The injection of bone cement is a promising surgical intervention for the treatment of osteoporosis.The aim of this study was to formulate a novel injectable bioactive bone cement to adress such medical problems.The b...The injection of bone cement is a promising surgical intervention for the treatment of osteoporosis.The aim of this study was to formulate a novel injectable bioactive bone cement to adress such medical problems.The bone cement primarily consists of tricalcium phosphate(β-TCP),konjac glucomannan(KGM),and hydroxyapatite whisker(HAw).An orthogonal experiment was designed to generate multiple sets of new composite calcium phosphate cement(NCPC)samples,and their setting times were measured.The in vitro compatibility of the new bone cement was assessed through relative cell proliferation rate(RGR)and in vitro cell growth experiments.Mechanical strength and porosity tests were conducted for each group of bone cement,and cross-sectional morphology was observed.The results demonstrate that the bone cement exhibits favorable properties such as self-curing,mechanical robustness,and resistance to collapse.The optimum formulation involves a doping ratio of 5/15(wt%)HAw and HA,an additional amount of 1.2wt%KGM,and a liquid citric acid concentration of 2wt%.Porosity tests confirmed that the material has high compressive strength and a favorable porosity of 27%,creating conducive conditions for cell growth,proliferation,and material degradation.Moreover,in vitro cell culture experiments revealed excellent biocompatibility of the material.Consequently,the developed NCPC emerges as a potential candidate material for applications of bone implantation.展开更多
The order-of-addition experiments are widely used in many fields,including food and industrial production,but the relative research under prior constraints is limited.The purpose of this paper is to select an optimal ...The order-of-addition experiments are widely used in many fields,including food and industrial production,but the relative research under prior constraints is limited.The purpose of this paper is to select an optimal sequence under the restriction that component i is added before component j,while it is unachievable to compare all sequences when the number of components m is large.To achieve this,a constrained PWO model is first provided,and then the D-optimal designs for order-of addition experiments with minimal-points via the modified threshold accepting algorithm is established.The effectiveness of the proposed method is demonstrated through a job scheduling problem with a prior constraint for teaching cases.展开更多
In this paper,we study the accuracy of delay-Doppler parameter estimation of targets in a passive radar using orthogonal frequency division multiplexing(OFDM)signal.A coarse-fine joint estimation method is proposed to...In this paper,we study the accuracy of delay-Doppler parameter estimation of targets in a passive radar using orthogonal frequency division multiplexing(OFDM)signal.A coarse-fine joint estimation method is proposed to achieve better estimation accuracy of target parameters without excessive computational burden.Firstly,the modulation symbol domain(MSD)method is used to roughly estimate the delay and Doppler of targets.Then,to obtain high-precision Doppler estimation,the atomic norm(AN)based on the multiple measurement vectors(MMV)model(MMV-AN)is used to manifest the signal sparsity in the continuous Doppler domain.At the same time,a reference signal compensation(RSC)method is presented to obtain highprecision delay estimation.Simulation results based on the OFDM signal show that the coarse-fine joint estimation method based on AN-RSC can obtain a more accurate estimation of target parameters compared with other algorithms.In addition,the proposed method also possesses computational advantages compared with the joint parameter estimation.展开更多
目的探讨orthogonal projection to latent structures(OPLS)方法的原理、特点及其在代谢组学高维数据分析中的应用。方法通过R语言编程实现OPLS方法,利用模拟试验探索OPLS的特性及适用条件,并通过实际数据进行验证。结果利用一个OPLS...目的探讨orthogonal projection to latent structures(OPLS)方法的原理、特点及其在代谢组学高维数据分析中的应用。方法通过R语言编程实现OPLS方法,利用模拟试验探索OPLS的特性及适用条件,并通过实际数据进行验证。结果利用一个OPLS预测主成分的模型拟合效果与利用偏最小二乘(PLS)多个主成分的模型拟合效果相同,同时具有较好的判别能力,其得分图的可视化效果优于PLS。结论 OPLS能够有效去除自变量矩阵X中与因变量Y无关的信息,使模型变得简单、易于解释,同时具有较好的可视化效果,可有效地用于代谢组学数据分析中。展开更多
The grid equations in decomposed domain by parallel computation are soled, and a method of local orthogonalization to solve the large-scaled numerical computation is presented. It constructs preconditioned iteration m...The grid equations in decomposed domain by parallel computation are soled, and a method of local orthogonalization to solve the large-scaled numerical computation is presented. It constructs preconditioned iteration matrix by the combination of predigesting LU decomposition and local orthogonalization, and the convergence of solution is proved. Indicated from the example, this algorithm can increase the rate of computation efficiently and it is quite stable.展开更多
应用基于气相色谱-质谱联用(GC-MS)的代谢组学方法结合细胞周期实验,研究羽扇豆醇体外抑制人乳腺癌细胞MCF-7增殖的作用机理。代谢组学的研究结果表明:通过正交偏最小方差判别分析(OPLS-DA)可以很好地区分羽扇豆醇作用的MCF-7细胞代谢...应用基于气相色谱-质谱联用(GC-MS)的代谢组学方法结合细胞周期实验,研究羽扇豆醇体外抑制人乳腺癌细胞MCF-7增殖的作用机理。代谢组学的研究结果表明:通过正交偏最小方差判别分析(OPLS-DA)可以很好地区分羽扇豆醇作用的MCF-7细胞代谢谱与对照组细胞代谢谱,模型参数为:R2 Ycum=0.988,Q2 Ycum=0.964。VIP(variable importance in the projection)值大于1的差异代谢物进一步用t检验进行单位分析,选择t<0.05(VIP>1)的代谢物作为羽扇豆醇作用组的生物标志物,得到琥珀酸、磷酸、亮氨酸、异亮氨酸等11种代谢差异物。结合羽扇豆醇将细胞周期抑制在G1期这一现象,推测羽扇豆醇可能是主要抑制了三羧酸循环中的琥珀酰辅酶A的生成和底物磷酸化生成ATP的反应来抑制MCF-7细胞的增殖。本实验从代谢组学角度为乳腺癌抗肿瘤机制提供新的线索。展开更多
Influence of multiple structural parameters on the performance of a gun launch system driven by highpressure reactive gases is important for structural design and performance adjustment.A coupled lumped parameter mode...Influence of multiple structural parameters on the performance of a gun launch system driven by highpressure reactive gases is important for structural design and performance adjustment.A coupled lumped parameter model was utilized to predict the propellant combustion,and a dynamic finite element method was applied to approximate the mechanical interactions between the projectile and the barrel.The combustion and the mechanical interactions were coupled through a user subroutine interface in ABAQUS.The correctness and the capability of the finite element approximations in capturing small structural changes were validated by comparing predicted resistance with experiments.Based on the coupled model,the influence of structural parameters of a medium-caliber gun on the system performance was investigated.In order to reduce the research costs,orthogonal tests were designed to investigate the comprehensive effects of the parameters.According to statistical analysis,the important order of the structural parameters on the launching process was obtained.The results indicate that the influence of the width of the rotating band stands out among the studied parameters in the gun.The work provides a method to investigate the influence of multiple parameters on system performance and gives guidance for controlling the system performance.展开更多
Using the orthogonal experimental design method involving three factors and three levels, the flexural strength and the compressive strength of copolymer grouting material were studied with different compositions of w...Using the orthogonal experimental design method involving three factors and three levels, the flexural strength and the compressive strength of copolymer grouting material were studied with different compositions of water-cement ratio （mass fraction of water to cement）, epoxy resin content, and waterborne epoxy curing agent content. By orthogonal range and variance analysis, the orders of three factors to influence the strength, the significance levels of different factors, and the optimized compound ratio scheme of copolymer grouting material mixture at different curing ages were determined. An empirical relationship among the strength of copolymer grouting material, the water-cement ratio, the epoxy resin content, and the waterborne epoxy curing agent content was established by multivariate regression analysis. The results indicate that water-cement ratio is the most principal and significant influencing factor on the strength. Epoxy resin content and waterbome epoxy curing agent content also have a significant influence on the strength. But epoxy resin content has a greater influence on the 7-day and 28-day flexural strength, and waterborne epoxy curing agent content has a greater influence on the 3-day flexural strength and the compressive strength. The copolymer grouting material with water-cement ratio of 0.4, epoxy resin content of 8% （mass fraction） and waterbome epoxy curing agent content of 2% （mass fraction） is the best one for repairing of cement concrete pavement. The flexural strength and the compressive strength have good correlation, and the ratio of compressive strength to flexural strength is between 1.0 and 3.3.展开更多
文摘The injection of bone cement is a promising surgical intervention for the treatment of osteoporosis.The aim of this study was to formulate a novel injectable bioactive bone cement to adress such medical problems.The bone cement primarily consists of tricalcium phosphate(β-TCP),konjac glucomannan(KGM),and hydroxyapatite whisker(HAw).An orthogonal experiment was designed to generate multiple sets of new composite calcium phosphate cement(NCPC)samples,and their setting times were measured.The in vitro compatibility of the new bone cement was assessed through relative cell proliferation rate(RGR)and in vitro cell growth experiments.Mechanical strength and porosity tests were conducted for each group of bone cement,and cross-sectional morphology was observed.The results demonstrate that the bone cement exhibits favorable properties such as self-curing,mechanical robustness,and resistance to collapse.The optimum formulation involves a doping ratio of 5/15(wt%)HAw and HA,an additional amount of 1.2wt%KGM,and a liquid citric acid concentration of 2wt%.Porosity tests confirmed that the material has high compressive strength and a favorable porosity of 27%,creating conducive conditions for cell growth,proliferation,and material degradation.Moreover,in vitro cell culture experiments revealed excellent biocompatibility of the material.Consequently,the developed NCPC emerges as a potential candidate material for applications of bone implantation.
基金supported by National Natural Science Foundation of China(Grant Nos.11971204,12271270)Natural Science Foundation of Jiangsu Province of China(Grant No.BK20200108)the Zhongwu Youth Innovative Talent Program of Jiangsu University of Technology and the Third Level Training Object of the Sixth“333 Project”in Jiangsu Province。
文摘The order-of-addition experiments are widely used in many fields,including food and industrial production,but the relative research under prior constraints is limited.The purpose of this paper is to select an optimal sequence under the restriction that component i is added before component j,while it is unachievable to compare all sequences when the number of components m is large.To achieve this,a constrained PWO model is first provided,and then the D-optimal designs for order-of addition experiments with minimal-points via the modified threshold accepting algorithm is established.The effectiveness of the proposed method is demonstrated through a job scheduling problem with a prior constraint for teaching cases.
基金supported by the National Natural Science Foundation of China(6193101562071335)+1 种基金the Technological Innovation Project of Hubei Province of China(2019AAA061)the Natural Science F oundation of Hubei Province of China(2021CFA002)。
文摘In this paper,we study the accuracy of delay-Doppler parameter estimation of targets in a passive radar using orthogonal frequency division multiplexing(OFDM)signal.A coarse-fine joint estimation method is proposed to achieve better estimation accuracy of target parameters without excessive computational burden.Firstly,the modulation symbol domain(MSD)method is used to roughly estimate the delay and Doppler of targets.Then,to obtain high-precision Doppler estimation,the atomic norm(AN)based on the multiple measurement vectors(MMV)model(MMV-AN)is used to manifest the signal sparsity in the continuous Doppler domain.At the same time,a reference signal compensation(RSC)method is presented to obtain highprecision delay estimation.Simulation results based on the OFDM signal show that the coarse-fine joint estimation method based on AN-RSC can obtain a more accurate estimation of target parameters compared with other algorithms.In addition,the proposed method also possesses computational advantages compared with the joint parameter estimation.
文摘The grid equations in decomposed domain by parallel computation are soled, and a method of local orthogonalization to solve the large-scaled numerical computation is presented. It constructs preconditioned iteration matrix by the combination of predigesting LU decomposition and local orthogonalization, and the convergence of solution is proved. Indicated from the example, this algorithm can increase the rate of computation efficiently and it is quite stable.
文摘应用基于气相色谱-质谱联用(GC-MS)的代谢组学方法结合细胞周期实验,研究羽扇豆醇体外抑制人乳腺癌细胞MCF-7增殖的作用机理。代谢组学的研究结果表明:通过正交偏最小方差判别分析(OPLS-DA)可以很好地区分羽扇豆醇作用的MCF-7细胞代谢谱与对照组细胞代谢谱,模型参数为:R2 Ycum=0.988,Q2 Ycum=0.964。VIP(variable importance in the projection)值大于1的差异代谢物进一步用t检验进行单位分析,选择t<0.05(VIP>1)的代谢物作为羽扇豆醇作用组的生物标志物,得到琥珀酸、磷酸、亮氨酸、异亮氨酸等11种代谢差异物。结合羽扇豆醇将细胞周期抑制在G1期这一现象,推测羽扇豆醇可能是主要抑制了三羧酸循环中的琥珀酰辅酶A的生成和底物磷酸化生成ATP的反应来抑制MCF-7细胞的增殖。本实验从代谢组学角度为乳腺癌抗肿瘤机制提供新的线索。
基金the financial support from the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYLX_0399)
文摘Influence of multiple structural parameters on the performance of a gun launch system driven by highpressure reactive gases is important for structural design and performance adjustment.A coupled lumped parameter model was utilized to predict the propellant combustion,and a dynamic finite element method was applied to approximate the mechanical interactions between the projectile and the barrel.The combustion and the mechanical interactions were coupled through a user subroutine interface in ABAQUS.The correctness and the capability of the finite element approximations in capturing small structural changes were validated by comparing predicted resistance with experiments.Based on the coupled model,the influence of structural parameters of a medium-caliber gun on the system performance was investigated.In order to reduce the research costs,orthogonal tests were designed to investigate the comprehensive effects of the parameters.According to statistical analysis,the important order of the structural parameters on the launching process was obtained.The results indicate that the influence of the width of the rotating band stands out among the studied parameters in the gun.The work provides a method to investigate the influence of multiple parameters on system performance and gives guidance for controlling the system performance.
基金Projects(40728003, 40772180, 40802064) supported by the National Natural Science Foundation of ChinaProject (07JJ4012) supported by the Hunan Provincial Natural Science Foundation of China+1 种基金project (20080430680) supported by China Postdoctoral Science FoundationProject(B308) supported by Shanghai Leading Academic Discipline Project
文摘Using the orthogonal experimental design method involving three factors and three levels, the flexural strength and the compressive strength of copolymer grouting material were studied with different compositions of water-cement ratio （mass fraction of water to cement）, epoxy resin content, and waterborne epoxy curing agent content. By orthogonal range and variance analysis, the orders of three factors to influence the strength, the significance levels of different factors, and the optimized compound ratio scheme of copolymer grouting material mixture at different curing ages were determined. An empirical relationship among the strength of copolymer grouting material, the water-cement ratio, the epoxy resin content, and the waterborne epoxy curing agent content was established by multivariate regression analysis. The results indicate that water-cement ratio is the most principal and significant influencing factor on the strength. Epoxy resin content and waterbome epoxy curing agent content also have a significant influence on the strength. But epoxy resin content has a greater influence on the 7-day and 28-day flexural strength, and waterborne epoxy curing agent content has a greater influence on the 3-day flexural strength and the compressive strength. The copolymer grouting material with water-cement ratio of 0.4, epoxy resin content of 8% （mass fraction） and waterbome epoxy curing agent content of 2% （mass fraction） is the best one for repairing of cement concrete pavement. The flexural strength and the compressive strength have good correlation, and the ratio of compressive strength to flexural strength is between 1.0 and 3.3.
