目的:探究单纯疱疹病毒(HSV)感染后脑脊液(CSF)中S100B、Cys-C、MMP-9水平对自身免疫性脑炎(AE)的预测价值。方法:选取2016年1月至2021年3月河北中石油中心医院收治的200例HSV感染患者为研究对象,根据是否继发AE分为研究组(继发AE,35例...目的:探究单纯疱疹病毒(HSV)感染后脑脊液(CSF)中S100B、Cys-C、MMP-9水平对自身免疫性脑炎(AE)的预测价值。方法:选取2016年1月至2021年3月河北中石油中心医院收治的200例HSV感染患者为研究对象,根据是否继发AE分为研究组(继发AE,35例)和对照组(未继发AE,165例)。多因素Logistic回归分析HSV感染患者继发AE的独立影响因素。Spearman法分析脑脊液中Cys-C、MMP-9与S100B水平的相关性。受试者工作特征(ROC)曲线分析S100B、Cys-C、MMP-9对AE的预测价值。构建风险预测模型并进行评价。结果:多因素Logistic回归分析显示,MRI异常、脑脊液S100B、MMP-9升高、EEG异常是HSV感染患者继发AE的独立危险因素,脑脊液Cys-C是其保护因素(P<0.05)。Spearman分析显示,HSV感染患者Cys-C浓度与S100B水平呈负相关(r=-0.83,P<0.05),MMP-9浓度与S100B水平呈正相关(r=0.88,P<0.05)。构建的联合预测因子pre1诊断HSV患者继发AE的AUC明显大于S100B、Cys-C、MMP-9单独预测的AUC(0.876 vs 0.827、0.787、0.750)。构建的风险预测模型具有良好的区分度和一致性。结论:脑脊液中S100B、Cys-C、MMP-9水平均可对HSV感染患者诱发AE的可能性进行有效预测,且三项指标联合预测价值最大,其次是S100B蛋白、Cys-C、MMP-9。展开更多
Evolving From principal-subordinate structure of C /S to flexible multileveled distributed structure, i.e. B/S architecture so as to form a wide, distributed and orderly Internet/Intranet integrated management inf orm...Evolving From principal-subordinate structure of C /S to flexible multileveled distributed structure, i.e. B/S architecture so as to form a wide, distributed and orderly Internet/Intranet integrated management inf ormation system, is the trend of development of application software of the whol e world. Advantages and disadvantages of the two modes: C/S and B/S are compared . It is pointed out that at present onefold B/S mode cannot yet fully fullfil th e demands of some complicated data processing, information statistics and analys is, etc, therefore it still awaits further development of technology to achieve 100% Internet. In this paper, a mode of B/S-C/S-blended multileveled architect ure is discussed; the logical levels of B/S mode is studied; Furthermore, combin ing some up-to-date software developing technology, combinatorial design of di fferent database application technology based on B/S is discussed. The expatiati on is made with following points: (1) Organic combination of the network distrib uted object technology of CORBA and the computation technology among different n etwork operating system ─ Java; (2) Organic combination of two modes of ASP and Plug_in; (3) JDBC Server and JDBC Client; (4) An expanded B/S model, i.e. the c lient application of browser communicates directly with Web server, and the serv er application communicates directly with database server through middle ware.展开更多
文摘目的:探究单纯疱疹病毒(HSV)感染后脑脊液(CSF)中S100B、Cys-C、MMP-9水平对自身免疫性脑炎(AE)的预测价值。方法:选取2016年1月至2021年3月河北中石油中心医院收治的200例HSV感染患者为研究对象,根据是否继发AE分为研究组(继发AE,35例)和对照组(未继发AE,165例)。多因素Logistic回归分析HSV感染患者继发AE的独立影响因素。Spearman法分析脑脊液中Cys-C、MMP-9与S100B水平的相关性。受试者工作特征(ROC)曲线分析S100B、Cys-C、MMP-9对AE的预测价值。构建风险预测模型并进行评价。结果:多因素Logistic回归分析显示,MRI异常、脑脊液S100B、MMP-9升高、EEG异常是HSV感染患者继发AE的独立危险因素,脑脊液Cys-C是其保护因素(P<0.05)。Spearman分析显示,HSV感染患者Cys-C浓度与S100B水平呈负相关(r=-0.83,P<0.05),MMP-9浓度与S100B水平呈正相关(r=0.88,P<0.05)。构建的联合预测因子pre1诊断HSV患者继发AE的AUC明显大于S100B、Cys-C、MMP-9单独预测的AUC(0.876 vs 0.827、0.787、0.750)。构建的风险预测模型具有良好的区分度和一致性。结论:脑脊液中S100B、Cys-C、MMP-9水平均可对HSV感染患者诱发AE的可能性进行有效预测,且三项指标联合预测价值最大,其次是S100B蛋白、Cys-C、MMP-9。
文摘Evolving From principal-subordinate structure of C /S to flexible multileveled distributed structure, i.e. B/S architecture so as to form a wide, distributed and orderly Internet/Intranet integrated management inf ormation system, is the trend of development of application software of the whol e world. Advantages and disadvantages of the two modes: C/S and B/S are compared . It is pointed out that at present onefold B/S mode cannot yet fully fullfil th e demands of some complicated data processing, information statistics and analys is, etc, therefore it still awaits further development of technology to achieve 100% Internet. In this paper, a mode of B/S-C/S-blended multileveled architect ure is discussed; the logical levels of B/S mode is studied; Furthermore, combin ing some up-to-date software developing technology, combinatorial design of di fferent database application technology based on B/S is discussed. The expatiati on is made with following points: (1) Organic combination of the network distrib uted object technology of CORBA and the computation technology among different n etwork operating system ─ Java; (2) Organic combination of two modes of ASP and Plug_in; (3) JDBC Server and JDBC Client; (4) An expanded B/S model, i.e. the c lient application of browser communicates directly with Web server, and the serv er application communicates directly with database server through middle ware.
