Selenium is a crucial trace element that contributes to physiological processes in the body as selenoproteins.Selenoproteins serve as an integral role in the body in controlling the redox state of cells and protecting...Selenium is a crucial trace element that contributes to physiological processes in the body as selenoproteins.Selenoproteins serve as an integral role in the body in controlling the redox state of cells and protecting against damage induced by oxidative stress.This study aimed to investigate the effects and possible mechanism of selenium on selenoproteins expression in EA.hy926 cells induced by oxidized low density lipoprotein(oxLDL).The impact of selenium on the viability of EA.hy926 cells was detected by the methylthiazolyldiphenyltetrazolium bromide(MTT)method,and intracellular reactive oxygen species(ROS)level and mitochondrial membrane potential were assessed by fluorescent probe DCFH-DA and JC-1,respectively.RNA-seq,quantitative real-time polymerase chain reaction(qPCR),and Western blot were used to investigate the selenoprotein expression.Selenoprotein mRNA translation efficiency was analyzed by ribosome profiling(Ribo-Seq)coupled with transcriptomics.Our data showed that selenium supplementation(0.5μmol/L)significantly decreased ROS production,increased mitochondrial inner membrane potential and increased the proliferative activity of EA.hy926 cells induced by oxLDL.Moreover,The protective effects of selenium against oxLDL-induced EA.hy926 cell injury were associated with the upregulation of the expressions of selenoproteins glutathione peroxidase 1(GPX1),glutathione peroxidase 4(GPX4),and thioredoxin reductase 1(TXNRD1).Furthermore,the expressions of selenoproteins GPX1 and GPX4 were hierarchically controlled,but the expressions of selenoproteins TXNRD1 were mainly regulated by oxLDL.Finally,Ribo-Seq coupled with transcriptomics results demonstrated that the expressions of selenoproteins GPX1,GPX4,and TXNRD1 were regulated at the translation process level.These findings suggested that selenium could have preventive effects in oxLDL induced EA.hy926 cell injury by regulating the selenoprotein expression,and the selenoproteins expressions at the translation level in vascular endothelial cells need further study.展开更多
Selenium is one of the essential trace elements in human body,however,due to the limitation of geographic factors,the intake of selenium is seriously insufficient in most regions.In this study,selenium-enriched peanut...Selenium is one of the essential trace elements in human body,however,due to the limitation of geographic factors,the intake of selenium is seriously insufficient in most regions.In this study,selenium-enriched peanut sprouts with high selenium content were prepared by soaking peanut seeds in sodium selenite.The content and distribution of selenium in germinated peanuts were investigated.The results showed that 200μmol/L sodium selenite and germination for 6 days resulted in the highest total selenium,organic selenium content,and organic selenium conversion in peanut sprouts.Selenium exists in peanut sprouts mainly in organic selenium form,of which selenoproteins are the most critical organic selenium carriers.ABTS free radical scavenging capacity and reducing power assays showed that alkali-soluble protein had the highest antioxidant activity among the four soluble proteins,attributed to its high selenium binding level.Radicle and cotyledons of peanut seedlings were significantly enriched with selenium compared to hypocotyl.Amino acid analysis and SDS-PAGE results showed that selenium increases significantly after peanut germination and selenium enrichment.This study provides a simple,environmentally friendly,and effective way of selenium enrichment and offers a theoretical basis for applying selenium-enriched foods in food and medicine.展开更多
Selenopeptides may be a valuable bioactive compound to promote gut microbiota-targeted therapeutic methods for intestinal disease and hepatopathy.However,limited information is available on the utilization of selenope...Selenopeptides may be a valuable bioactive compound to promote gut microbiota-targeted therapeutic methods for intestinal disease and hepatopathy.However,limited information is available on the utilization of selenopeptides by gut microbiota,especially Selenium(Se)function.For this purpose,the present study aimed to investigate the protective effect of selenopeptide(RYNA(Se)MNDYT,Se-P2,purity of≥95%)and its original peptide(RYNAMNDYT,P2,purity of≥95%)in vivo by the microbiota-metabolite axis and further analyze the potential contribution of Se biofortification to Se-P2 bioactivity.The results showed that Se-P2 exhibits a higher protective effect on lipopolysaccharide(LPS)-induced inflammation than P2,including pathology of the colon and liver,which suggested that the bioactivity of P2 was promoted by the organic combination of Se.Notably,gut microbiota composition tended to be a healthy structure by Se-P2 pretreatment in LPS-injured mice,which had a positive effect on LPS-induced gut microbiota dysbacteriosis.Additionally,only Se-P2 promoted an increase in the relative abundance of Lactobacillus,Alistipes,and Roseburia and a decrease in the relative abundance of Akkermansia,Erysipelatoclostridium,and Bacteroides in LPS-injured mice.The changes in gut microbiota were obviously correlated with the changes in metabolites and affected the metabolic pathways of valine,leucine,isoleucine,phenylalanine,tyrosine,and tryptophan biosynthesis and phenylalanine metabolism.This may be one of the key reasons for Se-P2 to exert bioactivity through the microbiota-metabolite axis.Furthermore,Se-biofortification in Se-enriched Cordyceps militaris affected the parental proteins of Se-P2 to modulate mitogen-activated protein kinase,GPI anchored protein,and carbohydrate metabolism,translation,folding,sorting and degradation,which may contribute to the bioactivity of Se-P2.Our study provides information on the effect of Se on selenopeptides in vivo,which further promotes the prospective applications of selenopeptides as dietary supplements.展开更多
Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic ac...Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application value.Herein,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse liver.Further elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also performed.The results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting study.PTR-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 expression.Besides,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial morphology.Furthermore,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective efficacy.Being a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.展开更多
A simple and fast ultraviolet spectrophotometric method was used to determineselenium (Ⅳ) through the formation, separaion and quantitative determination of potassium butylxanthae -selenium complex. The complex ab...A simple and fast ultraviolet spectrophotometric method was used to determineselenium (Ⅳ) through the formation, separaion and quantitative determination of potassium butylxanthae -selenium complex. The complex absorbed light sharply at 375 nm. The optimum acidity ofthe complex formation was between pH 3.4 - 4.0. The absorption value was no change in 120 minutesafter the comlex was extracted by Carbon tetraChioride. The sensitivity of the colour reation was 0.2ng cm-2, The content of selenimp (Ⅳ) was within 0-30 μg and linear rclation was good,Y=0.07X＋0.025, relevent coefficient r＝0.9997. A great quantity of I, Cu, Co, the and SO4-2, PO4-3contained in .the Sample had no effect on the results ofdetenninion when seldsum was determined.When content of Fe was over l00gμg/ml and Zn was over 180μg/ml, there was diotance to the determination, but the disturbance was rem0ved by adding EDTA. When making use of the method todetermine containin seldsum additivef Cv =6.85, rate of recovery was 97.2%, wild jujubef;Cv=3.22,rate of recovery was 90. 1%, soil Samlef Cv=4.64, rate of recovery was 86.2%. The method for sensitivity measured was apprtoate to 2, 3-diamino naphthalene (DAN) fluorescence method.展开更多
Lithium-selenium(Li-Se)batteries have attracted considerable attentions for next-generation energy storage systems owing to high volumetric capacity of 3265 m Ah cm^(-3) and excellent electronic conductivity(~10^(-5)S...Lithium-selenium(Li-Se)batteries have attracted considerable attentions for next-generation energy storage systems owing to high volumetric capacity of 3265 m Ah cm^(-3) and excellent electronic conductivity(~10^(-5)S cm^(-1))of selenium.However,the shuttling effect and capacity fading prevent their wide applications.Herein we report a low-cost strategy for scalable fabrication of lignin derived hierarchical porous carbon(LHPC)as a new high-loading Se host for high-capacity and long-term cycling Li-Se batteries in carbonate electrolyte.The resulting LHPC exhibits three-dimensional(3D)hierarchically porous structure,high specific surface area of 1696 m^(2) g^(-1),and hetero-atom doping(O,S),which can effectively confine the Se particles into the micropores,and meanwhile,offer effective chemical binding sites for selenides from hetero-atoms(O,S).As a result,our Li-Se batteries based on Se@LHPC demonstrate high capacity of 450 m Ah g^(-1) at 0.5 C after 500 cycles,with a low capacity fading rate of only 0.027%.The theoretical simulation confirmed the strong affinity of selenides on the O and S sites of LHPC effectively mitigating the Se losing.Therefore,our strategy of using lignin as the low-cost precursor of hierarchically porous carbon for high-loading Se host offers new opportunities for high-capacity and long-life Li-Se batteries.展开更多
Both tea polyphenols and selenium(Se)have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation,which make Se-enriched oolong tea a promising beverage as an anti-inflammator...Both tea polyphenols and selenium(Se)have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation,which make Se-enriched oolong tea a promising beverage as an anti-inflammatory diet.The aim of this study is to investigate the anti-inflammatory effects of Se-enriched oolong tea extract(Se-TE)and underlying mechanism in lipopolysaccharide(LPS)-induced RAW264.7 cells.Se-TE treatments(50 and 150μg/m L)significantly suppressed the over-production of nitric oxide(NO)and prostaglandin E2(PGE2)in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase(i NOS)and cyclooxygenase-2(COX-2).Moreover,Se-TEs also effectively inhibited the productions of inflammatory cytokines,such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-1β(IL-1β).Furthermore,Se-TE could block mitogen-activated protein kinase(MAPK)and nuclear factor-kappa B(NF-κB)signaling pathways through the inhibition of the phosphorylation of key proteins(IκB-α,p65,p38,ERK,and JNK)and the translocation of the p65 subunit into the nucleus.Collectively,our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases.展开更多
Vacancy engineering is a useful methodology in the development of catalysts and electrode materials.Herein,we report the introduction of Se-vacancy pairs in heteroatom-doped(N,B,and F)CoSe/Mo_(2)CT_(x) MXene(NBF-CoSe/...Vacancy engineering is a useful methodology in the development of catalysts and electrode materials.Herein,we report the introduction of Se-vacancy pairs in heteroatom-doped(N,B,and F)CoSe/Mo_(2)CT_(x) MXene(NBF-CoSe/Mo_(2)CT_(x))to enhance the hydrogen evolution reaction(HER)and supercapacitor activities via an ionic liquid-mediated method.Se vacancy pairs and heteroatom doping enable the reallocation of local electron states and add active sites,improving the electrochemical activity of NBF-CoSe/Mo_(2)CT_(x) with high HER activities over a broad range of pH.At a current density of 10 mA cm^(-2),overvoltages of 70 and 81 mV are respectively produced in 0.5 M H_(2)SO_(4)and 1 M KOH.The optimal structure also exhibits outstanding electrochemical performance in an asymmetric supercapacitor with an energy density of 34.2 Wh kg^(-1)at a power density of 15989.6Wkg^(-1).This study opens new avenues for the introduction of Se vacancies and heteroatom doping to improve the application performance.展开更多
Sulfur and selenium have been paid more and more attention in energy storage systems because of their high theoretical specific gravimetric and volumetric capacities.With the increasing scarcity of lithium resources,s...Sulfur and selenium have been paid more and more attention in energy storage systems because of their high theoretical specific gravimetric and volumetric capacities.With the increasing scarcity of lithium resources,secondary batteries made of sulfur and selenium coupled with other alkali metal/alkaline earth metals(e.g.Na,K,Mg)are expected to play a vital role in future production and human life.Due to the volume expansion,poor conductivity and shuttle effect,the structure design of cathode,as one of the important roles in metal-S/Se batteries,has always been a hot and difficult point.In the review,various host materials of S and Se are clarified and discussed.Typically,carbonaceous materials are the most widely used hosts,while polar materials are becoming more and more popular in metal-S/Se batteries.Through a comprehensive overview,it is hoped that previous research experiences can provide further reference and guidance for the sustainable development of metal-S/Se batteries.展开更多
基金supported by grants from the National Natural Science Foundation of China(NSFC,81960588)the Ningxia Natural Science Foundation(2020AAC03146)support from the Ningxia Medical University。
文摘Selenium is a crucial trace element that contributes to physiological processes in the body as selenoproteins.Selenoproteins serve as an integral role in the body in controlling the redox state of cells and protecting against damage induced by oxidative stress.This study aimed to investigate the effects and possible mechanism of selenium on selenoproteins expression in EA.hy926 cells induced by oxidized low density lipoprotein(oxLDL).The impact of selenium on the viability of EA.hy926 cells was detected by the methylthiazolyldiphenyltetrazolium bromide(MTT)method,and intracellular reactive oxygen species(ROS)level and mitochondrial membrane potential were assessed by fluorescent probe DCFH-DA and JC-1,respectively.RNA-seq,quantitative real-time polymerase chain reaction(qPCR),and Western blot were used to investigate the selenoprotein expression.Selenoprotein mRNA translation efficiency was analyzed by ribosome profiling(Ribo-Seq)coupled with transcriptomics.Our data showed that selenium supplementation(0.5μmol/L)significantly decreased ROS production,increased mitochondrial inner membrane potential and increased the proliferative activity of EA.hy926 cells induced by oxLDL.Moreover,The protective effects of selenium against oxLDL-induced EA.hy926 cell injury were associated with the upregulation of the expressions of selenoproteins glutathione peroxidase 1(GPX1),glutathione peroxidase 4(GPX4),and thioredoxin reductase 1(TXNRD1).Furthermore,the expressions of selenoproteins GPX1 and GPX4 were hierarchically controlled,but the expressions of selenoproteins TXNRD1 were mainly regulated by oxLDL.Finally,Ribo-Seq coupled with transcriptomics results demonstrated that the expressions of selenoproteins GPX1,GPX4,and TXNRD1 were regulated at the translation process level.These findings suggested that selenium could have preventive effects in oxLDL induced EA.hy926 cell injury by regulating the selenoprotein expression,and the selenoproteins expressions at the translation level in vascular endothelial cells need further study.
基金supported by the National Natural Science Foundation of China[32172259]Key Research and Development Project of Henan Province[231111111800]+1 种基金Innovative Funds Plan of Henan University of Technology [2021ZKCJ03]The Program for the Top Young Talents of Henan Associate for Science and Technology.
文摘Selenium is one of the essential trace elements in human body,however,due to the limitation of geographic factors,the intake of selenium is seriously insufficient in most regions.In this study,selenium-enriched peanut sprouts with high selenium content were prepared by soaking peanut seeds in sodium selenite.The content and distribution of selenium in germinated peanuts were investigated.The results showed that 200μmol/L sodium selenite and germination for 6 days resulted in the highest total selenium,organic selenium content,and organic selenium conversion in peanut sprouts.Selenium exists in peanut sprouts mainly in organic selenium form,of which selenoproteins are the most critical organic selenium carriers.ABTS free radical scavenging capacity and reducing power assays showed that alkali-soluble protein had the highest antioxidant activity among the four soluble proteins,attributed to its high selenium binding level.Radicle and cotyledons of peanut seedlings were significantly enriched with selenium compared to hypocotyl.Amino acid analysis and SDS-PAGE results showed that selenium increases significantly after peanut germination and selenium enrichment.This study provides a simple,environmentally friendly,and effective way of selenium enrichment and offers a theoretical basis for applying selenium-enriched foods in food and medicine.
基金Guangzhou Basic and Applied Basic Research Project(202201010197)State Key Laboratory of Applied Microbiology Southern China(SKLAM011-2021)+1 种基金National Natural Science Foundation of China(32202014),Guangdong Provincial Key Laboratory(2020B121201009)Guangdong Province Academy of Sciences Special Project for Capacity Building of Innovation Driven Development(2020GDASYL-20200401002).
文摘Selenopeptides may be a valuable bioactive compound to promote gut microbiota-targeted therapeutic methods for intestinal disease and hepatopathy.However,limited information is available on the utilization of selenopeptides by gut microbiota,especially Selenium(Se)function.For this purpose,the present study aimed to investigate the protective effect of selenopeptide(RYNA(Se)MNDYT,Se-P2,purity of≥95%)and its original peptide(RYNAMNDYT,P2,purity of≥95%)in vivo by the microbiota-metabolite axis and further analyze the potential contribution of Se biofortification to Se-P2 bioactivity.The results showed that Se-P2 exhibits a higher protective effect on lipopolysaccharide(LPS)-induced inflammation than P2,including pathology of the colon and liver,which suggested that the bioactivity of P2 was promoted by the organic combination of Se.Notably,gut microbiota composition tended to be a healthy structure by Se-P2 pretreatment in LPS-injured mice,which had a positive effect on LPS-induced gut microbiota dysbacteriosis.Additionally,only Se-P2 promoted an increase in the relative abundance of Lactobacillus,Alistipes,and Roseburia and a decrease in the relative abundance of Akkermansia,Erysipelatoclostridium,and Bacteroides in LPS-injured mice.The changes in gut microbiota were obviously correlated with the changes in metabolites and affected the metabolic pathways of valine,leucine,isoleucine,phenylalanine,tyrosine,and tryptophan biosynthesis and phenylalanine metabolism.This may be one of the key reasons for Se-P2 to exert bioactivity through the microbiota-metabolite axis.Furthermore,Se-biofortification in Se-enriched Cordyceps militaris affected the parental proteins of Se-P2 to modulate mitogen-activated protein kinase,GPI anchored protein,and carbohydrate metabolism,translation,folding,sorting and degradation,which may contribute to the bioactivity of Se-P2.Our study provides information on the effect of Se on selenopeptides in vivo,which further promotes the prospective applications of selenopeptides as dietary supplements.
基金financially supported by National Natural Science Foundation of China(81700524)Natural Science Foundation of Fujian Province(2022J01866)from Fujian Provincial Department of Science and Technology+1 种基金Key Project of Fujian University of Traditional Chinese Medicine(X2021019)Collaborative Innovation and Platform Establishment Project of Department of Science and Technology of Guangdong Province(2019A050520003)。
文摘Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application value.Herein,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse liver.Further elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also performed.The results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting study.PTR-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 expression.Besides,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial morphology.Furthermore,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective efficacy.Being a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.
文摘A simple and fast ultraviolet spectrophotometric method was used to determineselenium (Ⅳ) through the formation, separaion and quantitative determination of potassium butylxanthae -selenium complex. The complex absorbed light sharply at 375 nm. The optimum acidity ofthe complex formation was between pH 3.4 - 4.0. The absorption value was no change in 120 minutesafter the comlex was extracted by Carbon tetraChioride. The sensitivity of the colour reation was 0.2ng cm-2, The content of selenimp (Ⅳ) was within 0-30 μg and linear rclation was good,Y=0.07X＋0.025, relevent coefficient r＝0.9997. A great quantity of I, Cu, Co, the and SO4-2, PO4-3contained in .the Sample had no effect on the results ofdetenninion when seldsum was determined.When content of Fe was over l00gμg/ml and Zn was over 180μg/ml, there was diotance to the determination, but the disturbance was rem0ved by adding EDTA. When making use of the method todetermine containin seldsum additivef Cv =6.85, rate of recovery was 97.2%, wild jujubef;Cv=3.22,rate of recovery was 90. 1%, soil Samlef Cv=4.64, rate of recovery was 86.2%. The method for sensitivity measured was apprtoate to 2, 3-diamino naphthalene (DAN) fluorescence method.
基金financially supported by the National Key R&D Program of China(Grants 2016YBF0100100,2016YFA0200200)the National Natural Science Foundation of China(Grants 51872283,21805273)+1 种基金the Liaoning Bai Qian Wan Talents Program,Natural Science Foundation of Liaoning Province,Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science(Grant 20180510038)the Liao Ning Revitalization Talents Program(Grant XLYC1807153),DICP(DICP ZZBS201708,DICP ZZBS201802,DICP I202032),DNL Cooperation Fund,CAS(DNL180310,DNL180308,DNL201912,and DNL201915),DICP&QIBEBT(Grant DICP&QIBEBT UN201702)。
文摘Lithium-selenium(Li-Se)batteries have attracted considerable attentions for next-generation energy storage systems owing to high volumetric capacity of 3265 m Ah cm^(-3) and excellent electronic conductivity(~10^(-5)S cm^(-1))of selenium.However,the shuttling effect and capacity fading prevent their wide applications.Herein we report a low-cost strategy for scalable fabrication of lignin derived hierarchical porous carbon(LHPC)as a new high-loading Se host for high-capacity and long-term cycling Li-Se batteries in carbonate electrolyte.The resulting LHPC exhibits three-dimensional(3D)hierarchically porous structure,high specific surface area of 1696 m^(2) g^(-1),and hetero-atom doping(O,S),which can effectively confine the Se particles into the micropores,and meanwhile,offer effective chemical binding sites for selenides from hetero-atoms(O,S).As a result,our Li-Se batteries based on Se@LHPC demonstrate high capacity of 450 m Ah g^(-1) at 0.5 C after 500 cycles,with a low capacity fading rate of only 0.027%.The theoretical simulation confirmed the strong affinity of selenides on the O and S sites of LHPC effectively mitigating the Se losing.Therefore,our strategy of using lignin as the low-cost precursor of hierarchically porous carbon for high-loading Se host offers new opportunities for high-capacity and long-life Li-Se batteries.
基金funded by Fujian Special Research Projects for Public Scientific Research Institutions(grant number 2020R1032001)。
文摘Both tea polyphenols and selenium(Se)have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation,which make Se-enriched oolong tea a promising beverage as an anti-inflammatory diet.The aim of this study is to investigate the anti-inflammatory effects of Se-enriched oolong tea extract(Se-TE)and underlying mechanism in lipopolysaccharide(LPS)-induced RAW264.7 cells.Se-TE treatments(50 and 150μg/m L)significantly suppressed the over-production of nitric oxide(NO)and prostaglandin E2(PGE2)in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase(i NOS)and cyclooxygenase-2(COX-2).Moreover,Se-TEs also effectively inhibited the productions of inflammatory cytokines,such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-1β(IL-1β).Furthermore,Se-TE could block mitogen-activated protein kinase(MAPK)and nuclear factor-kappa B(NF-κB)signaling pathways through the inhibition of the phosphorylation of key proteins(IκB-α,p65,p38,ERK,and JNK)and the translocation of the p65 subunit into the nucleus.Collectively,our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases.
基金supported by the National Natural Science Foundation of China(21905069)the Shenzhen Science and Technology Innovation Committee(JCYJ20180507183907224 and KQTD20170809110344233)the Economic,Trade and Information Commission of Shenzhen Municipality through the Graphene Manufacture Innovation Center(201901161514)。
文摘Vacancy engineering is a useful methodology in the development of catalysts and electrode materials.Herein,we report the introduction of Se-vacancy pairs in heteroatom-doped(N,B,and F)CoSe/Mo_(2)CT_(x) MXene(NBF-CoSe/Mo_(2)CT_(x))to enhance the hydrogen evolution reaction(HER)and supercapacitor activities via an ionic liquid-mediated method.Se vacancy pairs and heteroatom doping enable the reallocation of local electron states and add active sites,improving the electrochemical activity of NBF-CoSe/Mo_(2)CT_(x) with high HER activities over a broad range of pH.At a current density of 10 mA cm^(-2),overvoltages of 70 and 81 mV are respectively produced in 0.5 M H_(2)SO_(4)and 1 M KOH.The optimal structure also exhibits outstanding electrochemical performance in an asymmetric supercapacitor with an energy density of 34.2 Wh kg^(-1)at a power density of 15989.6Wkg^(-1).This study opens new avenues for the introduction of Se vacancies and heteroatom doping to improve the application performance.
基金support from National Natural Science Foundation of China(No.21772188,No.22179109)Chongqing Natural Science Foundation(cstc2021ycjh-bgzxm0164,cstc2020jcyj-zdxmX0010)。
文摘Sulfur and selenium have been paid more and more attention in energy storage systems because of their high theoretical specific gravimetric and volumetric capacities.With the increasing scarcity of lithium resources,secondary batteries made of sulfur and selenium coupled with other alkali metal/alkaline earth metals(e.g.Na,K,Mg)are expected to play a vital role in future production and human life.Due to the volume expansion,poor conductivity and shuttle effect,the structure design of cathode,as one of the important roles in metal-S/Se batteries,has always been a hot and difficult point.In the review,various host materials of S and Se are clarified and discussed.Typically,carbonaceous materials are the most widely used hosts,while polar materials are becoming more and more popular in metal-S/Se batteries.Through a comprehensive overview,it is hoped that previous research experiences can provide further reference and guidance for the sustainable development of metal-S/Se batteries.
