目的探讨抑郁障碍和双相障碍患者脑白质网络节点强度的差异,分析患者不同脑区的结构连接受损情况及其在鉴别中的作用。方法纳入91例基线诊断为抑郁发作的患者,经过≥9年的自然观察随访后,最终确定23例维持抑郁障碍诊断(单相组)和18例维...目的探讨抑郁障碍和双相障碍患者脑白质网络节点强度的差异,分析患者不同脑区的结构连接受损情况及其在鉴别中的作用。方法纳入91例基线诊断为抑郁发作的患者,经过≥9年的自然观察随访后,最终确定23例维持抑郁障碍诊断(单相组)和18例维持双相障碍诊断(双相组)的患者纳入分析。同时纳入30名健康对照者(对照组)。受试者在入组时均接受弥散张量成像扫描,采用确定性纤维追踪技术构建脑白质结构加权网络。比较三组间脑白质网络的节点连接强度差异,进一步采用受试者操作特征(receiver operator characteristic,ROC)曲线评估差异脑区对抑郁障碍和双相障碍鉴别诊断的价值。结果双相组在左前扣带回的节点强度较单相组降低(3.89±0.76 vs.4.74±0.60),在右尾状核(4.94±1.26 vs.3.46±0.99)、右苍白球(1.98±0.67 vs.1.25±0.29)的节点强度较单相组升高(P<0.01,FWE校正)。左前扣带回、右尾状核、右苍白球3个脑区的连接强度联合鉴别抑郁障碍和双相障碍绘制ROC曲线,曲线下面积(area under the curve,AUC)为0.95(95%CI:0.91~0.99;P<0.01),敏感度0.89,特异度0.87。结论脑结构网络的节点强度差异可以作为一个潜在的影像学生物标志物识别抑郁障碍和双相障碍,联合差异脑区的节点强度可以得到更好的识别率。展开更多
抽动秽语综合征(Gilles de la Tourette syndrome,GTS)属于儿童期神经发育障碍类疾病,少数病例延至成年期;GTS典型征象包括不自主运动及发声抽动,多伴随注意缺陷多动障碍等,严重影响患者生存质量。GTS起病多与皮质-纹状体-丘脑-皮质(cor...抽动秽语综合征(Gilles de la Tourette syndrome,GTS)属于儿童期神经发育障碍类疾病,少数病例延至成年期;GTS典型征象包括不自主运动及发声抽动,多伴随注意缺陷多动障碍等,严重影响患者生存质量。GTS起病多与皮质-纹状体-丘脑-皮质(cortico-striato-thalamo-cortical,CSTC)环路功能异常关联。目前,基于MRI对GTS发病、先兆冲动、抽动程度及社会认知诸方面的机制研究,已逐渐成为业内热点;结构和功能MRI对GTS感觉、运动、情感、认知等相关脑区的激活及网络改变,能够予以揭示。笔者围绕近年内基于体素形态学分析(voxel-based morphometry,VBM)、弥散张量成像(diffusion tensor imaging,DTI)、功能MRI(functional MRI,fMRI)、磁共振波谱(magnetic resonance spectroscopy,MRS)等不同模态成像的相关文献,进行归纳总结,为疾病早期识别及后续的深入探索提供帮助。展开更多
多视图聚类方法随着数据获取途径日益多样化成为研究热点,但大多数聚类方法低估了噪声和数据多结构互补性信息对聚类结果的影响,并且忽略了聚类结果对低秩张量优化过程的反向引导作用。为解决这些问题,提出了基于结构化张量学习的多视...多视图聚类方法随着数据获取途径日益多样化成为研究热点,但大多数聚类方法低估了噪声和数据多结构互补性信息对聚类结果的影响,并且忽略了聚类结果对低秩张量优化过程的反向引导作用。为解决这些问题,提出了基于结构化张量学习的多视图聚类(multi-view clustering based on structured tensor learning,MCSTL)。首先,对初始表示张量进行再次去噪使其更具准确性和鲁棒性;同时,互补地学习局部结构、全局结构和各视图间的高阶相关性,提高表示张量与原始数据本质簇结构的一致性;然后,从跨视图信息融合的亲和矩阵中学习到统一的特征矩阵,利用其隐含的聚类结构信息反向引导表示张量的优化过程;最后,对特征矩阵施加了正交约束,使其提供数据的软标签信息,并对模型进行直接聚类解释。实验表明,MCSTL在6种聚类评价指标上均表现优异,30个指标数据中有27个达到最优,从而充分验证了MCSTL的有效性和优越性。展开更多
The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying t...The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying traditional maximum equivalent span beam(MESB)theory to determine deformation range,peak point,and angle influence poses a challenge.Considering the overall structure of the intersection roof,the maximum equivalent triangular plate(METP)theory is proposed,and its geometric parameter calculation formula and deflection calculation formula are obtained.The application of the two theories in 18 models with different intersection angles,roadway types,and surrounding rock lithology is verified by numerical analysis.The results show that:1)The METP structure of the intersection roof established by the simulation results of each model successfully determined the location of the roof’s high displacement zone;2)The area comparison method of the METP theory can be reasonably explained:①The roof subsidence of the intersection decreases with the increase of the intersection angle;②The roof subsidence at the intersection of different roadway types has a rectangular type>arch type>circular type;③The roof subsidence of the intersection with weak surrounding rock is significantly larger than that of the intersection with hard surrounding rock.According to the application results of the two theories,the four advantages of the METP theory are compared and clarified in the basic assumptions,mechanical models,main viewpoints,and mechanism analysis.The large deformation inducement of the intersection roof is then explored.The J 2 peak area of the roof drives the large deformation of the area,the peak point of which is consistent with the center of gravity position of the METP.Furthermore,the change in the range of this peak is consistent with the change law of the METP’s area.Hence,this theory clarifies the large deformation area of the intersection roof,which provides a clear guiding basis for its initial support design,mid-term monitoring,and late local reinforcement.展开更多
文摘目的探讨抑郁障碍和双相障碍患者脑白质网络节点强度的差异,分析患者不同脑区的结构连接受损情况及其在鉴别中的作用。方法纳入91例基线诊断为抑郁发作的患者,经过≥9年的自然观察随访后,最终确定23例维持抑郁障碍诊断(单相组)和18例维持双相障碍诊断(双相组)的患者纳入分析。同时纳入30名健康对照者(对照组)。受试者在入组时均接受弥散张量成像扫描,采用确定性纤维追踪技术构建脑白质结构加权网络。比较三组间脑白质网络的节点连接强度差异,进一步采用受试者操作特征(receiver operator characteristic,ROC)曲线评估差异脑区对抑郁障碍和双相障碍鉴别诊断的价值。结果双相组在左前扣带回的节点强度较单相组降低(3.89±0.76 vs.4.74±0.60),在右尾状核(4.94±1.26 vs.3.46±0.99)、右苍白球(1.98±0.67 vs.1.25±0.29)的节点强度较单相组升高(P<0.01,FWE校正)。左前扣带回、右尾状核、右苍白球3个脑区的连接强度联合鉴别抑郁障碍和双相障碍绘制ROC曲线,曲线下面积(area under the curve,AUC)为0.95(95%CI:0.91~0.99;P<0.01),敏感度0.89,特异度0.87。结论脑结构网络的节点强度差异可以作为一个潜在的影像学生物标志物识别抑郁障碍和双相障碍,联合差异脑区的节点强度可以得到更好的识别率。
文摘多视图聚类方法随着数据获取途径日益多样化成为研究热点,但大多数聚类方法低估了噪声和数据多结构互补性信息对聚类结果的影响,并且忽略了聚类结果对低秩张量优化过程的反向引导作用。为解决这些问题,提出了基于结构化张量学习的多视图聚类(multi-view clustering based on structured tensor learning,MCSTL)。首先,对初始表示张量进行再次去噪使其更具准确性和鲁棒性;同时,互补地学习局部结构、全局结构和各视图间的高阶相关性,提高表示张量与原始数据本质簇结构的一致性;然后,从跨视图信息融合的亲和矩阵中学习到统一的特征矩阵,利用其隐含的聚类结构信息反向引导表示张量的优化过程;最后,对特征矩阵施加了正交约束,使其提供数据的软标签信息,并对模型进行直接聚类解释。实验表明,MCSTL在6种聚类评价指标上均表现优异,30个指标数据中有27个达到最优,从而充分验证了MCSTL的有效性和优越性。
基金Project(52204164)supported by the National Natural Science Foundation of ChinaProject(2021QNRC001)supported by the Young Elite Scientists Sponsorship Program by CAST,China。
文摘The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying traditional maximum equivalent span beam(MESB)theory to determine deformation range,peak point,and angle influence poses a challenge.Considering the overall structure of the intersection roof,the maximum equivalent triangular plate(METP)theory is proposed,and its geometric parameter calculation formula and deflection calculation formula are obtained.The application of the two theories in 18 models with different intersection angles,roadway types,and surrounding rock lithology is verified by numerical analysis.The results show that:1)The METP structure of the intersection roof established by the simulation results of each model successfully determined the location of the roof’s high displacement zone;2)The area comparison method of the METP theory can be reasonably explained:①The roof subsidence of the intersection decreases with the increase of the intersection angle;②The roof subsidence at the intersection of different roadway types has a rectangular type>arch type>circular type;③The roof subsidence of the intersection with weak surrounding rock is significantly larger than that of the intersection with hard surrounding rock.According to the application results of the two theories,the four advantages of the METP theory are compared and clarified in the basic assumptions,mechanical models,main viewpoints,and mechanism analysis.The large deformation inducement of the intersection roof is then explored.The J 2 peak area of the roof drives the large deformation of the area,the peak point of which is consistent with the center of gravity position of the METP.Furthermore,the change in the range of this peak is consistent with the change law of the METP’s area.Hence,this theory clarifies the large deformation area of the intersection roof,which provides a clear guiding basis for its initial support design,mid-term monitoring,and late local reinforcement.
