Objective The aim of this study was to determine the effect of successful coronary revascularisation on left ventricular diastolic function.Methods We consecutively studied the diastolic function by Doppler echocardio...Objective The aim of this study was to determine the effect of successful coronary revascularisation on left ventricular diastolic function.Methods We consecutively studied the diastolic function by Doppler echocardiography in 125 patients with one vessel disease before and 48 hours after selective coronary angioplasty. The following parameters of left ventricular diastolic function were evaluated: peak early (VE, m/s) and peak late diastolic (VA, m/s) flow velocity, E/A ratio, acceleration time (AT, ms), deceleration time (DT, ms) and isovolumetric relaxation time (IVRT, ms). Ejection fraction (EF; %) was determined and used to characterise systolic left ventricular function. Results All of the patients were initially successful treated with coronary angioplasty (residual stenosis <40% ). In 98 patients( 78.4% ) stents were used to improve an inadequate result after coronary angioplasty. Both patient groups (27 patients with coronary angioplasty and 98 patients with combined coronary angioplasty and stent implantation) showed no relevant differences concerning sex, age, atherosclerotic risk factors, exercise capacity and results of exercise electrocardiography. All patients who underwent stent implantation showed an early improvement of left ventricular diastolic function 48 hours after revascularisation. Surprisingly there was no significant short term improvement (48 hours) of diastolic function in patients with initially successful angioplasty.Conclusions We suppose that stent implantation might normalize coronary blood flow faster than that of coronary balloon angioplasty.展开更多
Germplasm effect reflects the quantitative relation between production ability of germplasm elements and yield （quality） of a certain crop, which can be shown by mathematic function, namely, germplasm effect functio...Germplasm effect reflects the quantitative relation between production ability of germplasm elements and yield （quality） of a certain crop, which can be shown by mathematic function, namely, germplasm effect function. Germplasm effect of a crop variety is an aggregation of many effective factors, and is restrained by different effective factors; constant increase of any one effect of germplasm elements would lead to law of effect decline, therefore, possible modes of transgenic crops effect function were deduced according to the law of effect decline. The possible modes of single transgenic germplasm effect function and multi-transgenic germplasm effect regression equation were discussed, and the characteristics of germplasm effect regression equation were analyzed in this paper.展开更多
目的观察清热燥湿化瘀方治疗难治性肾病综合征临床效果及安全性,探讨患者有效及安全的临床治疗方案。方法总计纳入150例难治性肾病综合征患者(2022年1月—2023年10月收治)进行分组研究,采取随机数字表法将患者分为西医组与中药组,各组75...目的观察清热燥湿化瘀方治疗难治性肾病综合征临床效果及安全性,探讨患者有效及安全的临床治疗方案。方法总计纳入150例难治性肾病综合征患者(2022年1月—2023年10月收治)进行分组研究,采取随机数字表法将患者分为西医组与中药组,各组75例,西医组患者采取常规西医疗法,中药组患者在西医组治疗基础上应用中药清热燥湿化瘀方治疗,研究过程中各组均脱落2例,各73例,比较各组数据:治疗效果、治疗前后中医证候积分变化以及血尿素氮(blood urea nitrogen,BUN)、血肌酐(creatinine,SCr)、肾小球滤过率(glomerular filtration rate,GFR)等肾功能指标变化、24 h尿蛋白定量(24 h urinary protein quantity,24 h UPQ)及血清白蛋白(levels of serum albumin,Alb)、甘油三酯(triglyceride,TG)及胆固醇(cholesterol,TC)等四项指标变化、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)及补体C3水平等免疫功能指标变化、治疗不良反应。结果中药组治疗效果(93.15%,68/73)优于西医组(82.19%,60/73),P<0.05;治疗前各组患者中医证候积分、肾功能指标(BUN、SCr及GFR)、四项指标(24 h UPQ、Alb、TG及TC)、免疫功能指标(IgA、IgG及补体C3)比较,P>0.05;治疗后各组患者中医证候积分、肾功能指标(BUN、SCr及GFR)、四项指标(24 h UPQ、Alb、TG及TC)均改善,且中药组指标改善优于西医组,P<0.05;各组治疗后免疫功能指标(IgA、IgG及补体C3)均降低,中药组低于西医组,P<0.05;中药组治疗不良反应率(4.11%,3/73)比西医组(13.70%,10/73)更低,P<0.05。结论清热燥湿化瘀方治疗难治性肾病综合征临床效果良好,可改善患者肾功能及血脂情况,提升患者免疫功能,治疗不良反应少,安全可靠。展开更多
目的观察咳喘镇定汤在小儿咳嗽变异性哮喘治疗中的作用及对患儿嗜酸性粒细胞计数(eosinophil count,EOS)、白介素-23(interleukin-23,IL-23)/辅助性T细胞17(helper T cells17,Th17)轴的影响。方法选取2020年8月—2023年2月收治的小儿咳...目的观察咳喘镇定汤在小儿咳嗽变异性哮喘治疗中的作用及对患儿嗜酸性粒细胞计数(eosinophil count,EOS)、白介素-23(interleukin-23,IL-23)/辅助性T细胞17(helper T cells17,Th17)轴的影响。方法选取2020年8月—2023年2月收治的小儿咳嗽变异性哮喘患儿104例,将患儿采用简单随机法分为两组。常规组给予止咳化痰、抗炎、平喘等常规治疗,咳喘镇定汤组在常规组基础上采用咳喘镇定汤辅助治疗。检测组间及组内T淋巴亚群、EOS、巨噬细胞炎症蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)、Clara细胞分泌蛋白16(clara cell secreted protein 16,CC-16)、嗜酸细胞活化趋化因子(Eotaxin)、IL-23/Th17轴、小气道功能水平。评估组间及组内咳嗽症状评分、中医证候评分差异。统计组间疗效和不良反应。结果治疗前T淋巴亚群、CC-16、Eotaxin等差异无统计学意义(P>0.05)。两组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin降低,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)升高,咳喘镇定汤组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin低于常规组,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)高于常规组(P<0.05)。治疗前比较IL-23/Th17轴差异无统计学意义(P>0.05)。两组治疗后IL-23、Th17、白介素-17(interleukin-17,IL-17)降低,咳喘镇定汤组治疗后IL-23/Th17轴低于常规组(P<0.05)。治疗前相关评分无差异(P>0.05)。两组治疗后咳嗽症状评分、中医证候评分降低,咳喘镇定汤组治疗后咳嗽症状评分、中医症候评分低于常规组(P<0.05)。治疗前小气道功能无差异(P>0.05)。两组治疗后小气道功能升高,咳喘镇定汤组治疗后小气道功能高于常规组(P<0.05)。咳喘镇定汤组治愈13例,显效和有效共35例,总有效率92.31%高于常规组,差异有统计学意义(P<0.05)。结论咳喘镇定汤可通过调控小儿咳嗽变异性哮喘患儿IL-23/Th17轴,改善T淋巴亚群和小气道功能,减轻咳嗽症状,提高疗效。展开更多
目的观察黄芪多糖注射液联合调强适形放疗治疗中晚期宫颈癌效果。方法研究共计纳入82例中晚期宫颈癌患者,采取随机数字表法将患者分为两组,分别为放疗组及中成药组,每组41例,入组患者均接受常规化疗治疗,放疗组同时接受调强适形放疗治疗...目的观察黄芪多糖注射液联合调强适形放疗治疗中晚期宫颈癌效果。方法研究共计纳入82例中晚期宫颈癌患者,采取随机数字表法将患者分为两组,分别为放疗组及中成药组,每组41例,入组患者均接受常规化疗治疗,放疗组同时接受调强适形放疗治疗,中成药组在放疗组治疗基础上联合黄芪多糖注射液治疗,观察及对比两组数据情况:疗效与不良反应、治疗前后中医证候积分(下腹坠胀、乏力、气短、面色萎黄等)变化及鳞状上皮细胞癌抗原(squamous cell cancer,SCC)、糖类抗原125(carbohydrate antigen 125,CA125)及癌胚抗原(carcinoembryonic antigen,CEA)等肿瘤标志物水平变化、辅助性T细胞、细胞毒性T细胞、辅助性T细胞/细胞毒性T细胞等免疫功能指标变化、EORTC生存质量测定量表(European organization for research and treatment of cancer quality of life questionnaire,EORTC QLQ-C30)评分变化。结果中成药组近期治疗总有效率明显高于放疗组(P<0.05);中成药组白细胞下降率低于放疗组(P<0.05);两组其他不良反应率发生相当(P>0.05);两组治疗前中医证候积分(下腹坠胀、乏力、气短、面色萎黄等)、肿瘤标志物水平(CA125及CEA)、辅助性T细胞、细胞毒性T细胞、辅助性T细胞/细胞毒性T细胞、EORTC QLQ-C30评分等指标比较(P>0.05),治疗后两组中医证候积分(下腹坠胀、乏力、气短、面色萎黄等)及肿瘤标志物水平(SCC、CA125及CEA)均下降,EORTC QLQ-C30评分均提升,中成药组指标下降及提升程度明显高于放疗组(P<0.05);两组治疗后辅助性T细胞下降、细胞毒性T细胞上升,辅助性T细胞/细胞毒性T细胞下降,中成药组治疗后各项指标下降及上升程度均低于放疗组(P<0.05)。结论黄芪多糖注射液联合调强适形放疗治疗中晚期宫颈癌效果良好,可较好降低患者肿瘤标志物,改善患者病症,提升患者免疫功能与生活质量,治疗患者可耐受,较为安全可行。展开更多
文摘Objective The aim of this study was to determine the effect of successful coronary revascularisation on left ventricular diastolic function.Methods We consecutively studied the diastolic function by Doppler echocardiography in 125 patients with one vessel disease before and 48 hours after selective coronary angioplasty. The following parameters of left ventricular diastolic function were evaluated: peak early (VE, m/s) and peak late diastolic (VA, m/s) flow velocity, E/A ratio, acceleration time (AT, ms), deceleration time (DT, ms) and isovolumetric relaxation time (IVRT, ms). Ejection fraction (EF; %) was determined and used to characterise systolic left ventricular function. Results All of the patients were initially successful treated with coronary angioplasty (residual stenosis <40% ). In 98 patients( 78.4% ) stents were used to improve an inadequate result after coronary angioplasty. Both patient groups (27 patients with coronary angioplasty and 98 patients with combined coronary angioplasty and stent implantation) showed no relevant differences concerning sex, age, atherosclerotic risk factors, exercise capacity and results of exercise electrocardiography. All patients who underwent stent implantation showed an early improvement of left ventricular diastolic function 48 hours after revascularisation. Surprisingly there was no significant short term improvement (48 hours) of diastolic function in patients with initially successful angioplasty.Conclusions We suppose that stent implantation might normalize coronary blood flow faster than that of coronary balloon angioplasty.
文摘Germplasm effect reflects the quantitative relation between production ability of germplasm elements and yield （quality） of a certain crop, which can be shown by mathematic function, namely, germplasm effect function. Germplasm effect of a crop variety is an aggregation of many effective factors, and is restrained by different effective factors; constant increase of any one effect of germplasm elements would lead to law of effect decline, therefore, possible modes of transgenic crops effect function were deduced according to the law of effect decline. The possible modes of single transgenic germplasm effect function and multi-transgenic germplasm effect regression equation were discussed, and the characteristics of germplasm effect regression equation were analyzed in this paper.
文摘目的观察清热燥湿化瘀方治疗难治性肾病综合征临床效果及安全性,探讨患者有效及安全的临床治疗方案。方法总计纳入150例难治性肾病综合征患者(2022年1月—2023年10月收治)进行分组研究,采取随机数字表法将患者分为西医组与中药组,各组75例,西医组患者采取常规西医疗法,中药组患者在西医组治疗基础上应用中药清热燥湿化瘀方治疗,研究过程中各组均脱落2例,各73例,比较各组数据:治疗效果、治疗前后中医证候积分变化以及血尿素氮(blood urea nitrogen,BUN)、血肌酐(creatinine,SCr)、肾小球滤过率(glomerular filtration rate,GFR)等肾功能指标变化、24 h尿蛋白定量(24 h urinary protein quantity,24 h UPQ)及血清白蛋白(levels of serum albumin,Alb)、甘油三酯(triglyceride,TG)及胆固醇(cholesterol,TC)等四项指标变化、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)及补体C3水平等免疫功能指标变化、治疗不良反应。结果中药组治疗效果(93.15%,68/73)优于西医组(82.19%,60/73),P<0.05;治疗前各组患者中医证候积分、肾功能指标(BUN、SCr及GFR)、四项指标(24 h UPQ、Alb、TG及TC)、免疫功能指标(IgA、IgG及补体C3)比较,P>0.05;治疗后各组患者中医证候积分、肾功能指标(BUN、SCr及GFR)、四项指标(24 h UPQ、Alb、TG及TC)均改善,且中药组指标改善优于西医组,P<0.05;各组治疗后免疫功能指标(IgA、IgG及补体C3)均降低,中药组低于西医组,P<0.05;中药组治疗不良反应率(4.11%,3/73)比西医组(13.70%,10/73)更低,P<0.05。结论清热燥湿化瘀方治疗难治性肾病综合征临床效果良好,可改善患者肾功能及血脂情况,提升患者免疫功能,治疗不良反应少,安全可靠。
文摘目的观察咳喘镇定汤在小儿咳嗽变异性哮喘治疗中的作用及对患儿嗜酸性粒细胞计数(eosinophil count,EOS)、白介素-23(interleukin-23,IL-23)/辅助性T细胞17(helper T cells17,Th17)轴的影响。方法选取2020年8月—2023年2月收治的小儿咳嗽变异性哮喘患儿104例,将患儿采用简单随机法分为两组。常规组给予止咳化痰、抗炎、平喘等常规治疗,咳喘镇定汤组在常规组基础上采用咳喘镇定汤辅助治疗。检测组间及组内T淋巴亚群、EOS、巨噬细胞炎症蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)、Clara细胞分泌蛋白16(clara cell secreted protein 16,CC-16)、嗜酸细胞活化趋化因子(Eotaxin)、IL-23/Th17轴、小气道功能水平。评估组间及组内咳嗽症状评分、中医证候评分差异。统计组间疗效和不良反应。结果治疗前T淋巴亚群、CC-16、Eotaxin等差异无统计学意义(P>0.05)。两组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin降低,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)升高,咳喘镇定汤组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin低于常规组,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)高于常规组(P<0.05)。治疗前比较IL-23/Th17轴差异无统计学意义(P>0.05)。两组治疗后IL-23、Th17、白介素-17(interleukin-17,IL-17)降低,咳喘镇定汤组治疗后IL-23/Th17轴低于常规组(P<0.05)。治疗前相关评分无差异(P>0.05)。两组治疗后咳嗽症状评分、中医证候评分降低,咳喘镇定汤组治疗后咳嗽症状评分、中医症候评分低于常规组(P<0.05)。治疗前小气道功能无差异(P>0.05)。两组治疗后小气道功能升高,咳喘镇定汤组治疗后小气道功能高于常规组(P<0.05)。咳喘镇定汤组治愈13例,显效和有效共35例,总有效率92.31%高于常规组,差异有统计学意义(P<0.05)。结论咳喘镇定汤可通过调控小儿咳嗽变异性哮喘患儿IL-23/Th17轴,改善T淋巴亚群和小气道功能,减轻咳嗽症状,提高疗效。
文摘目的观察黄芪多糖注射液联合调强适形放疗治疗中晚期宫颈癌效果。方法研究共计纳入82例中晚期宫颈癌患者,采取随机数字表法将患者分为两组,分别为放疗组及中成药组,每组41例,入组患者均接受常规化疗治疗,放疗组同时接受调强适形放疗治疗,中成药组在放疗组治疗基础上联合黄芪多糖注射液治疗,观察及对比两组数据情况:疗效与不良反应、治疗前后中医证候积分(下腹坠胀、乏力、气短、面色萎黄等)变化及鳞状上皮细胞癌抗原(squamous cell cancer,SCC)、糖类抗原125(carbohydrate antigen 125,CA125)及癌胚抗原(carcinoembryonic antigen,CEA)等肿瘤标志物水平变化、辅助性T细胞、细胞毒性T细胞、辅助性T细胞/细胞毒性T细胞等免疫功能指标变化、EORTC生存质量测定量表(European organization for research and treatment of cancer quality of life questionnaire,EORTC QLQ-C30)评分变化。结果中成药组近期治疗总有效率明显高于放疗组(P<0.05);中成药组白细胞下降率低于放疗组(P<0.05);两组其他不良反应率发生相当(P>0.05);两组治疗前中医证候积分(下腹坠胀、乏力、气短、面色萎黄等)、肿瘤标志物水平(CA125及CEA)、辅助性T细胞、细胞毒性T细胞、辅助性T细胞/细胞毒性T细胞、EORTC QLQ-C30评分等指标比较(P>0.05),治疗后两组中医证候积分(下腹坠胀、乏力、气短、面色萎黄等)及肿瘤标志物水平(SCC、CA125及CEA)均下降,EORTC QLQ-C30评分均提升,中成药组指标下降及提升程度明显高于放疗组(P<0.05);两组治疗后辅助性T细胞下降、细胞毒性T细胞上升,辅助性T细胞/细胞毒性T细胞下降,中成药组治疗后各项指标下降及上升程度均低于放疗组(P<0.05)。结论黄芪多糖注射液联合调强适形放疗治疗中晚期宫颈癌效果良好,可较好降低患者肿瘤标志物,改善患者病症,提升患者免疫功能与生活质量,治疗患者可耐受,较为安全可行。
