With an aim to comprehend the precise regulatory mechanism of dioscin against endometrial carcinoma(EC), we firstly extracted the components from Polygonatum sibiricum followed by identification and structural charact...With an aim to comprehend the precise regulatory mechanism of dioscin against endometrial carcinoma(EC), we firstly extracted the components from Polygonatum sibiricum followed by identification and structural characterization. The anti-EC activity of dioscin was initially determined based on the inhibition of Ishikawa cell proliferation and tumor growth. The high-throughput sequencing data indicated that dioscin not only promoted apoptosis, including decrease of poly ADP-ribose polymerase(PARP) and B-cell lymphoma-2(Bcl-2) and increase of c-PARP and Bcl-2-associcated agonist of cell death(Bad), but also induced autophagy, including increase of autophagic lysosomes and LC3Ⅱ/LC3Ⅰ ratio. Mechanistic exploration suggested that dioscin induced autophagy and apoptosis through inhibition of PI3K/AKT/mTOR signaling pathway. Besides, the dioscin-regulated p53 pathway was mainly involved in autophagy induction. Furthermore, inhibition of Ishikawa cell autophagy was linked to dioscin-induced apoptosis. Our data suggest the immense potential of dioscin for the development of functional food for EC and related medical application.展开更多
The Q_(K)(p)-Teichmüller space is introduced and studied in this paper.Various characterizations of the Q_(K)(p)-Teichmüller space and the Q_(K,0)(p)-Teichmüller space are given.Their Schwarzian derivat...The Q_(K)(p)-Teichmüller space is introduced and studied in this paper.Various characterizations of the Q_(K)(p)-Teichmüller space and the Q_(K,0)(p)-Teichmüller space are given.Their Schwarzian derivative model and pre-logarithmic derivative model are also discussed.展开更多
Smoothed Particle Hydrodynamics (SPH) is a Lagrangian meshless particle method. However, its low accuracy of kernel approximation when particles are distributed disorderly or located near the boundary is an obstacle s...Smoothed Particle Hydrodynamics (SPH) is a Lagrangian meshless particle method. However, its low accuracy of kernel approximation when particles are distributed disorderly or located near the boundary is an obstacle standing in the way of its wide application. Adopting the Taylor series expansion method and solving the integral equation matrix, the second order kernel approximation method can be obtained, namely K2_SPH, which is discussed in this paper. This method is similar to the Finite Particle Method. With the improvement of kernel approximation, some numerical techniques should be adopted for different types of boundaries, such as a free surface boundary and solid boundary, which are two key numerical techniques of K2_SPH for water wave simulation. This paper gives some numerical results of two dimensional water wave simulations involving standing wave and sloshing tank problems by using K2_SPH. From the comparison of simulation results, the K2_SPH method is more reliable than standard SPH.展开更多
The extended F-expansion method or mapping method is used to construct exact solutions for the coupled KleinGordon Schr/Sdinger equations （K-G-S equations） by the aid of the symbolic computation system Mathematica. ...The extended F-expansion method or mapping method is used to construct exact solutions for the coupled KleinGordon Schr/Sdinger equations （K-G-S equations） by the aid of the symbolic computation system Mathematica. More solutions in the Jacobi elliptic function form are obtained, including the single Jacobi elliptic function solutions, combined Jacobi elliptic function solutions, rational solutions, triangular solutions, soliton solutions and combined soliton solutions.展开更多
In this article, we introduce a hybrid iterative scheme for finding a common element of the set of solutions for a generalized equilibrium problems, the set of common fixed point for a family of infinite k-strict pseu...In this article, we introduce a hybrid iterative scheme for finding a common element of the set of solutions for a generalized equilibrium problems, the set of common fixed point for a family of infinite k-strict pseudo-contractive mappings, and the set of solutions of the variational inclusion problem with multi-valued maximal monotone mappings and inverse-strongly monotone mappings in Hilbert space. Under suitable conditions, some strong convergence theorems are proved. Our results extends the recent results in G.L.Acedo and H.K.Xu [2], Zhang, Lee and Chan [8], Wakahashi and Toyoda [9], Takahashi and Takahashi [I0] and S. S. Chang, H. W. Joseph Lee and C. K. Chan [II], S.Takahashi and W.Takahashi [12]. Moreover, the method of proof adopted in this article is different from those of [4] and [12].展开更多
Approximate analytical bound-state solutions of the Dirac particle in the fields of attractive and repulsive Rosen–Morse （RM） potentials including the Coulomb-like tensor （CLT） potential are obtained for arbitrar...Approximate analytical bound-state solutions of the Dirac particle in the fields of attractive and repulsive Rosen–Morse （RM） potentials including the Coulomb-like tensor （CLT） potential are obtained for arbitrary spin–orbit quantum number κ. The Pekeris approximation is used to deal with the spin–orbit coupling terms κ（κ ± 1）r 2 . In the presence of exact spin and pseudospin （p-spin） symmetries, the energy eigenvalues and the corresponding normalized two-component wave functions are found by using the parametric generalization of the Nikiforov–Uvarov （NU） method. The numerical results show that the CLT interaction removes degeneracies between the spin and p-spin state doublets.展开更多
基金supported by the National Key Research&Development Program of China(2022YFF1100305)the National Natural Science Foundation of Ningxia Province(2021AAC02019,2022AAC03230)the Key research and development projects in Ningxia province(2021BEF02013).
文摘With an aim to comprehend the precise regulatory mechanism of dioscin against endometrial carcinoma(EC), we firstly extracted the components from Polygonatum sibiricum followed by identification and structural characterization. The anti-EC activity of dioscin was initially determined based on the inhibition of Ishikawa cell proliferation and tumor growth. The high-throughput sequencing data indicated that dioscin not only promoted apoptosis, including decrease of poly ADP-ribose polymerase(PARP) and B-cell lymphoma-2(Bcl-2) and increase of c-PARP and Bcl-2-associcated agonist of cell death(Bad), but also induced autophagy, including increase of autophagic lysosomes and LC3Ⅱ/LC3Ⅰ ratio. Mechanistic exploration suggested that dioscin induced autophagy and apoptosis through inhibition of PI3K/AKT/mTOR signaling pathway. Besides, the dioscin-regulated p53 pathway was mainly involved in autophagy induction. Furthermore, inhibition of Ishikawa cell autophagy was linked to dioscin-induced apoptosis. Our data suggest the immense potential of dioscin for the development of functional food for EC and related medical application.
基金supported by the National Natural Science Foundation of China(12271017)supported by the Natural Science Foundation of Shandong Province(ZR2022MA018)by the National Natural Science Foundation of China(12171221)。
文摘The Q_(K)(p)-Teichmüller space is introduced and studied in this paper.Various characterizations of the Q_(K)(p)-Teichmüller space and the Q_(K,0)(p)-Teichmüller space are given.Their Schwarzian derivative model and pre-logarithmic derivative model are also discussed.
基金Supported by the National Natural Science Fundation of China (51009034)Foundational Research Funds of Harbin Engineering University (HEUFT05023, HEUFP05001)+1 种基金Foundational Research Funds for the central Universities (HEUCF100102)The 111 program (B07019)
文摘Smoothed Particle Hydrodynamics (SPH) is a Lagrangian meshless particle method. However, its low accuracy of kernel approximation when particles are distributed disorderly or located near the boundary is an obstacle standing in the way of its wide application. Adopting the Taylor series expansion method and solving the integral equation matrix, the second order kernel approximation method can be obtained, namely K2_SPH, which is discussed in this paper. This method is similar to the Finite Particle Method. With the improvement of kernel approximation, some numerical techniques should be adopted for different types of boundaries, such as a free surface boundary and solid boundary, which are two key numerical techniques of K2_SPH for water wave simulation. This paper gives some numerical results of two dimensional water wave simulations involving standing wave and sloshing tank problems by using K2_SPH. From the comparison of simulation results, the K2_SPH method is more reliable than standard SPH.
基金Project supported by the National Nature Science Foundation of China （Grant No 49894190） of the Chinese Academy of Science （Grant No KZCXI-sw-18）, and Knowledge Innovation Program.
文摘The extended F-expansion method or mapping method is used to construct exact solutions for the coupled KleinGordon Schr/Sdinger equations （K-G-S equations） by the aid of the symbolic computation system Mathematica. More solutions in the Jacobi elliptic function form are obtained, including the single Jacobi elliptic function solutions, combined Jacobi elliptic function solutions, rational solutions, triangular solutions, soliton solutions and combined soliton solutions.
基金supported by Scientific Research Fund of Sichuan Provincial Education Department (09ZB102)Scientific Research Fund of Science and Technology Deportment of Sichuan Provincial (2011JYZ011)
文摘In this article, we introduce a hybrid iterative scheme for finding a common element of the set of solutions for a generalized equilibrium problems, the set of common fixed point for a family of infinite k-strict pseudo-contractive mappings, and the set of solutions of the variational inclusion problem with multi-valued maximal monotone mappings and inverse-strongly monotone mappings in Hilbert space. Under suitable conditions, some strong convergence theorems are proved. Our results extends the recent results in G.L.Acedo and H.K.Xu [2], Zhang, Lee and Chan [8], Wakahashi and Toyoda [9], Takahashi and Takahashi [I0] and S. S. Chang, H. W. Joseph Lee and C. K. Chan [II], S.Takahashi and W.Takahashi [12]. Moreover, the method of proof adopted in this article is different from those of [4] and [12].
基金Project partially supported by the Scientific and Technological Research Council of Turkey (Grant No. TBíTAK)
文摘Approximate analytical bound-state solutions of the Dirac particle in the fields of attractive and repulsive Rosen–Morse （RM） potentials including the Coulomb-like tensor （CLT） potential are obtained for arbitrary spin–orbit quantum number κ. The Pekeris approximation is used to deal with the spin–orbit coupling terms κ（κ ± 1）r 2 . In the presence of exact spin and pseudospin （p-spin） symmetries, the energy eigenvalues and the corresponding normalized two-component wave functions are found by using the parametric generalization of the Nikiforov–Uvarov （NU） method. The numerical results show that the CLT interaction removes degeneracies between the spin and p-spin state doublets.
