Purpose: To compare the short-term efficacy and side effects of betaxolol and timoloi in treatment of primary open angle glaucoma or ocular hypertension. Methods: Fourteen patients with newly diagnosed early primary o...Purpose: To compare the short-term efficacy and side effects of betaxolol and timoloi in treatment of primary open angle glaucoma or ocular hypertension. Methods: Fourteen patients with newly diagnosed early primary open angle glaucoma or ocular hypertension were included.Each patient received 0.5% timoloi and 0.5% betaxolol twice daily for four weeks in two phases. Between two courses of treatment there was four weeks wash out period. At the end of study the effect of these two drugs on intraocular pressure, mean arterial blood pressure,pulse rate,basic tear secretion and ocular symptoms were evaluated and statistically analyzed,using wilcoxon and chi-squar test.RESULTS:The study was performed on fourteen patients with baseline IOP of 26.7 ±1.5 mmHg.After four weeks treatmem,timoiol and betax-olol reduced IOP by 7.8±1.2mmHg or 29% and 6.1±1.3mmHg or 23%, respectively (P<0.001). The difference between two groups was significant(P<0.001). Mean arterial blood pressure was reduced with betaxolol and展开更多
目的:通过对近30 a原发性开角型青光眼(POAG)发病机制的相关文献进行计量学分析,了解该领域的发文情况、研究趋势及研究前沿和热点。方法:检索1993-09-01/2023-09-01在中国知网(CNKI)和Web of Science(WOS)核心数据库已发表的关于POAG...目的:通过对近30 a原发性开角型青光眼(POAG)发病机制的相关文献进行计量学分析,了解该领域的发文情况、研究趋势及研究前沿和热点。方法:检索1993-09-01/2023-09-01在中国知网(CNKI)和Web of Science(WOS)核心数据库已发表的关于POAG发病机制的相关文献986篇,运用CiteSpace(6.2.R.4)和VOSviewer(1.6.18)软件对检索到的文献进行知识图谱分析,分析内容包括发文量、作者、研究机构、国家/地区及关键词。结果:美国发文量最多(243篇),其次是中国(121篇)。发文量最多的国外研究机构是哈佛大学(37篇),国内研究机构中山医科大学中山眼科中心、首都医科大学宣武医院眼科、北京医科大学第一医院眼科发文量并列第一。Louis R. Pasquale(21篇)是最高产的英文作者,王宁利是该领域最活跃的中国研究者。该领域研究的关键词包括小梁网、眼压、房水、糖皮质激素、血液流变学等。结论:POAG发病机制的研究正处于蓬勃发展期,美国在该领域发文量最大,哈佛大学为该领域的领先研究机构。POAG研究领域的研究重点已经从结构方面转移到了基因层面,基因研究与中医治疗在该领域具有广泛的应用前景。展开更多
目的:利用两样本孟德尔随机化(MR)的研究方法探究肠道菌群(GM)与原发性开角型青光眼(POAG)的潜在因果关系。方法:利用英国布里斯托尔大学的GM的全基因组关联研究数据(GWAS)作为暴露和IEU Open GWAS数据库中POAG的GWAS数据作为结局,采用...目的:利用两样本孟德尔随机化(MR)的研究方法探究肠道菌群(GM)与原发性开角型青光眼(POAG)的潜在因果关系。方法:利用英国布里斯托尔大学的GM的全基因组关联研究数据(GWAS)作为暴露和IEU Open GWAS数据库中POAG的GWAS数据作为结局,采用逆方差加权(IVW)、MR Egger、加权中位数(WM)、Simple Mode、Weighted Mode方法分析POAG与GM之间存在的潜在关系,其中IVW为主要分析方法。敏感性分析检测该MR分析结果是否可靠。结果:IVW分析显示,Butyrivibrio(OR=1.170,95%CI:1.057-1.295,P=0.002)、Howardella(OR=1.188,95%CI:1.043-1.355,P=0.010)、LachnospiraceaeUCG001(OR=1.229,95%CI:1.016-1.485,P=0.033)增加了POAG的发病风险;而Candidatus Soleaferrea(OR=0.810,95%CI:0.670-0.981,P=0.031)、Ruminococcustorquesgroup(OR=0.656,95%CI:0.453-0.950,P=0.026)、Ruminococcaceae-UCG013(OR=0.770,95%CI:0.598-0.990,P=0.041)降低了POAG的发病风险。敏感性分析结果表明以上结果不存在异质性和多效性,分析结果具有可靠性。结论:GM与POAG存在潜在的因果关系,由于POAG具有致盲性,早期诊断和早期干预POAG的相关因素对该病的临床预后具有重要意义。展开更多
文摘Purpose: To compare the short-term efficacy and side effects of betaxolol and timoloi in treatment of primary open angle glaucoma or ocular hypertension. Methods: Fourteen patients with newly diagnosed early primary open angle glaucoma or ocular hypertension were included.Each patient received 0.5% timoloi and 0.5% betaxolol twice daily for four weeks in two phases. Between two courses of treatment there was four weeks wash out period. At the end of study the effect of these two drugs on intraocular pressure, mean arterial blood pressure,pulse rate,basic tear secretion and ocular symptoms were evaluated and statistically analyzed,using wilcoxon and chi-squar test.RESULTS:The study was performed on fourteen patients with baseline IOP of 26.7 ±1.5 mmHg.After four weeks treatmem,timoiol and betax-olol reduced IOP by 7.8±1.2mmHg or 29% and 6.1±1.3mmHg or 23%, respectively (P<0.001). The difference between two groups was significant(P<0.001). Mean arterial blood pressure was reduced with betaxolol and
文摘目的:通过对近30 a原发性开角型青光眼(POAG)发病机制的相关文献进行计量学分析,了解该领域的发文情况、研究趋势及研究前沿和热点。方法:检索1993-09-01/2023-09-01在中国知网(CNKI)和Web of Science(WOS)核心数据库已发表的关于POAG发病机制的相关文献986篇,运用CiteSpace(6.2.R.4)和VOSviewer(1.6.18)软件对检索到的文献进行知识图谱分析,分析内容包括发文量、作者、研究机构、国家/地区及关键词。结果:美国发文量最多(243篇),其次是中国(121篇)。发文量最多的国外研究机构是哈佛大学(37篇),国内研究机构中山医科大学中山眼科中心、首都医科大学宣武医院眼科、北京医科大学第一医院眼科发文量并列第一。Louis R. Pasquale(21篇)是最高产的英文作者,王宁利是该领域最活跃的中国研究者。该领域研究的关键词包括小梁网、眼压、房水、糖皮质激素、血液流变学等。结论:POAG发病机制的研究正处于蓬勃发展期,美国在该领域发文量最大,哈佛大学为该领域的领先研究机构。POAG研究领域的研究重点已经从结构方面转移到了基因层面,基因研究与中医治疗在该领域具有广泛的应用前景。
