BACKGROUND: Partial pressure of end-tidal carbon dioxide(PETCO2) has been used to monitor the effectiveness of precordial compression(PC) and regarded as a prognostic value of outcomes in cardiopulmonary resuscitation...BACKGROUND: Partial pressure of end-tidal carbon dioxide(PETCO2) has been used to monitor the effectiveness of precordial compression(PC) and regarded as a prognostic value of outcomes in cardiopulmonary resuscitation(CPR). This study was to investigate changes of PETCO2 during CPR in rats with ventricular fi brillation(VF) versus asphyxial cardiac arrest.METHODS: Sixty-two male Sprague-Dawley(SD) rats were randomly divided into an asphyxial group(n=32) and a VF group(n=30). PETCO2 was measured during CPR from a 6-minute period of VF or asphyxial cardiac arrest.RESULTS: The initial values of PETCO2 immediately after PC in the VF group were signifi cantly lower than those in the asphyxial group(12.8±4.87 mmHg vs. 49.2±8.13 mmHg, P=0.000). In the VF group, the values of PETCO2 after 6 minutes of PC were significantly higher in rats with return of spontaneous circulation(ROSC), compared with those in rats without ROSC(16.5±3.07 mmHg vs. 13.2±2.62 mmHg, P=0.004). In the asphyxial group, the values of PETCO2 after 2 minutes of PC in rats with ROSC were signifi cantly higher than those in rats without ROSC(20.8±3.24 mmHg vs. 13.9±1.50 mmHg, P=0.000). Receiver operator characteristic(ROC) curves of PETCO2 showed signifi cant sensitivity and specifi city for predicting ROSC in VF versus asphyxial cardiac arrest.CONCLUSIONS: The initial values of PETCO2 immediately after CPR may be helpful in differentiating the causes of cardiac arrest. Changes of PETCO2 during CPR can predict outcomes of CPR.展开更多
目的:探讨无创呼吸机对慢阻肺急性发作期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者临床症状及二氧化碳分压(Partial pressure of carbon dioxide,PaCO_(2))的影响。方法:选取2021年1月至2023年12月本...目的:探讨无创呼吸机对慢阻肺急性发作期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者临床症状及二氧化碳分压(Partial pressure of carbon dioxide,PaCO_(2))的影响。方法:选取2021年1月至2023年12月本院收治的60例AECOPD患者作为研究对象,按照治疗方式分为观察组和对照组,各30例。对照组有创采用呼吸机治疗,观察组采用无创呼吸机治疗。比较两组治疗疗效。采用改良版英国医院研究委员会呼吸困难量表(Modified medical British research council,mMRC)和急性生理学和慢性健康状况评价II(Acute physiology and chronic health e-valuationⅡ,APACHEII)评分比较两组患者临床症状和健康状况。比较两组患者治疗前后血气指标[动脉血氧分压(Partial pressure of oxygen in artery,PaO_(2))、PaCO_(2)]和炎症因子[白介素-8(Interleukine-8,IL-8)和基质金属蛋白酶-9(Matrix metalloprotein-9,MMP-9)]。比较两组并发症发生率。结果:两组治疗有效率无明显差异(P>0.05)。治疗后,观察组PaO_(2)明显高于对照组,而mMRC、APACHEII评分、PaCO_(2)、IL-8和MMP-9水平、并发症发生率均明显低于对照组(P<0.05)。结论:无创呼吸机治疗AECOPD患者与有创呼吸机具有同样的疗效,但是其能更好的恢复血气指标,降低炎症反应,改善临床症状和健康状况,且并发症少。展开更多
基金supported in part by grants from the National Natural Science Foundation of China(30700303)the National Clinical Key Subject Construction Project
文摘BACKGROUND: Partial pressure of end-tidal carbon dioxide(PETCO2) has been used to monitor the effectiveness of precordial compression(PC) and regarded as a prognostic value of outcomes in cardiopulmonary resuscitation(CPR). This study was to investigate changes of PETCO2 during CPR in rats with ventricular fi brillation(VF) versus asphyxial cardiac arrest.METHODS: Sixty-two male Sprague-Dawley(SD) rats were randomly divided into an asphyxial group(n=32) and a VF group(n=30). PETCO2 was measured during CPR from a 6-minute period of VF or asphyxial cardiac arrest.RESULTS: The initial values of PETCO2 immediately after PC in the VF group were signifi cantly lower than those in the asphyxial group(12.8±4.87 mmHg vs. 49.2±8.13 mmHg, P=0.000). In the VF group, the values of PETCO2 after 6 minutes of PC were significantly higher in rats with return of spontaneous circulation(ROSC), compared with those in rats without ROSC(16.5±3.07 mmHg vs. 13.2±2.62 mmHg, P=0.004). In the asphyxial group, the values of PETCO2 after 2 minutes of PC in rats with ROSC were signifi cantly higher than those in rats without ROSC(20.8±3.24 mmHg vs. 13.9±1.50 mmHg, P=0.000). Receiver operator characteristic(ROC) curves of PETCO2 showed signifi cant sensitivity and specifi city for predicting ROSC in VF versus asphyxial cardiac arrest.CONCLUSIONS: The initial values of PETCO2 immediately after CPR may be helpful in differentiating the causes of cardiac arrest. Changes of PETCO2 during CPR can predict outcomes of CPR.
文摘目的:探讨无创呼吸机对慢阻肺急性发作期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者临床症状及二氧化碳分压(Partial pressure of carbon dioxide,PaCO_(2))的影响。方法:选取2021年1月至2023年12月本院收治的60例AECOPD患者作为研究对象,按照治疗方式分为观察组和对照组,各30例。对照组有创采用呼吸机治疗,观察组采用无创呼吸机治疗。比较两组治疗疗效。采用改良版英国医院研究委员会呼吸困难量表(Modified medical British research council,mMRC)和急性生理学和慢性健康状况评价II(Acute physiology and chronic health e-valuationⅡ,APACHEII)评分比较两组患者临床症状和健康状况。比较两组患者治疗前后血气指标[动脉血氧分压(Partial pressure of oxygen in artery,PaO_(2))、PaCO_(2)]和炎症因子[白介素-8(Interleukine-8,IL-8)和基质金属蛋白酶-9(Matrix metalloprotein-9,MMP-9)]。比较两组并发症发生率。结果:两组治疗有效率无明显差异(P>0.05)。治疗后,观察组PaO_(2)明显高于对照组,而mMRC、APACHEII评分、PaCO_(2)、IL-8和MMP-9水平、并发症发生率均明显低于对照组(P<0.05)。结论:无创呼吸机治疗AECOPD患者与有创呼吸机具有同样的疗效,但是其能更好的恢复血气指标,降低炎症反应,改善临床症状和健康状况,且并发症少。
