Objective: To explore the biological role of ptotocatechualdehyde-thiosemicarbazone-copper(Ⅱ)complex (PTC), its scavenging O2- free radical mechanism and to develop a new drug with high effective and low-toxicity. On...Objective: To explore the biological role of ptotocatechualdehyde-thiosemicarbazone-copper(Ⅱ)complex (PTC), its scavenging O2- free radical mechanism and to develop a new drug with high effective and low-toxicity. One of the essential components of this metal complex is an extract from a traditional Chinese medicinal herb. Methods:①Xathine- Xathine oxidase-luminol chemiluminescence (CL)was applied to detect SOD-like activity of PTC. ②Effects of SOD and its mimic (PTC) on the free radical-mediated change of blood viscosity and zymosan-activated leukocytic chemiluminescence, as well as the prptectove effects of PTC on oxiditive damage after burn were observed. Results: ①PTC has a significantly high SOD-like activity with an [ID]50 of 150 μg/L (SOD-300 μg/L). ②PTC can significantly inhibit zymosan-activated leukocytic chemiluminescence.③PTC can lower phagocyte-dependent increase in blood viscosity and inhibit the lipid peroxidation in blood. ④PTC can alleviate secondary oxygen free radical injury after burn. Conclusion:PTC is a significantly effective O2- free radical scanvenger. It can be applied to treat diseases resulting from abnormality of active oxygen free radical reaction in the body.展开更多
The quantitative understanding of how atomic-level catalyst structural changes affect the reactivity of the electrochemical CO_(2)reduction reaction is challenging.Due to the complexity of catalytic systems,convention...The quantitative understanding of how atomic-level catalyst structural changes affect the reactivity of the electrochemical CO_(2)reduction reaction is challenging.Due to the complexity of catalytic systems,conventional in situ X-ray spectroscopy plays a limited role in tracing the underlying dynamic structural changes in catalysts active sites.Herein,operando high-energy resolution fluorescence-detected X-ray absorption spectroscopy was used to precisely identify the dynamic structural transformation of well-defined active sites of a representative model copper(Ⅱ)phthalocyanine catalyst which is of guiding significance in studying single-atom catalysis system.Comprehensive X-ray spectroscopy analyses,including surface sensitive△μspectra which isolates the surface changes by subtracting the disturb of bulk base and X-ray absorption near-edge structure spectroscopy simulation,were used to discover that Cu species aggregated with increasing applied potential,which is responsible for the observed evolution of C_(2)H_(4).The approach developed in this work,characterizing the active-site geometry and dynamic structural change,is a novel and powerful technique to elucidate complex catalytic mechanisms and is expected to con tribute to the rational design of highly effective catalysts.展开更多
Efficient heterojunction organic photovoltaic （OPV） cells are fabricated based on copper tetra-methyl phthalocyanine （CuMePc） as donor and fullerene （C60） as acceptor. The power conversion efficiency of CuMePc/C...Efficient heterojunction organic photovoltaic （OPV） cells are fabricated based on copper tetra-methyl phthalocyanine （CuMePc） as donor and fullerene （C60） as acceptor. The power conversion efficiency of CuMePc/C60 OPV cell （2.52%） is increased by 88% compared with that of the non-peripheral substituted copper phthalocyanine （CuPc）/C60 OPV cell （1.34%）. The introduction of methyl substituent leads to stronger π–π interaction of CuMePc （～ 3.5 ？） than that of CuPc （～ 3.8 ？）. The efficiency improvement is attributed to the enhanced carrier mobility of CuMePc thin film （1.1×10-3 cm2/V·s） and better film morphology by introducing methyl groups into the periphery of CuPc molecule.展开更多
In this work, with the purpose to explore the coordination chemistry of calcium complexes which could work as a partial model of manganese-calcium cluster, a spectrophotometric study to evaluate the stability of the c...In this work, with the purpose to explore the coordination chemistry of calcium complexes which could work as a partial model of manganese-calcium cluster, a spectrophotometric study to evaluate the stability of the complexes: Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine in acetonitrile, were carried on. By processing the spectrophotometric data with the HypSpec program allows the determination of the formation constants. The logarithmic values of the formation constants obtained for Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine were log β_(110) = 4.69, log β_(110)= 5.25 and log β_(110) = 4.072, respectively.展开更多
Five complexes of copper and lanthanide series containing iminodiacetic group Hgands have been synthesized and investigated. The structures of three compounds have been determined by X-ray single crystal diffraction. ...Five complexes of copper and lanthanide series containing iminodiacetic group Hgands have been synthesized and investigated. The structures of three compounds have been determined by X-ray single crystal diffraction. Their vibrational spectra have been measured and assigned rationally.展开更多
Dinuclear copper complex with biradical, [Cu(hfac) 2] 2PhBNOM\[PhBNOM=2,5 bimethoxyl 1,4 bis(4,4,5,5 tetramethyllimidazoline 1 oxyl 3 oxide)phenyl, hfac=hexafluoroacetylacetonate], has been synthesized and characteriz...Dinuclear copper complex with biradical, [Cu(hfac) 2] 2PhBNOM\[PhBNOM=2,5 bimethoxyl 1,4 bis(4,4,5,5 tetramethyllimidazoline 1 oxyl 3 oxide)phenyl, hfac=hexafluoroacetylacetonate], has been synthesized and characterized. It crystallized in the monoclinic system; space group C2/c with a = \{1\^877 3(8)\} nm, b =1.359 8(5) nm, c =2.237 1(7) nm, β =97.24(3)°, Z =4, R = 0.096 1 , R w=0 094 4 .展开更多
文摘Objective: To explore the biological role of ptotocatechualdehyde-thiosemicarbazone-copper(Ⅱ)complex (PTC), its scavenging O2- free radical mechanism and to develop a new drug with high effective and low-toxicity. One of the essential components of this metal complex is an extract from a traditional Chinese medicinal herb. Methods:①Xathine- Xathine oxidase-luminol chemiluminescence (CL)was applied to detect SOD-like activity of PTC. ②Effects of SOD and its mimic (PTC) on the free radical-mediated change of blood viscosity and zymosan-activated leukocytic chemiluminescence, as well as the prptectove effects of PTC on oxiditive damage after burn were observed. Results: ①PTC has a significantly high SOD-like activity with an [ID]50 of 150 μg/L (SOD-300 μg/L). ②PTC can significantly inhibit zymosan-activated leukocytic chemiluminescence.③PTC can lower phagocyte-dependent increase in blood viscosity and inhibit the lipid peroxidation in blood. ④PTC can alleviate secondary oxygen free radical injury after burn. Conclusion:PTC is a significantly effective O2- free radical scanvenger. It can be applied to treat diseases resulting from abnormality of active oxygen free radical reaction in the body.
基金supported by the National Natural Science Foundation of China,grant number:U1732267.
文摘The quantitative understanding of how atomic-level catalyst structural changes affect the reactivity of the electrochemical CO_(2)reduction reaction is challenging.Due to the complexity of catalytic systems,conventional in situ X-ray spectroscopy plays a limited role in tracing the underlying dynamic structural changes in catalysts active sites.Herein,operando high-energy resolution fluorescence-detected X-ray absorption spectroscopy was used to precisely identify the dynamic structural transformation of well-defined active sites of a representative model copper(Ⅱ)phthalocyanine catalyst which is of guiding significance in studying single-atom catalysis system.Comprehensive X-ray spectroscopy analyses,including surface sensitive△μspectra which isolates the surface changes by subtracting the disturb of bulk base and X-ray absorption near-edge structure spectroscopy simulation,were used to discover that Cu species aggregated with increasing applied potential,which is responsible for the observed evolution of C_(2)H_(4).The approach developed in this work,characterizing the active-site geometry and dynamic structural change,is a novel and powerful technique to elucidate complex catalytic mechanisms and is expected to con tribute to the rational design of highly effective catalysts.
基金Project supported by the Special Funds for the Development of Strategic Emerging Industries in Shenzhen City,China(Grant No.JCYJ20120830154526537)Start-up Funding of the South University of Science and Technology of China,and the Strategic Research Grant of the City University of Hong Kong(Grant No.7002724)
文摘Efficient heterojunction organic photovoltaic （OPV） cells are fabricated based on copper tetra-methyl phthalocyanine （CuMePc） as donor and fullerene （C60） as acceptor. The power conversion efficiency of CuMePc/C60 OPV cell （2.52%） is increased by 88% compared with that of the non-peripheral substituted copper phthalocyanine （CuPc）/C60 OPV cell （1.34%）. The introduction of methyl substituent leads to stronger π–π interaction of CuMePc （～ 3.5 ？） than that of CuPc （～ 3.8 ？）. The efficiency improvement is attributed to the enhanced carrier mobility of CuMePc thin film （1.1×10-3 cm2/V·s） and better film morphology by introducing methyl groups into the periphery of CuPc molecule.
基金the Secretaria de Educacion Publica(SEP)through PRODEP program for their economic support in the project "Equilibrios de Formacion de Complejos de Manganeso(Ⅱ)-Diamina para su Aplicacion en Sistemas de Fotosintesis Artificial"the Secretaria de Innovacion,Cienciay Educacion Superior(SICES)for its economic support through their program"Convocatoria de Investigadores Jovenes 2016",in the project "Obtencion de Clusteres Manganeso-Calcio para su Aplicacion Potencial en Sistemas de Fotosintesis Artificial"
文摘In this work, with the purpose to explore the coordination chemistry of calcium complexes which could work as a partial model of manganese-calcium cluster, a spectrophotometric study to evaluate the stability of the complexes: Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine in acetonitrile, were carried on. By processing the spectrophotometric data with the HypSpec program allows the determination of the formation constants. The logarithmic values of the formation constants obtained for Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine were log β_(110) = 4.69, log β_(110)= 5.25 and log β_(110) = 4.072, respectively.
文摘Five complexes of copper and lanthanide series containing iminodiacetic group Hgands have been synthesized and investigated. The structures of three compounds have been determined by X-ray single crystal diffraction. Their vibrational spectra have been measured and assigned rationally.
文摘Dinuclear copper complex with biradical, [Cu(hfac) 2] 2PhBNOM\[PhBNOM=2,5 bimethoxyl 1,4 bis(4,4,5,5 tetramethyllimidazoline 1 oxyl 3 oxide)phenyl, hfac=hexafluoroacetylacetonate], has been synthesized and characterized. It crystallized in the monoclinic system; space group C2/c with a = \{1\^877 3(8)\} nm, b =1.359 8(5) nm, c =2.237 1(7) nm, β =97.24(3)°, Z =4, R = 0.096 1 , R w=0 094 4 .
