Objective: To explore the possible factors influencing lumbar spinal bone mineral contents and bone mineral densities in Chinese adolescents with early ankylosing spondylitis(AS). Methods: Thirty-one male Chinese adol...Objective: To explore the possible factors influencing lumbar spinal bone mineral contents and bone mineral densities in Chinese adolescents with early ankylosing spondylitis(AS). Methods: Thirty-one male Chinese adolescent outpatients with early AS were included and compared with 31 age-matched male controls. Age (year), height (cm), total body weight (kg) together with body mass index (BMI, kg/m 2) of all subjects and disease duration (month), BASMI, BASFI, BASDAI, SASSS as well as ESR (mm/h) of AS patients were obtained. Lumbar 2-4 bone mineral content (L 2-4BMC, g) and lumbar 2-4 areal bone mineral density (L 2-4 BMD, g/cm 2) were evaluated using dual-energy X-ray absorptiometry (DEXA) with Lunar DPX-IQ device and lumbar 2-4 volumetric bone mineral apparent density (L 2-4 BMAD, g/cm 3) was subsequently calculated. Correlation and multiple regression analyses were performed. Results: Compared with 31 age-matched male controls, AS patients had significantly lower L 2-4BMD [(0.984±0.142) g/cm 2 vs (1.055±0.137) g/cm 2, P=0.049] and L 2-4BMAD [(0.1527±0.0173) g/cm 3 vs (0.1630±0.0195) g/cm 3, P=0.032]. In AS patients, multiple regression analysis identified that only the factor of height was significantly correlated with L 2-4BMC (R=0.673, P=0.000) and the factor of weight had predominant influences on L 2-4BMD (R=0.620, P=0.000) as well as L 2-4BMAD (R=0.510, P=0.003). Conclusion: The young patients with early AS had marked reduction in lumbar spine bone mineral densities, which indicated an important primary event leading to osteoporosis. Positive effects of height and weight on lumbar spine bone mass and densities could expectantly make favorable contributions to early prevention of AS associated bone loss and subsequent osteoporosis.展开更多
Objective.To investigate the distribution frequency of parathyroid hormone(PTH)gene polymorphism in healthy adults from Bejing area and to explore the association of PTH genotypes with bone mineral density(BMD).Method...Objective.To investigate the distribution frequency of parathyroid hormone(PTH)gene polymorphism in healthy adults from Bejing area and to explore the association of PTH genotypes with bone mineral density(BMD).Methods.PTH gene polymorphism was detected in270subjects by polymerase chain reaction(PCR)and PCR /restriction fragment length polymorphism(PCR /RFLP).The digestion products of restriction enzyme Bst B1were separated on1%agarose gels.PTH genotypes were confirmed by DNA sequences analysis.BMD was measured by dual-energy X-ray absorptiometry(DEXA,DPX -L ,Lunar).Results.Genotype frequencies of BB,Bb,bb were73.7%,25.9%and0.4%respectively in Beijing adults(P<0.01),67.1%,32.2%and0.7%in postmenopausal women,which was different from Japanese wom-en.We statistically compared bone mineral density at the lumbar2-4and proximal femur between BB and Bb genotypes.No obvious association was found between the BMD and PTH genotypes in Beijing women(P>0.05).Conclusion.PTH gene polymorphism is not associated with BMD in Chinese women.The further research to explore the genetic risk factors of osteoporosis should be committed.展开更多
This cohort study was designed to explore the relationship between maternal dietary patterns(DPs)and bone health in Chinese lactating mothers and infants.We recruited 150 lactating women at 1-month postpartum.The esti...This cohort study was designed to explore the relationship between maternal dietary patterns(DPs)and bone health in Chinese lactating mothers and infants.We recruited 150 lactating women at 1-month postpartum.The estimated bone mineral density(eBMD)of subjects’calcanei and the information on dietary intake were collected.After 5-month follow-up,the eBMD of mothers and their infants were measured again.Factor analysis was applied to determine maternal DPs.General linear models were used to evaluate the association between maternal DPs and maternal eBMD loss or infants’eBMD.With all potential covariates adjusted,Factor 2(high intake of whole grains,tubers,mixed beans,soybeans and soybean products,seaweeds,and nuts)showed a positive association with the changes of maternal eBMD(β=0.16,95%CI:0.005,0.310).Factor 3(high intake of soft drinks,fried foods,and puffed foods)was inversely correlated with the changes of maternal eBMD(β=-0.22,95%CI:-0.44,0.00).The changes of maternal eBMD were positively associated with 6-month infants’eBMD(β=0.34,95%CI:0.017,0.652).In conclusion,Factor 2 might contribute to the maintenance of eBMD in lactating women,while Factor 3 could exacerbate maternal eBMD loss.Additionally,the changes of maternal eBMD presented a positive correlation with 6-month infants’eBMD.展开更多
Objective To evaluate the role of sclerostin in bone loss of postmenopausal Chinese women with type 2 diabetes me｜litus. Methods The postmenopausal patients suffering from type 2 diabetes mellitus and age, body mass...Objective To evaluate the role of sclerostin in bone loss of postmenopausal Chinese women with type 2 diabetes me｜litus. Methods The postmenopausal patients suffering from type 2 diabetes mellitus and age, body mass index, and duration of menopause matched healthy controls were enrolled into this cross-sectional study according to criteria of inclusion and exclusion.展开更多
目的:探讨消增强骨丸对肝肾阴虚型骨质疏松症患者骨转换标志物的影响。方法:选取80例肝肾阴虚型骨质疏松症患者,随机分成观察组和对照组,每组40例。对照组予以碳酸钙D3片、骨化三醇软胶囊及阿仑膦酸钠片,观察组在对照组的基础上服用消...目的:探讨消增强骨丸对肝肾阴虚型骨质疏松症患者骨转换标志物的影响。方法:选取80例肝肾阴虚型骨质疏松症患者,随机分成观察组和对照组,每组40例。对照组予以碳酸钙D3片、骨化三醇软胶囊及阿仑膦酸钠片,观察组在对照组的基础上服用消增强骨丸,两组均治疗6个月。治疗后比较两组腰椎骨密度(bone mineral density,BMD)、髋部BMD、血清25-(OH)VitD、Ⅰ型胶原羧基端肽β特殊序列(β-C-terminal telopeptide of typeⅠcollagen,β-CTX)、Ⅰ型原胶原氨基端延长肽(propeptide of type 1 procollagen,PINP)、骨碱性磷酸酶(bone specific alkaline phosphatase,BALP)、骨钙素(bone gla protein,BGP)及腰部视觉模拟评分法(visual analogue scale,VAS)评分。结果:两组治疗前腰椎BMD、髋部BMD、25-(OH)VitD、β-CTX、PINP、BALP、BGP、腰部VAS评分之间比较,差异无统计学意义(P>0.05)。治疗后观察组腰椎BMD、髋部BMD、25-(OH)VitD、PINP、BALP、BGP较对照组增高,观察组β-CTX、腰部VAS评分较对照组降低(P<0.05)。结论:消增强骨丸治疗肝肾阴虚型骨质疏松症患者疗效可靠,可以影响骨转换标志物,提高骨密度,缓解患者腰部疼痛症状。展开更多
提出绝经后女性骨小梁的体密度(volume bone mineral density,vBMD)、力学特性与组织形态计量参数在体分析方法,揭示其在不同解剖学区域的特异性分布规律,骨小梁组织结构与力学特点的局部相关关系。运用高分辨率外周定量断层扫描(high r...提出绝经后女性骨小梁的体密度(volume bone mineral density,vBMD)、力学特性与组织形态计量参数在体分析方法,揭示其在不同解剖学区域的特异性分布规律,骨小梁组织结构与力学特点的局部相关关系。运用高分辨率外周定量断层扫描(high resolution peripheral quantitative computed tomographic,HR-pQCT),首次建立了骨密度区域映射方法和骨小梁与骨髓多材料有限元模型,在体分析了10名绝经后女性骨小梁在胫骨前、后、外、内侧4个解剖区域的骨密度分布与力学特点区域间特异性。运用统计学方法分析组织形态参数与刚度局部区域间的相关性。研究发现骨小梁力学特性、结构与密度在不同解剖学部位的差异具有显著性差异,最低(前侧)骨小梁的强度为最高(内侧)区域的29.11%(P<0.05)。并且发现胫骨前侧和后侧、内侧和外侧都表现出了显著的两两相关的关系。骨小梁与骨髓多材料有限元模型方法为在体分析骨小梁力学与材料特性提供了可能方法。骨组织结构存在区域间相关关系,对了解胫骨材料特点,预测胫骨骨折部位具有指导性意义。展开更多
文摘Objective: To explore the possible factors influencing lumbar spinal bone mineral contents and bone mineral densities in Chinese adolescents with early ankylosing spondylitis(AS). Methods: Thirty-one male Chinese adolescent outpatients with early AS were included and compared with 31 age-matched male controls. Age (year), height (cm), total body weight (kg) together with body mass index (BMI, kg/m 2) of all subjects and disease duration (month), BASMI, BASFI, BASDAI, SASSS as well as ESR (mm/h) of AS patients were obtained. Lumbar 2-4 bone mineral content (L 2-4BMC, g) and lumbar 2-4 areal bone mineral density (L 2-4 BMD, g/cm 2) were evaluated using dual-energy X-ray absorptiometry (DEXA) with Lunar DPX-IQ device and lumbar 2-4 volumetric bone mineral apparent density (L 2-4 BMAD, g/cm 3) was subsequently calculated. Correlation and multiple regression analyses were performed. Results: Compared with 31 age-matched male controls, AS patients had significantly lower L 2-4BMD [(0.984±0.142) g/cm 2 vs (1.055±0.137) g/cm 2, P=0.049] and L 2-4BMAD [(0.1527±0.0173) g/cm 3 vs (0.1630±0.0195) g/cm 3, P=0.032]. In AS patients, multiple regression analysis identified that only the factor of height was significantly correlated with L 2-4BMC (R=0.673, P=0.000) and the factor of weight had predominant influences on L 2-4BMD (R=0.620, P=0.000) as well as L 2-4BMAD (R=0.510, P=0.003). Conclusion: The young patients with early AS had marked reduction in lumbar spine bone mineral densities, which indicated an important primary event leading to osteoporosis. Positive effects of height and weight on lumbar spine bone mass and densities could expectantly make favorable contributions to early prevention of AS associated bone loss and subsequent osteoporosis.
文摘Objective.To investigate the distribution frequency of parathyroid hormone(PTH)gene polymorphism in healthy adults from Bejing area and to explore the association of PTH genotypes with bone mineral density(BMD).Methods.PTH gene polymorphism was detected in270subjects by polymerase chain reaction(PCR)and PCR /restriction fragment length polymorphism(PCR /RFLP).The digestion products of restriction enzyme Bst B1were separated on1%agarose gels.PTH genotypes were confirmed by DNA sequences analysis.BMD was measured by dual-energy X-ray absorptiometry(DEXA,DPX -L ,Lunar).Results.Genotype frequencies of BB,Bb,bb were73.7%,25.9%and0.4%respectively in Beijing adults(P<0.01),67.1%,32.2%and0.7%in postmenopausal women,which was different from Japanese wom-en.We statistically compared bone mineral density at the lumbar2-4and proximal femur between BB and Bb genotypes.No obvious association was found between the BMD and PTH genotypes in Beijing women(P>0.05).Conclusion.PTH gene polymorphism is not associated with BMD in Chinese women.The further research to explore the genetic risk factors of osteoporosis should be committed.
基金NSFC and CNS for funding the projectfunded by the National Natural Science Foundation of China(NSFC,82173500)“CNS-ZD Tizhi and Health Fund”(CNS-ZD2020-163).
文摘This cohort study was designed to explore the relationship between maternal dietary patterns(DPs)and bone health in Chinese lactating mothers and infants.We recruited 150 lactating women at 1-month postpartum.The estimated bone mineral density(eBMD)of subjects’calcanei and the information on dietary intake were collected.After 5-month follow-up,the eBMD of mothers and their infants were measured again.Factor analysis was applied to determine maternal DPs.General linear models were used to evaluate the association between maternal DPs and maternal eBMD loss or infants’eBMD.With all potential covariates adjusted,Factor 2(high intake of whole grains,tubers,mixed beans,soybeans and soybean products,seaweeds,and nuts)showed a positive association with the changes of maternal eBMD(β=0.16,95%CI:0.005,0.310).Factor 3(high intake of soft drinks,fried foods,and puffed foods)was inversely correlated with the changes of maternal eBMD(β=-0.22,95%CI:-0.44,0.00).The changes of maternal eBMD were positively associated with 6-month infants’eBMD(β=0.34,95%CI:0.017,0.652).In conclusion,Factor 2 might contribute to the maintenance of eBMD in lactating women,while Factor 3 could exacerbate maternal eBMD loss.Additionally,the changes of maternal eBMD presented a positive correlation with 6-month infants’eBMD.
文摘Objective To evaluate the role of sclerostin in bone loss of postmenopausal Chinese women with type 2 diabetes me｜litus. Methods The postmenopausal patients suffering from type 2 diabetes mellitus and age, body mass index, and duration of menopause matched healthy controls were enrolled into this cross-sectional study according to criteria of inclusion and exclusion.
文摘目的:探讨消增强骨丸对肝肾阴虚型骨质疏松症患者骨转换标志物的影响。方法:选取80例肝肾阴虚型骨质疏松症患者,随机分成观察组和对照组,每组40例。对照组予以碳酸钙D3片、骨化三醇软胶囊及阿仑膦酸钠片,观察组在对照组的基础上服用消增强骨丸,两组均治疗6个月。治疗后比较两组腰椎骨密度(bone mineral density,BMD)、髋部BMD、血清25-(OH)VitD、Ⅰ型胶原羧基端肽β特殊序列(β-C-terminal telopeptide of typeⅠcollagen,β-CTX)、Ⅰ型原胶原氨基端延长肽(propeptide of type 1 procollagen,PINP)、骨碱性磷酸酶(bone specific alkaline phosphatase,BALP)、骨钙素(bone gla protein,BGP)及腰部视觉模拟评分法(visual analogue scale,VAS)评分。结果:两组治疗前腰椎BMD、髋部BMD、25-(OH)VitD、β-CTX、PINP、BALP、BGP、腰部VAS评分之间比较,差异无统计学意义(P>0.05)。治疗后观察组腰椎BMD、髋部BMD、25-(OH)VitD、PINP、BALP、BGP较对照组增高,观察组β-CTX、腰部VAS评分较对照组降低(P<0.05)。结论:消增强骨丸治疗肝肾阴虚型骨质疏松症患者疗效可靠,可以影响骨转换标志物,提高骨密度,缓解患者腰部疼痛症状。
文摘提出绝经后女性骨小梁的体密度(volume bone mineral density,vBMD)、力学特性与组织形态计量参数在体分析方法,揭示其在不同解剖学区域的特异性分布规律,骨小梁组织结构与力学特点的局部相关关系。运用高分辨率外周定量断层扫描(high resolution peripheral quantitative computed tomographic,HR-pQCT),首次建立了骨密度区域映射方法和骨小梁与骨髓多材料有限元模型,在体分析了10名绝经后女性骨小梁在胫骨前、后、外、内侧4个解剖区域的骨密度分布与力学特点区域间特异性。运用统计学方法分析组织形态参数与刚度局部区域间的相关性。研究发现骨小梁力学特性、结构与密度在不同解剖学部位的差异具有显著性差异,最低(前侧)骨小梁的强度为最高(内侧)区域的29.11%(P<0.05)。并且发现胫骨前侧和后侧、内侧和外侧都表现出了显著的两两相关的关系。骨小梁与骨髓多材料有限元模型方法为在体分析骨小梁力学与材料特性提供了可能方法。骨组织结构存在区域间相关关系,对了解胫骨材料特点,预测胫骨骨折部位具有指导性意义。
