目的探讨丹红注射液联合左西孟旦对脓毒症心肌病患者N-末端B型脑钠肽前体(NT-proBNP)、肌钙蛋白I(cTnⅠ)水平及血流动力学的影响。方法研究中共纳入85例脓毒症心肌病患者,选取时间为2018年1月—2023年10月,进行回顾性分析。将所有患者...目的探讨丹红注射液联合左西孟旦对脓毒症心肌病患者N-末端B型脑钠肽前体(NT-proBNP)、肌钙蛋白I(cTnⅠ)水平及血流动力学的影响。方法研究中共纳入85例脓毒症心肌病患者,选取时间为2018年1月—2023年10月,进行回顾性分析。将所有患者根据治疗方法的不同分为A组(42例,左西孟旦治疗)和B组(43例,丹红注射液联合左西孟旦治疗),14 d为1个疗程,两组患者均进行为期2个疗程的治疗。将两组患者治疗前后NT-proBNP、cTnⅠ水平的变化进行对比,将两组患者治疗前后中医证候积分进行比较,将两组患者治疗前,治疗后24、48、72 h血流动力学指标、心功能指标水平及miR-133a、miR-499a-5p、miR-21-3指标水平进行对比。结果治疗后两组患者NT-proBNP、cTnⅠ指标水平均相较于治疗前下降,且B组患者上述指标比A组下降;治疗后两组患者主症、次症中医证候积分均相较于治疗前下降,且B组患者上述评分比A组低;治疗后不同时间点B组患者心率(HR)均相较于A组下降,随着治疗时间的延长,两组患者HR呈下降趋势,而平均动脉压(MAP)呈上升趋势;治疗后不同时间点两组患者左心室射血分数(LVEF)均相较于治疗前上升,B组患者治疗72 h LVEF指标水平相较于A组上升,治疗后不同时间点两组患者左室舒张末期内径(LVEDD)均相较于治疗前上升,B组患者治疗72 h LVEDD指标水平相较于A组下降(均P<0.05);治疗后两组患者miR-133a、miR-499a-5p、miR-21-3指标水平均相较于治疗前下降,且B组患者上述指标比A组下降(均P<0.05)。结论丹红注射液联合左西孟旦应用于脓毒症心肌病患者的治疗中,可有效缓解患者临床症状,减轻心肌受损程度,降低miRNAs相关指标的表达水平,有助于血流动力学指标的改善。展开更多
目的探究PROS1基因单核苷酸多态性(SNP)与包头地区汉族人群复发性流产(RSA)发生风险之间的相关性。方法选取RSA患者及对照人群各158例作为研究对象,测定蛋白S、蛋白C、抗凝血酶-Ⅲ活性;使用聚合酶链式反应-限制性片段长度多态性(PCR-RF...目的探究PROS1基因单核苷酸多态性(SNP)与包头地区汉族人群复发性流产(RSA)发生风险之间的相关性。方法选取RSA患者及对照人群各158例作为研究对象,测定蛋白S、蛋白C、抗凝血酶-Ⅲ活性;使用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术对PROS1基因rs13062355、rs6441600和rs12634349位点进行基因分型。采用非条件性Logistic回归分析PROS1基因三种SNP与RSA发生风险的相关性。结果RSA患者的蛋白S、抗凝血酶-Ⅲ活性下降(P<0.05);PROS1 SNP rs13062355在显性模型下与RSA发病风险相关:与携带TT基因型患者比较,携带CT+CC基因型的患者RSA发病风险下降(OR=0.398,95%CI:0.249~0.638)。SNP rs6441600、rs12634349与RSA的发病风险无关联。在PROS1 rs13062355、rs6441600、rs12634349构建的单体型中,单体型C-C-C在两组间差异有统计学意义(P<0.05);三阶交互模型rs13062355-rs6441600-rs12634349与RSA发病风险相关。结论PROS1 SNP rs13062355可能与包头地区汉族女性RSA患病风险相关;PROS1 rs13062355、rs6441600、rs12634349的单体型C-C-C降低了RSA发病风险;三阶模型rs13062355-rs6441600-rs12634349的交互作用在RSA的发生中具有协同效应。展开更多
Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(...Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(anti⁃MDA5+)dermatomyositis(DM)develop into the rapidly progressive interstitial lung disease(RPILD).Methods:We retrospectively analyzed the clinical and laboratory data of 124 anti⁃MDA5+DM patients from the First Affiliated Hospital of Nanjing Medical University between March 2019 and September 2023.We identified independent risk factors associated with the development and mortality of RPILD with the Cox regression analysis,and determined the optimal cut⁃off values for predicting adverse outcomes with the receiver operating characteristic(ROC)curve analysis.Results:Among the 124 patients,36 patients(29.03%)developed RPILD,and 39 patients(31.45%)died during the follow⁃up period.The results of multivariate Cox regression analysis showed that the elevated NLR was an independent risk factor for RPILD development,while the elevated SII expression was independently associated with the increased mortality of RPILD.Based on the ROC curve analysis,NLR>6.12 was a predictor for RPILD,and SII>875.79 was associated with increased mortality risk of RPILD.Conclusion:Both NLR and SII are accessible,cost⁃effective,and reliable prognostic indicators for the prognosis of patients with anti⁃MDA5^(+)DM,providing a valuable guidance for clinical management and risk stratification of the disease.展开更多
文摘目的探讨丹红注射液联合左西孟旦对脓毒症心肌病患者N-末端B型脑钠肽前体(NT-proBNP)、肌钙蛋白I(cTnⅠ)水平及血流动力学的影响。方法研究中共纳入85例脓毒症心肌病患者,选取时间为2018年1月—2023年10月,进行回顾性分析。将所有患者根据治疗方法的不同分为A组(42例,左西孟旦治疗)和B组(43例,丹红注射液联合左西孟旦治疗),14 d为1个疗程,两组患者均进行为期2个疗程的治疗。将两组患者治疗前后NT-proBNP、cTnⅠ水平的变化进行对比,将两组患者治疗前后中医证候积分进行比较,将两组患者治疗前,治疗后24、48、72 h血流动力学指标、心功能指标水平及miR-133a、miR-499a-5p、miR-21-3指标水平进行对比。结果治疗后两组患者NT-proBNP、cTnⅠ指标水平均相较于治疗前下降,且B组患者上述指标比A组下降;治疗后两组患者主症、次症中医证候积分均相较于治疗前下降,且B组患者上述评分比A组低;治疗后不同时间点B组患者心率(HR)均相较于A组下降,随着治疗时间的延长,两组患者HR呈下降趋势,而平均动脉压(MAP)呈上升趋势;治疗后不同时间点两组患者左心室射血分数(LVEF)均相较于治疗前上升,B组患者治疗72 h LVEF指标水平相较于A组上升,治疗后不同时间点两组患者左室舒张末期内径(LVEDD)均相较于治疗前上升,B组患者治疗72 h LVEDD指标水平相较于A组下降(均P<0.05);治疗后两组患者miR-133a、miR-499a-5p、miR-21-3指标水平均相较于治疗前下降,且B组患者上述指标比A组下降(均P<0.05)。结论丹红注射液联合左西孟旦应用于脓毒症心肌病患者的治疗中,可有效缓解患者临床症状,减轻心肌受损程度,降低miRNAs相关指标的表达水平,有助于血流动力学指标的改善。
文摘目的探究PROS1基因单核苷酸多态性(SNP)与包头地区汉族人群复发性流产(RSA)发生风险之间的相关性。方法选取RSA患者及对照人群各158例作为研究对象,测定蛋白S、蛋白C、抗凝血酶-Ⅲ活性;使用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术对PROS1基因rs13062355、rs6441600和rs12634349位点进行基因分型。采用非条件性Logistic回归分析PROS1基因三种SNP与RSA发生风险的相关性。结果RSA患者的蛋白S、抗凝血酶-Ⅲ活性下降(P<0.05);PROS1 SNP rs13062355在显性模型下与RSA发病风险相关:与携带TT基因型患者比较,携带CT+CC基因型的患者RSA发病风险下降(OR=0.398,95%CI:0.249~0.638)。SNP rs6441600、rs12634349与RSA的发病风险无关联。在PROS1 rs13062355、rs6441600、rs12634349构建的单体型中,单体型C-C-C在两组间差异有统计学意义(P<0.05);三阶交互模型rs13062355-rs6441600-rs12634349与RSA发病风险相关。结论PROS1 SNP rs13062355可能与包头地区汉族女性RSA患病风险相关;PROS1 rs13062355、rs6441600、rs12634349的单体型C-C-C降低了RSA发病风险;三阶模型rs13062355-rs6441600-rs12634349的交互作用在RSA的发生中具有协同效应。
文摘Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(anti⁃MDA5+)dermatomyositis(DM)develop into the rapidly progressive interstitial lung disease(RPILD).Methods:We retrospectively analyzed the clinical and laboratory data of 124 anti⁃MDA5+DM patients from the First Affiliated Hospital of Nanjing Medical University between March 2019 and September 2023.We identified independent risk factors associated with the development and mortality of RPILD with the Cox regression analysis,and determined the optimal cut⁃off values for predicting adverse outcomes with the receiver operating characteristic(ROC)curve analysis.Results:Among the 124 patients,36 patients(29.03%)developed RPILD,and 39 patients(31.45%)died during the follow⁃up period.The results of multivariate Cox regression analysis showed that the elevated NLR was an independent risk factor for RPILD development,while the elevated SII expression was independently associated with the increased mortality of RPILD.Based on the ROC curve analysis,NLR>6.12 was a predictor for RPILD,and SII>875.79 was associated with increased mortality risk of RPILD.Conclusion:Both NLR and SII are accessible,cost⁃effective,and reliable prognostic indicators for the prognosis of patients with anti⁃MDA5^(+)DM,providing a valuable guidance for clinical management and risk stratification of the disease.
