An experiment was conducted to study the effects of different Chinese herbs on lactation in the rat. Seventy-two Sprague Dawley female rats at gestation day 18 were assigned to 9 groups randomly, with 8 rats each. Con...An experiment was conducted to study the effects of different Chinese herbs on lactation in the rat. Seventy-two Sprague Dawley female rats at gestation day 18 were assigned to 9 groups randomly, with 8 rats each. Control rats were offered basal diets until the end of the weaning period. Rats in the other 8 groups were administered diets supplemented with 1% Medulla tetmpanacis （MT）, Astragalus membranacens （AM）, Vaccaria segetalis （VS）, Leonurus heterophyllus sweet （LHS）, Radix rehmarmiae preparata （RRP）, Squama man/t/s （SM）, Schisandra chinensis （SC）, Ligustrum lucidum （LL）, respectively. After parturition, the litter size was culled to 8 pups per dam. Pup weight and milk yield were significantly higher in the VS, LHS, AM and SM groups than these in the control group during middle and late lactation （P〈0.05 or P〈0.01）. The weight and feed intake were not different in the dams fed either diet.展开更多
"Herb-Pairs",also known as pair drugs,refers to a prescription consisted of two relatively fixed traditional Chinese medicine,is the most basic,most simple and most common form of medication prescription in ..."Herb-Pairs",also known as pair drugs,refers to a prescription consisted of two relatively fixed traditional Chinese medicine,is the most basic,most simple and most common form of medication prescription in traditional Chinese medicine compound compatibility.It is not a random combination of two herbs,nor is the simple accumulation of efficacy,but the simple and delicate experience of ancient Chinese medicine practitioners.As a bridge between single drug and prescriptions,it is the embodiment of the regular and dialectical connotation.Therefore,research on Herb-Pairs has always been the most basic and most important entry point for compound compatibility studies.However,the interaction between herbs and herbs is an effect with a downside as well as benefits.The beneficial herb-herb interaction in Herb-Pairs include mutual promotion,mutual enhancement,mutual restraint between two drugs and counteract toxicity of another drug.And the harmful herb-herb interaction in Herb-Pairs includes mutual inhibition and antagonism.Al of these interactions areby means of affecting the metabolism of components to play a therapeutic effect.Using the pharmacokinetic-pharmacodynamic(PK-PD)binding model,the combination of drug metabolism and pharmacodynamics can further elucidate the influence on effect caused by drug concentration and metabolism,which can help elucidate the mechanism of drug action.Consequently,in this review,the herb-herb interactions in terms of pharmacokinetic were summarized to elucidate rule of TCM compatibility.展开更多
背景我们前期在论述“胰-脾一体”新观点时,提出湿热滞脾、因滞而虚是胰腺“炎-癌转化”的中医病机要素,其中湿热是“炎-癌转化”的土壤。目的基于以“湿热”为主的胰腺炎-癌转化中医病机要素,运用数据挖掘技术对兼具抗炎抗肿瘤作用的...背景我们前期在论述“胰-脾一体”新观点时,提出湿热滞脾、因滞而虚是胰腺“炎-癌转化”的中医病机要素,其中湿热是“炎-癌转化”的土壤。目的基于以“湿热”为主的胰腺炎-癌转化中医病机要素,运用数据挖掘技术对兼具抗炎抗肿瘤作用的清热类中药的药性、归经、活性成分进行分析,归纳总结此类中药的药物特性。对胰腺炎-癌转化过程中的用药提出前瞻性预测。方法以《中药学》(第10版)(中国中医药出版社)为药物数据的主要来源,对其中66味清热药进行以“炎*中药名”或“(炎+肿瘤)*中药名”以及inflammation*name of traditional Chinese medicine or(inflammation+tumor)*name of traditional Chinese medicine”在中国知网和PubMed文献库中进行文献检索,在Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)数据库中筛选药物活性成分。结果66味清热药(未统计附药)中有58味中药具有抗炎作用,有53味中药具有抗肿瘤作用,有48味中药同时具有抗炎及抗肿瘤作用。兼具抗炎抗肿瘤的清热类中药在性味上以苦、甘、辛味为主,在归经上以肝、胃、肺、心、大肠经为主。在TCMSP数据库中运用“类药五原则”对抗炎抗肿瘤药物进行活性成分筛选,共筛选出1041种活性成分数据,删除掉重复项后最终获得798种活性成分。排名前三的活性成分分别为Luteolin、Kaempferol、Acacetin。结论本研究通过对清热类药五味、归经和有效成分的分析发现,具有抗炎和抗肿瘤作用的中药具有高度重合性,这一发现对胰腺炎-癌转化疾病的药物研究及临床遣方用药具有重要指导意义。展开更多
基金Supported by NationalBasicResearchProgramof China(2004CB11750-5)
文摘An experiment was conducted to study the effects of different Chinese herbs on lactation in the rat. Seventy-two Sprague Dawley female rats at gestation day 18 were assigned to 9 groups randomly, with 8 rats each. Control rats were offered basal diets until the end of the weaning period. Rats in the other 8 groups were administered diets supplemented with 1% Medulla tetmpanacis （MT）, Astragalus membranacens （AM）, Vaccaria segetalis （VS）, Leonurus heterophyllus sweet （LHS）, Radix rehmarmiae preparata （RRP）, Squama man/t/s （SM）, Schisandra chinensis （SC）, Ligustrum lucidum （LL）, respectively. After parturition, the litter size was culled to 8 pups per dam. Pup weight and milk yield were significantly higher in the VS, LHS, AM and SM groups than these in the control group during middle and late lactation （P〈0.05 or P〈0.01）. The weight and feed intake were not different in the dams fed either diet.
文摘"Herb-Pairs",also known as pair drugs,refers to a prescription consisted of two relatively fixed traditional Chinese medicine,is the most basic,most simple and most common form of medication prescription in traditional Chinese medicine compound compatibility.It is not a random combination of two herbs,nor is the simple accumulation of efficacy,but the simple and delicate experience of ancient Chinese medicine practitioners.As a bridge between single drug and prescriptions,it is the embodiment of the regular and dialectical connotation.Therefore,research on Herb-Pairs has always been the most basic and most important entry point for compound compatibility studies.However,the interaction between herbs and herbs is an effect with a downside as well as benefits.The beneficial herb-herb interaction in Herb-Pairs include mutual promotion,mutual enhancement,mutual restraint between two drugs and counteract toxicity of another drug.And the harmful herb-herb interaction in Herb-Pairs includes mutual inhibition and antagonism.Al of these interactions areby means of affecting the metabolism of components to play a therapeutic effect.Using the pharmacokinetic-pharmacodynamic(PK-PD)binding model,the combination of drug metabolism and pharmacodynamics can further elucidate the influence on effect caused by drug concentration and metabolism,which can help elucidate the mechanism of drug action.Consequently,in this review,the herb-herb interactions in terms of pharmacokinetic were summarized to elucidate rule of TCM compatibility.
文摘背景我们前期在论述“胰-脾一体”新观点时,提出湿热滞脾、因滞而虚是胰腺“炎-癌转化”的中医病机要素,其中湿热是“炎-癌转化”的土壤。目的基于以“湿热”为主的胰腺炎-癌转化中医病机要素,运用数据挖掘技术对兼具抗炎抗肿瘤作用的清热类中药的药性、归经、活性成分进行分析,归纳总结此类中药的药物特性。对胰腺炎-癌转化过程中的用药提出前瞻性预测。方法以《中药学》(第10版)(中国中医药出版社)为药物数据的主要来源,对其中66味清热药进行以“炎*中药名”或“(炎+肿瘤)*中药名”以及inflammation*name of traditional Chinese medicine or(inflammation+tumor)*name of traditional Chinese medicine”在中国知网和PubMed文献库中进行文献检索,在Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)数据库中筛选药物活性成分。结果66味清热药(未统计附药)中有58味中药具有抗炎作用,有53味中药具有抗肿瘤作用,有48味中药同时具有抗炎及抗肿瘤作用。兼具抗炎抗肿瘤的清热类中药在性味上以苦、甘、辛味为主,在归经上以肝、胃、肺、心、大肠经为主。在TCMSP数据库中运用“类药五原则”对抗炎抗肿瘤药物进行活性成分筛选,共筛选出1041种活性成分数据,删除掉重复项后最终获得798种活性成分。排名前三的活性成分分别为Luteolin、Kaempferol、Acacetin。结论本研究通过对清热类药五味、归经和有效成分的分析发现,具有抗炎和抗肿瘤作用的中药具有高度重合性,这一发现对胰腺炎-癌转化疾病的药物研究及临床遣方用药具有重要指导意义。
