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Scheduling transactions in mobile distributed real-time database systems 被引量:1
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作者 雷向东 赵跃龙 +1 位作者 陈松乔 袁晓莉 《Journal of Central South University of Technology》 EI 2008年第4期545-551,共7页
A DMVOCC-MVDA (distributed multiversion optimistic concurrency control with multiversion dynamic adjustment) protocol was presented to process mobile distributed real-time transaction in mobile broadcast environment... A DMVOCC-MVDA (distributed multiversion optimistic concurrency control with multiversion dynamic adjustment) protocol was presented to process mobile distributed real-time transaction in mobile broadcast environments. At the mobile hosts, all transactions perform local pre-validation. The local pre-validation process is carried out against the committed transactions at the server in the last broadcast cycle. Transactions that survive in local pre-validation must be submitted to the server for local final validation. The new protocol eliminates conflicts between mobile read-only and mobile update transactions, and resolves data conflicts flexibly by using multiversion dynamic adjustment of serialization order to avoid unnecessary restarts of transactions. Mobile read-only transactions can be committed with no-blocking, and respond time of mobile read-only transactions is greatly shortened. The tolerance of mobile transactions of disconnections from the broadcast channel is increased. In global validation mobile distributed transactions have to do check to ensure distributed serializability in all participants. The simulation results show that the new concurrency control protocol proposed offers better performance than other protocols in terms of miss rate, restart rate, commit rate. Under high work load (think time is ls) the miss rate of DMVOCC-MVDA is only 14.6%, is significantly lower than that of other protocols. The restart rate of DMVOCC-MVDA is only 32.3%, showing that DMVOCC-MVDA can effectively reduce the restart rate of mobile transactions. And the commit rate of DMVOCC-MVDA is up to 61.2%, which is obviously higher than that of other protocols. 展开更多
关键词 mobile distributed real-time database systems muliversion optimistic concurrency control multiversion dynamic adjustment pre-validation multiversion data broadcast
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CRF:A Scheduling of Multi-Granularity Locks in Object-Oriented Database Systems
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作者 Qin Xiao & Pang Liping(Department of Computer Science, Huazhong University of Science and Technology,Wuhan 430074, P. R. China) 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1998年第4期51-57,共7页
This paper introduces a multi-granularity locking model (MGL) for concurrency control in object-oriented database system briefiy, and presents a MGL model formally. Four lockingscheduling algorithms for MGL are propos... This paper introduces a multi-granularity locking model (MGL) for concurrency control in object-oriented database system briefiy, and presents a MGL model formally. Four lockingscheduling algorithms for MGL are proposed in the paper. The ideas of single queue scheduling(SQS) and dual queue scheduling (DQS) are proposed and the algorithm and the performance evaluation for these two scheduling are presented in some paper. This paper describes a new idea of thescheduling for MGL, compatible requests first (CRF). Combining the new idea with SQS and DQS,we propose two new scheduling algorithms called CRFS and CRFD. After describing the simulationmodel, this paper illustrates the comparisons of the performance among these four algorithms. Asshown in the experiments, DQS has better performance than SQS, CRFD is better than DQS, CRFSperforms better than SQS, and CRFS is the best one of these four scheduling algorithms. 展开更多
关键词 Lock scheduling Multi-granularity lock Concurrency control Compatible requestsfirst Single queue scheduling Dual queue scheduling Object-oriented database system
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Validation concurrency control protocol in parallel real-time database systems 被引量:3
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作者 LEI Xiang-dong(雷向东) YUAN Xiao-li(袁晓莉) 《Journal of Central South University of Technology》 2002年第3期197-201,共5页
In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can e... In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can enhance the performance of real-time concurrency control mechanism by reducing the number of transactions that might miss their deadlines, and compare the performance of validation concurrency control protocol with that of HP2PL(High priority two phase locking) protocol and OCC-TI-WAIT-50(Optimistic concurrency control-time interval-wait-50) protocol under shared-disk architecture by simulation. The simulation results reveal that the protocol the author presented can effectively reduce the number of transactions restarting which might miss their deadlines and performs better than HP2PL and OCC-TI-WAIT-50. It works well when arrival rate of transaction is lesser than threshold. However, due to resource contention the percentage of missing deadline increases sharply when arrival rate is greater than the threshold. 展开更多
关键词 PARALLEL database system REAL-TIME database CONCURRENCY control VALIDATION TRANSACTIONS
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Security Research on Engineering Database System
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作者 REN Jian-ping 1,2, SONG Han-tao 2, LIANG Yun-rong 2 (1. North China Institute of Technology, Taiyuan 030051, China 2. Beijing Institute of Technology, Beijing 100081, China) 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期288-289,共2页
Engine engineering database system is an oriented C AD applied database management system that has the capability managing distributed data. The paper discusses the security issue of the engine engineering database ma... Engine engineering database system is an oriented C AD applied database management system that has the capability managing distributed data. The paper discusses the security issue of the engine engineering database management system (EDBMS). Through studying and analyzing the database security, to draw a series of securi ty rules, which reach B1, level security standard. Which includes discretionary access control (DAC), mandatory access control (MAC) and audit. The EDBMS implem ents functions of DAC, MAC and multigranularity audit. DAC solves the problems o f role inheritance, right contain, authorization identify and cascade revoke, et c; MAC includes subject and object security setup rule, security modify rule and multilevel relation access operation rule, etc; Audit allows making the sub ject, object or operation type as different audit object to implement flexible a nd multigranularity audit method. The model is designed act as a security agent to access daemon database. At present, the model is implemented which runs on th e Windows 2000 environments. 展开更多
关键词 engineering database management system (EDBMS) s ecurity agent security level
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基于Agricultural Animal Omics Database(AAOD)数据库挖掘绵羊GDF9基因变异
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作者 潘晔君 刘耿 +2 位作者 潘传英 张清峰 蓝贤勇 《畜牧兽医杂志》 2025年第3期1-9,共9页
目前利用大数据和组学数据库提高绵羊繁殖性能成为解决当前产业发展的关键之一。绵羊生长分化因子9(GDF9)基因对卵泡发育、排卵率及产羔数起着至关重要的作用,也是目前确定的绵羊多胎性状的主效基因之一;虽然其部分重要突变位点与产羔... 目前利用大数据和组学数据库提高绵羊繁殖性能成为解决当前产业发展的关键之一。绵羊生长分化因子9(GDF9)基因对卵泡发育、排卵率及产羔数起着至关重要的作用,也是目前确定的绵羊多胎性状的主效基因之一;虽然其部分重要突变位点与产羔数有关,但绵羊该基因所有可能基因变异如何挖掘仍然是一个尚待解决的问题。近年来,西北农林科技大学动物科技学院姜雨团队开发出Agricultural Animal Omics Database(AAOD)数据库,它整合了全球公共数据及中国本地特色绵羊品种的高深度基因组数据,涵盖50多个品种的遗传变异(SNPs、InDels)、表观标记及表型关联信息,并实现每月动态更新。基于此,本研究旨在利用AAOD数据库挖掘绵羊GDF9基因变异,并期望深入解析GDF9基因的分子结构、表达模式、富集分析、挖掘新的与繁殖力相关的突变位点及其在绵羊繁殖力中的潜在作用。这些结果将为基因编辑技术改良绵羊繁殖力提供新的潜在位点,将为提高绵羊繁殖力提供了遗传改良的理论依据与策略。 展开更多
关键词 绵羊 GDF9基因 Agricultural Animal Omics database(AAOD)数据库 单核苷酸多态性 插入缺失
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Gender differences in the burden of near vision loss in China:An analysis based on GBD 2021 data
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作者 LIU Yu ZHU Liping +4 位作者 LIN Yanhui WANG Yanbing XIONG Kun LI Xuhong YAN Wenguang 《中南大学学报(医学版)》 北大核心 2025年第6期1030-1041,共12页
Objective:Near vision loss(NVL)is one of the leading causes of visual impairment worldwide,exerting a profound impact on individual quality of life and socio-economic development.This study aims to analyze the burden ... Objective:Near vision loss(NVL)is one of the leading causes of visual impairment worldwide,exerting a profound impact on individual quality of life and socio-economic development.This study aims to analyze the burden of NVL in China by sex and age groups from 1990 to 2021 and to project trends over the next 15 years.Methods:Using data from the Global Burden of Disease(GBD)2021 database,we conducted descriptive analyses of NVL prevalence in China,calculated age-standardized prevalence rates(ASPR)and age-standardized disability-adjusted life years rates(ASDR)to compare burden differences between sexes and age groups,and applied an autoregressive integrated moving average(ARIMA)model to predict NVL trends for the next 15 years.The model selection was based on best-fit criteria to ensure reliable projections.Results:From 1990 to 2021,China’s ASPR of NVL rose from 10096.24/100000 to 15624.54/100000,and ASDR increased from 101.75/100000 to 158.75/100000.In 2021,ASPR(16551.70/100000)and ASDR(167.69/100000)were higher among females than males(14686.21/100000 and 149.76/100000,respectively).China ranked highest globally in both NVL cases and disability-adjusted life years(DALYs),with female burden significantly exceeding male burden.Projections indicated this trend and sex gap will persist until 2036.Compared with 1990,the prevalence cases and DALYs increased by 239.20%and 238.82%,respectively in 2021,with the highest burden among females and the 55−59 age group.The ARIMA model predicted continued increases in prevalence and DALYs by 2036,with females maintaining a higher burden than males.Conclusion:This study reveals a marked increase in the NVL burden in China and predicts continued growth in the coming years.Public health policies should prioritize NVL prevention and control,with special attention to women and middle-aged populations to mitigate long-term societal and health impacts. 展开更多
关键词 China near vision loss Global Burden of Disease database autoregressive integrated moving average model gender differences
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期刊国际数据库简介(Embase)
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《介入放射学杂志》 北大核心 2025年第6期623-623,共1页
全名:荷兰医学文摘(电子版)(Excerpta Medica Dtabasea)所属国家及机构:荷兰爱思唯尔(Elsevier)公司收录形式及规模:Embase是印刷版检索工具Excerpta Medica(荷兰《医学文摘》)的电子版,是全球最大最具权威性的生物医学与药理学文摘数据... 全名:荷兰医学文摘(电子版)(Excerpta Medica Dtabasea)所属国家及机构:荷兰爱思唯尔(Elsevier)公司收录形式及规模:Embase是印刷版检索工具Excerpta Medica(荷兰《医学文摘》)的电子版,是全球最大最具权威性的生物医学与药理学文摘数据库,以及全球最大的医疗器械数据库。Embase包含全部Medline的内容,共计涵盖8,500种期刊以及7,000多个会议超过295万条的会议摘要(从2009年起),其中2,900种期刊在Medline中无法检索到。收录学科领域:主要收录生物医学和药理学相关领域,如药理学、临床医学、遗传学、生化&分子生物学、微生物&传染病学、精神病&精神卫生、肿瘤学、公共卫生等相关学科。 展开更多
关键词 荷兰医学文摘 Excerpta Medica database
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Analysis and Study of Parallel Processing Mode inVLDB Decision Support System
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作者 Zhang, Liming Feng, Qiujie 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2000年第2期66-72,共7页
Nowadays, many kinds of computer network data management systems have been built widely in China. People have realized widely that management information system (MIS) has brought a revolution to the management mechani... Nowadays, many kinds of computer network data management systems have been built widely in China. People have realized widely that management information system (MIS) has brought a revolution to the management mechanism. Moreover, the managers of company need wide-range and comprehensive decision information more and more urgently which is the character of information explosion era. The needs of users become harsher and harsher in the design of MIS, and these needs have brought new problems to the general designers of MIS. Furthermore, the current method of traditional database development can't solve so big and complex problems of wide-range and comprehensive information processing. This paper proposes the adoption of parallel processing mode, the built of new decision support system (DSS) is to discuss and analyze the problems of information collection, processing and the acquirement of full-merit information with cross-domain and cross-VLDB (very-large database). 展开更多
关键词 Computer systems programming Data acquisition Data reduction database systems Decision support systems Response time (computer systems)
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Study on the System Design of Multiple Expert Systems Integrated Decision Support System
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作者 Wang, Zongjun 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1993年第1期74-81,共8页
There has been an increasing interest in integrating decision support systems (DSS) and expert systems (ES) to provide decision makers a more accessible, productive and domain-independent information and computing env... There has been an increasing interest in integrating decision support systems (DSS) and expert systems (ES) to provide decision makers a more accessible, productive and domain-independent information and computing environment. This paper is aimed at designing a multiple expert systems integrated decision support system (MESIDSS) to enhance decision makers' ability in more complex cases. The basic framework, management system of multiple ESs, and functions of MESIDSS are presented. The applications of MESIDSS in large-scale decision making processes are discussed from the following aspects of problem decomposing, dynamic combination of multiple ESs, link of multiple bases and decision coordinating. Finally, a summary and some ideas for the future are presented. 展开更多
关键词 Computational methods Computer architecture database systems Expert systems Information management Knowledge based systems Large scale systems Logic design systems analysis User interfaces
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Event-based incremental updating of spatio-temporal database 被引量:10
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作者 周晓光 陈军 +2 位作者 蒋捷 朱建军 李志林 《Journal of Central South University of Technology》 2004年第2期192-198,共7页
Based on the relationship among the geographic events, spatial changes and the database operations, a new automatic (semi-automatic) incremental updating approach of spatio-temporal database (STDB) named as (event-bas... Based on the relationship among the geographic events, spatial changes and the database operations, a new automatic (semi-automatic) incremental updating approach of spatio-temporal database (STDB) named as (event-based) incremental updating (E-BIU) is proposed in this paper. At first, the relationship among the events, spatial changes and the database operations is analyzed, then a total architecture of E-BIU implementation is designed, which includes an event queue, three managers and two sets of rules, each component is presented in detail. The process of the E-BIU of master STDB is described successively. An example of building’s incremental updating is given to illustrate this approach at the end. The result shows that E-BIU is an efficient automatic updating approach for master STDB. 展开更多
关键词 incremental updating geographic event spatial change database operation MANAGER
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Rules-based object-relational databases ontology construction 被引量:6
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作者 Chen Jia Wu Yue 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第1期211-215,共5页
To solve the problems of shaving and reusing information in the information system, a rules-based ontology constructing approach from object-relational databases is proposed. A 3-tuple ontology constructing model is p... To solve the problems of shaving and reusing information in the information system, a rules-based ontology constructing approach from object-relational databases is proposed. A 3-tuple ontology constructing model is proposed first. Then, four types of ontology constructing rules including class, property, property characteristics, and property restrictions ave formalized according to the model. Experiment results described in Web ontology language prove that our proposed approach is feasible for applying in the semantic objects project of semantic computing laboratory in UC Irvine. Our approach reduces about twenty percent constructing time compared with the ontology construction from relational databases. 展开更多
关键词 ontology constructing semantic objects object-relational databases RULES ONTOLOGY Web ontologylanguage.
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Networked control and supervision system based on LonWorks fieldbus and Intranet/Internet 被引量:2
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作者 吴敏 赵虹 +1 位作者 刘国平 佘锦华 《Journal of Central South University of Technology》 EI 2007年第2期260-265,共6页
A networked control and supervision system (NCSS) based on LonWorks fieldbus and lntranet/Intemet was designed, which was composed of the universal intelligent control nodes (ICNs), the visual control and supervis... A networked control and supervision system (NCSS) based on LonWorks fieldbus and lntranet/Intemet was designed, which was composed of the universal intelligent control nodes (ICNs), the visual control and supervision configuration platforms (VCCP and VSCP) and an Intranet/Internet-based remote supervision platform (RSP). The ICNs were connected to field devices, such as sensors, actuators and controllers. The VCCP and VSCP were implemented by means of a graphical programming environment and network management so as to simplify the tasks of programming and maintaining the ICNs. The RSP was employed to perform the remote supervision function, which was based on a three-layer browser/server(B/S) structure mode. The validity of the NCSS was demonstrated by laboratory experiments. 展开更多
关键词 FIELDBUS LONWORKS networked control visual control configuration Web database
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A product module mining method for PLM database 被引量:2
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作者 雷佻钰 彭卫平 +3 位作者 雷金 钟院华 张秋华 窦俊豪 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第7期1754-1766,共13页
Modular technology can effectively support the rapid design of products, and it is one of the key technologies to realize mass customization design. With the application of product lifecycle management(PLM) system in ... Modular technology can effectively support the rapid design of products, and it is one of the key technologies to realize mass customization design. With the application of product lifecycle management(PLM) system in enterprises, the product lifecycle data have been effectively managed. However, these data have not been fully utilized in module division, especially for complex machinery products. To solve this problem, a product module mining method for the PLM database is proposed to improve the effect of module division. Firstly, product data are extracted from the PLM database by data extraction algorithm. Then, data normalization and structure logical inspection are used to preprocess the extracted defective data. The preprocessed product data are analyzed and expressed in a matrix for module mining. Finally, the fuzzy c-means clustering(FCM) algorithm is used to generate product modules, which are stored in product module library after module marking and post-processing. The feasibility and effectiveness of the proposed method are verified by a case study of high pressure valve. 展开更多
关键词 product design module division product module mining product lifecycle management (PLM) database
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Unified Platform About Information Issuing,Integration and Management of Meta-Database and Spatial-Database Based on Geology Metadata Standard 被引量:1
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作者 Tao Xue,Mingguang Diao School of Software,China University of Geosciences(Beijing),Beijing 100083,China. 《地学前缘》 EI CAS CSCD 北大核心 2009年第S1期288-288,共1页
With the deepening informationization of Resources & Environment Remote Sensing geological survey conducted,some potential problems and deficiency are:(1) shortage of unified-planed running environment;(2) inconsi... With the deepening informationization of Resources & Environment Remote Sensing geological survey conducted,some potential problems and deficiency are:(1) shortage of unified-planed running environment;(2) inconsistent methods of data integration;and(3) disadvantages of different performing ways of data integration.This paper solves the above problems through overall planning and design,constructs unified running environment, consistent methods of data integration and system structure in order to advance the informationization 展开更多
关键词 METADATA SPATIAL database data INTEGRATION RESOURCES & environment remote sensing
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A new product family mining method based on PLM database 被引量:1
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作者 HU Xiang-yang PENG Wei-ping +3 位作者 LEI Jin DOU Jun-hao ZHONG Yuan-hua JIANG Rui 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第11期2513-2523,共11页
Product family(PF) is the most important part of product platform. A new method is proposed to mine PF based on multi-space product data in PLM database. Product structure tree(PST) and bill of material(BOM) are used ... Product family(PF) is the most important part of product platform. A new method is proposed to mine PF based on multi-space product data in PLM database. Product structure tree(PST) and bill of material(BOM) are used as the data source. A PF can be obtained by mining physics space, logic space and attribute space of product data. In this work, firstly, a PLM database is described, consisting of data organization form, data structure, and data characteristics. Then the PF mining method introduces the sequence alignment techniques used in bio-informatics, which mainly includes data pre-processing, regularization, mining algorithm and cluster analysis. Finally, the feasibility and effectiveness of the proposed method are verified by a case study of high and middle pressure valve, demonstrating a feasible method to obtain PF from PLM database. 展开更多
关键词 PRODUCT FAMILY PRODUCT LIFE-CYCLE management database multi-space PRODUCT DATA DATA mining
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Combinatorial Design of Some Database Application Technologies Based on B/S 被引量:1
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作者 ZHOU Sun, LIN Qiang-yong, JI Guo-li, BAI Jun-hai (Department of Automation, Xiamen University, Xiamen 361005, China) 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期288-,共1页
Evolving From principal-subordinate structure of C /S to flexible multileveled distributed structure, i.e. B/S architecture so as to form a wide, distributed and orderly Internet/Intranet integrated management inf orm... Evolving From principal-subordinate structure of C /S to flexible multileveled distributed structure, i.e. B/S architecture so as to form a wide, distributed and orderly Internet/Intranet integrated management inf ormation system, is the trend of development of application software of the whol e world. Advantages and disadvantages of the two modes: C/S and B/S are compared . It is pointed out that at present onefold B/S mode cannot yet fully fullfil th e demands of some complicated data processing, information statistics and analys is, etc, therefore it still awaits further development of technology to achieve 100% Internet. In this paper, a mode of B/S-C/S-blended multileveled architect ure is discussed; the logical levels of B/S mode is studied; Furthermore, combin ing some up-to-date software developing technology, combinatorial design of di fferent database application technology based on B/S is discussed. The expatiati on is made with following points: (1) Organic combination of the network distrib uted object technology of CORBA and the computation technology among different n etwork operating system ─ Java; (2) Organic combination of two modes of ASP and Plug_in; (3) JDBC Server and JDBC Client; (4) An expanded B/S model, i.e. the c lient application of browser communicates directly with Web server, and the serv er application communicates directly with database server through middle ware. 展开更多
关键词 B/S C/S database application technology MIS
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The Most Comprehensive Database of Ionic Transport Characteristics to Date 被引量:1
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作者 HE Bing MI Penghui +3 位作者 ZHANG Liwen CHI Shuting YE Anjiang SHI Siqi 《材料导报》 EI CAS CSCD 北大核心 2020年第20期20001-20002,共2页
(a)The architecture of the ionic transport characteristics database;(b)the flow chart of the combination of geometric analysis and BVSE method;(c)the architecture of high-throughput screening platform for solid electr... (a)The architecture of the ionic transport characteristics database;(b)the flow chart of the combination of geometric analysis and BVSE method;(c)the architecture of high-throughput screening platform for solid electrolytes.The blue bidirectional lines indicate dataflow Transport characteristics of ionic conductors play a key role in the performance of electrochemical devices[1-2].Any optimization of the performance of the ionic compounds is inseparable from the understanding of the basic transport characteristics.It has been previously established that ion transport properties are defined by framework transport channel geometry,e.g.bottleneck size,and resulting migration energy[3-4]. 展开更多
关键词 database FLOW CHARACTERISTICS
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Intelligent Information Management and Knowledge Discovery in Large Numeric and Scientific Databases 被引量:1
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作者 Patrick Perrin Frederick E. Petry & William Thomason(Center for Intelligent and Knowledge-Based Systems)(Computer Science Department, Tulane University, New Orleans LA) 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1996年第2期73-86,共14页
The present article outlines progress made in designing an intelligent information system for automatic management and knowledge discovery in large numeric and scientific databases, with a validating application to th... The present article outlines progress made in designing an intelligent information system for automatic management and knowledge discovery in large numeric and scientific databases, with a validating application to the CAST-NEONS environmental databases used for ocean modeling and prediction. We describe a discovery-learning process (Automatic Data Analysis System) which combines the features of two machine learning techniques to generate sets of production rules that efficiently describe the observational raw data contained in the database. Data clustering allows the system to classify the raw data into meaningful conceptual clusters, which the system learns by induction to build decision trees, from which are automatically deduced the production rules. 展开更多
关键词 Knowledge discovery in databases Machine learning Decision tree inducers
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Concepts and Applications of Spatial Database for Geo-Archives Catalog
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作者 Xiaoguang Li~1,Chao Xing~2,Lei Li~1,Xiaoxi Zhou~1 1.Geo-Information and Archives Center,Tianjin Institute of Geological & Mineral Resources,Tianjin 300170,China. 2.ESRI China(Beijing) Learning Center,Beijing 100101,China 《地学前缘》 EI CAS CSCD 北大核心 2009年第S1期289-289,共1页
The searching method of spatial information on traditional geo-archives catalog database(TGCD) is based on the text,and the result of retrieval can be only from the text of fields of relational database.The informatio... The searching method of spatial information on traditional geo-archives catalog database(TGCD) is based on the text,and the result of retrieval can be only from the text of fields of relational database.The information queried must be input into the relational database as a text form in advance,otherwise,the visitors would not get any result from it.So。 展开更多
关键词 SEARCHING method geo-archives CATALOG GIS SPATIAL database
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Integrative database for multi-compound drug discovery in complementary medicine
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作者 SunyongYOO JaejoonCHOI +4 位作者 MoonshikSHIN SuhyunHA KyungrinNOH HojungNAM DoheonLEE 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2015年第S1期98-98,共1页
OBJECTIVE To construct an integrative database for multi-compound drug discovery.METHODS We designed and constructed a database system,which integrates traditional herbal medicine,functional food,and drug combination ... OBJECTIVE To construct an integrative database for multi-compound drug discovery.METHODS We designed and constructed a database system,which integrates traditional herbal medicine,functional food,and drug combination information.Our database consists of six entity tables,namely drug combinations,functional foods,prescriptions,herbs,compounds and phenotypes.We established strategies for data integration and entity resolution to facilitate heterogeneous information of multi-compound therapies.To standardize the data,instances of entity tables are mapped to international identifiers,and phenotype terms in narrative text are extracted by using the named entity recognition(NER)method.RESULTS The database integrates therapeutic information of traditional herbal medicine,functional foods and combination drugs which is acquired from Traditional Chinese Medicine Information Database(TCM-ID),Food and Drug Administration(FDA)and Drug Combination Database(DCDB).The herb information is mapped to NCBI taxonomy identifiers,and compound information is mapped to PubChem and ChEMBL identifiers for standardization.We also applied MetaMap,a tool for recognizing UMLS concepts from narrative text,to extract phenotype terms.The current version of the database contains 6 291 drug combinations,1 615 functional foods,20 091 prescriptions,8889herbs,227 636 compounds and 11 744 phenotypes.CONCLUSION Our database provides various therapeutic information of multi-compound therapies which serve as a fundamental resource for the polypharmacology research. 展开更多
关键词 database database INTEGRATION TRADITIONAL MEDICINE
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