Cooperative pursuit poses challenges across natural,social,and technical systems,particularly when decentralized,slow-speed pursuers attempt to capture a high-speed evader with limited observation.Most existing contri...Cooperative pursuit poses challenges across natural,social,and technical systems,particularly when decentralized,slow-speed pursuers attempt to capture a high-speed evader with limited observation.Most existing contributions place the focus on the greedy pursuit of the evader,overlooking potential collaborations among pursuers.To tackle this issue,a decisionmaking framework of multi-agent coordinated reciprocity formation pursuit(MACRFP)via deep reinforcement learning is introduced.This framework integrates the actor-critic algorithm with the coordinated reciprocity mechanism to enhance the capability of capturing a faster evader.Initially,a local perception model is created by utilizing a cellular network to simulate limitations caused by obstacles.Next,the formation coalition of pursuit is guided by the Cartesian Oval,enabling dispersed pursuers to create a siege against the faster evader.Furthermore,a coordinated reciprocity model based on the coordination graph and the attention-based graph neural networks is developed,addressing the global coordination problem by estimating a reciprocity coefficient to adjust agents'rewards.Numerical simulations demonstrate the emergence of cooperative behaviors in cooperative besiegement,target tracking,and intelligent interception during the pursuit,indicating that the proposed algorithm enhances the feasibility and effectiveness of capturing a fast-escaping target by integrating coordinated reciprocity and coalition formation.展开更多
The unique characteristics of the deep space environment,microgravity,cosmic radiation,and extreme temperature fluctuations,are emerging as major driving forces for pharmaceutical innovation.These factors provide new ...The unique characteristics of the deep space environment,microgravity,cosmic radiation,and extreme temperature fluctuations,are emerging as major driving forces for pharmaceutical innovation.These factors provide new avenues for optimizing drug formulations,improving crystal structure quality,and accelerating the discovery of therapeutic targets.Advances in deep space research not only help overcome critical bottlenecks in terrestrial drug development but also promote progress in structure-based drug design and deepen understanding of cellular stress-response mechanisms.Current progress in space-based pharmaceutical research primarily includes the study of disease mechanisms under microgravity,protein crystallization in microgravity,and drug development utilizing deep space radiation and resources.However,the operational complexity,high costs,and limited data reproducibility of space experiments remain key challenges hindering widespread application.Looking ahead,with the integration of automation,artificial intelligence analysis,and on-orbit manufacturing,deep space drug development is expected to achieve greater scalability and precision,opening a new frontier in biopharmaceutical science.展开更多
Background Aquaporins(AQPs)are integral membrane proteins belonging to the major intrinsic protein(MIP)family,playing a crucial role in water transport,cell elongation,and stress responses.However,their evolutionary d...Background Aquaporins(AQPs)are integral membrane proteins belonging to the major intrinsic protein(MIP)family,playing a crucial role in water transport,cell elongation,and stress responses.However,their evolutionary dynamics and functional roles in Gossypium species remain poorly characterized.Results In the present study,a total of 55,54,54,103,106,108,and 104 AQP genes were found in G.herbaceum,G.arboreum,G.raimondii,G.barbadense,G.tomentosum,G.mustelinum,and G.darwinii,respectively.Phylogenetic analysis classified them into five conserved subfamilies(PIP,TIP,NIP,SIP,and XIP),with 95 genes showing synteny across species and 17 displaying divergence,suggesting subgenome differentiation.Transcriptome analysis revealed that specific Gb AQP genes are involved in early salt stress responses and fiber development.Physiological assays demonstrated stronger salt tolerance in tetraploid cottons,particularly G.darwinii,compared with diploids.Co-expression network analysis linked AQPs to abiotic stress and fiber traits,and virus-induced gene silencing(VIGS)confirmed four AQP genes as critical for salt tolerance.Conclusion This study provides comprehensive insights into the evolution,expression,and functional roles of AQPs in cotton,identifying key candidate genes for improving salt tolerance and fiber quality in Gossypium species.展开更多
This study takes the patent information of China's electric agricultural machinery technology as the research object,and uses patent measurement analysis method and visual analysis tools to carry out statistical a...This study takes the patent information of China's electric agricultural machinery technology as the research object,and uses patent measurement analysis method and visual analysis tools to carry out statistical analysis and comparative research on the relevant patent information from the perspectives of annual patent applications,patent structure,technological key,main applicants,patent layout,technology lifecycle and so on.The research results show that China's electric agricultural machinery technology innovation is developing rapidly,and the patent categories are mainly utility model and invention patents,and the proportion of invention patents is lower than utility model patents.Universities are the most important innovation subjects in this field,and technology research and development focuses on IPC(international patent classification)subcategories such as A01C(seeding,fertilization),B60K(power,transmission),and A01D(harvesting.mowing).Jiangsu Province and Shandong Province rank the top 2 in the number of domestic patent applications,and the United States and Japan are the two countries with the most layout in China.At present,the growth of electric agricultural machinery technology is weak,but the new technology has strong features,there is no sign of maturity,and it does not have signs of technological aging and still has greater development potential.The results of the study can provide information reference for clarifying the status quo,characteristics and development trend of China's electric agricultural machinery technology innovation.展开更多
基金supported by the National Natural Science Foundation of China(72371052,71871042)。
文摘Cooperative pursuit poses challenges across natural,social,and technical systems,particularly when decentralized,slow-speed pursuers attempt to capture a high-speed evader with limited observation.Most existing contributions place the focus on the greedy pursuit of the evader,overlooking potential collaborations among pursuers.To tackle this issue,a decisionmaking framework of multi-agent coordinated reciprocity formation pursuit(MACRFP)via deep reinforcement learning is introduced.This framework integrates the actor-critic algorithm with the coordinated reciprocity mechanism to enhance the capability of capturing a faster evader.Initially,a local perception model is created by utilizing a cellular network to simulate limitations caused by obstacles.Next,the formation coalition of pursuit is guided by the Cartesian Oval,enabling dispersed pursuers to create a siege against the faster evader.Furthermore,a coordinated reciprocity model based on the coordination graph and the attention-based graph neural networks is developed,addressing the global coordination problem by estimating a reciprocity coefficient to adjust agents'rewards.Numerical simulations demonstrate the emergence of cooperative behaviors in cooperative besiegement,target tracking,and intelligent interception during the pursuit,indicating that the proposed algorithm enhances the feasibility and effectiveness of capturing a fast-escaping target by integrating coordinated reciprocity and coalition formation.
基金supported by the National Natural Science Foundation of China(82272067).
文摘The unique characteristics of the deep space environment,microgravity,cosmic radiation,and extreme temperature fluctuations,are emerging as major driving forces for pharmaceutical innovation.These factors provide new avenues for optimizing drug formulations,improving crystal structure quality,and accelerating the discovery of therapeutic targets.Advances in deep space research not only help overcome critical bottlenecks in terrestrial drug development but also promote progress in structure-based drug design and deepen understanding of cellular stress-response mechanisms.Current progress in space-based pharmaceutical research primarily includes the study of disease mechanisms under microgravity,protein crystallization in microgravity,and drug development utilizing deep space radiation and resources.However,the operational complexity,high costs,and limited data reproducibility of space experiments remain key challenges hindering widespread application.Looking ahead,with the integration of automation,artificial intelligence analysis,and on-orbit manufacturing,deep space drug development is expected to achieve greater scalability and precision,opening a new frontier in biopharmaceutical science.
基金supported by the National Natural Science Foundation of China(Grant No.32460522,32372128,and 32201713)。
文摘Background Aquaporins(AQPs)are integral membrane proteins belonging to the major intrinsic protein(MIP)family,playing a crucial role in water transport,cell elongation,and stress responses.However,their evolutionary dynamics and functional roles in Gossypium species remain poorly characterized.Results In the present study,a total of 55,54,54,103,106,108,and 104 AQP genes were found in G.herbaceum,G.arboreum,G.raimondii,G.barbadense,G.tomentosum,G.mustelinum,and G.darwinii,respectively.Phylogenetic analysis classified them into five conserved subfamilies(PIP,TIP,NIP,SIP,and XIP),with 95 genes showing synteny across species and 17 displaying divergence,suggesting subgenome differentiation.Transcriptome analysis revealed that specific Gb AQP genes are involved in early salt stress responses and fiber development.Physiological assays demonstrated stronger salt tolerance in tetraploid cottons,particularly G.darwinii,compared with diploids.Co-expression network analysis linked AQPs to abiotic stress and fiber traits,and virus-induced gene silencing(VIGS)confirmed four AQP genes as critical for salt tolerance.Conclusion This study provides comprehensive insights into the evolution,expression,and functional roles of AQPs in cotton,identifying key candidate genes for improving salt tolerance and fiber quality in Gossypium species.
基金Special Fund for Basic Scientific Research Business Expenses of Central Public Welfare Scientific Research Institutions(S201947)。
文摘This study takes the patent information of China's electric agricultural machinery technology as the research object,and uses patent measurement analysis method and visual analysis tools to carry out statistical analysis and comparative research on the relevant patent information from the perspectives of annual patent applications,patent structure,technological key,main applicants,patent layout,technology lifecycle and so on.The research results show that China's electric agricultural machinery technology innovation is developing rapidly,and the patent categories are mainly utility model and invention patents,and the proportion of invention patents is lower than utility model patents.Universities are the most important innovation subjects in this field,and technology research and development focuses on IPC(international patent classification)subcategories such as A01C(seeding,fertilization),B60K(power,transmission),and A01D(harvesting.mowing).Jiangsu Province and Shandong Province rank the top 2 in the number of domestic patent applications,and the United States and Japan are the two countries with the most layout in China.At present,the growth of electric agricultural machinery technology is weak,but the new technology has strong features,there is no sign of maturity,and it does not have signs of technological aging and still has greater development potential.The results of the study can provide information reference for clarifying the status quo,characteristics and development trend of China's electric agricultural machinery technology innovation.
