Bifidobacterium longum subsp.infantis is a commensal bacterium that predominates in the infant gut,playing a critical role in both preventing foreign infections and facilitating immune development.This study aimed to ...Bifidobacterium longum subsp.infantis is a commensal bacterium that predominates in the infant gut,playing a critical role in both preventing foreign infections and facilitating immune development.This study aimed to explore the effects of B.longum subsp.infantis supplementation on interferon-beta(IFN-β)secretion and intestinal barrier improvement in growing mice.Female and male mice were orally administered either saline or B.longum subsp.infantis CCFM1269 or I5TI(1×10^(9) CFU/mice per day,n=8)from 1-week-age until 3-,4-,and 5-week-age.RNA sequencing analysis revealed that CCFM1269 exhibited potential antiviral capacity through increasing 2'-5'oligoadenylate synthetase(OAS).Additionally,CCFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLR4-TRIF-dependent signaling pathway.However,this effect was not observed in 4-and 5-week-old mice.Furthermore,both CCFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-,4-,and 5-week-old mice.In summary,the results of this study suggested that B.longum subsp.infantis CCFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.展开更多
The mutual-interference phenomenon among multiple applications delivered as services through Cloud Services Delivery Network(CSDN)influences their QoS seriously.In order to deploy multiple applications dependably and ...The mutual-interference phenomenon among multiple applications delivered as services through Cloud Services Delivery Network(CSDN)influences their QoS seriously.In order to deploy multiple applications dependably and efficiently,we propose the Multiple Applications Co-Exist(MACE)method.MACE classifies multiple applications into different types and deploys them using isolation to some extent.Meanwhile,resource static allocation,dynamic supplement and resource reserved mechanism to minimize mutual-interference and maximize resource utilization are designed.After MACE is applied to a real large-scale CSDN and evaluated through 6-month measurement,we find that the CSDN load is more balanced,the bandwidth utilization increases by about 20%,the multiple applications'potential statistical multiplexing ratio decreases from 12% to 5%,and the number of complaint events affecting the dependability of CSDN services caused by multiple applications'mutual-interference has dropped to 0.Obviously,MACE offers a tradeoff and improvement for the dependability and efficiency goals of CSDN.展开更多
第六届IEEE International Conference on Dependable Systems and Their Applications(DSA)将于2020年1月3日~6日在美丽的哈尔滨举行。我们诚挚地邀请您投稿参与。除了regular(12页)和short papers(6页),DSA也接受Fast abstract(2页)...第六届IEEE International Conference on Dependable Systems and Their Applications(DSA)将于2020年1月3日~6日在美丽的哈尔滨举行。我们诚挚地邀请您投稿参与。除了regular(12页)和short papers(6页),DSA也接受Fast abstract(2页)的投稿。截稿日期2019年10月31日。展开更多
Based on the force-heat equivalence energy density principle,a theoretical model for magnetic metallic materials is developed,which characterizes the temperature-dependent magnetic anisotropy energy by considering the...Based on the force-heat equivalence energy density principle,a theoretical model for magnetic metallic materials is developed,which characterizes the temperature-dependent magnetic anisotropy energy by considering the equivalent relationship between magnetic anisotropy energy and heat energy;then the relationship between the magnetic anisotropy constant and saturation magnetization is considered.Finally,we formulate a temperature-dependent model for saturation magnetization,revealing the inherent relationship between temperature and saturation magnetization.Our model predicts the saturation magnetization for nine different magnetic metallic materials at different temperatures,exhibiting satisfactory agreement with experimental data.Additionally,the experimental data used as reference points are at or near room temperature.Compared to other phenomenological theoretical models,this model is considerably more accessible than the data required at 0 K.The index included in our model is set to a constant value,which is equal to 10/3 for materials other than Fe,Co,and Ni.For transition metals(Fe,Co,and Ni in this paper),the index is 6 in the range of 0 K to 0.65T_(cr)(T_(cr) is the critical temperature),and 3 in the range of 0.65T_(cr) to T_(cr),unlike other models where the adjustable parameters vary according to each material.In addition,our model provides a new way to design and evaluate magnetic metallic materials with superior magnetic properties over a wide range of temperatures.展开更多
The recent discovery of field emission devices based on one-dimensional nanostructures has attracted much interest in emerging applications on next-generation flat panel displays,molecule-based sensors,and so forth.To...The recent discovery of field emission devices based on one-dimensional nanostructures has attracted much interest in emerging applications on next-generation flat panel displays,molecule-based sensors,and so forth.To achieve a comprehensive understanding of surface potentials at the nano-emitters during the tunneling process,in this study we systematically investigated the image potentials of single-walled boron nitride nanotubes with different edges,diameters and lengths in the frame of a composite first-principles calculation.The image potentials of zigzag single-walled boron nitride nanotubes are found to be dependent on the non-equivalent sides.Only the image potentials of isolated armchair single-walled boron nitride nanotube can be well fitted with the image potential of an ideal metal sphere of a size comparable to the tube diameter.On the contrary,the image potentials of zigzag and grounded armchair single-walled boron nitride nanotubes exhibit a strong length-dependence characteristic and are significantly different from that of an ideal metal sphere,which originates from the significant axial symmetry breaking of induced charge at the tip for the long tube.The correlation between the testing electron and electronic structure of single-walled boron nitride nanotube has also been discussed.展开更多
基金funded by the National Key R&D Program of China(2021YFD2100700)National Natural Science Foundation of China(32021005)+1 种基金111 project(BP0719028)Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。
文摘Bifidobacterium longum subsp.infantis is a commensal bacterium that predominates in the infant gut,playing a critical role in both preventing foreign infections and facilitating immune development.This study aimed to explore the effects of B.longum subsp.infantis supplementation on interferon-beta(IFN-β)secretion and intestinal barrier improvement in growing mice.Female and male mice were orally administered either saline or B.longum subsp.infantis CCFM1269 or I5TI(1×10^(9) CFU/mice per day,n=8)from 1-week-age until 3-,4-,and 5-week-age.RNA sequencing analysis revealed that CCFM1269 exhibited potential antiviral capacity through increasing 2'-5'oligoadenylate synthetase(OAS).Additionally,CCFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLR4-TRIF-dependent signaling pathway.However,this effect was not observed in 4-and 5-week-old mice.Furthermore,both CCFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-,4-,and 5-week-old mice.In summary,the results of this study suggested that B.longum subsp.infantis CCFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.
基金National Basic Research Program of China under Grant No. 2011CB302600National Natural Science Foundation of China under Grant No. 90818028,No. 61003226National Science Fund for Distinguished Young Scholars under Grant No. 60625203
文摘The mutual-interference phenomenon among multiple applications delivered as services through Cloud Services Delivery Network(CSDN)influences their QoS seriously.In order to deploy multiple applications dependably and efficiently,we propose the Multiple Applications Co-Exist(MACE)method.MACE classifies multiple applications into different types and deploys them using isolation to some extent.Meanwhile,resource static allocation,dynamic supplement and resource reserved mechanism to minimize mutual-interference and maximize resource utilization are designed.After MACE is applied to a real large-scale CSDN and evaluated through 6-month measurement,we find that the CSDN load is more balanced,the bandwidth utilization increases by about 20%,the multiple applications'potential statistical multiplexing ratio decreases from 12% to 5%,and the number of complaint events affecting the dependability of CSDN services caused by multiple applications'mutual-interference has dropped to 0.Obviously,MACE offers a tradeoff and improvement for the dependability and efficiency goals of CSDN.
文摘第六届IEEE International Conference on Dependable Systems and Their Applications(DSA)将于2020年1月3日~6日在美丽的哈尔滨举行。我们诚挚地邀请您投稿参与。除了regular(12页)和short papers(6页),DSA也接受Fast abstract(2页)的投稿。截稿日期2019年10月31日。
基金Project supported by the Natural Science Foundation of Chongqing(Grant No.CSTB2022NSCQ-MSX0391)。
文摘Based on the force-heat equivalence energy density principle,a theoretical model for magnetic metallic materials is developed,which characterizes the temperature-dependent magnetic anisotropy energy by considering the equivalent relationship between magnetic anisotropy energy and heat energy;then the relationship between the magnetic anisotropy constant and saturation magnetization is considered.Finally,we formulate a temperature-dependent model for saturation magnetization,revealing the inherent relationship between temperature and saturation magnetization.Our model predicts the saturation magnetization for nine different magnetic metallic materials at different temperatures,exhibiting satisfactory agreement with experimental data.Additionally,the experimental data used as reference points are at or near room temperature.Compared to other phenomenological theoretical models,this model is considerably more accessible than the data required at 0 K.The index included in our model is set to a constant value,which is equal to 10/3 for materials other than Fe,Co,and Ni.For transition metals(Fe,Co,and Ni in this paper),the index is 6 in the range of 0 K to 0.65T_(cr)(T_(cr) is the critical temperature),and 3 in the range of 0.65T_(cr) to T_(cr),unlike other models where the adjustable parameters vary according to each material.In addition,our model provides a new way to design and evaluate magnetic metallic materials with superior magnetic properties over a wide range of temperatures.
基金the financial support from the National Natural Science Foundation of China(Grant Nos.12004083 and 51972069)the Science and Technology Projects in Guangzhou(Grant Nos.202102020350 and 202102010470)+7 种基金the National Key R&D Program of China(Grant No.2016YFB0200800)the Opening Project of Joint Laboratory for Planetary Science and Supercomputing(Grant No.CSYYGS-QT-2024-14)the Key-Area Research and Development Program of Guangdong Province(Grant No.2019B030330001)the College Students Innovation and Entrepreneurship Training Program of Guangdong Province(Grant No.S202311078133)Key Discipline of Materials Science and Engineering,Bureau of Education of Guangzhou(Grant No.202255464)the National Supercomputer Center in Guangzhouthe National Supercomputing Center in Chengduthe Network Center of Guangzhou University。
文摘The recent discovery of field emission devices based on one-dimensional nanostructures has attracted much interest in emerging applications on next-generation flat panel displays,molecule-based sensors,and so forth.To achieve a comprehensive understanding of surface potentials at the nano-emitters during the tunneling process,in this study we systematically investigated the image potentials of single-walled boron nitride nanotubes with different edges,diameters and lengths in the frame of a composite first-principles calculation.The image potentials of zigzag single-walled boron nitride nanotubes are found to be dependent on the non-equivalent sides.Only the image potentials of isolated armchair single-walled boron nitride nanotube can be well fitted with the image potential of an ideal metal sphere of a size comparable to the tube diameter.On the contrary,the image potentials of zigzag and grounded armchair single-walled boron nitride nanotubes exhibit a strong length-dependence characteristic and are significantly different from that of an ideal metal sphere,which originates from the significant axial symmetry breaking of induced charge at the tip for the long tube.The correlation between the testing electron and electronic structure of single-walled boron nitride nanotube has also been discussed.
