Objective:Oleic acid,a subtype of monounsaturated fatty acid(MUFA),is present in abundance in certain edible oils,particularly olive oils.Epidemiological evidence concerning dietary oleic acid intake and the long-term...Objective:Oleic acid,a subtype of monounsaturated fatty acid(MUFA),is present in abundance in certain edible oils,particularly olive oils.Epidemiological evidence concerning dietary oleic acid intake and the long-term risk of mortality is lacking.This study aimed to evaluate the associations of the dietary intake of oleic acid and other specific subtypes of MUFAs,olive oil,and other vegetable oils with cardiovascular disease(CVD)and all-cause mortality.Methods:This prospective cohort study included adults aged 40 years or older who participated in the included U.S.adults National Health and Nutrition Examination Survey(NHANES).Dietary MUFA intake was assessed via 24-h dietary recall interviews in NHANES 1999–2018,and the consumption of olive oil and other vegetable oils was assessed via a food frequency questionnaire in NHANES 2003–2006.Deaths and underlying causes of death were ascertained by linkage to the National Death Index through December 31,2019.Weighted Cox proportional hazards regression models were used to estimate the hazard ratio(HR)and 95%CIs.Results:Dietary intake of total MUFAs and oleic acid was associated with a lower risk of CVD mortality,with HRs(95%CI)of 0.62(0.39–0.99)and 0.61(0.39–0.97),respectively.Total MUFA and oleic acid intake were inversely associated with all-cause mortality;the multivariable-adjusted HRs were 0.77(95%CI:0.60–0.99)and 0.78(95%CI:0.62–0.99),respectively.There was no significant association between palmitoleic acid intake and all-cause mortality.The habitual consumption of olive oil,but not the consumption of other vegetable oils,was inversely associated with the risk of cardiovascular mortality.In the joint association analysis,the HRs(95%CI)of cardiovascular mortality were 0.36(0.19–0.69)for people who exclusively consumed olive oil,0.59(0.27–1.32)for people who consumed both olive oil and other vegetable oils,and 0.73(0.46–1.14)for people who exclusively consumed other vegetable oils compared with people who never consumed vegetable oils.Conclusions:In a U.S.nationally representative prospective cohort,higher dietary oleic acid intake and olive oil consumption were associated with a lower risk of cardiovascular mortality.展开更多
Mortality is normal and natural in aquaculture experiments. However, it becomes a problem when measuring feed intake as a component of nutrient utilization parameters such as： feed conversion ratio, feed conversion e...Mortality is normal and natural in aquaculture experiments. However, it becomes a problem when measuring feed intake as a component of nutrient utilization parameters such as： feed conversion ratio, feed conversion efficiency, apparent net protein utilization, protein efficiency ratio and protein productive value. In order to accurately evaluate feed intake with due consideration of mortality encountered, a formulae was developed using empirical data obtained from an experiement that had mortality. The formulae Fwas： total feed consumed by numbers of survived fishes=DL∑i=1n（Fi/Ni）N. Where, D=Numbers of days fishes were fed within each period ibefore it was adjusted（e.g fortnight）, it was constant throught period of experiment; F=Uantity of feed fed per day for a fortnight before the quantity was adjusted, it changed every fortnight; L=Numbers of living fishes at the end of experimental period; N=Numbers of fishes at each weighing period, it might change every fortnight or might be constant if no mortality occurred; while n=Numbers of times fishes were weighed and quantity of feed was adjusted but this did not include the final weighing at the termination of experiment. However, if the fishes were weighed weekly, then D=6.展开更多
Objective To investigate the risk factors for prolonged postoperative mechanical ventilation patients with atrioventricular septal defect(AVSD).Methods We retrospectively analyzed the clinical data of 76 patients with...Objective To investigate the risk factors for prolonged postoperative mechanical ventilation patients with atrioventricular septal defect(AVSD).Methods We retrospectively analyzed the clinical data of 76 patients with atrioventricular septal defect aged more than 18 years in our hospital from January 1^st 2011 to December 31^st 2017.展开更多
Background and objectives:Lung cancer(LC)is the leading cause of cancer death.Patients treated with chemotherapy are at risk of developing chemotherapy-induced febrile neutropenia(FN),a potentially life-threatening co...Background and objectives:Lung cancer(LC)is the leading cause of cancer death.Patients treated with chemotherapy are at risk of developing chemotherapy-induced febrile neutropenia(FN),a potentially life-threatening complication.The aims of this study were(1)to characterize FN admissions of patients with LC in a pulmonology department,and(2)to determine associations between patient profiles,first-line antibiotic failure(FLAF)and mortality.Methods:Retrospective observational case-series,based on the analysis of medical records of LC patients that required hospitalization due to chemotherapy-induced FN.Results:A total of 42 cases of FN were revised,corresponding to 36 patients,of which 86.1%were male,with a mean age of 66.71±9.83 years.Most patients had a performance status(PS)equal or less than 1,and metastatic disease was present in 40.5%(n=17).Respiratory tract infections accounted for 42.9%(n=18)of FN cases,and multidrug-resistant Staphylococcus aureus was the most isolated agent.The mortality rate was 16.7%(n=7),and the FLAF was 26.2%(n=11).Mortality was associated with a PS≥2(P=0.011),infection by a Gram-negative agent(P=0.001)and severe anemia(P=0.048).FLAF was associated with longer hospitalizations(P=0.020),PS≥2(P=0.049),respiratory infections(P=0.024),and infection by a Gram-negative(P=0.003)or multidrug-resistant agent(P=0.014).Conclusions:Lower PS,severe anemia,and infections by Gram-negative or multi-resistant agents seem to be associated with worse outcomes in FN patients.展开更多
Objective: With improved and sustained efforts in the prevention and management of pneumonia, diarrhea and vaccine preventable diseases, neonatal mortality is increasingly becoming a major contributor to childhood mor...Objective: With improved and sustained efforts in the prevention and management of pneumonia, diarrhea and vaccine preventable diseases, neonatal mortality is increasingly becoming a major contributor to childhood mortality particularly in developing countries. Evaluation of neonatal mortality pattern is an essential step in the effort to curb its incidence. We therefore, set out to determine the neonatal mortality pattern and its associated factors in a tertiary hospital in southern Nigeria. Methods: This is a retrospective study of neonatal mortality in a tertiary hospital from August 2004 to July 2007(a 3 year period). Data obtained include total live births, neonatal deaths, relevant information on pregnancy, labour and delivery, neonatal morbidity and duration of life. Results: There were a total of 3,051 live births and 44 neonatal deaths with a neonatal mortality rate of 14.4/1000 live births. Early neonatal mortality constituted 81.8%of over all neonatal mortality with the major causes being prematurity 40% severe birth asphyxia 29.5%and neonatal sepsis 18.3%. Low birth weight babies (<2500 grams) constituted 55.5% of total neonatal mortality. Conclusion: Early neonatal mortality constitutes an overwhelming proportion of neonatal mortality in Southern Nigeria. This can be significantly curtailed by reducing the incidence and death from prematurity, severe birth asphyxia and neonatal sepsis.展开更多
In order to define the mortality criteria of planarian objectively,a case study of Dugesia japonica exposed to 1-octyl-3-methylimidazolium bromide([C8mim]Br)was performed followed by a recovery culture.The results sho...In order to define the mortality criteria of planarian objectively,a case study of Dugesia japonica exposed to 1-octyl-3-methylimidazolium bromide([C8mim]Br)was performed followed by a recovery culture.The results showed that defining planarian mortality in light of its body disintegration was appropriate.If the disintegrated tissue of a planarian was more than 1/4 of its body length,it would completely degenerate.However,a planarian would regenerate the lost tissue and return to normal after a few days’recovery culture if the disintegrated part was less than 1/4 of body length.Therefore,we propose to use body disintegration as the endpoint of planarian mortality,i.e.,1/4 body length degenerated is the critical threshold of mortality and survival of planarians when exposed to toxicants.This criterion could be adapted in the standardization of testing protocols and comparability of acute toxicity test or other toxicological research using planarian as the test animal.展开更多
目的分析2012—2023年重庆市老年人自杀死亡率与死亡疾病负担变化趋势,为开展有针对性的干预提供建议。方法利用重庆市2012—2023年死因监测数据中根本死因为自杀(《国际疾病与相关健康问题统计分类第10版》编码:X60~X84、Y87)的60岁及...目的分析2012—2023年重庆市老年人自杀死亡率与死亡疾病负担变化趋势,为开展有针对性的干预提供建议。方法利用重庆市2012—2023年死因监测数据中根本死因为自杀(《国际疾病与相关健康问题统计分类第10版》编码:X60~X84、Y87)的60岁及以上老年人死亡个案,分析死亡率、标化死亡率、早死寿命损失年(years of life lost,YLL)率、平均寿命损失年(average years of life lost,AYLL)及不同死因构成比,比较不同性别和地区死亡率,率的趋势变化采用年度变化百分比(annual percent of change,APC)和平均年度变化百分比(average annual percent of change,AAPC)进行分析。结果2012—2023年60岁及以上老年人自杀死亡率与标化死亡率总体呈下降的趋势,分别以年均3.54%与4.02%下降,变化趋势均有统计学意义(P<0.05)。2012—2016年自杀死亡率以年均4.53%上升,2016—2021年以年均8.91%下降,变化趋势均有统计学意义(P<0.05)。仅2020年与2022年男性自杀死亡率高于女性(P<0.05)。2012—2023年男性自杀死亡率与标化死亡率分别以年均2.86%和3.44%下降,女性分别以年均4.21%和4.69%下降,变化趋势均有统计学意义(P<0.05)。农村地区老年人历年自杀死亡率均高于城市地区,差异均有统计学意义(P<0.05)。2012—2023年城市地区老年人自杀死亡率与标化死亡率均保持相对平稳的水平(P>0.05),而农村地区老年人自杀死亡率与标化死亡率分别以年均3.44%与4.02%下降(P<0.05)。60岁及以上老年人自杀导致的YLL率与AYLL分别由2012年的3.03‰与18.54年下降至2023年的2.26‰与17.50年,AAPC分别为-4.02%与-0.60%,变化趋势均有统计学意义(P<0.05)。比较历年不同自杀方式构成发现,杀虫剂中毒死亡占比呈下降的趋势,而悬吊死亡、从高处跳下、淹溺占比均呈上升的趋势(P<0.05)。结论重庆市60岁及以上老年人自杀死亡率较高,疾病负担较重,总体呈下降的趋势,应重视老年人自杀的早期识别与干预。展开更多
基金supported by the Joint Fund for New Medicine of the University of Science and Technology of China(YD9100002029).
文摘Objective:Oleic acid,a subtype of monounsaturated fatty acid(MUFA),is present in abundance in certain edible oils,particularly olive oils.Epidemiological evidence concerning dietary oleic acid intake and the long-term risk of mortality is lacking.This study aimed to evaluate the associations of the dietary intake of oleic acid and other specific subtypes of MUFAs,olive oil,and other vegetable oils with cardiovascular disease(CVD)and all-cause mortality.Methods:This prospective cohort study included adults aged 40 years or older who participated in the included U.S.adults National Health and Nutrition Examination Survey(NHANES).Dietary MUFA intake was assessed via 24-h dietary recall interviews in NHANES 1999–2018,and the consumption of olive oil and other vegetable oils was assessed via a food frequency questionnaire in NHANES 2003–2006.Deaths and underlying causes of death were ascertained by linkage to the National Death Index through December 31,2019.Weighted Cox proportional hazards regression models were used to estimate the hazard ratio(HR)and 95%CIs.Results:Dietary intake of total MUFAs and oleic acid was associated with a lower risk of CVD mortality,with HRs(95%CI)of 0.62(0.39–0.99)and 0.61(0.39–0.97),respectively.Total MUFA and oleic acid intake were inversely associated with all-cause mortality;the multivariable-adjusted HRs were 0.77(95%CI:0.60–0.99)and 0.78(95%CI:0.62–0.99),respectively.There was no significant association between palmitoleic acid intake and all-cause mortality.The habitual consumption of olive oil,but not the consumption of other vegetable oils,was inversely associated with the risk of cardiovascular mortality.In the joint association analysis,the HRs(95%CI)of cardiovascular mortality were 0.36(0.19–0.69)for people who exclusively consumed olive oil,0.59(0.27–1.32)for people who consumed both olive oil and other vegetable oils,and 0.73(0.46–1.14)for people who exclusively consumed other vegetable oils compared with people who never consumed vegetable oils.Conclusions:In a U.S.nationally representative prospective cohort,higher dietary oleic acid intake and olive oil consumption were associated with a lower risk of cardiovascular mortality.
文摘Mortality is normal and natural in aquaculture experiments. However, it becomes a problem when measuring feed intake as a component of nutrient utilization parameters such as： feed conversion ratio, feed conversion efficiency, apparent net protein utilization, protein efficiency ratio and protein productive value. In order to accurately evaluate feed intake with due consideration of mortality encountered, a formulae was developed using empirical data obtained from an experiement that had mortality. The formulae Fwas： total feed consumed by numbers of survived fishes=DL∑i=1n（Fi/Ni）N. Where, D=Numbers of days fishes were fed within each period ibefore it was adjusted（e.g fortnight）, it was constant throught period of experiment; F=Uantity of feed fed per day for a fortnight before the quantity was adjusted, it changed every fortnight; L=Numbers of living fishes at the end of experimental period; N=Numbers of fishes at each weighing period, it might change every fortnight or might be constant if no mortality occurred; while n=Numbers of times fishes were weighed and quantity of feed was adjusted but this did not include the final weighing at the termination of experiment. However, if the fishes were weighed weekly, then D=6.
文摘Objective To investigate the risk factors for prolonged postoperative mechanical ventilation patients with atrioventricular septal defect(AVSD).Methods We retrospectively analyzed the clinical data of 76 patients with atrioventricular septal defect aged more than 18 years in our hospital from January 1^st 2011 to December 31^st 2017.
文摘Background and objectives:Lung cancer(LC)is the leading cause of cancer death.Patients treated with chemotherapy are at risk of developing chemotherapy-induced febrile neutropenia(FN),a potentially life-threatening complication.The aims of this study were(1)to characterize FN admissions of patients with LC in a pulmonology department,and(2)to determine associations between patient profiles,first-line antibiotic failure(FLAF)and mortality.Methods:Retrospective observational case-series,based on the analysis of medical records of LC patients that required hospitalization due to chemotherapy-induced FN.Results:A total of 42 cases of FN were revised,corresponding to 36 patients,of which 86.1%were male,with a mean age of 66.71±9.83 years.Most patients had a performance status(PS)equal or less than 1,and metastatic disease was present in 40.5%(n=17).Respiratory tract infections accounted for 42.9%(n=18)of FN cases,and multidrug-resistant Staphylococcus aureus was the most isolated agent.The mortality rate was 16.7%(n=7),and the FLAF was 26.2%(n=11).Mortality was associated with a PS≥2(P=0.011),infection by a Gram-negative agent(P=0.001)and severe anemia(P=0.048).FLAF was associated with longer hospitalizations(P=0.020),PS≥2(P=0.049),respiratory infections(P=0.024),and infection by a Gram-negative(P=0.003)or multidrug-resistant agent(P=0.014).Conclusions:Lower PS,severe anemia,and infections by Gram-negative or multi-resistant agents seem to be associated with worse outcomes in FN patients.
文摘Objective: With improved and sustained efforts in the prevention and management of pneumonia, diarrhea and vaccine preventable diseases, neonatal mortality is increasingly becoming a major contributor to childhood mortality particularly in developing countries. Evaluation of neonatal mortality pattern is an essential step in the effort to curb its incidence. We therefore, set out to determine the neonatal mortality pattern and its associated factors in a tertiary hospital in southern Nigeria. Methods: This is a retrospective study of neonatal mortality in a tertiary hospital from August 2004 to July 2007(a 3 year period). Data obtained include total live births, neonatal deaths, relevant information on pregnancy, labour and delivery, neonatal morbidity and duration of life. Results: There were a total of 3,051 live births and 44 neonatal deaths with a neonatal mortality rate of 14.4/1000 live births. Early neonatal mortality constituted 81.8%of over all neonatal mortality with the major causes being prematurity 40% severe birth asphyxia 29.5%and neonatal sepsis 18.3%. Low birth weight babies (<2500 grams) constituted 55.5% of total neonatal mortality. Conclusion: Early neonatal mortality constitutes an overwhelming proportion of neonatal mortality in Southern Nigeria. This can be significantly curtailed by reducing the incidence and death from prematurity, severe birth asphyxia and neonatal sepsis.
基金supported by the National Natural Science Foundation of China(31471965)the Natural Science Foundation of Henan P rovince(142300410457)the National Student Innovation Training P roject of Henan Normal University(201410476051)
文摘In order to define the mortality criteria of planarian objectively,a case study of Dugesia japonica exposed to 1-octyl-3-methylimidazolium bromide([C8mim]Br)was performed followed by a recovery culture.The results showed that defining planarian mortality in light of its body disintegration was appropriate.If the disintegrated tissue of a planarian was more than 1/4 of its body length,it would completely degenerate.However,a planarian would regenerate the lost tissue and return to normal after a few days’recovery culture if the disintegrated part was less than 1/4 of body length.Therefore,we propose to use body disintegration as the endpoint of planarian mortality,i.e.,1/4 body length degenerated is the critical threshold of mortality and survival of planarians when exposed to toxicants.This criterion could be adapted in the standardization of testing protocols and comparability of acute toxicity test or other toxicological research using planarian as the test animal.
文摘目的分析2012—2023年重庆市老年人自杀死亡率与死亡疾病负担变化趋势,为开展有针对性的干预提供建议。方法利用重庆市2012—2023年死因监测数据中根本死因为自杀(《国际疾病与相关健康问题统计分类第10版》编码:X60~X84、Y87)的60岁及以上老年人死亡个案,分析死亡率、标化死亡率、早死寿命损失年(years of life lost,YLL)率、平均寿命损失年(average years of life lost,AYLL)及不同死因构成比,比较不同性别和地区死亡率,率的趋势变化采用年度变化百分比(annual percent of change,APC)和平均年度变化百分比(average annual percent of change,AAPC)进行分析。结果2012—2023年60岁及以上老年人自杀死亡率与标化死亡率总体呈下降的趋势,分别以年均3.54%与4.02%下降,变化趋势均有统计学意义(P<0.05)。2012—2016年自杀死亡率以年均4.53%上升,2016—2021年以年均8.91%下降,变化趋势均有统计学意义(P<0.05)。仅2020年与2022年男性自杀死亡率高于女性(P<0.05)。2012—2023年男性自杀死亡率与标化死亡率分别以年均2.86%和3.44%下降,女性分别以年均4.21%和4.69%下降,变化趋势均有统计学意义(P<0.05)。农村地区老年人历年自杀死亡率均高于城市地区,差异均有统计学意义(P<0.05)。2012—2023年城市地区老年人自杀死亡率与标化死亡率均保持相对平稳的水平(P>0.05),而农村地区老年人自杀死亡率与标化死亡率分别以年均3.44%与4.02%下降(P<0.05)。60岁及以上老年人自杀导致的YLL率与AYLL分别由2012年的3.03‰与18.54年下降至2023年的2.26‰与17.50年,AAPC分别为-4.02%与-0.60%,变化趋势均有统计学意义(P<0.05)。比较历年不同自杀方式构成发现,杀虫剂中毒死亡占比呈下降的趋势,而悬吊死亡、从高处跳下、淹溺占比均呈上升的趋势(P<0.05)。结论重庆市60岁及以上老年人自杀死亡率较高,疾病负担较重,总体呈下降的趋势,应重视老年人自杀的早期识别与干预。
