作者 刘欣 孙昊雪 +1 位作者 宋子琪 吴冰 《化学研究与应用》 北大核心 2025年第1期40-46,共7页
以农林废弃物栗蓬为原料,过氧化氢为改性剂,制备了对Cr(Ⅵ)具有良好吸附性能的生物吸附材料。以吸附率为优化目标,在单因素实验的基础上进行正交试验得到最佳改性条件为温度80℃、过氧化氢浓度10.0%、盐酸浓度0.01 mol·L^(-1)、时... 以农林废弃物栗蓬为原料,过氧化氢为改性剂,制备了对Cr(Ⅵ)具有良好吸附性能的生物吸附材料。以吸附率为优化目标,在单因素实验的基础上进行正交试验得到最佳改性条件为温度80℃、过氧化氢浓度10.0%、盐酸浓度0.01 mol·L^(-1)、时间0.5 h。采用傅立叶红外光谱(FT-IR)及扫描电镜(SEM)对改性栗蓬结构进行了表征。通过正交试验优化改性栗蓬对Cr(Ⅵ)的吸附条件,在改性栗蓬投加量0.8 g、Cr(Ⅵ)初始浓度20 mg·L^(-1)、吸附时间60 min条件下,对Cr(Ⅵ)的吸附率为61.8%。通过动力学方程拟合得到改性栗蓬对Cr(Ⅵ)的吸附过程符合准二级动力学方程。热力学实验表明,改性栗蓬对Cr(Ⅵ)的吸附为放热、熵减小的过程。 展开更多
关键词 栗蓬 过氧化氢 改性 生物吸附剂 铬(Ⅵ)
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语域-功能研究法框架下的学术英语语法复杂度研究 被引量:1
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作者 林生淑 袁周敏 《北京第二外国语学院学报》 北大核心 2025年第1期142-156,F0003,共16页
Biber等学者开创的语域-功能(RF)研究法强调语域情景特征和交际目的对语法复杂度的解释力,其主要贡献是在语料库研究的基础上确立了短语修饰语在学术英语中的重要地位,并提出了英语语言发展次序假设。本文介绍了RF研究法的理论基础及优... Biber等学者开创的语域-功能(RF)研究法强调语域情景特征和交际目的对语法复杂度的解释力,其主要贡献是在语料库研究的基础上确立了短语修饰语在学术英语中的重要地位,并提出了英语语言发展次序假设。本文介绍了RF研究法的理论基础及优势,回顾了10余年来英语写作领域的RF研究法相关研究和最新动态,并提出未来RF研究法发展的5个方向:①细化语言发展次序假设中的词汇语法结构的功能和意义;②开展更多个案研究,考察短语复杂度的(非)线性发展轨迹;③综合使用自动化工具扩展RF研究法研究主题;④在基于源文写作的课堂上探究提升短语复杂度使用的教学模式;⑤开展其他语言的RF研究法研究,构建适用于语言独特性的复杂度特征体系。同时,结合国内英语教学和研究的实际情况,本文提出了推动国内RF研究法研究的3个突破口。 展开更多
关键词 语域-功能研究法 学术英语 语法复杂度 短语修饰语
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废机油复配再生SBS改性沥青及混合料性能研究 被引量:1
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作者 马峰 司少锋 +2 位作者 温雅噜 傅珍 郭兴隆 《应用化工》 北大核心 2025年第1期39-43,49,共6页
为进一步恢复老化SBS改性沥青性能,以聚丙二醇二缩水甘油醚(PPGDGE)与废机油(WEO)复配制备再生沥青,深入研究不同PPGDGE掺量下再生剂与老化SBS改性沥青之间的作用规律,确定再生剂最佳掺量。在此基础上,对复配再生沥青混合料的路用性能... 为进一步恢复老化SBS改性沥青性能,以聚丙二醇二缩水甘油醚(PPGDGE)与废机油(WEO)复配制备再生沥青,深入研究不同PPGDGE掺量下再生剂与老化SBS改性沥青之间的作用规律,确定再生剂最佳掺量。在此基础上,对复配再生沥青混合料的路用性能进行分析。结果表明,复配再生剂能够有效恢复老化SBS改性沥青的低温抗裂性、抗疲劳性、黏滞性,并且对于高温稳定性没有明显影响;综合考虑各项指标,确定复配再生剂最佳配方为6%WEO+2%PPGDGE。在最佳配方下,复配再生剂的加入改善了老化沥青混合料的低温抗裂性和水稳定性,虽然抗车辙性能同未老化混合料相比有所降低,但仍满足规范要求。 展开更多
关键词 道路工程 SBS改性沥青 复配再生沥青 废机油 聚丙二醇二缩水甘油醚
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