Cardiac fibrosis is a common pathway to heart injury and failure,where continued activation of cardiac fibroblasts(CFs)during myocardium damage causes excessive deposition of the extracellular matrix and thus increase...Cardiac fibrosis is a common pathway to heart injury and failure,where continued activation of cardiac fibroblasts(CFs)during myocardium damage causes excessive deposition of the extracellular matrix and thus increases matrix stiffness.Increasing evidence has shown that stiff matrix plays an important positive role in promoting CF differentiation and cardiac fibrosis,with several signaling factors medicating CF mechanotransduction already identified.However,key moleculesthat perceive matrix stiffness to regulate CF differentiation remain to be fully defined.Recently,Hippo pathway transcriptional coactivators,i.e.,Yes-associated protein(YAP)and transcriptional coactivator with PDZ-binding motif(TAZ),have been found to work as mechanical signal transductors.Importantly,it has shown that YAP plays important roles in various types of fibrosis.Despite these findings,the role of YAP in CF mechanotransduction and cardiac fibrosis still remains elusive.Moreover,several several types of GPCRs have also been found to enable cells to sense mechanical cues,however,the relationship between these GPCRs and YAP in cell mechanotransduction is still not clear.Our recent work demonstrated that blocking of angiotensin II type 1 receptor(AT1R,the first GPCRs found to be mechanosensors)with losartan significantly inhibited the differentiation of CFs to myofibroblasts induced by stiff substrate.Taken these findings into account,we speculate that YAP may work as an important downstream signaling molecule of AT1R in mediating matrix stiffness-induced CF differentiation.In this work,we first characterized the expression of YAP in normal control(NC)and myocardial infarct(Ml)tissues of rats by using immunohistochemistry,immunofluorescence and Western blot analysis.We then investigated the role of YAP in matrix stiffness-induced CF differentiation in vitro by culturing CFs on mechanically tunable gelatin hydrogels.Finally,we explored the relationship between YAP and AT1R in CF mechanotransduction by selective transfection and inhibition experiments.The expression of YAP andα-SMA in cultured CFs were evaluated with immunofluorescence staining,Western blot and real-time quantitative PCR analysis.Immunohistochemical analysis revealed that both YAP andα-SMA significantly increased in Ml tissue compared with NC tissue.The expression and nuclear localization of YAP increased in CFs cultured on stiff matrix.YAP-deficient CFs cultured on soft and stiff matrix both showed decreased expression ofα-SMA.Meanwhile,YAP-overexpressing CFs cultured on soft and stiff matrix both showed increased expression ofα-SMA.Blocking of AT1R decreased the expression levels ofα-SMA and YAP and thus affected the responses of CFs to matrix stiffness.To sum up,our results identified an important role of YAP in mediating matrix stiffness-induced CF differentiation and also established the YAP pathway as an important signaling branch downstream of AT1R in CF mechanotransduction.This study may help to better understand the mechanism of fibrotic mechanotransduction and inspire the development of new approaches for treating cardiac fibrosis.展开更多
This work proposes the application of an iterative learning model predictive control(ILMPC)approach based on an adaptive fault observer(FOBILMPC)for fault-tolerant control and trajectory tracking in air-breathing hype...This work proposes the application of an iterative learning model predictive control(ILMPC)approach based on an adaptive fault observer(FOBILMPC)for fault-tolerant control and trajectory tracking in air-breathing hypersonic vehicles.In order to increase the control amount,this online control legislation makes use of model predictive control(MPC)that is based on the concept of iterative learning control(ILC).By using offline data to decrease the linearized model’s faults,the strategy may effectively increase the robustness of the control system and guarantee that disturbances can be suppressed.An adaptive fault observer is created based on the suggested ILMPC approach in order to enhance overall fault tolerance by estimating and compensating for actuator disturbance and fault degree.During the derivation process,a linearized model of longitudinal dynamics is established.The suggested ILMPC approach is likely to be used in the design of hypersonic vehicle control systems since numerical simulations have demonstrated that it can decrease tracking error and speed up convergence when compared to the offline controller.展开更多
The present technical paper outlines the details of the controlled blasting techniques used to optimize blasting pattern for excavation of hard rock near the Bhira Earthen Dam in Maharashtra,India.In this connection,a...The present technical paper outlines the details of the controlled blasting techniques used to optimize blasting pattern for excavation of hard rock near the Bhira Earthen Dam in Maharashtra,India.In this connection,a series of experimental blasts were conducted by adjusting various blast design parameters at project site.The safe charge weight per delay was kept between 0.125 and 0.375 kg.The outcomes of these experimental blasts were analyzed to recommend optimized blasting patterns and methods for the overall excavation process during actual blasting operations.Blast design parameters,including the maximum quantity of explosive per delay,hole depth,burden and spacing between holes were optimized by using a site-specific attenuation equation,taking into account the proximity of the dam and tunnel from the blasting area.Peak particle velocity(PPV)level of 10 mm/s and 50 mm/s respectively were adopted as the safe vibration level for ensuring safety of the Bhira Earthen Dam and the nearby tunnel from the adverse effects of blast vibrations by analyzing the dominant frequency of ground vibrations observed and also by reviewing various international standards.Frequency of the ground vibrations observed on the dam and tunnel from majority of the blasts was found to be more than 10 Hz and 50 Hz respectively.During the entire period of blasting,the blast vibrations were recorded to be far lower than the safe vibration level set for these structures.Maximum Vibration level of about 0.8 mm/s and 35 mm/s were observed on dam and tunnel respectively which are far lower than the safe vibration level adopted for these structures.Hence,the entire excavation work was completed successfully and safely,without endangering the safety of dam or tunnel.展开更多
Metal Additive Manufacturing(MAM) technology has become an important means of rapid prototyping precision manufacturing of special high dynamic heterogeneous complex parts. In response to the micromechanical defects s...Metal Additive Manufacturing(MAM) technology has become an important means of rapid prototyping precision manufacturing of special high dynamic heterogeneous complex parts. In response to the micromechanical defects such as porosity issues, significant deformation, surface cracks, and challenging control of surface morphology encountered during the selective laser melting(SLM) additive manufacturing(AM) process of specialized Micro Electromechanical System(MEMS) components, multiparameter optimization and micro powder melt pool/macro-scale mechanical properties control simulation of specialized components are conducted. The optimal parameters obtained through highprecision preparation and machining of components and static/high dynamic verification are: laser power of 110 W, laser speed of 600 mm/s, laser diameter of 75 μm, and scanning spacing of 50 μm. The density of the subordinate components under this reference can reach 99.15%, the surface hardness can reach 51.9 HRA, the yield strength can reach 550 MPa, the maximum machining error of the components is 4.73%, and the average surface roughness is 0.45 μm. Through dynamic hammering and high dynamic firing verification, SLM components meet the requirements for overload resistance. The results have proven that MEM technology can provide a new means for the processing of MEMS components applied in high dynamic environments. The parameters obtained in the conclusion can provide a design basis for the additive preparation of MEMS components.展开更多
The graded density impactor(GDI)dynamic loading technique is crucial for acquiring the dynamic physical property parameters of materials used in weapons.The accuracy and timeliness of GDI structural design are key to ...The graded density impactor(GDI)dynamic loading technique is crucial for acquiring the dynamic physical property parameters of materials used in weapons.The accuracy and timeliness of GDI structural design are key to achieving controllable stress-strain rate loading.In this study,we have,for the first time,combined one-dimensional fluid computational software with machine learning methods.We first elucidated the mechanisms by which GDI structures control stress and strain rates.Subsequently,we constructed a machine learning model to create a structure-property response surface.The results show that altering the loading velocity and interlayer thickness has a pronounced regulatory effect on stress and strain rates.In contrast,the impedance distribution index and target thickness have less significant effects on stress regulation,although there is a matching relationship between target thickness and interlayer thickness.Compared with traditional design methods,the machine learning approach offers a10^(4)—10^(5)times increase in efficiency and the potential to achieve a global optimum,holding promise for guiding the design of GDI.展开更多
This paper presents an investigation on the target-guided coordinated control(TACC)of unmanned surface vehicles(USVs).In the scenario of tracking non-cooperative targets,the status information of the target can only b...This paper presents an investigation on the target-guided coordinated control(TACC)of unmanned surface vehicles(USVs).In the scenario of tracking non-cooperative targets,the status information of the target can only be obtained by some USVs.In order to achieve semi-encirclement tracking of noncooperative targets under maritime security conditions,a fixed-time tracking control method based on dynamic surface control(DSC)is proposed in this paper.Firstly,a novel TACC architecture with decoupled kinematic control law and decoupled kinetic control law was designed to reduce the complexity of control system design.Secondly,the proposed DSC-based target-guided kinematic control law including tracking points pre-allocation strategy and sigmoid artificial potential functions(SigAPFs)can avoid collisions during tracking process and optimize kinematic control output.Finally,a fixed-time TACC system was proposed to achieve fast convergence of kinematic and kinetics errors.The effectiveness of the proposed TACC approach in improving target tracking safety and reducing control output chattering was verified by simulation comparison results.展开更多
The liquid cooling system(LCS)of fuel cells is challenged by significant time delays,model uncertainties,pump and fan coupling,and frequent disturbances,leading to overshoot and control oscillations that degrade tempe...The liquid cooling system(LCS)of fuel cells is challenged by significant time delays,model uncertainties,pump and fan coupling,and frequent disturbances,leading to overshoot and control oscillations that degrade temperature regulation performance.To address these challenges,we propose a composite control scheme combining fuzzy logic and a variable-gain generalized supertwisting algorithm(VG-GSTA).Firstly,a one-dimensional(1D)fuzzy logic controler(FLC)for the pump ensures stable coolant flow,while a two-dimensional(2D)FLC for the fan regulates the stack temperature near the reference value.The VG-GSTA is then introduced to eliminate steady-state errors,offering resistance to disturbances and minimizing control oscillations.The equilibrium optimizer is used to fine-tune VG-GSTA parameters.Co-simulation verifies the effectiveness of our method,demonstrating its advantages in terms of disturbance immunity,overshoot suppression,tracking accuracy and response speed.展开更多
The operating environment of the diesel engine air path system is complex and may be affected by external random disturbances.Potentially leading to faults.This paper addresses the fault-tolerant control problem of th...The operating environment of the diesel engine air path system is complex and may be affected by external random disturbances.Potentially leading to faults.This paper addresses the fault-tolerant control problem of the diesel engine air path system,assuming that the system may simultaneously be affected by actuator faults and external random disturbances,a disturbance observer-based sliding mode controller is designed.Through the linear matrix inequality technique for solving observer and controller gains,optimal gain matrices can be obtained,eliminating the manual adjustment process of controller parameters and reducing the chattering phenomenon of the sliding mode surface.Finally,the effectiveness of the proposed method is verified through simulation analysis.展开更多
Projective synchronization problems of a drive system and a particular response network were investigated,where the drive system is an arbitrary system with n+1 dimensions;it may be a linear or nonlinear system,and ev...Projective synchronization problems of a drive system and a particular response network were investigated,where the drive system is an arbitrary system with n+1 dimensions;it may be a linear or nonlinear system,and even a chaotic or hyperchaotic system,the response network is complex system coupled by N nodes,and every node is showed by the approximately linear part of the drive system.Only controlling any one node of the response network by designed controller can achieve the projective synchronization.Some numerical examples were employed to verify the effectiveness and correctness of the designed controller.展开更多
Metal-organic frameworks(MOFs)represent a class of multifunctional hybrid materials distinguished by their tunable structural architectures,adjustable pore dimensions,and tailorable surface chemical functionalities,wh...Metal-organic frameworks(MOFs)represent a class of multifunctional hybrid materials distinguished by their tunable structural architectures,adjustable pore dimensions,and tailorable surface chemical functionalities,which underpin their broad applicability across diverse domains.Within the cosmetics industry,MOFs exhibit significant application potential owing to their high thermal and chemical stability,substantial loading capacity,low biological toxicity,favorable luminescent characteristics,and robust catalytic activity,leading to their increasing deployment in various cosmetic-related applications.This article systematically outlines the structural features and functional properties of MOFs,emphasizing their suitability for integration into cosmetic systems.Furthermore,it provides a comprehensive review of recent advances in the utilization of MOFs in cosmetics,encompassing the detection of organic contaminants and metal ions,ultraviolet protection,encapsulation,and controlled release of volatile active ingredients,as well as targeted delivery of dermatological therapeutic agents.The structure-property-application relationships of MOFs are critically examined.Building upon the foundation of existing research,this study offers a comprehensive outlook on the future development of MOFs in the field of cosmetics.It presents several strategic perspectives,including an in-depth analysis of current application studies,the expansion of MOFs applications into additional cosmetic domains,the integration of multifunctional MOFs systems,the development of MOFs-based composite materials,and the scale-up of synthesis processes from laboratory-scale research to industrial production.It is expected that the present piece of paper can contribute valuable guidance for further exploration and practical implementation in this emerging field of cosmetics.展开更多
The highly selective catalytic hydrogenation of halogenated nitroaromatics was achieved by employing Pd‑based catalysts that were co‑modified with organic and inorganic ligands.It was demonstrated that the catalysts c...The highly selective catalytic hydrogenation of halogenated nitroaromatics was achieved by employing Pd‑based catalysts that were co‑modified with organic and inorganic ligands.It was demonstrated that the catalysts contained Pd species in mixed valence states,with high valence Pd at the metal‑support interface and zero valence Pd at the metal surface.While the strong coordination of triphenylphosphine(PPh3)to Pd0 on the Pd surface prevents the adsorption of halogenated nitroaromatics and thus dehalogenation,the coordination of sodium metavanadate(NaVO3)to high‑valence Pd sites at the interface helps to activate H2 in a heterolytic pathway for the selective hydrogenation of nitro‑groups.The excellent catalytic performance of the interfacial active sites enables the selective hydrogenation of a wide range of halogenated nitroaromatics.展开更多
OBJECTIVE To investigate the intervention effects of tissue-bone homeostasis manipulation(TBHM)on peripatellar biomechanical parameters and knee joint function in knee osteoarthritis(KOA)patients.METHODS Sixty patient...OBJECTIVE To investigate the intervention effects of tissue-bone homeostasis manipulation(TBHM)on peripatellar biomechanical parameters and knee joint function in knee osteoarthritis(KOA)patients.METHODS Sixty patients with KOA(Kellgren-Lawrence gradeⅡ-Ⅲ)were recruited from the Acupuncture-Moxibustion Rehabilitation Department,Anhui University of Chinese Medicine between October 2024 and May 2025.Participants were randomized into a TBHM group(n=30)or a transcutaneous electrical neuromuscular stimulation(TENS)group(n=30).Using two-way repeated measures ANOVA,biomechanical indicators,including rectus femoris tension,vastus medialis tension,vastus lateralis tension,patellar ligament tension,lateral patellar displacement(LPD),medial patellar displacement(MPD),normalized patellar mobility(LPD/patellar width[PW],MPD/PW),knee flexion range of motion,and functional indicators,including KOOS subscales,time up and go test(TUGT),were compared between groups at baseline and after 6 weeks of intervention.RESULTS After intervention,all biomechanical and knee joint function indicators in the TBHM group were significantly improved(P<0.05,P<0.01),while only the vastus medialis tension,TUGT and KOOS Pain,ADL and QoL scores in the control group were significantly improved(P<0.01).The improvement amplitudes of biomechanical indicators in the TBHM group,including rectus femoris tension,vastus lateralis tension,patellar ligament tension,MPD/PW,LPD/PW and knee flexion range of motion were better than those in the control group(P<0.05,P<0.01).In the functional evaluation,the interaction effects of the TBHM group in all dimensions of the KOOS score and TUGT were statistically significant(P<0.05,P<0.01).Post-hoc simple effect analysis confirmed that there were significant differences in the above indicators between the two groups after intervention(P<0.05),and all indicators showed a significant main effect of time(P<0.01),suggesting that the intervention measures had continuous and cumulative curative effects.CONCLUSION TBHM effectively improves joint function and quality of life in KOA patients by restoring dynamic equilibrium in soft tissue tension and patellar mobility,ultimately achieving the therapeutic goal of concurrent tissue-bone management.展开更多
High-performance graphite materials have important roles in aerospace and nuclear reactor technologies because of their outstanding chemical stability and high-temperature performance.Their traditional production meth...High-performance graphite materials have important roles in aerospace and nuclear reactor technologies because of their outstanding chemical stability and high-temperature performance.Their traditional production method relies on repeated impregnation-carbonization and graphitization,and is plagued by lengthy preparation cycles and high energy consumption.Phase transition-assisted self-pressurized selfsintering technology can rapidly produce high-strength graphite materials,but the fracture strain of the graphite materials produced is poor.To solve this problem,this study used a two-step sintering method to uniformly introduce micro-nano pores into natural graphite-based bulk graphite,achieving improved fracture strain of the samples without reducing their density and mechanical properties.Using natural graphite powder,micron-diamond,and nano-diamond as raw materials,and by precisely controlling the staged pressure release process,the degree of diamond phase transition expansion was effectively regulated.The strain-to-failure of the graphite samples reached 1.2%,a 35%increase compared to samples produced by fullpressure sintering.Meanwhile,their flexural strength exceeded 110 MPa,and their density was over 1.9 g/cm^(3).The process therefore produced both a high strength and a high fracture strain.The interface evolution and toughening mechanism during the two-step sintering process were investigated.It is believed that the micro-nano pores formed have two roles:as stress concentrators they induce yielding by shear and as multi-crack propagation paths they significantly lengthen the crack propagation path.The two-step sintering phase transition strategy introduces pores and provides a new approach for increasing the fracture strain of brittle materials.展开更多
During the propagation of high-power lasers within internal channels,the laser beam heats the propagation medium,causing the thermal blooming effect that degrades the beam quality at the output.The intricate configura...During the propagation of high-power lasers within internal channels,the laser beam heats the propagation medium,causing the thermal blooming effect that degrades the beam quality at the output.The intricate configuration of the optical path within the internal channel necessitates complex and time-consuming efforts to assess the impact of thermal blooming effect on the optical path.To meet the engineering need for rapid evaluation of thermal blooming effect in optical paths,this study proposed a rapid simulation method for the thermal blooming effect in internal optical paths based on the finite element method.This method discretized the fluid region into infinitesimal elements and employed finite element method for flow field analysis.A simplified analytical model of the flow field region in complex internal channels was established,and regions with similar thermal blooming effect were divided within this model.Based on the calculated optical path differences within these regions,numerical simulations of phase distortion caused by thermal blooming were conducted.The calculated result were compared with those obtained using the existing methods.The findings reveal that for complex optical paths,the discrepancy between the two approaches is less than 3.6%,with similar phase distortion patterns observed.For L-type units,this method and the existing methods identify the same primary factors influencing aberrations and exhibit consistent trends in their variation.This method was used to analyze the impact of thermal blooming effect in a straight channel under different gravity directions.The results show that phase distortion varies with changes in the direction of gravity,and the magnitude of the phase difference is strongly correlated with the component of gravity perpendicular to the optical axis.Compared to the existing methods,this approach offers greater flexibility,obviates the need for complex custom analysis programming.The analytical results of this method enable a rapid assessment of the thermal blooming effect in optical paths within the internal channel.This is especially useful during the engineering design.These results also provide crucial references for developing strategies to suppress thermal blooming effect.展开更多
[Objective]Under the combined impact of climate change and urbanization,urban rainstorm flood disasters occur frequently,seriously restricting urban safety and sustainable development.Relying on traditional grey infra...[Objective]Under the combined impact of climate change and urbanization,urban rainstorm flood disasters occur frequently,seriously restricting urban safety and sustainable development.Relying on traditional grey infrastructure such as pipe networks for urban stormwater management is not enough to deal with urban rainstorm flood disasters under extreme rainfall events.The integration of green,grey and blue systems(GGB-integrated system)is gradually gaining recognition in the field of global flood prevention.It is necessary to further clarify the connotation,technical and engineering implementation strategies of the GGB-integrated system,to provide support for the resilient city construction.[Methods]Through literature retrieval and analysis,the relevant research and progress related to the layout optimization and joint scheduling optimization of the GGBintegrated system were systematically reviewed.In response to existing limitations and future engineering application requirements,key supporting technologies including the utilization of overground emergency storage spaces,safety protection of underground important infrastructure and multi-departmental collaboration,were proposed.A layout optimization framework and a joint scheduling framework for the GGB-integrated system were also developed.[Results]Current research on layout optimization predominantly focuses on the integration of green system and grey system,with relatively fewer studies incorporating blue system infrastructure into the optimization process.Moreover,these studies tend to be on a smaller scale with simpler scenarios,which do not fully capture the complexity of real-world systems.Additionally,optimization objective tend to prioritize environmental and economic goals,while social and ecological factors are less frequently considered.Current research on joint scheduling optimization is often limited to small-scale plots,with insufficient attention paid to the entire system.There is a deficiency in method for real-time,automated determination of optimal control strategies for combinations of multiple system facilities based on actual rainfall-runoff processes.Additionally,the application of emergency facilities during extreme conditions is not sufficiently addressed.Furthermore,both layout optimization and joint scheduling optimization lack consideration of the mute feed effect of flood and waterlogging in urban,watershed and regional scales.[Conclusion]Future research needs to improve the theoretical framework for layout optimization and joint scheduling optimization of GGB-integrated system.Through the comprehensive application of the Internet of things,artificial intelligence,coupling model development,multi-scale analysis,multi-scenario simulation,and the establishment of multi-departmental collaboration mechanisms,it can enhance the flood resilience of urban areas in response to rainfall events of varying intensities,particularly extreme rainfall events.展开更多
In order to enhance the control performance of piezo-positioning system,the influence of hysteresis characteristics and its compensation method are studied.Hammerstein model is used to represent the dynamic hysteresis...In order to enhance the control performance of piezo-positioning system,the influence of hysteresis characteristics and its compensation method are studied.Hammerstein model is used to represent the dynamic hysteresis nonlinear characteristics of piezo-positioning actuator.The static nonlinear part and dynamic linear part of the Hammerstein model are represented by models obtained through the Prandtl-Ishlinskii(PI)model and Hankel matrix system identification method,respectively.This model demonstrates good generalization capability for typical input frequencies below 200 Hz.A sliding mode inverse compensation tracking control strategy based on P-I inverse model and integral augmentation is proposed.Experimental results show that compared with PID inverse compensation control and sliding mode control without inverse compensation,the sliding mode inverse compensation control has a more ideal step response and no overshoot,moreover,the settling time is only 6.2 ms.In the frequency domain,the system closed-loop tracking bandwidth reaches 119.9 Hz,and the disturbance rejection bandwidth reaches 86.2 Hz.The proposed control strategy can effectively compensate the hysteresis nonlinearity,and improve the tracking accuracy and antidisturbance capability of piezo-positioning system.展开更多
In order to meet the urgent need of infrared search and track applications for accurate identification and positioning of infrared guidance aircraft,an active-detection mid-wave infrared search and track system(ADMWIR...In order to meet the urgent need of infrared search and track applications for accurate identification and positioning of infrared guidance aircraft,an active-detection mid-wave infrared search and track system(ADMWIRSTS)based on"cat-eye effect"was developed.The ADMWIRSTS mainly consists of both a light beam control subsystem and an infrared search and track subsystem.The light beam control subsystem uses an integrated opto-mechanical two-dimensional pointing mirror to realize the control function of the azimuth and pitch directions of the system,which can cover the whole airspace range of 360°×90°.The infrared search and track subsystem uses two mid-wave infrared cooled 640×512 focal plane detectors for co-aperture beam expanding,infrared and illumination laser beam combining,infrared search,and two-stage track opto-mechanical design.In this work,the system integration design and structural finite-element analysis were conducted,the search imaging and two-stage track imaging for external scenes were performed,and the active-detection technologies were experimentally verified in the laboratory.The experimental investigation results show that the system can realize the infrared search and track imaging,and the accurate identification and positioning of the mid-wave infrared guidance,or infrared detection system through the echo of the illumination laser.The aforementioned work has important technical significance and practical application value for the development of compactly-integrated high-precision infrared search and track,and laser suppression system,and has broad application prospects in the protection of equipment,assets and infrastructures.展开更多
When the proton exchange membrane fuel cell(PEMFC)system is running,there will be a condition that does not require power output for a short time.In order to achieve zero power output under low power consumption,it is...When the proton exchange membrane fuel cell(PEMFC)system is running,there will be a condition that does not require power output for a short time.In order to achieve zero power output under low power consumption,it is necessary to consider the diversity of control targets and the complexity of dynamic models,which brings the challenge of high-precision tracking control of the stack output power and cathode intake flow.For system idle speed control,a modelbased nonlinear control framework is constructed in this paper.Firstly,the nonlinear dynamic model of output power and cathode intake flow is derived.Secondly,a control scheme combining nonlinear extended Kalman filter observer and state feedback controller is designed.Finally,the control scheme is verified on the PEMFC experimental platform and compared with the proportion-integration-differentiation(PID)controller.The experimental results show that the control strategy proposed in this paper can realize the idle speed control of the fuel cell system and achieve the purpose of zero power output.Compared with PID controller,it has faster response speed and better system dynamics.展开更多
学报简介:《指挥与控制学报》(Journal of Command and Control)是中国指挥与控制学会会刊,由北方自动控制技术研究所和中国指挥与控制学会共同主办,2015年创刊。现为中文核心期刊、CSCD核心期刊、中国科技核心期刊、RCCSE中国权威学术...学报简介:《指挥与控制学报》(Journal of Command and Control)是中国指挥与控制学会会刊,由北方自动控制技术研究所和中国指挥与控制学会共同主办,2015年创刊。现为中文核心期刊、CSCD核心期刊、中国科技核心期刊、RCCSE中国权威学术期刊(A+)等。展开更多
基金financially supported by the National Natural Science Foundation of China ( 11872298, 11602191,11532009)the China Postdoctoral Science Foundation ( 2018M631141)+1 种基金the Natural Science Basic Research Plan in Shaanxi Province of China ( 2017JM1026)the Shaanxi Postdoctoral Science Foundation,and the Fundamental Research Funds for the Central Universities ( Z201811336)
文摘Cardiac fibrosis is a common pathway to heart injury and failure,where continued activation of cardiac fibroblasts(CFs)during myocardium damage causes excessive deposition of the extracellular matrix and thus increases matrix stiffness.Increasing evidence has shown that stiff matrix plays an important positive role in promoting CF differentiation and cardiac fibrosis,with several signaling factors medicating CF mechanotransduction already identified.However,key moleculesthat perceive matrix stiffness to regulate CF differentiation remain to be fully defined.Recently,Hippo pathway transcriptional coactivators,i.e.,Yes-associated protein(YAP)and transcriptional coactivator with PDZ-binding motif(TAZ),have been found to work as mechanical signal transductors.Importantly,it has shown that YAP plays important roles in various types of fibrosis.Despite these findings,the role of YAP in CF mechanotransduction and cardiac fibrosis still remains elusive.Moreover,several several types of GPCRs have also been found to enable cells to sense mechanical cues,however,the relationship between these GPCRs and YAP in cell mechanotransduction is still not clear.Our recent work demonstrated that blocking of angiotensin II type 1 receptor(AT1R,the first GPCRs found to be mechanosensors)with losartan significantly inhibited the differentiation of CFs to myofibroblasts induced by stiff substrate.Taken these findings into account,we speculate that YAP may work as an important downstream signaling molecule of AT1R in mediating matrix stiffness-induced CF differentiation.In this work,we first characterized the expression of YAP in normal control(NC)and myocardial infarct(Ml)tissues of rats by using immunohistochemistry,immunofluorescence and Western blot analysis.We then investigated the role of YAP in matrix stiffness-induced CF differentiation in vitro by culturing CFs on mechanically tunable gelatin hydrogels.Finally,we explored the relationship between YAP and AT1R in CF mechanotransduction by selective transfection and inhibition experiments.The expression of YAP andα-SMA in cultured CFs were evaluated with immunofluorescence staining,Western blot and real-time quantitative PCR analysis.Immunohistochemical analysis revealed that both YAP andα-SMA significantly increased in Ml tissue compared with NC tissue.The expression and nuclear localization of YAP increased in CFs cultured on stiff matrix.YAP-deficient CFs cultured on soft and stiff matrix both showed decreased expression ofα-SMA.Meanwhile,YAP-overexpressing CFs cultured on soft and stiff matrix both showed increased expression ofα-SMA.Blocking of AT1R decreased the expression levels ofα-SMA and YAP and thus affected the responses of CFs to matrix stiffness.To sum up,our results identified an important role of YAP in mediating matrix stiffness-induced CF differentiation and also established the YAP pathway as an important signaling branch downstream of AT1R in CF mechanotransduction.This study may help to better understand the mechanism of fibrotic mechanotransduction and inspire the development of new approaches for treating cardiac fibrosis.
基金supported by the National Natural Science Foundation of China(12072090).
文摘This work proposes the application of an iterative learning model predictive control(ILMPC)approach based on an adaptive fault observer(FOBILMPC)for fault-tolerant control and trajectory tracking in air-breathing hypersonic vehicles.In order to increase the control amount,this online control legislation makes use of model predictive control(MPC)that is based on the concept of iterative learning control(ILC).By using offline data to decrease the linearized model’s faults,the strategy may effectively increase the robustness of the control system and guarantee that disturbances can be suppressed.An adaptive fault observer is created based on the suggested ILMPC approach in order to enhance overall fault tolerance by estimating and compensating for actuator disturbance and fault degree.During the derivation process,a linearized model of longitudinal dynamics is established.The suggested ILMPC approach is likely to be used in the design of hypersonic vehicle control systems since numerical simulations have demonstrated that it can decrease tracking error and speed up convergence when compared to the offline controller.
文摘The present technical paper outlines the details of the controlled blasting techniques used to optimize blasting pattern for excavation of hard rock near the Bhira Earthen Dam in Maharashtra,India.In this connection,a series of experimental blasts were conducted by adjusting various blast design parameters at project site.The safe charge weight per delay was kept between 0.125 and 0.375 kg.The outcomes of these experimental blasts were analyzed to recommend optimized blasting patterns and methods for the overall excavation process during actual blasting operations.Blast design parameters,including the maximum quantity of explosive per delay,hole depth,burden and spacing between holes were optimized by using a site-specific attenuation equation,taking into account the proximity of the dam and tunnel from the blasting area.Peak particle velocity(PPV)level of 10 mm/s and 50 mm/s respectively were adopted as the safe vibration level for ensuring safety of the Bhira Earthen Dam and the nearby tunnel from the adverse effects of blast vibrations by analyzing the dominant frequency of ground vibrations observed and also by reviewing various international standards.Frequency of the ground vibrations observed on the dam and tunnel from majority of the blasts was found to be more than 10 Hz and 50 Hz respectively.During the entire period of blasting,the blast vibrations were recorded to be far lower than the safe vibration level set for these structures.Maximum Vibration level of about 0.8 mm/s and 35 mm/s were observed on dam and tunnel respectively which are far lower than the safe vibration level adopted for these structures.Hence,the entire excavation work was completed successfully and safely,without endangering the safety of dam or tunnel.
基金funded by the National Natural Science Foundation of China Youth Fund(Grant No.62304022)Science and Technology on Electromechanical Dynamic Control Laboratory(China,Grant No.6142601012304)the 2022e2024 China Association for Science and Technology Innovation Integration Association Youth Talent Support Project(Grant No.2022QNRC001).
文摘Metal Additive Manufacturing(MAM) technology has become an important means of rapid prototyping precision manufacturing of special high dynamic heterogeneous complex parts. In response to the micromechanical defects such as porosity issues, significant deformation, surface cracks, and challenging control of surface morphology encountered during the selective laser melting(SLM) additive manufacturing(AM) process of specialized Micro Electromechanical System(MEMS) components, multiparameter optimization and micro powder melt pool/macro-scale mechanical properties control simulation of specialized components are conducted. The optimal parameters obtained through highprecision preparation and machining of components and static/high dynamic verification are: laser power of 110 W, laser speed of 600 mm/s, laser diameter of 75 μm, and scanning spacing of 50 μm. The density of the subordinate components under this reference can reach 99.15%, the surface hardness can reach 51.9 HRA, the yield strength can reach 550 MPa, the maximum machining error of the components is 4.73%, and the average surface roughness is 0.45 μm. Through dynamic hammering and high dynamic firing verification, SLM components meet the requirements for overload resistance. The results have proven that MEM technology can provide a new means for the processing of MEMS components applied in high dynamic environments. The parameters obtained in the conclusion can provide a design basis for the additive preparation of MEMS components.
基金supported by the Guangdong Major Project of Basic and Applied Basic Research(Grant No.2021B0301030001)the National Key Research and Development Program of China(Grant No.2021YFB3802300)the Foundation of National Key Laboratory of Shock Wave and Detonation Physics(Grant No.JCKYS2022212004)。
文摘The graded density impactor(GDI)dynamic loading technique is crucial for acquiring the dynamic physical property parameters of materials used in weapons.The accuracy and timeliness of GDI structural design are key to achieving controllable stress-strain rate loading.In this study,we have,for the first time,combined one-dimensional fluid computational software with machine learning methods.We first elucidated the mechanisms by which GDI structures control stress and strain rates.Subsequently,we constructed a machine learning model to create a structure-property response surface.The results show that altering the loading velocity and interlayer thickness has a pronounced regulatory effect on stress and strain rates.In contrast,the impedance distribution index and target thickness have less significant effects on stress regulation,although there is a matching relationship between target thickness and interlayer thickness.Compared with traditional design methods,the machine learning approach offers a10^(4)—10^(5)times increase in efficiency and the potential to achieve a global optimum,holding promise for guiding the design of GDI.
文摘This paper presents an investigation on the target-guided coordinated control(TACC)of unmanned surface vehicles(USVs).In the scenario of tracking non-cooperative targets,the status information of the target can only be obtained by some USVs.In order to achieve semi-encirclement tracking of noncooperative targets under maritime security conditions,a fixed-time tracking control method based on dynamic surface control(DSC)is proposed in this paper.Firstly,a novel TACC architecture with decoupled kinematic control law and decoupled kinetic control law was designed to reduce the complexity of control system design.Secondly,the proposed DSC-based target-guided kinematic control law including tracking points pre-allocation strategy and sigmoid artificial potential functions(SigAPFs)can avoid collisions during tracking process and optimize kinematic control output.Finally,a fixed-time TACC system was proposed to achieve fast convergence of kinematic and kinetics errors.The effectiveness of the proposed TACC approach in improving target tracking safety and reducing control output chattering was verified by simulation comparison results.
基金Supported by the Major Science and Technology Project of Jilin Province(20220301010GX)the International Scientific and Technological Cooperation(20240402071GH).
文摘The liquid cooling system(LCS)of fuel cells is challenged by significant time delays,model uncertainties,pump and fan coupling,and frequent disturbances,leading to overshoot and control oscillations that degrade temperature regulation performance.To address these challenges,we propose a composite control scheme combining fuzzy logic and a variable-gain generalized supertwisting algorithm(VG-GSTA).Firstly,a one-dimensional(1D)fuzzy logic controler(FLC)for the pump ensures stable coolant flow,while a two-dimensional(2D)FLC for the fan regulates the stack temperature near the reference value.The VG-GSTA is then introduced to eliminate steady-state errors,offering resistance to disturbances and minimizing control oscillations.The equilibrium optimizer is used to fine-tune VG-GSTA parameters.Co-simulation verifies the effectiveness of our method,demonstrating its advantages in terms of disturbance immunity,overshoot suppression,tracking accuracy and response speed.
基金Supported by the National Key R&D Program of China(2021YFB2011300)the National Natural Science Foundation of China(52275044,52205299)+1 种基金the Zhejiang Provincial Natural Science Foundation of China(Z23E050032)the China Postdoctoral Science Foundation(2022M710304).
文摘The operating environment of the diesel engine air path system is complex and may be affected by external random disturbances.Potentially leading to faults.This paper addresses the fault-tolerant control problem of the diesel engine air path system,assuming that the system may simultaneously be affected by actuator faults and external random disturbances,a disturbance observer-based sliding mode controller is designed.Through the linear matrix inequality technique for solving observer and controller gains,optimal gain matrices can be obtained,eliminating the manual adjustment process of controller parameters and reducing the chattering phenomenon of the sliding mode surface.Finally,the effectiveness of the proposed method is verified through simulation analysis.
基金Supported by the National Natural Science Foundation of China (11161027)。
文摘Projective synchronization problems of a drive system and a particular response network were investigated,where the drive system is an arbitrary system with n+1 dimensions;it may be a linear or nonlinear system,and even a chaotic or hyperchaotic system,the response network is complex system coupled by N nodes,and every node is showed by the approximately linear part of the drive system.Only controlling any one node of the response network by designed controller can achieve the projective synchronization.Some numerical examples were employed to verify the effectiveness and correctness of the designed controller.
文摘Metal-organic frameworks(MOFs)represent a class of multifunctional hybrid materials distinguished by their tunable structural architectures,adjustable pore dimensions,and tailorable surface chemical functionalities,which underpin their broad applicability across diverse domains.Within the cosmetics industry,MOFs exhibit significant application potential owing to their high thermal and chemical stability,substantial loading capacity,low biological toxicity,favorable luminescent characteristics,and robust catalytic activity,leading to their increasing deployment in various cosmetic-related applications.This article systematically outlines the structural features and functional properties of MOFs,emphasizing their suitability for integration into cosmetic systems.Furthermore,it provides a comprehensive review of recent advances in the utilization of MOFs in cosmetics,encompassing the detection of organic contaminants and metal ions,ultraviolet protection,encapsulation,and controlled release of volatile active ingredients,as well as targeted delivery of dermatological therapeutic agents.The structure-property-application relationships of MOFs are critically examined.Building upon the foundation of existing research,this study offers a comprehensive outlook on the future development of MOFs in the field of cosmetics.It presents several strategic perspectives,including an in-depth analysis of current application studies,the expansion of MOFs applications into additional cosmetic domains,the integration of multifunctional MOFs systems,the development of MOFs-based composite materials,and the scale-up of synthesis processes from laboratory-scale research to industrial production.It is expected that the present piece of paper can contribute valuable guidance for further exploration and practical implementation in this emerging field of cosmetics.
文摘The highly selective catalytic hydrogenation of halogenated nitroaromatics was achieved by employing Pd‑based catalysts that were co‑modified with organic and inorganic ligands.It was demonstrated that the catalysts contained Pd species in mixed valence states,with high valence Pd at the metal‑support interface and zero valence Pd at the metal surface.While the strong coordination of triphenylphosphine(PPh3)to Pd0 on the Pd surface prevents the adsorption of halogenated nitroaromatics and thus dehalogenation,the coordination of sodium metavanadate(NaVO3)to high‑valence Pd sites at the interface helps to activate H2 in a heterolytic pathway for the selective hydrogenation of nitro‑groups.The excellent catalytic performance of the interfacial active sites enables the selective hydrogenation of a wide range of halogenated nitroaromatics.
文摘OBJECTIVE To investigate the intervention effects of tissue-bone homeostasis manipulation(TBHM)on peripatellar biomechanical parameters and knee joint function in knee osteoarthritis(KOA)patients.METHODS Sixty patients with KOA(Kellgren-Lawrence gradeⅡ-Ⅲ)were recruited from the Acupuncture-Moxibustion Rehabilitation Department,Anhui University of Chinese Medicine between October 2024 and May 2025.Participants were randomized into a TBHM group(n=30)or a transcutaneous electrical neuromuscular stimulation(TENS)group(n=30).Using two-way repeated measures ANOVA,biomechanical indicators,including rectus femoris tension,vastus medialis tension,vastus lateralis tension,patellar ligament tension,lateral patellar displacement(LPD),medial patellar displacement(MPD),normalized patellar mobility(LPD/patellar width[PW],MPD/PW),knee flexion range of motion,and functional indicators,including KOOS subscales,time up and go test(TUGT),were compared between groups at baseline and after 6 weeks of intervention.RESULTS After intervention,all biomechanical and knee joint function indicators in the TBHM group were significantly improved(P<0.05,P<0.01),while only the vastus medialis tension,TUGT and KOOS Pain,ADL and QoL scores in the control group were significantly improved(P<0.01).The improvement amplitudes of biomechanical indicators in the TBHM group,including rectus femoris tension,vastus lateralis tension,patellar ligament tension,MPD/PW,LPD/PW and knee flexion range of motion were better than those in the control group(P<0.05,P<0.01).In the functional evaluation,the interaction effects of the TBHM group in all dimensions of the KOOS score and TUGT were statistically significant(P<0.05,P<0.01).Post-hoc simple effect analysis confirmed that there were significant differences in the above indicators between the two groups after intervention(P<0.05),and all indicators showed a significant main effect of time(P<0.01),suggesting that the intervention measures had continuous and cumulative curative effects.CONCLUSION TBHM effectively improves joint function and quality of life in KOA patients by restoring dynamic equilibrium in soft tissue tension and patellar mobility,ultimately achieving the therapeutic goal of concurrent tissue-bone management.
基金Natural Science Foundation of Shanghai(24ZR1400800)he Natural Science Foundation of China(U23A20685,52073058,91963204)+1 种基金the National Key R&D Program of China(2021YFB3701400)Shanghai Sailing Program(23YF1400200)。
文摘High-performance graphite materials have important roles in aerospace and nuclear reactor technologies because of their outstanding chemical stability and high-temperature performance.Their traditional production method relies on repeated impregnation-carbonization and graphitization,and is plagued by lengthy preparation cycles and high energy consumption.Phase transition-assisted self-pressurized selfsintering technology can rapidly produce high-strength graphite materials,but the fracture strain of the graphite materials produced is poor.To solve this problem,this study used a two-step sintering method to uniformly introduce micro-nano pores into natural graphite-based bulk graphite,achieving improved fracture strain of the samples without reducing their density and mechanical properties.Using natural graphite powder,micron-diamond,and nano-diamond as raw materials,and by precisely controlling the staged pressure release process,the degree of diamond phase transition expansion was effectively regulated.The strain-to-failure of the graphite samples reached 1.2%,a 35%increase compared to samples produced by fullpressure sintering.Meanwhile,their flexural strength exceeded 110 MPa,and their density was over 1.9 g/cm^(3).The process therefore produced both a high strength and a high fracture strain.The interface evolution and toughening mechanism during the two-step sintering process were investigated.It is believed that the micro-nano pores formed have two roles:as stress concentrators they induce yielding by shear and as multi-crack propagation paths they significantly lengthen the crack propagation path.The two-step sintering phase transition strategy introduces pores and provides a new approach for increasing the fracture strain of brittle materials.
文摘During the propagation of high-power lasers within internal channels,the laser beam heats the propagation medium,causing the thermal blooming effect that degrades the beam quality at the output.The intricate configuration of the optical path within the internal channel necessitates complex and time-consuming efforts to assess the impact of thermal blooming effect on the optical path.To meet the engineering need for rapid evaluation of thermal blooming effect in optical paths,this study proposed a rapid simulation method for the thermal blooming effect in internal optical paths based on the finite element method.This method discretized the fluid region into infinitesimal elements and employed finite element method for flow field analysis.A simplified analytical model of the flow field region in complex internal channels was established,and regions with similar thermal blooming effect were divided within this model.Based on the calculated optical path differences within these regions,numerical simulations of phase distortion caused by thermal blooming were conducted.The calculated result were compared with those obtained using the existing methods.The findings reveal that for complex optical paths,the discrepancy between the two approaches is less than 3.6%,with similar phase distortion patterns observed.For L-type units,this method and the existing methods identify the same primary factors influencing aberrations and exhibit consistent trends in their variation.This method was used to analyze the impact of thermal blooming effect in a straight channel under different gravity directions.The results show that phase distortion varies with changes in the direction of gravity,and the magnitude of the phase difference is strongly correlated with the component of gravity perpendicular to the optical axis.Compared to the existing methods,this approach offers greater flexibility,obviates the need for complex custom analysis programming.The analytical results of this method enable a rapid assessment of the thermal blooming effect in optical paths within the internal channel.This is especially useful during the engineering design.These results also provide crucial references for developing strategies to suppress thermal blooming effect.
文摘[Objective]Under the combined impact of climate change and urbanization,urban rainstorm flood disasters occur frequently,seriously restricting urban safety and sustainable development.Relying on traditional grey infrastructure such as pipe networks for urban stormwater management is not enough to deal with urban rainstorm flood disasters under extreme rainfall events.The integration of green,grey and blue systems(GGB-integrated system)is gradually gaining recognition in the field of global flood prevention.It is necessary to further clarify the connotation,technical and engineering implementation strategies of the GGB-integrated system,to provide support for the resilient city construction.[Methods]Through literature retrieval and analysis,the relevant research and progress related to the layout optimization and joint scheduling optimization of the GGBintegrated system were systematically reviewed.In response to existing limitations and future engineering application requirements,key supporting technologies including the utilization of overground emergency storage spaces,safety protection of underground important infrastructure and multi-departmental collaboration,were proposed.A layout optimization framework and a joint scheduling framework for the GGB-integrated system were also developed.[Results]Current research on layout optimization predominantly focuses on the integration of green system and grey system,with relatively fewer studies incorporating blue system infrastructure into the optimization process.Moreover,these studies tend to be on a smaller scale with simpler scenarios,which do not fully capture the complexity of real-world systems.Additionally,optimization objective tend to prioritize environmental and economic goals,while social and ecological factors are less frequently considered.Current research on joint scheduling optimization is often limited to small-scale plots,with insufficient attention paid to the entire system.There is a deficiency in method for real-time,automated determination of optimal control strategies for combinations of multiple system facilities based on actual rainfall-runoff processes.Additionally,the application of emergency facilities during extreme conditions is not sufficiently addressed.Furthermore,both layout optimization and joint scheduling optimization lack consideration of the mute feed effect of flood and waterlogging in urban,watershed and regional scales.[Conclusion]Future research needs to improve the theoretical framework for layout optimization and joint scheduling optimization of GGB-integrated system.Through the comprehensive application of the Internet of things,artificial intelligence,coupling model development,multi-scale analysis,multi-scenario simulation,and the establishment of multi-departmental collaboration mechanisms,it can enhance the flood resilience of urban areas in response to rainfall events of varying intensities,particularly extreme rainfall events.
文摘In order to enhance the control performance of piezo-positioning system,the influence of hysteresis characteristics and its compensation method are studied.Hammerstein model is used to represent the dynamic hysteresis nonlinear characteristics of piezo-positioning actuator.The static nonlinear part and dynamic linear part of the Hammerstein model are represented by models obtained through the Prandtl-Ishlinskii(PI)model and Hankel matrix system identification method,respectively.This model demonstrates good generalization capability for typical input frequencies below 200 Hz.A sliding mode inverse compensation tracking control strategy based on P-I inverse model and integral augmentation is proposed.Experimental results show that compared with PID inverse compensation control and sliding mode control without inverse compensation,the sliding mode inverse compensation control has a more ideal step response and no overshoot,moreover,the settling time is only 6.2 ms.In the frequency domain,the system closed-loop tracking bandwidth reaches 119.9 Hz,and the disturbance rejection bandwidth reaches 86.2 Hz.The proposed control strategy can effectively compensate the hysteresis nonlinearity,and improve the tracking accuracy and antidisturbance capability of piezo-positioning system.
基金Supported by the Fundamental Scientific Research Plan of China(JCKY2021130B033)。
文摘In order to meet the urgent need of infrared search and track applications for accurate identification and positioning of infrared guidance aircraft,an active-detection mid-wave infrared search and track system(ADMWIRSTS)based on"cat-eye effect"was developed.The ADMWIRSTS mainly consists of both a light beam control subsystem and an infrared search and track subsystem.The light beam control subsystem uses an integrated opto-mechanical two-dimensional pointing mirror to realize the control function of the azimuth and pitch directions of the system,which can cover the whole airspace range of 360°×90°.The infrared search and track subsystem uses two mid-wave infrared cooled 640×512 focal plane detectors for co-aperture beam expanding,infrared and illumination laser beam combining,infrared search,and two-stage track opto-mechanical design.In this work,the system integration design and structural finite-element analysis were conducted,the search imaging and two-stage track imaging for external scenes were performed,and the active-detection technologies were experimentally verified in the laboratory.The experimental investigation results show that the system can realize the infrared search and track imaging,and the accurate identification and positioning of the mid-wave infrared guidance,or infrared detection system through the echo of the illumination laser.The aforementioned work has important technical significance and practical application value for the development of compactly-integrated high-precision infrared search and track,and laser suppression system,and has broad application prospects in the protection of equipment,assets and infrastructures.
基金Supported by the Major Science and Technology Projects in Jilin Province and Changchun City(20220301010GX).
文摘When the proton exchange membrane fuel cell(PEMFC)system is running,there will be a condition that does not require power output for a short time.In order to achieve zero power output under low power consumption,it is necessary to consider the diversity of control targets and the complexity of dynamic models,which brings the challenge of high-precision tracking control of the stack output power and cathode intake flow.For system idle speed control,a modelbased nonlinear control framework is constructed in this paper.Firstly,the nonlinear dynamic model of output power and cathode intake flow is derived.Secondly,a control scheme combining nonlinear extended Kalman filter observer and state feedback controller is designed.Finally,the control scheme is verified on the PEMFC experimental platform and compared with the proportion-integration-differentiation(PID)controller.The experimental results show that the control strategy proposed in this paper can realize the idle speed control of the fuel cell system and achieve the purpose of zero power output.Compared with PID controller,it has faster response speed and better system dynamics.
