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HPLC-MS/MS法同时测定黄芪桂枝五物汤中21种成分的含量 被引量:2
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作者 陈秋谷 吴锦如 +3 位作者 李常慧 张尚斌 赵元 陈剑平 《中成药》 北大核心 2025年第2期365-371,共7页
目的建立HPLC-MS/MS法同时测定黄芪桂枝五物汤中没食子酸、原儿茶酸、氧化芍药苷、儿茶素、表儿茶素、芍药内酯苷、芍药苷、芦丁、毛蕊异黄酮葡萄糖苷、丁香醛、阿魏酸、香豆素、芒柄花苷、毛蕊异黄酮、肉桂醇、肉桂酸、苯甲酰芍药苷、... 目的建立HPLC-MS/MS法同时测定黄芪桂枝五物汤中没食子酸、原儿茶酸、氧化芍药苷、儿茶素、表儿茶素、芍药内酯苷、芍药苷、芦丁、毛蕊异黄酮葡萄糖苷、丁香醛、阿魏酸、香豆素、芒柄花苷、毛蕊异黄酮、肉桂醇、肉桂酸、苯甲酰芍药苷、桂皮醛、黄芪甲苷、黄芪皂苷Ⅲ、6-姜酚的含量。方法分析采用Thermo Scientific Hypersil GOLD色谱柱(150 mm×4.6 mm,3μm);流动相0.015%甲酸-乙腈,梯度洗脱;体积流量0.4 mL/min;柱温30℃;电喷雾离子源;正负离子扫描;多反应监测模式。结果21种成分在各自范围内线性关系良好(r>0.9905),平均加样回收率93.99%~108.52%,RSD 1.04%~5.97%。结论该方法简便可行,稳定可靠,可用于黄芪桂枝五物汤的质量控制。 展开更多
关键词 黄芪桂枝五物汤 化学成分 含量测定 hplc-ms/ms
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基于HPLC-MS/MS的2种乙酰氨基阿维菌素注射剂在兔体内的药代动力学对比研究
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作者 张贺超 张振东 +4 位作者 刘希望 杨亚军 李世宏 秦哲 李剑勇 《中国畜牧兽医》 北大核心 2025年第5期2295-2304,共10页
【目的】建立兔血浆中乙酰氨基阿维菌素(EPR)的高效液相色谱-串联质谱(HPLC-MS/MS)检测方法,比较2种EPR注射剂在商品兔体内的药代动力学,为后续制剂开发提供支持。【方法】将12只健康新西兰商品兔,雌雄各半,分为参比制剂(市售EPR注射剂... 【目的】建立兔血浆中乙酰氨基阿维菌素(EPR)的高效液相色谱-串联质谱(HPLC-MS/MS)检测方法,比较2种EPR注射剂在商品兔体内的药代动力学,为后续制剂开发提供支持。【方法】将12只健康新西兰商品兔,雌雄各半,分为参比制剂(市售EPR注射剂)组和受试制剂(自研EPR缓释注射剂)组,皮下注射相同剂量的2种制剂,于不同时间点采集血液样本,以莫西菌素为内标,采用HPLC-MS/MS法检测EPR的浓度,并对所建立的方法进行特异性、检测限和定量限、标准曲线、准确度和精密度、基质效应、稳定性考察,以软件Phoenix WinNonlin对实际的采样时间-血药浓度数据进行权重为1/Y的非房室分析,求得2种制剂在兔体内的药代动力学参数。【结果】建立的HPLC-MS/MS分析方法检测限和定量限分别为0.5和1 ng/mL;标准曲线在1~200 ng/mL范围内线性关系良好,且相关系数(R^(2))>0.99;高、中、低及定量限4个浓度的批内和批间准确度在93.70%~107.73%范围内,批内和批间相对标准差(RSD)均<15%。参比制剂和受试制剂中EPR达峰时间(T_(max))分别为(0.39±0.09)和(0.22±0.04)d;峰浓度(C_(max))分别为(112.82±29.40)和(30.86±5.11)ng/mL;半衰期(t_(1/2))分别为(7.14±0.58)和(22.15±1.22)d;药时曲线下面积(AUC_(0→∞))分别为(420.55±21.74)和(300.65±13.62)ng·d/mL;平均滞留时间(MRT)分别为(3.74±0.80)和(41.62±9.04)d。【结论】本研究建立的HPLC-MS/MS分析方法灵敏度和准确度高,稳定可靠,可用于兔血浆中EPR的检测。2种制剂在吸收速率、吸收程度及消除速率方面具有明显差异,与参比制剂相比,受试制剂能显著延长商品兔血浆中EPR存在的时间。 展开更多
关键词 乙酰氨基阿维菌素 高效液相色谱-串联质谱(hplc-ms/ms) 药代动力学 缓释注射剂
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HPLC-MS/MS法同时测定人参固本制剂中11种植物生长调节剂残留量及暴露风险评估
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作者 朱伟堃 王静 +3 位作者 曲国晶 刘延娟 窦希波 赵丹彤 《中成药》 北大核心 2025年第7期2255-2262,共8页
目的建立HPLC-MS/MS法同时测定人参固本制剂中11种植物生长调节剂(PGRs)的残留量,并进行风险评估。方法分析采用ACQUITY UPLC^(®)Waters HSS T3色谱柱(2.1 mm×100 mm,1.8μm);流动相乙腈-0.1%甲酸(含5 mmol/L甲酸铵),梯度洗脱... 目的建立HPLC-MS/MS法同时测定人参固本制剂中11种植物生长调节剂(PGRs)的残留量,并进行风险评估。方法分析采用ACQUITY UPLC^(®)Waters HSS T3色谱柱(2.1 mm×100 mm,1.8μm);流动相乙腈-0.1%甲酸(含5 mmol/L甲酸铵),梯度洗脱;体积流量0.30 mL/min;柱温40℃;电喷雾离子源;正负离子扫描;多反应监测模式。采用残留量、健康指导值和暴露量对实际检出PGRs的慢性暴露风险值和急性暴露风险值进行计算和风险评估。结果11种PGRs在各自范围内线性关系良好(R^(2)≥0.990),平均加样回收率70.0%~120.0%,RSD均小于12.0%。合剂和丸剂中平均残留量最高的均为甲哌鎓,急性风险值和慢性风险值最高的均为5-硝基愈创木酚钠,分别为0.7657、0.0231和0.9081、0.0270。结论人参固本制剂存在PGRs残留风险,但均处于安全水平。 展开更多
关键词 人参固本制剂 植物生长调节剂 残留 hplc-ms/ms 暴露风险评估
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Transcriptomics Analysis of Penicillium expansumΔWSC1 Infection and Defense Mechanism against It in Pear Fruits
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作者 ZHAO Lina HU Yize +4 位作者 SHU Yuling Solairaj DHANASEKARAN ZHANG Xiaoyun YANG Qiya ZHANG Hongyin 《食品科学》 北大核心 2025年第13期75-85,共11页
The WSC proteins produced by Penicillium expansum play a crucial role in causing blue mold on pears.To analyze the role of the WSC1 gene in the pathogenic process of this fungal pathogen,we conducted transcriptomic an... The WSC proteins produced by Penicillium expansum play a crucial role in causing blue mold on pears.To analyze the role of the WSC1 gene in the pathogenic process of this fungal pathogen,we conducted transcriptomic analysis of a WSC1 knockout(ΔWSC1)strain.The knockout of WSC1 significantly altered the gene expression profile in P.expansum,particularly for genes involved in cell wall integrity,signaling,stress response,and toxin production.The differential expression of these genes might make theΔWSC1 strain more vulnerable to environmental stress,while reducing the toxin production capacity,ultimately leading to a decrease in the pathogenicity.The transcriptomic analysis revealed that the expression of genes related to stress response signals,defense mechanisms and oxidative stress management changed when pear fruits were infected with theΔWSC1 strain.These changes may trigger a cascade of responses in pear fruits.In addition,compared with those infected with the wild-type strain,pear fruits infected with theΔWSC1 strain exhibited up-regulated expression of genes related to defense and oxidative stress.This study clarifies how the WSC1 gene influences P.expansum’s ability to infect pear fruits and how pear fruits respond to the infection. 展开更多
关键词 pear fruit Penicillium expansum transcriptomic analysis INFECTION
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基于HPLC-MS法的细辛和防风药材中黄曲霉毒素残留限量研究
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作者 李根悦 杜连云 +3 位作者 韩路生 杨凯丽 陈长宝 王恩鹏 《特产研究》 2025年第1期143-146,151,共5页
本研究旨在检测黄曲霉毒素残留量,保证药材质量。药材样品经提取、净化、柱后衍生处理后,参照中国药典(2020版四部,通则2351)中黄曲霉毒素检测方法中的液相色谱-串联质谱法(High-performance liquid chromatography-mass spectromete,HP... 本研究旨在检测黄曲霉毒素残留量,保证药材质量。药材样品经提取、净化、柱后衍生处理后,参照中国药典(2020版四部,通则2351)中黄曲霉毒素检测方法中的液相色谱-串联质谱法(High-performance liquid chromatography-mass spectromete,HPLC-MS)进行测定,以黄曲霉毒素B_(1)(AflatoxinB_(1),AFB_(1))、黄曲霉毒素B_(2)(AflatoxinB_(2),AFB_(2))、黄曲霉毒素G_(1)(AflatoxinG_(1),AFG_(1))和黄曲霉毒素G_(2)(AflatoxinG_(2),AFG_(2))总量计。结果表明,检测的33批北细辛和34批防风药材中的黄曲霉毒素,两种药材均未检测出黄曲霉毒素。本研究可为细辛、防风药材质量控制、安全使用及储藏规范的制定提供依据。 展开更多
关键词 细辛 防风 黄曲霉毒素 hplc-ms
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HPLC-MS/MS法测定食品接触塑料产品中13种荧光增白剂迁移量
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作者 宋梓锋 刘德云 +5 位作者 何国山 陈意光 熊小婷 李慧勇 饶璞 李泽荣 《包装工程》 北大核心 2025年第15期144-153,共10页
目的建立食品接触塑料产品中13种荧光增白剂迁移量的测定方法,可用于食品接触塑料产品中相关物质的风险监控。方法采用不同类型食品模拟物进行迁移试验,对水基和酒精类模拟物,用四氢呋喃稀释2倍后测定,对于化学替代溶剂95%(体积分数)乙... 目的建立食品接触塑料产品中13种荧光增白剂迁移量的测定方法,可用于食品接触塑料产品中相关物质的风险监控。方法采用不同类型食品模拟物进行迁移试验,对水基和酒精类模拟物,用四氢呋喃稀释2倍后测定,对于化学替代溶剂95%(体积分数)乙醇,过膜后测定;对于化学替代溶剂异辛烷,FWA121采用50%甲醇水(含0.4%乙酸),两者按照体积比1∶1萃取后测定,其他化合物用氮气吹至近干后用95%乙醇按体积比1∶1复溶后测定。用高效液相色谱-三重四极杆质谱检测。采用液相色谱XB Phenyl色谱柱(2.1 mm×50 mm,3μm)进行分离,质谱采用电化学喷雾正模式电离,多重反应监测(MRM)模式,外标法定量。结果在优化的条件下,13种荧光增白剂线性关系良好,r^(2)均大于0.999,方法检出限在0.03~6μg/kg之间,加标回收率在85.3%~104%,相对标准偏差(n=6)在0.1%~9.7%。对30批次塑料材质样品进行检测,发现2批次阳性样品。结论方法前处理步骤简单,各化合物色谱分离度好,灵敏度高,专一性好,满足食品接触塑料产品中13种荧光增白剂迁移量的检测需求。 展开更多
关键词 荧光增白剂 迁移量 食品接触塑料 高效液相色谱-三重四极杆质谱(hplc-ms/ms)
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Influencing factor of the characterization and restoration of phase aberrations resulting from atmospheric turbulence based on Principal Component Analysis
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作者 WANG Jiang-pu-zhen WANG Zhi-qiang +2 位作者 ZHANG Jing-hui QIAO Chun-hong FAN Cheng-yu 《中国光学(中英文)》 北大核心 2025年第4期899-907,共9页
Restoration of phase aberrations is crucial for addressing atmospheric turbulence in light propagation.Traditional restoration algorithms based on Zernike polynomials(ZPs)often encounter challenges related to high com... Restoration of phase aberrations is crucial for addressing atmospheric turbulence in light propagation.Traditional restoration algorithms based on Zernike polynomials(ZPs)often encounter challenges related to high computational complexity and insufficient capture of high-frequency phase aberration components,so we proposed a Principal-Component-Analysis-based method for representing phase aberrations.This paper discusses the factors influencing the accuracy of restoration,mainly including the sample space size and the sampling interval of D/r_(0),on the basis of characterizing phase aberrations by Principal Components(PCs).The experimental results show that a larger D/r_(0)sampling interval can ensure the generalization ability and robustness of the principal components in the case of a limited amount of original data,which can help to achieve high-precision deployment of the model in practical applications quickly.In the environment with relatively strong turbulence in the test set of D/r_(0)=24,the use of 34 terms of PCs can improve the corrected Strehl ratio(SR)from 0.007 to 0.1585,while the Strehl ratio of the light spot after restoration using 34 terms of ZPs is only 0.0215,demonstrating almost no correction effect.The results indicate that PCs can serve as a better alternative in representing and restoring the characteristics of atmospheric turbulence induced phase aberrations.These findings pave the way to use PCs of phase aberrations with fewer terms than traditional ZPs to achieve data dimensionality reduction,and offer a reference to accelerate and stabilize the model and deep learning based adaptive optics correction. 展开更多
关键词 phase aberration atmospheric turbulence principal component analysis Zernike polynomials
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Error Analysis of MSAV Scheme for Two Phase Magnetohydrodynamic Diffuse Interface Model
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作者 HU Kun WANG Danxia +1 位作者 ZHANG Jianwen JIA Hongen 《应用数学》 北大核心 2025年第2期348-371,共24页
In this paper,we develop a multi-scalar auxiliary variables(MSAV)scheme for the Cahn-Hilliard Magnetohydrodynamics system by introducing two scalar auxiliary variables(SAV).This scheme is linear,fully decoupled and un... In this paper,we develop a multi-scalar auxiliary variables(MSAV)scheme for the Cahn-Hilliard Magnetohydrodynamics system by introducing two scalar auxiliary variables(SAV).This scheme is linear,fully decoupled and unconditionally stable in energy.Subsequently,we provide a detailed implementation procedure for full decoupling.Thus,at each time step,only a series of linear differential equations with constant coefficients need to be solved.To validate the effectiveness of our approach,we conduct an error analysis for this first-order scheme.Finally,some numerical experiments are provided to verify the energy dissipation of the system and the convergence of the proposed approach. 展开更多
关键词 Cahn-Hilliard Magnetohydrodynamics system Fully decoupled Stability in energy Error analysis
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Simulation and Experimental Analysis of Mechanical Properties of a Bidirectional Adjustable Magnetorheological Fluid Damper
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作者 YANG Zhi−rong YE Zhong−min +2 位作者 LIU Jin−liang RAO Zhu−shi XIAO Wang−qiang 《船舶力学》 北大核心 2025年第6期1000-1012,共13页
The aim of this study is to address the issues associated with traditional magnetorheological fluid(MRF)dampers,such as insufficient damping force after power failure and susceptibility to settlement.In order to achie... The aim of this study is to address the issues associated with traditional magnetorheological fluid(MRF)dampers,such as insufficient damping force after power failure and susceptibility to settlement.In order to achieve this,a bidirectional adjustable MRF damper was designed and developed.Magnetic field simulation analysis was conducted on the damper,along with simulation analysis on its dynamic characteristics.The dynamic characteristics were ultimately validated through experimental testing on the material testing machine,thereby corroborating the theoretical simulation results.Concurrently,this process generated valuable test data for subsequent implementation of the semi-active vibration control system.The simulation and test results demonstrate that the integrated permanent magnet effectively accomplishes bidirectional regulation.The magnetic induction intensity of the damping channel is 0.2 T in the absence of current,increases to 0.5 T when a maximum forward current of 4 A is applied,and becomes 0 T when a maximum reverse current of 3.8 A is applied.When the excitation amplitude is 8 mm and the frequency is 2 Hz,with the applied currents varying,the maximum damping force reaches 8 kN,while the minimum damping force measures at 511 N.Additionally,at zero current,the damping force stands at 2 kN,which aligns closely with simulation results.The present paper can serve as a valuable reference for the design and research of semi-active MRF dampers. 展开更多
关键词 magnetorheological fluid(MRF) DAMPER permanent magnet finite element analysis test of mechanical properties
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Novel grey variation relational analysis model for panel data and its application
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作者 WU Honghua QU Zhongfeng 《Journal of Systems Engineering and Electronics》 2025年第2期483-493,共11页
Based on the variation of discrete surface,a new grey relational analysis model,called the grey variation relational ana-lysis(GVRA)model,is proposed in this paper.Meanwhile,the proposed model avoids the inconsistent ... Based on the variation of discrete surface,a new grey relational analysis model,called the grey variation relational ana-lysis(GVRA)model,is proposed in this paper.Meanwhile,the proposed model avoids the inconsistent results caused by diffe-rent construction of discrete surface of panel data or the change in the order of indicators or objects in existing grey relational analysis models.Firstly,the submatrix of the sample matrix is given according to the permutation and combination theory.Secondly,the amplitude of the submatrix is calculated and the variation of discrete surface is obtained.Then,a grey relational coefficient is presented by variation difference,and the GVRA model is established.Furthermore,the properties of the pro-posed model,such as normality,symmetry,reflexivity,transla-tion invariant,and number multiplication invariant,are also veri-fied.Finally,the proposed model is used to identify the driving factors of haze in the cities along the Yellow River in Shandong Province,China.The result reveals that the proposed model can effectively measure the relationship between panel data. 展开更多
关键词 grey relational analysis grey system theory varia-tion discrete surface.
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Reliability analysis of modular charge swinging-loading positioning accuracy under new failure criterion based on spatial geometric relationship
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作者 Zihan Wang Linfang Qian +3 位作者 Liu Yang Taisu Liu Weiwei Chen Haolin Zhang 《Defence Technology(防务技术)》 2025年第6期115-130,共16页
The swinging-loading process is essential for automatic artillery loading systems.This study focuses on the problems of reliability analysis that affect swinging-loading positioning accuracy.A dynamic model for a mult... The swinging-loading process is essential for automatic artillery loading systems.This study focuses on the problems of reliability analysis that affect swinging-loading positioning accuracy.A dynamic model for a multi degree-of-freedom swinging-loading-integrated rigid-flexible coupling system is established.This model is based on the identification of key parameters and platform experiments.Based on the spatial geometric relationship between the breech and loader during modular charge transfer and the possible maximum interference depth of the modular charge,a new failure criterion for estimating the reliability of swinging-loading positioning accuracy is proposed.Considering the uncertainties in the operation of the pendulum loader,the direct probability integration method is introduced to analyze the reliability of the swinging-loading positioning accuracy under three different charge numbers.The results indicate that under two and four charges,the swinging-loading process shows outstanding reliability.However,an unstable stage appears when the swinging motion occurred under six charges,with a maximum positioning failure probability of 0.0712.A comparison between the results obtained under the conventional and proposed criteria further reveals the effectiveness and necessity of the proposed criterion. 展开更多
关键词 Artillery loading system Pendulum loader Dynamic model Failure criterion Reliability analysis
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Micromechanical analysis of particle corner effect on bearing and deformation behaviors of coral sand slope foundation under a strip footing
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作者 PENG Yu LUO Zhao-gang +2 位作者 HE Shao-heng QU Li-ming DING Xuan-ming 《Journal of Central South University》 2025年第2期624-642,共19页
To understand the specific behaviors of coastal coral sand slope foundations,discrete element method(DEM)was employed to examine the effect of breakable particle corners on the performance of coral sand slope foundati... To understand the specific behaviors of coastal coral sand slope foundations,discrete element method(DEM)was employed to examine the effect of breakable particle corners on the performance of coral sand slope foundations under a strip footing,from macro to micro scales.The results demonstrate that the bearing characteristics of coral sand slope foundations can be successfully modeled by utilizing breakable corner particles in simulations.The dual effects of interlocking and breakage of corners well explained the specific shallower load transmission and narrower shear stress zones in breakable corner particle slopes.Additionally,the study revealed the significant influence of breakable corners on soil behaviors on slopes.Furthermore,progressive corner breakage within slip bands was successfully identified as the underling mechanism in determining the unique bearing characteristics and the distinct failure patterns of breakable corner particle slopes.This study provides a new perspective to clarify the behaviors of slope foundations composed of breakable corner particle materials. 展开更多
关键词 micromechanical analysis coral sand slope foundation particle corner breakage corner interlock
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Cascading failure analysis of an interdependent network with power-combat coupling
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作者 WANG Yang TAO Junyong +2 位作者 ZHANG Yun’an BAI Guanghan DUI Hongyan 《Journal of Systems Engineering and Electronics》 2025年第2期405-422,共18页
Cutting off or controlling the enemy’s power supply at critical moments or strategic locations may result in a cascade failure,thus gaining an advantage in a war.However,the exist-ing cascading failure modeling analy... Cutting off or controlling the enemy’s power supply at critical moments or strategic locations may result in a cascade failure,thus gaining an advantage in a war.However,the exist-ing cascading failure modeling analysis of interdependent net-works is insufficient for describing the load characteristics and dependencies of subnetworks,and it is difficult to use for model-ing and failure analysis of power-combat(P-C)coupling net-works.This paper considers the physical characteristics of the two subnetworks and studies the mechanism of fault propaga-tion between subnetworks and across systems.Then the surviv-ability of the coupled network is evaluated.Firstly,an integrated modeling approach for the combat system and power system is predicted based on interdependent network theory.A heteroge-neous one-way interdependent network model based on proba-bility dependence is constructed.Secondly,using the operation loop theory,a load-capacity model based on combat-loop betweenness is proposed,and the cascade failure model of the P-C coupling system is investigated from three perspectives:ini-tial capacity,allocation strategy,and failure mechanism.Thirdly,survivability indexes based on load loss rate and network sur-vival rate are proposed.Finally,the P-C coupling system is con-structed based on the IEEE 118-bus system to demonstrate the proposed method. 展开更多
关键词 cascading failure survivability analysis interdepen-dent network power-combat(P-C)coupling.
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Link-16 anti-jamming performance evaluation based on grey relational analysis and cloud model
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作者 NING Xiaoyan WANG Ying +1 位作者 WANG Zhenduo SUN Zhiguo 《Journal of Systems Engineering and Electronics》 2025年第1期62-72,共11页
Anti-jamming performance evaluation has recently received significant attention. For Link-16, the anti-jamming performance evaluation and selection of the optimal anti-jamming technologies are urgent problems to be so... Anti-jamming performance evaluation has recently received significant attention. For Link-16, the anti-jamming performance evaluation and selection of the optimal anti-jamming technologies are urgent problems to be solved. A comprehensive evaluation method is proposed, which combines grey relational analysis (GRA) and cloud model, to evaluate the anti-jamming performances of Link-16. Firstly, on the basis of establishing the anti-jamming performance evaluation indicator system of Link-16, the linear combination of analytic hierarchy process(AHP) and entropy weight method (EWM) are used to calculate the combined weight. Secondly, the qualitative and quantitative concept transformation model, i.e., the cloud model, is introduced to evaluate the anti-jamming abilities of Link-16 under each jamming scheme. In addition, GRA calculates the correlation degree between evaluation indicators and the anti-jamming performance of Link-16, and assesses the best anti-jamming technology. Finally, simulation results prove that the proposed evaluation model can achieve the objective of feasible and practical evaluation, which opens up a novel way for the research of anti-jamming performance evaluations of Link-16. 展开更多
关键词 LINK-16 ANTI-JAMMING grey relational analysis(GRA) cloud model combination weights
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Current development and future prospects of multi-target assignment problem:A bibliometric analysis review
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作者 Shuangxi Liu Zehuai Lin +1 位作者 Wei Huang Binbin Yan 《Defence Technology(防务技术)》 2025年第1期44-59,共16页
The multi-target assignment(MTA)problem,a crucial challenge in command control,mission planning,and a fundamental research focus in military operations,has garnered significant attention over the years.Extensively stu... The multi-target assignment(MTA)problem,a crucial challenge in command control,mission planning,and a fundamental research focus in military operations,has garnered significant attention over the years.Extensively studied across various domains such as land,sea,air,space,and electronics,the MTA problem has led to the emergence of numerous models and algorithms.To delve deeper into this field,this paper starts by conducting a bibliometric analysis on 463 Scopus database papers using CiteSpace software.The analysis includes examining keyword clustering,co-occurrence,and burst,with visual representations of the results.Following this,the paper provides an overview of current classification and modeling techniques for addressing the MTA problem,distinguishing between static multi-target assignment(SMTA)and dynamic multi-target assignment(DMTA).Subsequently,existing solution algorithms for the MTA problem are reviewed,generally falling into three categories:exact algorithms,heuristic algorithms,and machine learning algorithms.Finally,a development framework is proposed based on the"HIGH"model(high-speed,integrated,great,harmonious)to guide future research and intelligent weapon system development concerning the MTA problem.This framework emphasizes application scenarios,modeling mechanisms,solution algorithms,and system efficiency to offer a roadmap for future exploration in this area. 展开更多
关键词 Multi-target assignment Offensive and defensive confrontation Cooperative operation Modeling mechanism Solution algorithm CiteSpace analysis
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Damage analysis caused by ^(60)Co ions in functionally graded materials
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作者 Zübeyde Özkan Ugur Gökmen Sema Bilge Ocak 《Defence Technology(防务技术)》 2025年第2期248-256,共9页
Functionally graded composite/hybrid materials(FGCM/FGHCM)were produced by adding B_(4)C,TiO_(2),and B_(4)C+TiO_(2)ceramic materials at various ratios(0-50%)into the AA6082 matrix.The analysis of the damage caused by^... Functionally graded composite/hybrid materials(FGCM/FGHCM)were produced by adding B_(4)C,TiO_(2),and B_(4)C+TiO_(2)ceramic materials at various ratios(0-50%)into the AA6082 matrix.The analysis of the damage caused by^(60) ions'(1.173-1.1332 MeV)on the material was examined using the SRIM/TRIM Monte Carlo simulation software.In the simulation,the following data regarding the atoms of the target materials were obtained:ion distribution,target ionization,total displacements,surface binding energy,lattice binding energy,and displacement energy.Among the studied four materials,the one with the highest ion range value was found to be AA6082 with 8550A.TiO_(2)was found to be the reinforcement material that reduced the ion range the most in the material.Due to its high binding energy,B_(4)C reinforced AA6082+(0-50%)B_(4)C FGCM was found to have the least vacancy with 4782/ion. 展开更多
关键词 SRIM/TRIM Damage analysis AA6082 ^(60)Co ion
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Face stability analysis of longitudinally inclined shield tunnel considering the effect of tensile strength cut-off and pore water pressure
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作者 HUANG Fu WANG Yong-tao +1 位作者 ZHANG Min YANG Zi-han 《Journal of Central South University》 2025年第3期1080-1098,共19页
Because of actual requirement,shield machine always excavates with an inclined angle in longitudinal direction.Since many previous studies mainly focus on the face stability of the horizontal shield tunnel,the effects... Because of actual requirement,shield machine always excavates with an inclined angle in longitudinal direction.Since many previous studies mainly focus on the face stability of the horizontal shield tunnel,the effects of tensile strength cut-off and pore water pressure on the face stability of the longitudinally inclined shield tunnel are not well investigated.A failure mechanism of a longitudinally inclined shield tunnel face is constructed based on the spatial discretization technique and the tensile strength cut-off criterion is introduced to modify the constructed failure mechanism.The pore water pressure is introduced as an external force into the equation of virtual work and the objective function of the chamber pressure of the shield machine is obtained.Moreover,the critical chamber pressure of the longitudinally inclined shield tunnel is computed by optimal calculation.Parametric analysis indicates that both tensile strength cut-off and pore water pressure have a significant impact on the chamber pressure and the range of the collapse block.Finally,the theoretical results are compared with the numerical results calculated by FLAC3D software which proves that the proposed approach is effective. 展开更多
关键词 longitudinally inclined tunnel pore water pressure tensile strength cut-off spatial discretization technique limit analysis
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Seismic pseudo-static stability analysis of bedding jointed rock slope stability under the interaction of the upper dangerous rock mass and lower stepped slope mass based on acceleration assessment
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作者 LI De-jian XIAO Yu +3 位作者 YANG Yan-song YU Peng-cheng ZHANG Ying-bin ZHAO Lian-heng 《Journal of Central South University》 2025年第7期2619-2637,共19页
In the practical slope engineering,the stability of lower sliding mass(region A)with back tensile cracks of the jointed rock slope attracts more attentions,but the upper rock mass(region B)may also be unstable.Therefo... In the practical slope engineering,the stability of lower sliding mass(region A)with back tensile cracks of the jointed rock slope attracts more attentions,but the upper rock mass(region B)may also be unstable.Therefore,in this study,based on the stepped failure mode of bedding jointed rock slopes,considering the influence of the upper rock mass on the lower stepped sliding mass,the improved failure model for analyzing the interaction force(F_(AB))between two regions is constructed,and the safety factors(F_(S))of two regions and whole region are derived.In addition,this paper proposes a method to determine the existence of F_(AB) using their respective acceleration values(a_(A) and a_(B))when regions A and B are unstable.The influences of key parameters on two regions and the whole region are analyzed.The results show that the variation of the F_(AB) and F_(S) of two regions can be obtained accurately based on the improved failure model.The accuracy of the improved failure model is verified by comparative analysis.The research results can explain the interaction mechanism of two regions and the natural phenomenon of slope failure caused by the development of cracks. 展开更多
关键词 bedding jointed rock slope upper dangerous rock mass stepped sliding interaction mechanism stability analysis
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Analysis of meshing characteristics of planetary gear system considering tooth surface roughness and elastohydrodynamic lubrication
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作者 LIU Ning MA Hui +4 位作者 GUAN Hong ZHOU Sai-nan ZHAO Tian-yu CAO Peng WU Yu-ping 《Journal of Central South University》 2025年第7期2511-2534,共24页
The contact characteristics of the rough tooth surface during the meshing process are significantly affected by the lubrication state.The coupling effect of tooth surface roughness and lubrication on meshing character... The contact characteristics of the rough tooth surface during the meshing process are significantly affected by the lubrication state.The coupling effect of tooth surface roughness and lubrication on meshing characteristics of planetary gear is studied.An improved three-dimensional(3 D)anisotropic tooth surface roughness fractal model is proposed based on the experimental parameters.Considering asperity contact and elastohydrodynamic lubrication(EHL),the contact load and flexibility deformation of the tooth surface are derived,and the deformation compatibility equation of the 3 D loaded tooth contact analysis(3 D-LTCA)method is improved.The asperity of the tooth surface changes the system from EHL to mixed lubrication and reduces the stiffness of the oil film.Compared with the sun planet gear,the asperity has a greater effect on the meshing characteristics of the ring-planet gear.Compared with the proposed method,the comprehensive stiffness obtained by the traditional calculation method considering the lubrication effect is smaller,especially for the ring-planet gear.Compared with roughness,speed and viscosity,the meshing characteristics of planetary gears are most sensitive to torque. 展开更多
关键词 planetary gear tooth surface roughness three-dimensional loaded tooth contact analysis elastohydrodynamic lubrication meshing stiffness
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A new theory for determining large deformation area of roof at intersection and verification analysis
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作者 WU Yi-yi GAO Yu-bing +2 位作者 MA Xiang ZHANG Xing-xing HE Man-chao 《Journal of Central South University》 2025年第2期656-677,共22页
The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying t... The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying traditional maximum equivalent span beam(MESB)theory to determine deformation range,peak point,and angle influence poses a challenge.Considering the overall structure of the intersection roof,the maximum equivalent triangular plate(METP)theory is proposed,and its geometric parameter calculation formula and deflection calculation formula are obtained.The application of the two theories in 18 models with different intersection angles,roadway types,and surrounding rock lithology is verified by numerical analysis.The results show that:1)The METP structure of the intersection roof established by the simulation results of each model successfully determined the location of the roof’s high displacement zone;2)The area comparison method of the METP theory can be reasonably explained:①The roof subsidence of the intersection decreases with the increase of the intersection angle;②The roof subsidence at the intersection of different roadway types has a rectangular type>arch type>circular type;③The roof subsidence of the intersection with weak surrounding rock is significantly larger than that of the intersection with hard surrounding rock.According to the application results of the two theories,the four advantages of the METP theory are compared and clarified in the basic assumptions,mechanical models,main viewpoints,and mechanism analysis.The large deformation inducement of the intersection roof is then explored.The J 2 peak area of the roof drives the large deformation of the area,the peak point of which is consistent with the center of gravity position of the METP.Furthermore,the change in the range of this peak is consistent with the change law of the METP’s area.Hence,this theory clarifies the large deformation area of the intersection roof,which provides a clear guiding basis for its initial support design,mid-term monitoring,and late local reinforcement. 展开更多
关键词 roadway intersection roof deformation equivalent span theory triangular plate structure numerical analysis stress partial tensor
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