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Functional cartography of heterogeneous combat networks using operational chain-based label propagation algorithm
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作者 CHEN Kebin JIANG Xuping +2 位作者 ZENG Guangjun YANG Wenjing ZHENG Xue 《Journal of Systems Engineering and Electronics》 2025年第5期1202-1215,共14页
To extract and display the significant information of combat systems,this paper introduces the methodology of functional cartography into combat networks and proposes an integrated framework named“functional cartogra... To extract and display the significant information of combat systems,this paper introduces the methodology of functional cartography into combat networks and proposes an integrated framework named“functional cartography of heterogeneous combat networks based on the operational chain”(FCBOC).In this framework,a functional module detection algorithm named operational chain-based label propagation algorithm(OCLPA),which considers the cooperation and interactions among combat entities and can thus naturally tackle network heterogeneity,is proposed to identify the functional modules of the network.Then,the nodes and their modules are classified into different roles according to their properties.A case study shows that FCBOC can provide a simplified description of disorderly information of combat networks and enable us to identify their functional and structural network characteristics.The results provide useful information to help commanders make precise and accurate decisions regarding the protection,disintegration or optimization of combat networks.Three algorithms are also compared with OCLPA to show that FCBOC can most effectively find functional modules with practical meaning. 展开更多
关键词 functional cartography heterogeneous combat network functional module label propagation algorithm operational chain
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磁性Fe_3O_4纳米颗粒对大鼠脏器组织中Caveolin-1和Clathrin Heavy Chain蛋白表达的影响 被引量:1
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作者 孙维琦 张晶 +3 位作者 靳曙光 王洪艳 李环 孙志伟 《吉林大学学报(医学版)》 CAS CSCD 北大核心 2017年第2期260-265,共6页
目的:探讨磁性Fe_3O_4纳米颗粒对大鼠主要脏器组织中Caveolin-1及Clathrin Heavy Chain蛋白表达的影响,阐明其作用机制。方法:将24只Wistar大鼠按体质量随机分成对照组和低、中、高剂量磁性Fe_3O_4纳米颗粒组,尾静脉注射不同剂量磁性Fe_... 目的:探讨磁性Fe_3O_4纳米颗粒对大鼠主要脏器组织中Caveolin-1及Clathrin Heavy Chain蛋白表达的影响,阐明其作用机制。方法:将24只Wistar大鼠按体质量随机分成对照组和低、中、高剂量磁性Fe_3O_4纳米颗粒组,尾静脉注射不同剂量磁性Fe_3O_4纳米颗粒24h后取脏器组织,Western blotting法检测大鼠主要脏器组织中Caveolin-1及Clathrin Heavy Chain蛋白的表达水平,荧光实时定量PCR法检测大鼠主要脏器组织中Caveolin-1及Clathrin Heavy Chain mRNA的表达水平。结果:与对照组比较,中和高剂量组大鼠肝脏和脾脏组织中Clathrin Heavy Chain蛋白和mRNA表达水平明显升高(P<0.05)。高剂量组大鼠肾脏组织中Clathrin Heavy Chain mRNA的表达水平与其他3组比较明显升高(P<0.05)。Caveolin-1蛋白表达水平在各剂量组之间比较差异无统计学意义(P>0.05);与对照组比较,低、中和高剂量组大鼠肝脏、肺脏和脾脏组织中Caveolin-1mRNA表达水平明显升高(P<0.05);各组肾脏组织中Caveolin-1 mRNA表达水平差异无统计学意义(P>0.05)。结论:磁性Fe_3O_4纳米颗粒能够诱导大鼠肝脏、肺脏、脾脏中Clathrin Heavy Chain蛋白表达增强,通过Clathrin Heavy Chain蛋白的内吞作用是磁性Fe_3O_4纳米颗粒进入大鼠肝脏、肺脏和脾脏细胞的途径之一。 展开更多
关键词 磁性Fe3O4纳米颗粒 CLATHRIN HEAVY chain蛋白 CAVEOLIN-1蛋白
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Collaborative supply chain planning under dynamic lot sizing costs with capacity decision 被引量:3
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作者 Hongyan Li Tianhui You Xiaoyi Luo 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第2期247-256,共10页
Studies show that supply chain cooperation improves supply chain performance. However, it remains a challenge to develop and implement the realistic supply chain cooperation scheme. We investigate a two-echelon supply... Studies show that supply chain cooperation improves supply chain performance. However, it remains a challenge to develop and implement the realistic supply chain cooperation scheme. We investigate a two-echelon supply chain planning problem with capacity acquisition decision under asymmetric cost and demand information. A simple negotiation-based coordination mechanism is developed to synchronize production/order strategies of a supplier and a buyer. The coordination scheme shows how the supplier and the buyer modify their production and order policy in order to find a joint economic lot sizing plan, which saves the overall supply chain cost. The allocation of the cooperation benefit is determined by negotiation. Due to the complexity of the multiple periods, multiple level supply chain lot sizing with capacity decision, a heuristic algorithm is developed to find coordination solutions. Finally, the results of the numerical study indicate the performance of supply chain coordination scheme. 展开更多
关键词 supply chain coordination joint economic lot sizing NEGOTIATION supply chain management capacity acquisition heuristics.
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基于Markov chain理论的科技成果转化的市场预测 被引量:1
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作者 徐辉 张延飞 彭萍 《东华理工学院学报》 2005年第2期196-200,共5页
科技成果成功转化的主要标志是其产品的市场畅销度。产品的畅销度由于受各种内外部不确定因素影响,具有随机不确定性。基于这种随机不确定性,运用Markovchain对其产品进行市场预测,并通过实证分析说明其有效性,为科技成果的转化提供具... 科技成果成功转化的主要标志是其产品的市场畅销度。产品的畅销度由于受各种内外部不确定因素影响,具有随机不确定性。基于这种随机不确定性,运用Markovchain对其产品进行市场预测,并通过实证分析说明其有效性,为科技成果的转化提供具体可行的定量依据。 展开更多
关键词 科技成果 MARKOV chain 市场预测
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Issues on Supply Chain Management 被引量:1
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作者 WU Shun-xiang, ZHANG Min, CHEN Jian-hui (Department of Automation, Xiamen University, Xiamen 361005, China) 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期281-282,共2页
Although supply chain is regarded as an integrated pr ocess, actually, researchers and practitioners have primarily investigated the v arious processes of the supply chain individually. The competitive field in most m... Although supply chain is regarded as an integrated pr ocess, actually, researchers and practitioners have primarily investigated the v arious processes of the supply chain individually. The competitive field in most markets requires well-designed integrated supply chain instead of individual o perations. In this paper, some traditional thinking of supply chain is given fir st, then SCM (Supply Chain Management) is introduced, which views the entire sup ply chain as a whole rather than individual process and aims to increase transpa rency and alignment of the supply chain’s coordination and configuration, regar dless of functional or corporate boundaries. Secondly, issues regarding the significance and the situation of supply chain management in enterprises of Chin a are briefly described. In china, most enterprises haven’t established the ide a of supply chain management, supply chain are just focused on the step from sup pliers to manufacturers, which is a partial but not whole supply chain. Challeng ed by intense competition in the global market, further research on supply chain management is badly needed in China, if not, traditional pattern must be overwh elmed by world competition. Finally, suggestions for future research, especial ly the required conditions for a successful adoption of supply chain managemen t, are outlined. Organizations with Supply chain management can realize the advantages of backward vertical integration. However the following issues must b e paid attention to before supply chain management pattern is established.(1) Ch anging the corporate cultures of all members in the value chain to make it condu cive to supply chain management.(2) Developing long-term, cooperative and certi fied relationship with key suppliers.(3) Developing supply chain management soft ware that includes a completely integrated information system based on distr ibuted database throughout supply chain.(4) Reconstructing organization structur e adapting to supply chain management pattern.(5) Developing evaluation system f or performance measures of supply chain. In a word, supply chain management patt ern is necessary for domestic enterprises to win in intense world competition, w hile developing fitting pattern with key prerequisites is the most important. 展开更多
关键词 supply chain Supply chain Management (SCM)
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基于HR Value Chain的农民工HRM实践研究
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作者 张永生 《安徽农业科学》 CAS 北大核心 2005年第12期2416-2417,2420,共3页
从价值链理论(Value Chain)发展而来的人力资源价值链(HR Value Chain)肯定了HRM实践是企业价值的来源。在概要介绍HR Value Chain的基础上,着重分析企业内部针对农民工的HRM实践所存在的问题,并提出了相应的改进措施。
关键词 HR VALUE chain 农民工 HRM实践
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PREPARATION AND CHARACTERIZATION OF TWO MONOCLONAL ANTIBODIES AGAINST A_α CHAIN'S C TERMINUS OF FIBRINOGEN
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作者 阮长耿 《中国实验血液学杂志》 CAS CSCD 1995年第1期91-95,共5页
Two monoclonal antibodies (McAbs) against Aα chain's C terminus offibrinogen (Fg) have been prepared and designated SZ-78 and SZ-79. Both theantigens in binding assay and immunoblot analysis showed that the two M... Two monoclonal antibodies (McAbs) against Aα chain's C terminus offibrinogen (Fg) have been prepared and designated SZ-78 and SZ-79. Both theantigens in binding assay and immunoblot analysis showed that the two McAbs recognized the epitopes located in residues 549-560 of the Aαchain. The two McAbs couldaccelerate rate of fibrin polymer assembly both in the purified system and in the humanplasma. From the pictures of transmission electronmicroscope, the average diametersof the fibers increase significantly to an average diameters of 375 nm after incubationwith the McAbs, while it was only 75nm without addition of the McAbs. There were al-so more branchings of fibers with addition of McAbs. These observations demonstratethat the amino acid sequences ofα 549-560 in the COOH terminus of the Aα chain mayplay an important role in the assembly of a fibrin clot, presumably being involved in lat-eral aggregation of protofibrils. The preparation of the McAbs supplies a usuful probe for the investigation of the 展开更多
关键词 MONOCLONAL antibody polymerization FIBRIN chain
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基于Markov Chain Monte Carlo模型对医院调查资料中缺失数据的多重估算 被引量:3
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作者 李树威 钟晓妮 《中国卫生统计》 CSCD 北大核心 2013年第6期837-841,共5页
目的探讨基于Markov Chain Monte Carlo(MCMC)模型的多重估算法在处理医院调查资料缺失数据中的应用。方法运用SAS9.2编写程序,在分析数据的分布类型和缺失机制的基础上,采用MCMC法对缺失数据进行多次填补和联合统计推断,分析多重估算... 目的探讨基于Markov Chain Monte Carlo(MCMC)模型的多重估算法在处理医院调查资料缺失数据中的应用。方法运用SAS9.2编写程序,在分析数据的分布类型和缺失机制的基础上,采用MCMC法对缺失数据进行多次填补和联合统计推断,分析多重估算法的优势。结果数据服从多元正态分布与随机缺失,采用MCMC法填补10次所得的结果最佳。结论多重估算既可反映缺失数据的不确定性,又可充分利用现有资料的信息、提高统计效率、对模型的估计结果更加可信,是处理缺失数据的有效方法。 展开更多
关键词 缺失数据 MARKOV chain MONTE Carlo 多重估算 医院调查资料
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Research on supply chain management of complex product system based on blockchain
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作者 DING Jie WANG Qingguo +1 位作者 ZHANG Haifeng ZANG Xuejing 《Journal of Systems Engineering and Electronics》 CSCD 2024年第6期1530-1541,共12页
Blockchain technology has attracted worldwide atten-tion,and has strong application potential in complex product system supply chain and other fields.This paper focuses on the supply chain management issues of complex... Blockchain technology has attracted worldwide atten-tion,and has strong application potential in complex product system supply chain and other fields.This paper focuses on the supply chain management issues of complex product systems,and combines the technical characteristics of blockchain,such as tamper resistance and strong resistance to destruction,to conduct research on the application of blockchain based supply chain management for complex product systems.The block-chain technology is integrated into functional modules such as business interaction,privacy protection,data storage,and sys-tem services.The application technology architecture of com-plex product system supply chain integrated with blockchain is constructed.The application practice in complex product sys-tem supply chain is carried out.The results show that the sup-ply chain of complex product systems has the functions of traceability,cost reduction,and anti-counterfeiting protection.Finally,the future development direction and research focus of the complex product system supply chain based on blockchain are prospected,which provides a reference for the equipment manufacturing supply chain management in the mili-tary industry. 展开更多
关键词 supply chain block chain complex product system
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基于Markov Chain的协议异常检测模型 被引量:6
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作者 李娜 秦拯 +1 位作者 张大方 陈蜀宇 《计算机科学》 CSCD 北大核心 2004年第10期66-68,95,共4页
本文介绍了基于Markov链的协议异常检测模型,此外,通过对MIT Lincoln实验室1999评估数据的分析,证明此模型的正确性和有效性。
关键词 异常检测模型 协议 正确性 数据 MARKOV链 MIT 证明 实验室 有效性
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Intrusion detection based on system calls and homogeneous Markov chains 被引量:8
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作者 Tian Xinguang Duan Miyi +1 位作者 Sun Chunlai Li Wenfa 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第3期598-605,共8页
A novel method for detecting anomalous program behavior is presented, which is applicable to hostbased intrusion detection systems that monitor system call activities. The method constructs a homogeneous Markov chain ... A novel method for detecting anomalous program behavior is presented, which is applicable to hostbased intrusion detection systems that monitor system call activities. The method constructs a homogeneous Markov chain model to characterize the normal behavior of a privileged program, and associates the states of the Markov chain with the unique system calls in the training data. At the detection stage, the probabilities that the Markov chain model supports the system call sequences generated by the program are computed. A low probability indicates an anomalous sequence that may result from intrusive activities. Then a decision rule based on the number of anomalous sequences in a locality frame is adopted to classify the program's behavior. The method gives attention to both computational efficiency and detection accuracy, and is especially suitable for on-line detection. It has been applied to practical host-based intrusion detection systems. 展开更多
关键词 intrusion detection Markov chain anomaly detection system call.
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Revenue-sharing contract to coordinate independent participants within the supply chain 被引量:10
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作者 Chen Kebing Gao Chengxiu Wang Yan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2007年第3期520-526,共7页
To improve the performance of the supply chain with one supplier and multiple retailers under deterministic price-sensitive customer demand, an optimal strategy is proposed based on knowledge discovery. First the dece... To improve the performance of the supply chain with one supplier and multiple retailers under deterministic price-sensitive customer demand, an optimal strategy is proposed based on knowledge discovery. First the decentralized system in which the supplier and the retailers are independent, profit-maximizing participants with the supplier acting as a Stackelberg game leader is studied. Numerical examples illustrate the importance of the coordination. The conventional quantity discount mechanism needs to be modified to coordinate the supply chain, so a revenue-sharing contract is proposed to coordinate such supply chain. Lastly, a special decision under certain demand rates is studied. The pricing and replenishment policies can be decided sequentially, which yields much less loss comparing with optimal decision when the demand rates are sufficiently large. 展开更多
关键词 supply chain management coordination mechanism revenue-sharing contract Stackelberg game sequential strategy.
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基于MLP-ANN与Markov Chain的土地利用变化预测方法——以锡林郭勒盟为例 被引量:8
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作者 徐广才 康慕谊 李亚飞 《生态环境学报》 CSCD 北大核心 2010年第10期2386-2392,共7页
以北方草地典型地区—内蒙古锡林郭勒盟为案例区,在1995年到2000年的土地利用变化与驱动力分析的基础上,利用土地利用转换类型和驱动力模型,采用多层感知人工神经网络模型分析了各种土地利用类型未来的转换潜力;利用马尔可夫链模型,预测... 以北方草地典型地区—内蒙古锡林郭勒盟为案例区,在1995年到2000年的土地利用变化与驱动力分析的基础上,利用土地利用转换类型和驱动力模型,采用多层感知人工神经网络模型分析了各种土地利用类型未来的转换潜力;利用马尔可夫链模型,预测了2005和2010年土地利用格局。预测结果显示:高覆盖度草地减少幅度最大,中覆盖度草地减少相对和缓,高、中覆盖度草地的减少造成了未利用地和低覆盖度草地的增加,尤其是前者增加的幅度最大;从空间分布看,高覆盖度草地的减少集中在西北部地区,主要转变为中低覆盖度草地,中覆盖度草地的减少主要集中在西南部地区,其流向主要是以沙化土地为主的未利用地;案例研究表明,多层感知人工神经网络模型与马尔可夫链模型的结合与应用能够在很大程度上预测稳定驱动力作用下的土地利用变化趋势,从而为生态干预提供指导。 展开更多
关键词 土地利用与覆被变化 模拟 多层感知人工神经网络模型 马尔可夫链 锡林郭勒盟
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Supply chain coordination mechanisms under flexible contracts 被引量:7
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作者 Jianhu Cai Liping Wang Gengui Zhou 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第3期440-448,共9页
In supply chain management,an important research direction is to coordinate the supply chain through introducing flexible contracts.A supply chain contract is flexible if it can satisfy two conditions at the same time... In supply chain management,an important research direction is to coordinate the supply chain through introducing flexible contracts.A supply chain contract is flexible if it can satisfy two conditions at the same time:the supply chain is coordinated,and the total profit of the supply chain can be arbitrarily divided between the supply chain members.This paper puts out two contracts,a flexible return contract and a flexible wholesale price discount contract.In contrast to many of literature,the supply chain contracts with an endogenous wholesale price is specifically considered,and a detailed sensitivity analysis of the contract parameters is given.The paper also discusses the application of the contract in vendor-managed inventory(VMI) mode.The results show that the supply chain's performance is improved after introducing above contracts.All the findings are illustrated by numerical examples. 展开更多
关键词 supply chain flexible contract COORDINATION newsvendor model.
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Chain damage effects of multi-spaced plates by reactive jet impact 被引量:16
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作者 Yuan-feng Zheng Cheng-hai Su +2 位作者 Huan-guo Guo Qing-bo Yu Hai-fu Wang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第2期393-404,共12页
Chain damage is a new phenomenon that occurs when a reactive jet impacts and penetrates multispaced plates.The reactive jet produces mechanical perforations on the spaced plates by its kinetic energy(KE),and then resu... Chain damage is a new phenomenon that occurs when a reactive jet impacts and penetrates multispaced plates.The reactive jet produces mechanical perforations on the spaced plates by its kinetic energy(KE),and then results in unusual chain rupturing effects and excessive structural damage on the spaced plates by its deflagration reaction.In the present study,the chain damage behavior is initially demonstrated by experiments.The reactive liners,composed of 26 wt%Al and 74 wt%PTFE,are fabricated through a pressing and sintering process.Three reactive liner thicknesses of 0.08 CD,0.10 CD and 0.12 CD(charge diameter)are chosen to carry out the chain damage experiments.The results show a chain rupturing phenomenon caused by reactive jet.The constant reaction delay time and the different penetration velocities of reactive jets from liners with different thicknesses result in the variation of the deflagration position,which consequently determines the number of ruptured plates behind the armor.Then,the finite-element code AUTODYN-3D has been used to simulate the kinetic energy only-induced rupturing effects on plates,based on the mechanism of behind armor debris(BAD).The significant discrepancies between simulations and experiments indicate that one enhanced damage mechanism,the behind armor blast(BAB),has acted on the ruptured plates.Finally,a theoretical model is used to consider the BAB-induced enhancement,and the analysis shows that the rupturing area on aluminum plates depends strongly upon the KE only-induced pre-perforations,the mass of reactive materials,and the thickness of plates. 展开更多
关键词 Reactive materials Reactive jet chain damage Behind armor blast
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Coordination game model of co-opetition relationship on cluster supply chains 被引量:7
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作者 Zhou Min Deng Feiqi Wu Sai 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第3期499-506,共8页
The research of cluster supply chains is a new direction and a hotspot of the industrial cluster theory. On the condition of the coordination game, the enterprises may be stuck on the non-efficient equilibrium status,... The research of cluster supply chains is a new direction and a hotspot of the industrial cluster theory. On the condition of the coordination game, the enterprises may be stuck on the non-efficient equilibrium status, which becomes an important problem that must be considered on cluster supply chains. A symmetrical coordination game model is constituted to describe the competition and cooperation relationship of the same-quality manufacturers on cluster supply chains. The methods of the non-cooperation game theory and the evolutionary game theory are respectively used to analyze the model, whose parameters' influences under each method are then compared. It can be concluded that the analysis of the evolutionary game theory is more realistic and practical. Finally, three approaches are considered to break away from being path-dependence locked-in non-efficient status during this coordination game evolutionary process, which provide the development of cluster supply chains with an effective forecasting and Pareto optimizing method. 展开更多
关键词 cluster supply chains coordination game non-cooperation game theory evolutionary game theory path-dependence.
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Function chain neural network prediction on heat transfer performance of oscillating heat pipe based on grey relational analysis 被引量:12
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作者 鄂加强 李玉强 龚金科 《Journal of Central South University》 SCIE EI CAS 2011年第5期1733-1737,共5页
As for the factors affecting the heat transfer performance of complex and nonlinear oscillating heat pipe (OHP),grey relational analysis (GRA) was used to deal with the relationship between heat transfer rate of a loo... As for the factors affecting the heat transfer performance of complex and nonlinear oscillating heat pipe (OHP),grey relational analysis (GRA) was used to deal with the relationship between heat transfer rate of a looped copper-water OHP and charging ratio,inner diameter,inclination angel,heat input,number of turns,and the main influencing factors were defined.Then,forecasting model was obtained by using main influencing factors (such as charging ratio,interior diameter,and inclination angel) as the inputs of function chain neural network.The results show that the relative average error between the predicted and actual value is 4%,which illustrates that the function chain neural network can be applied to predict the performance of OHP accurately. 展开更多
关键词 oscillating heat pipe grey relational analysis fimction chain neural network heat transfer
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Grey Markov chain and its application in drift prediction model of FOGs 被引量:5
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作者 Fan Chunling 1,2 , Jin Zhihua1, Tian Weifeng1 & Qian Feng11. Department of Information Measurement Technology and Instrument, Shanghai Jiaotong University,Shanghai 200030, P. R. China 2. College of Automation and Electric Engineering, Qingdao University of Science and Technology,Qingdao 266042, P. R. China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2005年第2期388-393,共6页
A novel grey Markov chain predictive model is discussed to reduce drift influence on the output of fiber optical gyroscopes (FOGs) and to improve FOGs' measurement precision. The proposed method possesses advantag... A novel grey Markov chain predictive model is discussed to reduce drift influence on the output of fiber optical gyroscopes (FOGs) and to improve FOGs' measurement precision. The proposed method possesses advantages of grey model and Markov chain. It makes good use of dynamic modeling idea of the grey model to predict general trend of original data. Then according to the trend, states are divided so that it can overcome the disadvantage of high computational cost of state transition probability matrix in Markov chain. Moreover, the presented approach expands the applied scope of the grey model and makes it be fit for prediction of random data with bigger fluctuation. The numerical results of real drift data from a certain type FOG verify the effectiveness of the proposed grey Markov chain model powerfully. The Markov chain is also investigated to provide a comparison with the grey Markov chain model. It is shown that the hybrid grey Markov chain prediction model has higher modeling precision than Markov chain itself, which prove this proposed method is very applicable and effective. 展开更多
关键词 grey model Markov chain FOG drift.
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Remanufacturing closed-loop supply chain network design based on genetic particle swarm optimization algorithm 被引量:10
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作者 周鲜成 赵志学 +1 位作者 周开军 贺彩虹 《Journal of Central South University》 SCIE EI CAS 2012年第2期482-487,共6页
As the huge computation and easily trapped local optimum in remanufacturing closed-loop supply chain network (RCSCN) design considered, a genetic particle swarm optimization algorithm was proposed. The total cost of c... As the huge computation and easily trapped local optimum in remanufacturing closed-loop supply chain network (RCSCN) design considered, a genetic particle swarm optimization algorithm was proposed. The total cost of closed-loop supply chain was selected as fitness function, and a unique and tidy coding mode was adopted in the proposed algorithm. Then, some mutation and crossover operators were introduced to achieve discrete optimization of RCSCN structure. The simulation results show that the proposed algorithm can gain global optimal solution with good convergent performance and rapidity. The computing speed is only 22.16 s, which is shorter than those of the other optimization algorithms. 展开更多
关键词 genetic particle swarm optimization closed-loop supply chain REMANUFACTURING network design reverse logistics
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黑眉锦蛇J-chain基因的克隆与序列分析
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作者 杨文龙 王春光 +2 位作者 潘庆杰 闵令江 王涛 《青岛农业大学学报(自然科学版)》 2014年第1期5-8,12,共5页
J-chain是由浆细胞产生的约15KDa大小的糖蛋白,其可以通过与IgM和IgA尾部半胱氨酸的连接启动多聚化过程并利用二硫键共价稳定地与多聚IgA和IgM结合。本研究克隆并分析了黑眉锦蛇(以下简称蛇)J-chain基因在各组织中的表达情况,发现与其... J-chain是由浆细胞产生的约15KDa大小的糖蛋白,其可以通过与IgM和IgA尾部半胱氨酸的连接启动多聚化过程并利用二硫键共价稳定地与多聚IgA和IgM结合。本研究克隆并分析了黑眉锦蛇(以下简称蛇)J-chain基因在各组织中的表达情况,发现与其它物种一致,J-chain基因中用于形成二硫键的半胱氨酸残基是高度保守的;蛇J-chain基因在脾脏、肠道中的表达量相对较高,这也正符合免疫球蛋白基因在各组织中的表达情况。蛇J-chain基因的克隆为研究其多聚免疫球蛋白的特点奠定了良好的基础。 展开更多
关键词 J—chain 多聚免疫球蛋白
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