In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can e...In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can enhance the performance of real-time concurrency control mechanism by reducing the number of transactions that might miss their deadlines, and compare the performance of validation concurrency control protocol with that of HP2PL(High priority two phase locking) protocol and OCC-TI-WAIT-50(Optimistic concurrency control-time interval-wait-50) protocol under shared-disk architecture by simulation. The simulation results reveal that the protocol the author presented can effectively reduce the number of transactions restarting which might miss their deadlines and performs better than HP2PL and OCC-TI-WAIT-50. It works well when arrival rate of transaction is lesser than threshold. However, due to resource contention the percentage of missing deadline increases sharply when arrival rate is greater than the threshold.展开更多
近似串匹配技术在网络信息搜索、数字图书馆、模式识别、文本挖掘、IP路由查找、网络入侵检测、生物信息学、音乐研究计算等领域具有广泛的应用.基于CREW-PRAM(parallel random access machine with concurrent read and exclusive wri...近似串匹配技术在网络信息搜索、数字图书馆、模式识别、文本挖掘、IP路由查找、网络入侵检测、生物信息学、音乐研究计算等领域具有广泛的应用.基于CREW-PRAM(parallel random access machine with concurrent read and exclusive write)模型,采用波前式并行推进的方法直接计算编辑距离矩阵D,设计了一个允许k-差别的近似串匹配动态规划并行算法,该算法使用(m+1)个处理器,时间复杂度为O(n),算法理论上达到线性加速;采取水平和斜向双并行计算编辑距离矩阵D的方法,设计了一个使用a(m+1)个处理器和O(n/a+m)时间的、可伸缩的、允许k-差别的近似串匹配动态规划并行算法,+<11mna.基于分治策略,通过灵活拆分总线和合并子总线动态重构光总线系统,并充分利用光总线的消息播送技术和并行计算前缀和的方法,实现了汉明距离的并行计算,设计了两个基于LARPBS(linear arrays with reconfigurable pipelined bus system)模型的通信高效、可扩放的允许k-误配的近似串匹配并行算法,其中一个算法使用n个处理器,时间为O(m);另一个为常数时间算法,使用mn个处理器.展开更多
A DMVOCC-MVDA （distributed multiversion optimistic concurrency control with multiversion dynamic adjustment） protocol was presented to process mobile distributed real-time transaction in mobile broadcast environment...A DMVOCC-MVDA （distributed multiversion optimistic concurrency control with multiversion dynamic adjustment） protocol was presented to process mobile distributed real-time transaction in mobile broadcast environments. At the mobile hosts, all transactions perform local pre-validation. The local pre-validation process is carried out against the committed transactions at the server in the last broadcast cycle. Transactions that survive in local pre-validation must be submitted to the server for local final validation. The new protocol eliminates conflicts between mobile read-only and mobile update transactions, and resolves data conflicts flexibly by using multiversion dynamic adjustment of serialization order to avoid unnecessary restarts of transactions. Mobile read-only transactions can be committed with no-blocking, and respond time of mobile read-only transactions is greatly shortened. The tolerance of mobile transactions of disconnections from the broadcast channel is increased. In global validation mobile distributed transactions have to do check to ensure distributed serializability in all participants. The simulation results show that the new concurrency control protocol proposed offers better performance than other protocols in terms of miss rate, restart rate, commit rate. Under high work load （think time is ls） the miss rate of DMVOCC-MVDA is only 14.6%, is significantly lower than that of other protocols. The restart rate of DMVOCC-MVDA is only 32.3%, showing that DMVOCC-MVDA can effectively reduce the restart rate of mobile transactions. And the commit rate of DMVOCC-MVDA is up to 61.2%, which is obviously higher than that of other protocols.展开更多
This paper introduces a multi-granularity locking model (MGL) for concurrency control in object-oriented database system briefiy, and presents a MGL model formally. Four lockingscheduling algorithms for MGL are propos...This paper introduces a multi-granularity locking model (MGL) for concurrency control in object-oriented database system briefiy, and presents a MGL model formally. Four lockingscheduling algorithms for MGL are proposed in the paper. The ideas of single queue scheduling(SQS) and dual queue scheduling (DQS) are proposed and the algorithm and the performance evaluation for these two scheduling are presented in some paper. This paper describes a new idea of thescheduling for MGL, compatible requests first (CRF). Combining the new idea with SQS and DQS,we propose two new scheduling algorithms called CRFS and CRFD. After describing the simulationmodel, this paper illustrates the comparisons of the performance among these four algorithms. Asshown in the experiments, DQS has better performance than SQS, CRFD is better than DQS, CRFSperforms better than SQS, and CRFS is the best one of these four scheduling algorithms.展开更多
The high precision assemblies with considerable radial interference should be accompanied by heating and cooling processes.However,the mechanical properties of metals are greatly affected by thermal operations.So,for ...The high precision assemblies with considerable radial interference should be accompanied by heating and cooling processes.However,the mechanical properties of metals are greatly affected by thermal operations.So,for evaluating the stress distribution and distortion of teeth profiles in a gear/shaft assembly,a transient thermal analysis is necessary for finding the change in mechanical properties.The friction on the contact surface is another important parameter in interaction of the gear with the shaft.Evaluating the gear stress and deformation fields for several modes of heat transfer and friction coefficients showed that the maximum radial or tangential stresses on contact surface of the joint may have more than 8%increase by increasing friction coefficient;while the intensity of heat transfer at cooling stage has lower effect on stress distribution.展开更多
Building a cloud geodatabase for a sponge city is crucial to integrate the geospatial information dispersed in various departments for multi-user high concurrent access and retrieval,high scalability and availability,...Building a cloud geodatabase for a sponge city is crucial to integrate the geospatial information dispersed in various departments for multi-user high concurrent access and retrieval,high scalability and availability,efficient storage and management.In this study,Hadoop distributed computing framework,including Hadoop distributed file system and MapReduce(mapper and reducer),is firstly designed with a parallel computing framework to process massive spatial data.Then,access control with a series of standard application programming interfaces for different functions is designed,including spatial data storage layer,cloud geodatabase access layer,spatial data access layer and spatial data analysis layer.Subsequently,a retrieval model is designed,including direct addressing via file name,three-level concurrent retrieval and block data retrieval strategies.Main functions are realised,including real-time concurrent access,high-performance computing,communication,massive data storage,efficient retrieval and scheduling decisions on the multi-scale,multi-source and massive spatial data.Finally,the performance of Hadoop cloud geodatabases is validated and compared with that of the Oracle database.The cloud geodatabase for the sponge city can avoid redundant configuration of personnel,hardware and software,support the data transfer,model debugging and application development,and provide accurate,real-time,virtual,intelligent,reliable,elastically scalable,dynamic and on-demand cloud services of the basic and thematic geographic information for the construction and management of the sponge city.展开更多
Background and objective Recent studies have showed that combination of chemotherapy and radiotherapy might result in better outcome for locally advanced non-small cell lung cancer (NSCLC). The aim of this study is to...Background and objective Recent studies have showed that combination of chemotherapy and radiotherapy might result in better outcome for locally advanced non-small cell lung cancer (NSCLC). The aim of this study is to determine the maximal tolerance dose (MTD) and efficacy of full-dose gemcitabine and oxaliplatin when given concurrently with 3-dimentional radiation therapy (3D-RT) for locally advanced NSCLC. Methods Oxaliplatin was administered at a fixed dose of 130mg/m^2, and gemcitabine was administered at a starting dose of 800mg/m^2 with an incremental dose gradient of 200mg/m^2 for 3 dose levels. MTD was defined as the immediate dose level lower than the dose at which dose-limiting toxicity (DLT) occurred in more than one-third of the patients. The chemotherapy was administered at 3-week cycle. The RT was given as 3-D conformal manner at a single daily dose of 2Gy for 5 days per week. Results Twenty-two patients were evaluable and distributed to three different dose levels: 6 at level 1, 8 at level 2 and 8 at level 3. Pulmonary toxicity, esophageal and hematologic toxicity were the main DLT. Grade Ⅲ acute pulmonary toxicity occurred in one patient each at level 2 and level 3, both with V20>20%, and grade Ⅲ esophagitis in two patients at level 3. The MTD of gemcitabine in this study was 1000mg/m^2. The overall response rate was 75.0% (9/12). The 1- and 2-year survival rate was 70.0% and 30.5% respectively. The median time to progression was 8.7 months (range 5--11.8 months). Conclusion With reduced radiation volume, gemcitabine of 1000mg/m^2 in combination with oxaliplatin of 130mg/m^2 was effective and could be safely administered for NSCLC.展开更多
The paper proposes a decentralized concurrent transmission strategy in shared channels based on an incomplete information game in Ad Hoc networks.Based on the nodal channel quality,the game can work out a channel gain...The paper proposes a decentralized concurrent transmission strategy in shared channels based on an incomplete information game in Ad Hoc networks.Based on the nodal channel quality,the game can work out a channel gain threshold,which decides the candidates for taking part in the concurrent transmission.The utility formula is made for maximizing the overall throughput based on channel quality variation.For an achievable Bayesian Nash equilibrium（BNE） solution,this paper further prices the selfish players in utility functions for attempting to improve the channel gain one-sidedly.Accordingly,this game allows each node to distributedly decide whether to transmit concurrently with others depending on the Nash equilibrium（NE）.Besides,to make the proposed game practical,this paper next presents an efficient particle swarm optimization（PSO） model to fasten the otherwise very slow convergence procedure due to the large computational complexity.Numerical results show the proposed approach is feasible to increase concurrent transmission opportunities for active nodes and the convergence can be swiftly obtained with a few of iteration times by the proposed PSO algorithm.展开更多
Osteoporosis and osteopenia are major health issues that mainly affect elderly people,women after menopause and immobilized patients.Our previous studies have proved that sclerostin antibody(Scl-Ab)can dramatically en...Osteoporosis and osteopenia are major health issues that mainly affect elderly people,women after menopause and immobilized patients.Our previous studies have proved that sclerostin antibody(Scl-Ab)can dramatically enhance bone formation and reduce bone resorption in a severe osteoporosis rat model with the combination of ovariectomy(OVX)and hindlimb immobilization(HLS).However,the mechanism in the cellular level is unclear.The objective of this study is to assess the effect of Scl-Ab on osteocytic morphology change in a combined OVX and HLS rat model via quantification of long-and short-axis and the ratio and osteocyte volume in midshaft cortical bone.Four-month-old virgin female SD rats were divided into 7 groups(n=11 per group):Sham+Veh,Sham+HLS+Veh,Sham+HLS+Scl-Ab,OVX+Veh,OVX+Scl-Ab,OVX+HLS+Veh,OVX+HLS+Scl-Ab.HLS was performed 2 weeks after sham or OVX surgery;and treatment was initiated at the time of HLS.Scl-Ab(25 mg/kg)or vehicle was subcutaneously injected twice per week for 5 weeks.Femurs were harvested at the end of study and embedded in PMMA and polished for SEM imaging.Cortical bone mid shaft osteocyte number per bone area was quantified under 1K magnification;the ratios between long axis and short axis of osteocytes were quantified under 2K magnification;osteocyte dendrite number and surface area were quantified under 5K magnification.Osteocyte dendrites width was quantified using 10K magnification.All the quantification was done by ImageJ.We have reported that multiple morphological and structural changes in osteocytes,including a decreased osteocyte density and reduced osteocyte dendrite number in HLS,OVX or the combination group and Scl-Ab’s ability to abolish these unfavorable alterations.We continued our SEM analysis on osteocytes and discovered that the oval shape of osteocyte under HLS,OVX or HLS+OVX has been distorted toward a spindle-like shape,with relatively longer long axis and shorter short axis,assuming osteocyte has a perfect spheroid shape.The ratio between long-and short-axis showed an increased trend in OVX and HLS condition,but Scl-Ab inhibited these increases(P<0.001,P<0.01,respectively).The volume decreased in HLS,OVX group,but Scl-Ab maintained osteocytes’volume in HLS condition(P<0.001).It indicates that cortical bone responds to HLS and/or OVX and Scl-Ab treatment via multiple cellular mechanisms,including density of osteocyte,dendrite number and osteocyte shape.The change of osteocyte shape may imply an altered cytoskeleton system within osteocyte and a subsequent disruption of mechanosensing ability for osteocyte,which lead to bone loss macroscopically.These data suggest Scl-Ab’s therapeutic potential could be related with its ability to maintain osteocyte’s morphologic and structural changes induced by OVX,HLS or both.展开更多
We conducted this study to determine if marker-assisted mass recurrent selection for fiberstrength and resistance to Helicoverpa armigerawithin an upland cotton complex populationcould he more efficient than conventio...We conducted this study to determine if marker-assisted mass recurrent selection for fiberstrength and resistance to Helicoverpa armigerawithin an upland cotton complex populationcould he more efficient than conventionalphenotype selection.Two cycles of marker-assisted selection,phenotypic selection,andmarker and phenotype concurrent selection,展开更多
Military petroleum equipment, as the special device a nd tool for petroleum storage, transportation, filling, chemical analysis, detec tion and maintenance for the army, is an important means and basis of petroleum in...Military petroleum equipment, as the special device a nd tool for petroleum storage, transportation, filling, chemical analysis, detec tion and maintenance for the army, is an important means and basis of petroleum indemnificatory. To adapt to modern war in high-tech conditions, the petroleum equipment have to develop towards higher reliability, adaptability, maneuverabil ity, standardization, container and cell type with versatile multi-functions. As a new design theory and design process, concurrent engineering may prod uce remarkable benefit when applying to product development. With the aid of the state-of-the-art modeling and simulation technology, it foresees the future or even the whole life cycle of the products designed. Based on wide statistics and survey, the product design period is reduced by 1/2～1/3 with concurrent des i gn process. The application of concurrent design process in new petroleum equi pment development shall greatly accelerate the petroleum equipment updating an d promote their indemnificatory.展开更多
This paper studies the scheduling of design projects in concurrent development process with uncertain number of feedback revisions. An optimization based methodology that combines heuristic algorithm, artificial intel...This paper studies the scheduling of design projects in concurrent development process with uncertain number of feedback revisions. An optimization based methodology that combines heuristic algorithm, artificial intelligence (fuzzy, genetic algorithm) and scheduling theory is developed. In the algorithm, weighting values of some key factors are defined by genetic algorithm. In addition, fuzzy logic is used to decide the ability coefficients of different roles taken by designers. Moreover, the process of pre-release and feedback revision is realized. Simulation example is a fraction of practical development project, and satisfied results are obtained.展开更多
文摘In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can enhance the performance of real-time concurrency control mechanism by reducing the number of transactions that might miss their deadlines, and compare the performance of validation concurrency control protocol with that of HP2PL(High priority two phase locking) protocol and OCC-TI-WAIT-50(Optimistic concurrency control-time interval-wait-50) protocol under shared-disk architecture by simulation. The simulation results reveal that the protocol the author presented can effectively reduce the number of transactions restarting which might miss their deadlines and performs better than HP2PL and OCC-TI-WAIT-50. It works well when arrival rate of transaction is lesser than threshold. However, due to resource contention the percentage of missing deadline increases sharply when arrival rate is greater than the threshold.
文摘近似串匹配技术在网络信息搜索、数字图书馆、模式识别、文本挖掘、IP路由查找、网络入侵检测、生物信息学、音乐研究计算等领域具有广泛的应用.基于CREW-PRAM(parallel random access machine with concurrent read and exclusive write)模型,采用波前式并行推进的方法直接计算编辑距离矩阵D,设计了一个允许k-差别的近似串匹配动态规划并行算法,该算法使用(m+1)个处理器,时间复杂度为O(n),算法理论上达到线性加速;采取水平和斜向双并行计算编辑距离矩阵D的方法,设计了一个使用a(m+1)个处理器和O(n/a+m)时间的、可伸缩的、允许k-差别的近似串匹配动态规划并行算法,+<11mna.基于分治策略,通过灵活拆分总线和合并子总线动态重构光总线系统,并充分利用光总线的消息播送技术和并行计算前缀和的方法,实现了汉明距离的并行计算,设计了两个基于LARPBS(linear arrays with reconfigurable pipelined bus system)模型的通信高效、可扩放的允许k-误配的近似串匹配并行算法,其中一个算法使用n个处理器,时间为O(m);另一个为常数时间算法,使用mn个处理器.
基金Project(20030533011)supported by the National Research Foundation for the Doctoral Program of Higher Education of China
文摘A DMVOCC-MVDA （distributed multiversion optimistic concurrency control with multiversion dynamic adjustment） protocol was presented to process mobile distributed real-time transaction in mobile broadcast environments. At the mobile hosts, all transactions perform local pre-validation. The local pre-validation process is carried out against the committed transactions at the server in the last broadcast cycle. Transactions that survive in local pre-validation must be submitted to the server for local final validation. The new protocol eliminates conflicts between mobile read-only and mobile update transactions, and resolves data conflicts flexibly by using multiversion dynamic adjustment of serialization order to avoid unnecessary restarts of transactions. Mobile read-only transactions can be committed with no-blocking, and respond time of mobile read-only transactions is greatly shortened. The tolerance of mobile transactions of disconnections from the broadcast channel is increased. In global validation mobile distributed transactions have to do check to ensure distributed serializability in all participants. The simulation results show that the new concurrency control protocol proposed offers better performance than other protocols in terms of miss rate, restart rate, commit rate. Under high work load （think time is ls） the miss rate of DMVOCC-MVDA is only 14.6%, is significantly lower than that of other protocols. The restart rate of DMVOCC-MVDA is only 32.3%, showing that DMVOCC-MVDA can effectively reduce the restart rate of mobile transactions. And the commit rate of DMVOCC-MVDA is up to 61.2%, which is obviously higher than that of other protocols.
文摘This paper introduces a multi-granularity locking model (MGL) for concurrency control in object-oriented database system briefiy, and presents a MGL model formally. Four lockingscheduling algorithms for MGL are proposed in the paper. The ideas of single queue scheduling(SQS) and dual queue scheduling (DQS) are proposed and the algorithm and the performance evaluation for these two scheduling are presented in some paper. This paper describes a new idea of thescheduling for MGL, compatible requests first (CRF). Combining the new idea with SQS and DQS,we propose two new scheduling algorithms called CRFS and CRFD. After describing the simulationmodel, this paper illustrates the comparisons of the performance among these four algorithms. Asshown in the experiments, DQS has better performance than SQS, CRFD is better than DQS, CRFSperforms better than SQS, and CRFS is the best one of these four scheduling algorithms.
基金Project supported by National Natural Science Foundation of China(10374025)Natural Science Foundation of Hunan Province(07JJ3013)Education Ministry of Hunan Province(06A038)
文摘The high precision assemblies with considerable radial interference should be accompanied by heating and cooling processes.However,the mechanical properties of metals are greatly affected by thermal operations.So,for evaluating the stress distribution and distortion of teeth profiles in a gear/shaft assembly,a transient thermal analysis is necessary for finding the change in mechanical properties.The friction on the contact surface is another important parameter in interaction of the gear with the shaft.Evaluating the gear stress and deformation fields for several modes of heat transfer and friction coefficients showed that the maximum radial or tangential stresses on contact surface of the joint may have more than 8%increase by increasing friction coefficient;while the intensity of heat transfer at cooling stage has lower effect on stress distribution.
基金Project(NZ1628)supported by the Natural Science Foundation of Ningxia,China
文摘Building a cloud geodatabase for a sponge city is crucial to integrate the geospatial information dispersed in various departments for multi-user high concurrent access and retrieval,high scalability and availability,efficient storage and management.In this study,Hadoop distributed computing framework,including Hadoop distributed file system and MapReduce(mapper and reducer),is firstly designed with a parallel computing framework to process massive spatial data.Then,access control with a series of standard application programming interfaces for different functions is designed,including spatial data storage layer,cloud geodatabase access layer,spatial data access layer and spatial data analysis layer.Subsequently,a retrieval model is designed,including direct addressing via file name,three-level concurrent retrieval and block data retrieval strategies.Main functions are realised,including real-time concurrent access,high-performance computing,communication,massive data storage,efficient retrieval and scheduling decisions on the multi-scale,multi-source and massive spatial data.Finally,the performance of Hadoop cloud geodatabases is validated and compared with that of the Oracle database.The cloud geodatabase for the sponge city can avoid redundant configuration of personnel,hardware and software,support the data transfer,model debugging and application development,and provide accurate,real-time,virtual,intelligent,reliable,elastically scalable,dynamic and on-demand cloud services of the basic and thematic geographic information for the construction and management of the sponge city.
文摘Background and objective Recent studies have showed that combination of chemotherapy and radiotherapy might result in better outcome for locally advanced non-small cell lung cancer (NSCLC). The aim of this study is to determine the maximal tolerance dose (MTD) and efficacy of full-dose gemcitabine and oxaliplatin when given concurrently with 3-dimentional radiation therapy (3D-RT) for locally advanced NSCLC. Methods Oxaliplatin was administered at a fixed dose of 130mg/m^2, and gemcitabine was administered at a starting dose of 800mg/m^2 with an incremental dose gradient of 200mg/m^2 for 3 dose levels. MTD was defined as the immediate dose level lower than the dose at which dose-limiting toxicity (DLT) occurred in more than one-third of the patients. The chemotherapy was administered at 3-week cycle. The RT was given as 3-D conformal manner at a single daily dose of 2Gy for 5 days per week. Results Twenty-two patients were evaluable and distributed to three different dose levels: 6 at level 1, 8 at level 2 and 8 at level 3. Pulmonary toxicity, esophageal and hematologic toxicity were the main DLT. Grade Ⅲ acute pulmonary toxicity occurred in one patient each at level 2 and level 3, both with V20>20%, and grade Ⅲ esophagitis in two patients at level 3. The MTD of gemcitabine in this study was 1000mg/m^2. The overall response rate was 75.0% (9/12). The 1- and 2-year survival rate was 70.0% and 30.5% respectively. The median time to progression was 8.7 months (range 5--11.8 months). Conclusion With reduced radiation volume, gemcitabine of 1000mg/m^2 in combination with oxaliplatin of 130mg/m^2 was effective and could be safely administered for NSCLC.
基金supported by the National Natural Science Foundation of China (6120113361172055+6 种基金60832005U083500461072067)the Postdoctoral Science Foundation of China (20100481323)the Program for New Century Excellent Talents (NCET-11-0691)the "111 Project"of China (B08038)the Foundation of Guangxi Key Lab of Wireless Wideband Communication & Signal Processing (11105)
文摘The paper proposes a decentralized concurrent transmission strategy in shared channels based on an incomplete information game in Ad Hoc networks.Based on the nodal channel quality,the game can work out a channel gain threshold,which decides the candidates for taking part in the concurrent transmission.The utility formula is made for maximizing the overall throughput based on channel quality variation.For an achievable Bayesian Nash equilibrium（BNE） solution,this paper further prices the selfish players in utility functions for attempting to improve the channel gain one-sidedly.Accordingly,this game allows each node to distributedly decide whether to transmit concurrently with others depending on the Nash equilibrium（NE）.Besides,to make the proposed game practical,this paper next presents an efficient particle swarm optimization（PSO） model to fasten the otherwise very slow convergence procedure due to the large computational complexity.Numerical results show the proposed approach is feasible to increase concurrent transmission opportunities for active nodes and the convergence can be swiftly obtained with a few of iteration times by the proposed PSO algorithm.
文摘Osteoporosis and osteopenia are major health issues that mainly affect elderly people,women after menopause and immobilized patients.Our previous studies have proved that sclerostin antibody(Scl-Ab)can dramatically enhance bone formation and reduce bone resorption in a severe osteoporosis rat model with the combination of ovariectomy(OVX)and hindlimb immobilization(HLS).However,the mechanism in the cellular level is unclear.The objective of this study is to assess the effect of Scl-Ab on osteocytic morphology change in a combined OVX and HLS rat model via quantification of long-and short-axis and the ratio and osteocyte volume in midshaft cortical bone.Four-month-old virgin female SD rats were divided into 7 groups(n=11 per group):Sham+Veh,Sham+HLS+Veh,Sham+HLS+Scl-Ab,OVX+Veh,OVX+Scl-Ab,OVX+HLS+Veh,OVX+HLS+Scl-Ab.HLS was performed 2 weeks after sham or OVX surgery;and treatment was initiated at the time of HLS.Scl-Ab(25 mg/kg)or vehicle was subcutaneously injected twice per week for 5 weeks.Femurs were harvested at the end of study and embedded in PMMA and polished for SEM imaging.Cortical bone mid shaft osteocyte number per bone area was quantified under 1K magnification;the ratios between long axis and short axis of osteocytes were quantified under 2K magnification;osteocyte dendrite number and surface area were quantified under 5K magnification.Osteocyte dendrites width was quantified using 10K magnification.All the quantification was done by ImageJ.We have reported that multiple morphological and structural changes in osteocytes,including a decreased osteocyte density and reduced osteocyte dendrite number in HLS,OVX or the combination group and Scl-Ab’s ability to abolish these unfavorable alterations.We continued our SEM analysis on osteocytes and discovered that the oval shape of osteocyte under HLS,OVX or HLS+OVX has been distorted toward a spindle-like shape,with relatively longer long axis and shorter short axis,assuming osteocyte has a perfect spheroid shape.The ratio between long-and short-axis showed an increased trend in OVX and HLS condition,but Scl-Ab inhibited these increases(P<0.001,P<0.01,respectively).The volume decreased in HLS,OVX group,but Scl-Ab maintained osteocytes’volume in HLS condition(P<0.001).It indicates that cortical bone responds to HLS and/or OVX and Scl-Ab treatment via multiple cellular mechanisms,including density of osteocyte,dendrite number and osteocyte shape.The change of osteocyte shape may imply an altered cytoskeleton system within osteocyte and a subsequent disruption of mechanosensing ability for osteocyte,which lead to bone loss macroscopically.These data suggest Scl-Ab’s therapeutic potential could be related with its ability to maintain osteocyte’s morphologic and structural changes induced by OVX,HLS or both.
文摘We conducted this study to determine if marker-assisted mass recurrent selection for fiberstrength and resistance to Helicoverpa armigerawithin an upland cotton complex populationcould he more efficient than conventionalphenotype selection.Two cycles of marker-assisted selection,phenotypic selection,andmarker and phenotype concurrent selection,
文摘Military petroleum equipment, as the special device a nd tool for petroleum storage, transportation, filling, chemical analysis, detec tion and maintenance for the army, is an important means and basis of petroleum indemnificatory. To adapt to modern war in high-tech conditions, the petroleum equipment have to develop towards higher reliability, adaptability, maneuverabil ity, standardization, container and cell type with versatile multi-functions. As a new design theory and design process, concurrent engineering may prod uce remarkable benefit when applying to product development. With the aid of the state-of-the-art modeling and simulation technology, it foresees the future or even the whole life cycle of the products designed. Based on wide statistics and survey, the product design period is reduced by 1/2～1/3 with concurrent des i gn process. The application of concurrent design process in new petroleum equi pment development shall greatly accelerate the petroleum equipment updating an d promote their indemnificatory.
文摘This paper studies the scheduling of design projects in concurrent development process with uncertain number of feedback revisions. An optimization based methodology that combines heuristic algorithm, artificial intelligence (fuzzy, genetic algorithm) and scheduling theory is developed. In the algorithm, weighting values of some key factors are defined by genetic algorithm. In addition, fuzzy logic is used to decide the ability coefficients of different roles taken by designers. Moreover, the process of pre-release and feedback revision is realized. Simulation example is a fraction of practical development project, and satisfied results are obtained.
