目的:观察中药二至丸对老年痴呆(alzhe im er d isease AD)模型小鼠脑组织Na+-K+-ATPase、Ca2+-ATPase活性及学习记忆的影响。方法:颈背部皮下注射D-半乳糖建立亚急性老年痴呆模型,测定脑组织中Na+-K+-ATPase、Ca2+-ATPase活性、采用跳...目的:观察中药二至丸对老年痴呆(alzhe im er d isease AD)模型小鼠脑组织Na+-K+-ATPase、Ca2+-ATPase活性及学习记忆的影响。方法:颈背部皮下注射D-半乳糖建立亚急性老年痴呆模型,测定脑组织中Na+-K+-ATPase、Ca2+-ATPase活性、采用跳台法测定小鼠的学习记忆能力。结果:中药二至丸能明显提高Na+-K+-ATPase、Ca2+-ATPase活性、缩短小鼠学习潜伏期,延长记忆潜伏期、减少错误次数。结论:中药二至丸能改善老年痴呆模型小鼠的学习记忆能力,提高ATP酶的活性,维持脑组织的正常功能。展开更多
In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis ...In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis (AS) in the rabbit. An experimental model of atherosclerosis was established in cholesterol-fed rabbits. In the 2nd, 4th, 8th and 12th week, the parametersmentioned above were determined and the pathological changes of the aorta examined. It was found that serum triglyceride (TG)was increased in the 4th week and total serum cholesterol (TCh) was significantly higher in the 4th, 8th and 12th week than thatin the control. Erythrocytic Na+ -K+ -ATPase activity decreased progressively and it was negatively correlated to TCh in the 4thand 12th week (r = - 0.67 and - 0.51, P < 0.01 and 0.05). G’ was significantly increased in the 4th week only when theshear rate was 0. 190 Hz whereas G and η’ increased progressively from the 8th to 12th week. It is believed that the determinationof blood lipids, Na+ -K+ -ATPase activity and viscoelastic parameters of the whole blood is useful for the prediction of the propession of the pathological changes in different stages of AS.展开更多
文摘目的:观察中药二至丸对老年痴呆(alzhe im er d isease AD)模型小鼠脑组织Na+-K+-ATPase、Ca2+-ATPase活性及学习记忆的影响。方法:颈背部皮下注射D-半乳糖建立亚急性老年痴呆模型,测定脑组织中Na+-K+-ATPase、Ca2+-ATPase活性、采用跳台法测定小鼠的学习记忆能力。结果:中药二至丸能明显提高Na+-K+-ATPase、Ca2+-ATPase活性、缩短小鼠学习潜伏期,延长记忆潜伏期、减少错误次数。结论:中药二至丸能改善老年痴呆模型小鼠的学习记忆能力,提高ATP酶的活性,维持脑组织的正常功能。
文摘In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis (AS) in the rabbit. An experimental model of atherosclerosis was established in cholesterol-fed rabbits. In the 2nd, 4th, 8th and 12th week, the parametersmentioned above were determined and the pathological changes of the aorta examined. It was found that serum triglyceride (TG)was increased in the 4th week and total serum cholesterol (TCh) was significantly higher in the 4th, 8th and 12th week than thatin the control. Erythrocytic Na+ -K+ -ATPase activity decreased progressively and it was negatively correlated to TCh in the 4thand 12th week (r = - 0.67 and - 0.51, P < 0.01 and 0.05). G’ was significantly increased in the 4th week only when theshear rate was 0. 190 Hz whereas G and η’ increased progressively from the 8th to 12th week. It is believed that the determinationof blood lipids, Na+ -K+ -ATPase activity and viscoelastic parameters of the whole blood is useful for the prediction of the propession of the pathological changes in different stages of AS.
