A new alkaloid,diacedolinate(1),along with fourteen known compounds(2-15)was isolated from the sponge associated fungus Penicillium crustosum SCSIO 41442.The structures of these compounds were determined by spectrum a...A new alkaloid,diacedolinate(1),along with fourteen known compounds(2-15)was isolated from the sponge associated fungus Penicillium crustosum SCSIO 41442.The structures of these compounds were determined by spectrum analysis and ECD.All compounds were evaluated for their antioxidant and antimicrobial activities.The results showed that compound 1 exhibited weak antioxidant activity with an IC_(50)value of(71.00±0.14)μg·mL^(−1),while compound 2,in contrast,displayed broad antioxidant activity with an IC_(50)value of(1.25±0.10)μg·mL^(−1),compared with the positive control,vitamin C.In addition,compounds 9,10,11,and 15 demonstrated broad-spectrum antimicrobial activity against a variety of pathogens,including MRSA,Colletotrichum asianum HNM 408,Colletotrichum acutatum HNM RC178,and Alternaria alternate,with MIC values ranging from 2.5 to 160μg·mL^(−1).The bioactivities of these compounds are reported here for the first time.展开更多
文摘A new alkaloid,diacedolinate(1),along with fourteen known compounds(2-15)was isolated from the sponge associated fungus Penicillium crustosum SCSIO 41442.The structures of these compounds were determined by spectrum analysis and ECD.All compounds were evaluated for their antioxidant and antimicrobial activities.The results showed that compound 1 exhibited weak antioxidant activity with an IC_(50)value of(71.00±0.14)μg·mL^(−1),while compound 2,in contrast,displayed broad antioxidant activity with an IC_(50)value of(1.25±0.10)μg·mL^(−1),compared with the positive control,vitamin C.In addition,compounds 9,10,11,and 15 demonstrated broad-spectrum antimicrobial activity against a variety of pathogens,including MRSA,Colletotrichum asianum HNM 408,Colletotrichum acutatum HNM RC178,and Alternaria alternate,with MIC values ranging from 2.5 to 160μg·mL^(−1).The bioactivities of these compounds are reported here for the first time.
