Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to asse...Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to assess this complex toxicity endpoint and will be valuable for screening emerging pollutants as well as for m anaging new chemicals in China.Currently,there are few published DART prediction models in China,but many related research and development projects are in progress.In 2013,WU et al.published an expert rule-based DART decision tree(DT).This DT relies on known chemical structures linked to DART to forecast DART potential of a given chemical.Within this procedure,an accurate DART data interpretation is the foundation of building and expanding the DT.This paper excerpted case studies demonstrating DART data curation and interpretation of four chemicals(including 8-hydroxyquinoline,3,5,6-trichloro-2-pyridinol,thiacloprid,and imidacloprid)to expand the existing DART DT.Chemicals were first selected from the database of Solid Waste and Chemicals Management Center,Ministry of Ecology and Environment(MEESCC)in China.The structures of these 4 chemicals were analyzed and preliminarily grouped by chemists based on core structural features,functional groups,receptor binding property,metabolism,and possible mode of actions.Then,the DART conclusion was derived by collecting chemical information,searching,integrating,and interpreting DART data by the toxicologists.Finally,these chemicals were classified into either an existing category or a new category via integrating their chemical features,DART conclusions,and biological properties.The results showed that 8-hydroxyquinoline impacted estrous cyclicity,s exual organ weights,and embryonal development,and 3,5,6-trichloro-2-pyridinol caused central nervous system(CNS)malformations,which were added to an existing subcategory 8e(aromatic compounds with multi-halogen and nitro groups)of the DT.Thiacloprid caused dystocia and fetal skeletal malformation,and imidacloprid disrupted the endocrine system and male fertility.They both contain 2-chloro-5-methylpyridine substituted imidazolidine c yclic ring,which were expected to create a new category of neonicotinoids.The current work delineates a t ransparent process of curating toxicological data for the purpose of DART data interpretation.In the presence of sufficient related structures and DART data,the DT can be expanded by iteratively adding chemicals within the a pplicable domain of each category or subcategory.This DT can potentially serve as a tool for screening emerging pollutants and assessing new chemicals in China.展开更多
To investigate the differences in combustion and energy release characteristics of metastable intermolecular composite materials composed of aluminum alloys and polyvinylidene fluoride(PVDF)with different compositions...To investigate the differences in combustion and energy release characteristics of metastable intermolecular composite materials composed of aluminum alloys and polyvinylidene fluoride(PVDF)with different compositions,two types of alloys were selected:Al-Mg and Al-Si.Pure aluminum powder of the same size was also chosen for comparison.The PVDF-coated metal particle composites and the mixtures of PVDF with metal particles were prepared using electrospray(ES)and physical blending methods(PM),respectively.A systematic study was conducted on the morphology,compositional structure,combustion performance,energy release characteristics,and thermal reactivity of the fabricated composites and their combustion products through scanning electron microscopy(SEM),energy-dispersive X-ray spectroscopy(EDS),X-ray diffraction(XRD),combustion performance experiments,closed vessel pressure tests,and simultaneous thermogravimetric-differential scanning calorimetry(TG-DSC).The experimental results indicated that the PVDF-coated metal particles prepared by the electrospray method exhibited a distinct core-shell structure,with the metal particles in close contact with the PVDF matrix.Compared to the PM blended materials,the ES composites demonstrated superior combustion performance and energy release characteristics during combustion.Analysis of different metal fuel systems under identical preparation conditions revealed that Al-Mg and Al-Si fuels modulate the combustion and energy release properties of aluminum alloy-PVDF MICs through two distinct pathways.展开更多
为了解决板料成形中起皱和拉裂的问题,以某汽车挡泥板为研究对象,基于Design-exper软件,建立了摩擦系数、压边力、拉延筋阻力系数与板料拉裂、起皱之间关系的数学模型。并利用该软件进行了多目标优化,得到了最佳的参数组合:摩擦系数为0....为了解决板料成形中起皱和拉裂的问题,以某汽车挡泥板为研究对象,基于Design-exper软件,建立了摩擦系数、压边力、拉延筋阻力系数与板料拉裂、起皱之间关系的数学模型。并利用该软件进行了多目标优化,得到了最佳的参数组合:摩擦系数为0.13,压边力为350 k N,拉延筋阻力系数为35%。通过有限元模拟和生产实践验证,证明了该方法的可行的。展开更多
Rotary kiln process for iron ore oxide pellet production is hard to detect and control.Construction of one-dimensional model of temperature field in rotary kiln was described.And the results lay a solid foundation for...Rotary kiln process for iron ore oxide pellet production is hard to detect and control.Construction of one-dimensional model of temperature field in rotary kiln was described.And the results lay a solid foundation for online control.Establishment of kiln process control expert system was presented,with maximum temperature of pellet and gas temperature at the feed end as control cores,and interval estimate as control strategy.Software was developed and put into application in a pellet plant.The results show that control guidance of this system is accurate and effective.After production application for nearly one year,the compressive strength and first grade rate of pellet are increased by 86 N and 2.54%,respectively,while FeO content is 0.05% lowered.This system can reveal detailed information of real time kiln process,and provide a powerful tool for online control of pellet production.展开更多
HEST is a practical integrated expert system tool. Its basis is a knowledge programming language FFLL, characterized by a combination of fuzzy logic and function paradigms. The tool integrates alot of important knowle...HEST is a practical integrated expert system tool. Its basis is a knowledge programming language FFLL, characterized by a combination of fuzzy logic and function paradigms. The tool integrates alot of important knowledge processing capabilities such as fuzzy reasoning, function computation, knowledge compilation and explanation, knowledge base maintenance, as well as practical programming functions, e.g., editing, filing, compiling, module imbedding, etc., constructing, a user--friendly knowledge application environment, HEST can enable expert system development in various domaills quickly and easily.This paper gives an outline of the design and implementation of HEST.展开更多
为降低紫外线对聚丙烯(Polyethylene,PP)非织造土工布的影响,选择ES(Ethylene-Propylene Side By Side)纤维和含有抗老化母粒的PP纤维为原料,TiO_(2)浸轧处理为后整理工序,采用针刺加固和热黏合加固技术制备了具有抗紫外老化功能的PP/E...为降低紫外线对聚丙烯(Polyethylene,PP)非织造土工布的影响,选择ES(Ethylene-Propylene Side By Side)纤维和含有抗老化母粒的PP纤维为原料,TiO_(2)浸轧处理为后整理工序,采用针刺加固和热黏合加固技术制备了具有抗紫外老化功能的PP/ES高强非织造土工布。研究了抗老化工艺对PP/ES土工布力学性能和抗紫外老化性能的影响。结果表明:添加抗老化母粒和TiO_(2)浸轧后整理的PP/ES土工布力学性能少许上升;该土工布紫外老化后的羰基吸收峰强度最弱,T 5%仅下降4.73℃,纵向和横向的断裂强度保留率仅下降26.55%和26.76%,表现出最佳的抗紫外老化性能。展开更多
In order to control sintering process,improve permeability and stabilize burn through point, a control scheme which combines thermal state with permeability state is proposed, and an expert system for controlling sint...In order to control sintering process,improve permeability and stabilize burn through point, a control scheme which combines thermal state with permeability state is proposed, and an expert system for controlling sintering process state is developed, the software which includes about 1000 expert rules is successfully applied to off line control of sintering process.展开更多
文摘Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to assess this complex toxicity endpoint and will be valuable for screening emerging pollutants as well as for m anaging new chemicals in China.Currently,there are few published DART prediction models in China,but many related research and development projects are in progress.In 2013,WU et al.published an expert rule-based DART decision tree(DT).This DT relies on known chemical structures linked to DART to forecast DART potential of a given chemical.Within this procedure,an accurate DART data interpretation is the foundation of building and expanding the DT.This paper excerpted case studies demonstrating DART data curation and interpretation of four chemicals(including 8-hydroxyquinoline,3,5,6-trichloro-2-pyridinol,thiacloprid,and imidacloprid)to expand the existing DART DT.Chemicals were first selected from the database of Solid Waste and Chemicals Management Center,Ministry of Ecology and Environment(MEESCC)in China.The structures of these 4 chemicals were analyzed and preliminarily grouped by chemists based on core structural features,functional groups,receptor binding property,metabolism,and possible mode of actions.Then,the DART conclusion was derived by collecting chemical information,searching,integrating,and interpreting DART data by the toxicologists.Finally,these chemicals were classified into either an existing category or a new category via integrating their chemical features,DART conclusions,and biological properties.The results showed that 8-hydroxyquinoline impacted estrous cyclicity,s exual organ weights,and embryonal development,and 3,5,6-trichloro-2-pyridinol caused central nervous system(CNS)malformations,which were added to an existing subcategory 8e(aromatic compounds with multi-halogen and nitro groups)of the DT.Thiacloprid caused dystocia and fetal skeletal malformation,and imidacloprid disrupted the endocrine system and male fertility.They both contain 2-chloro-5-methylpyridine substituted imidazolidine c yclic ring,which were expected to create a new category of neonicotinoids.The current work delineates a t ransparent process of curating toxicological data for the purpose of DART data interpretation.In the presence of sufficient related structures and DART data,the DT can be expanded by iteratively adding chemicals within the a pplicable domain of each category or subcategory.This DT can potentially serve as a tool for screening emerging pollutants and assessing new chemicals in China.
基金the National Natural Science Foundation of China(NSFC,Grant Nos.52176114 and 52306145)Natural Science Foundation of Jiangsu Province(Grant No.BK20230929)+3 种基金China Postdoctoral Science Foundation(Grant No.2023M731693)Fundamental Research Funds for the Central Universities,Grant No.30924010505Jiangsu Funding Program for Excellent Postdoctoral Talentthe Center of Analytical Facilities,Nanjing University of Science and Technology for providing technical equipment support for this article。
文摘To investigate the differences in combustion and energy release characteristics of metastable intermolecular composite materials composed of aluminum alloys and polyvinylidene fluoride(PVDF)with different compositions,two types of alloys were selected:Al-Mg and Al-Si.Pure aluminum powder of the same size was also chosen for comparison.The PVDF-coated metal particle composites and the mixtures of PVDF with metal particles were prepared using electrospray(ES)and physical blending methods(PM),respectively.A systematic study was conducted on the morphology,compositional structure,combustion performance,energy release characteristics,and thermal reactivity of the fabricated composites and their combustion products through scanning electron microscopy(SEM),energy-dispersive X-ray spectroscopy(EDS),X-ray diffraction(XRD),combustion performance experiments,closed vessel pressure tests,and simultaneous thermogravimetric-differential scanning calorimetry(TG-DSC).The experimental results indicated that the PVDF-coated metal particles prepared by the electrospray method exhibited a distinct core-shell structure,with the metal particles in close contact with the PVDF matrix.Compared to the PM blended materials,the ES composites demonstrated superior combustion performance and energy release characteristics during combustion.Analysis of different metal fuel systems under identical preparation conditions revealed that Al-Mg and Al-Si fuels modulate the combustion and energy release properties of aluminum alloy-PVDF MICs through two distinct pathways.
文摘为了解决板料成形中起皱和拉裂的问题,以某汽车挡泥板为研究对象,基于Design-exper软件,建立了摩擦系数、压边力、拉延筋阻力系数与板料拉裂、起皱之间关系的数学模型。并利用该软件进行了多目标优化,得到了最佳的参数组合:摩擦系数为0.13,压边力为350 k N,拉延筋阻力系数为35%。通过有限元模拟和生产实践验证,证明了该方法的可行的。
基金Project(NCET-05-0630) supported by Program for New Century Excellent Talents in University of China
文摘Rotary kiln process for iron ore oxide pellet production is hard to detect and control.Construction of one-dimensional model of temperature field in rotary kiln was described.And the results lay a solid foundation for online control.Establishment of kiln process control expert system was presented,with maximum temperature of pellet and gas temperature at the feed end as control cores,and interval estimate as control strategy.Software was developed and put into application in a pellet plant.The results show that control guidance of this system is accurate and effective.After production application for nearly one year,the compressive strength and first grade rate of pellet are increased by 86 N and 2.54%,respectively,while FeO content is 0.05% lowered.This system can reveal detailed information of real time kiln process,and provide a powerful tool for online control of pellet production.
文摘HEST is a practical integrated expert system tool. Its basis is a knowledge programming language FFLL, characterized by a combination of fuzzy logic and function paradigms. The tool integrates alot of important knowledge processing capabilities such as fuzzy reasoning, function computation, knowledge compilation and explanation, knowledge base maintenance, as well as practical programming functions, e.g., editing, filing, compiling, module imbedding, etc., constructing, a user--friendly knowledge application environment, HEST can enable expert system development in various domaills quickly and easily.This paper gives an outline of the design and implementation of HEST.
文摘为降低紫外线对聚丙烯(Polyethylene,PP)非织造土工布的影响,选择ES(Ethylene-Propylene Side By Side)纤维和含有抗老化母粒的PP纤维为原料,TiO_(2)浸轧处理为后整理工序,采用针刺加固和热黏合加固技术制备了具有抗紫外老化功能的PP/ES高强非织造土工布。研究了抗老化工艺对PP/ES土工布力学性能和抗紫外老化性能的影响。结果表明:添加抗老化母粒和TiO_(2)浸轧后整理的PP/ES土工布力学性能少许上升;该土工布紫外老化后的羰基吸收峰强度最弱,T 5%仅下降4.73℃,纵向和横向的断裂强度保留率仅下降26.55%和26.76%,表现出最佳的抗紫外老化性能。
文摘In order to control sintering process,improve permeability and stabilize burn through point, a control scheme which combines thermal state with permeability state is proposed, and an expert system for controlling sintering process state is developed, the software which includes about 1000 expert rules is successfully applied to off line control of sintering process.
