Passive bionic feet,known for their human-like compliance,have garnered attention for their potential to achieve notable environmental adaptability.In this paper,a method was proposed to unifying passive bionic feet s...Passive bionic feet,known for their human-like compliance,have garnered attention for their potential to achieve notable environmental adaptability.In this paper,a method was proposed to unifying passive bionic feet static supporting stability and dynamic terrain adaptability through the utilization of the Rigid-Elastic Hybrid(REH)dynamics model.First,a bionic foot model,named the Hinge Tension Elastic Complex(HTEC)model,was developed by extracting key features from human feet.Furthermore,the kinematics and REH dynamics of the HTEC model were established.Based on the foot dynamics,a nonlinear optimization method for stiffness matching(NOSM)was designed.Finally,the HTEC-based foot was constructed and applied onto BHR-B2 humanoid robot.The foot static stability is achieved.The enhanced adaptability is observed as the robot traverses square steel,lawn,and cobblestone terrains.Through proposed design method and structure,the mobility of the humanoid robot is improved.展开更多
The effect of geosynthetic reinforcing on bearing capacity of a strip footing resting on georeinforced clayey slopes was investigated.The results of a series of numerical study using finite element analyses on strip f...The effect of geosynthetic reinforcing on bearing capacity of a strip footing resting on georeinforced clayey slopes was investigated.The results of a series of numerical study using finite element analyses on strip footing upon both reinforced and unreinforced clayey slopes were presented.The objectives of this work are to:1) determine the influence of reinforcement on the bearing-capacity of the strip footings adjacent slopes,2) suggest an optimum number of reinforcement and 3) survey the effect of friction angle in clayey soils reinforced by geogrids.The investigations were carried out by varying the edge distance of the footing from slope.Also different numbers of geosynthetic layers were applied to obtaining the maximum bearing capacity and minimum settlement.To achieve the third objective,two different friction angles were used.The results show that the load?settlement behavior and ultimate bearing capacity of footing can be considerably improved by the inclusion of reinforcing layer.But using more than one layer reinforcement,the ultimate bearing capacity does not change considerably.It is also shown that for both reinforced and unreinforced slopes,the bearing capacity increases with an increase in edge distance.In addition,as the soil friction angle is increased,the efficiency of reinforcing reduces.展开更多
A series of dynamic model tests that were performed on a geogrid-reinforced square footing are presented.The dynamic(sinusoidal)loading was applied using a mechanical testing and simulation(MTS)electro-hydraulic servo...A series of dynamic model tests that were performed on a geogrid-reinforced square footing are presented.The dynamic(sinusoidal)loading was applied using a mechanical testing and simulation(MTS)electro-hydraulic servo loading system.In all the tests,the amplitude of loading was±160 kPa;the frequency of loading was 2 Hz.To better ascertain the effect of reinforcement,an unreinforced square footing was first tested.This was followed by a series of tests,each with a single layer of reinforcement.The reinforcement was placed at depths of 0.3B,0.6B and 0.9B,where B is the width of footing.The optimal depth of reinforcement was found to be 0.6B.The effect of adopting this value versus the other two depths was quantified.The single layer of geogrid had an effective reinforcement depth of 1.7B below the footing base.The increase of the depth between the topmost geogrid layer and the bottom of the footing(within the range of 0.9B)did not change the failure mode of the foundation.展开更多
From a financial point of view,urbanization frequently enforces the clients to construct superstructures near the slopes,giving rise to increasing the risk of building instability.By conducting a series of small-scale...From a financial point of view,urbanization frequently enforces the clients to construct superstructures near the slopes,giving rise to increasing the risk of building instability.By conducting a series of small-scale plate load tests,this work aims to investigate the effects of installing geotextile reinforcement layers in sandy slope and reducing the apex angle of triangular shell strip footings.The results show considerable effect of using geotextile-reinforced layers and decreasing the apex angle on the ultimate bearing capacity of shell foundations.With increasing foundation distance from the slope,the adverse effect of the slope is reduced.However,as the distance decreases,the effect of reinforcement and apex angle is increased.For practical applications,empirical equations are also presented for determining the ultimate bearing capacity of the footings and scale effect as well.Finally,3D numerical simulations are executed and compared with the experimental results.展开更多
EV71-type virus is one of the main pathogens causing the occurrence of hand,foot and mouth disease(HFMD),and VP1 protein,a factor that directly determines the antigenicity of the virus,has been isolated.The tomato was...EV71-type virus is one of the main pathogens causing the occurrence of hand,foot and mouth disease(HFMD),and VP1 protein,a factor that directly determines the antigenicity of the virus,has been isolated.The tomato was selected as a bioreactor for the production of an edible EV71 vaccine designed for the VP1 capsid protein.Using molecular biology techniques,the fusion gene EV71-VP1 was cut from vector PGEX-4T-2,a vector containing the p2300-EV71 gene with CaMV35S promoter and TL regulatory elements was constructed,and the hypocotyl and cotyledons of tomato were transformed using Agrobacterium(EHA105)-mediated method,screened,elongated and rooted,and finally 20 resistant tomato plants were obtained.Five transgenic positive seedlings were obtained by digestion and PCR assay,among which three plants were detected by RT-PCR to be capable of transcriptional translation at the RNA level.The experimental results aimed to explore new material support for the preparation of transgenic plant oral vaccines against EV71 infection and provide a theoretical basis for accelerating the development of transgenic plant vaccines in the future.展开更多
Objectives: To investigate foot transverse arch biomechanical stability contributed by the second metatarsal and the three ligaments connecting medial cuneiform to the second metatarsal base.Methods: Six fresh-frozen ...Objectives: To investigate foot transverse arch biomechanical stability contributed by the second metatarsal and the three ligaments connecting medial cuneiform to the second metatarsal base.Methods: Six fresh-frozen cadaveric lower extremities were dissected to expose the展开更多
Objective:To assess potential risk factors for diabetic foot ulcers infected with multidrug-resistant-organisms(MDROs)and to investigate antibiotic susceptibility patterns and extended-spectrum-β-lactamase(ESBL)-prod...Objective:To assess potential risk factors for diabetic foot ulcers infected with multidrug-resistant-organisms(MDROs)and to investigate antibiotic susceptibility patterns and extended-spectrum-β-lactamase(ESBL)-production in bacteria isolated from these ulcers.Methods:Seventy-seven diabetic foot ulcer-patients were studied in a consecutive series.Forty-four study factors were recorded for each patient.Specimens were obtained by scraping the ulcer base or the deep portion of the wound edge with a sterile curette.The soft tissue specimens were quickly sent to the laboratory and processed for microbial pathogens.Gram-negative bacterial isolates were tested for ESBL production by double-disc-diffusion method.The association of study variables with MDRO and non-MDRO infection status of ulcers was tested by Student's t test or Fisher's exact test using SPSS(version 11.5,Chicago).Results:An alarming number of patients were MDRO-positive(72.7%).ESBL-positive strains constituted 19.8% of total isolates.Staphylococcal isolates identified as methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Staphylococcus aureus(VRSA),were 3.7%(n=8)and 0.5%(n=1)respectively.Twenty-two study factors were found to be significantly associated with MDRO infection status of ulcers in the univariate analysis.Multiple logistic regressions proved that MDRO status was the only significant,independent predictor of glycemic control(Odds ratio = 4.22,P<0.01).Conclusion:It is concluded that MDRO infected patients have poor glycemic control.Imipenem and linezolid can be suggested as the drugs of choice in the described setting.展开更多
通过检索PubMed、Web of Science、中国知网和万方等数据库,对近年来发表的有关扁平足在生物力学上的成因和治疗方法的相关内容进行综述。其中,扁平足的形成原因包括先天性因素和后天性因素,而治疗方法主要有矫形鞋垫、物理疗法、手术...通过检索PubMed、Web of Science、中国知网和万方等数据库,对近年来发表的有关扁平足在生物力学上的成因和治疗方法的相关内容进行综述。其中,扁平足的形成原因包括先天性因素和后天性因素,而治疗方法主要有矫形鞋垫、物理疗法、手术治疗和运动疗法。这些方法在一定程度上能够纠正足部结构异常,优化生物力学性能,提高足部的稳定性和活动范围。对于未来的研究,将利用先进的影像和仿真技术进行精确的病情评估,新型材料和非手术疗法的应用将能够长期缓解症状,而基因研究将推动早期诊断和个性化治疗的发展,智能矫形器的使用将实现实时监测和动态调整,从而为扁平足的评估、干预和治疗提供更多更有效的方法和手段。展开更多
基金supported by the National Natural Science Foundation of China(Grant No.62073041)the Open Fund of Laboratory of Aerospace Servo Actuation and Transmission(Grant No.LASAT-2023A04)the Fundamental Research Funds for the Central Universities(Grant Nos.2024CX06011,2024CX06079)。
文摘Passive bionic feet,known for their human-like compliance,have garnered attention for their potential to achieve notable environmental adaptability.In this paper,a method was proposed to unifying passive bionic feet static supporting stability and dynamic terrain adaptability through the utilization of the Rigid-Elastic Hybrid(REH)dynamics model.First,a bionic foot model,named the Hinge Tension Elastic Complex(HTEC)model,was developed by extracting key features from human feet.Furthermore,the kinematics and REH dynamics of the HTEC model were established.Based on the foot dynamics,a nonlinear optimization method for stiffness matching(NOSM)was designed.Finally,the HTEC-based foot was constructed and applied onto BHR-B2 humanoid robot.The foot static stability is achieved.The enhanced adaptability is observed as the robot traverses square steel,lawn,and cobblestone terrains.Through proposed design method and structure,the mobility of the humanoid robot is improved.
文摘The effect of geosynthetic reinforcing on bearing capacity of a strip footing resting on georeinforced clayey slopes was investigated.The results of a series of numerical study using finite element analyses on strip footing upon both reinforced and unreinforced clayey slopes were presented.The objectives of this work are to:1) determine the influence of reinforcement on the bearing-capacity of the strip footings adjacent slopes,2) suggest an optimum number of reinforcement and 3) survey the effect of friction angle in clayey soils reinforced by geogrids.The investigations were carried out by varying the edge distance of the footing from slope.Also different numbers of geosynthetic layers were applied to obtaining the maximum bearing capacity and minimum settlement.To achieve the third objective,two different friction angles were used.The results show that the load?settlement behavior and ultimate bearing capacity of footing can be considerably improved by the inclusion of reinforcing layer.But using more than one layer reinforcement,the ultimate bearing capacity does not change considerably.It is also shown that for both reinforced and unreinforced slopes,the bearing capacity increases with an increase in edge distance.In addition,as the soil friction angle is increased,the efficiency of reinforcing reduces.
基金Projects(41962017,51469005)supported by the National Natural Science Foundation of ChinaProject(2017GXNSFAA198170)supported by the Natural Science Foundation in Guangxi Province,China+1 种基金Project supported by the Guangxi University of Science and Technology Innovation Team Support Plan,ChinaProject supported by the High Level Innovation Team and Outstanding Scholars Program of Guangxi Institutions of Higher Learning,China。
文摘A series of dynamic model tests that were performed on a geogrid-reinforced square footing are presented.The dynamic(sinusoidal)loading was applied using a mechanical testing and simulation(MTS)electro-hydraulic servo loading system.In all the tests,the amplitude of loading was±160 kPa;the frequency of loading was 2 Hz.To better ascertain the effect of reinforcement,an unreinforced square footing was first tested.This was followed by a series of tests,each with a single layer of reinforcement.The reinforcement was placed at depths of 0.3B,0.6B and 0.9B,where B is the width of footing.The optimal depth of reinforcement was found to be 0.6B.The effect of adopting this value versus the other two depths was quantified.The single layer of geogrid had an effective reinforcement depth of 1.7B below the footing base.The increase of the depth between the topmost geogrid layer and the bottom of the footing(within the range of 0.9B)did not change the failure mode of the foundation.
文摘From a financial point of view,urbanization frequently enforces the clients to construct superstructures near the slopes,giving rise to increasing the risk of building instability.By conducting a series of small-scale plate load tests,this work aims to investigate the effects of installing geotextile reinforcement layers in sandy slope and reducing the apex angle of triangular shell strip footings.The results show considerable effect of using geotextile-reinforced layers and decreasing the apex angle on the ultimate bearing capacity of shell foundations.With increasing foundation distance from the slope,the adverse effect of the slope is reduced.However,as the distance decreases,the effect of reinforcement and apex angle is increased.For practical applications,empirical equations are also presented for determining the ultimate bearing capacity of the footings and scale effect as well.Finally,3D numerical simulations are executed and compared with the experimental results.
基金Supported by the Natural Science Foundation of Heilongjiang Province(LH2021C032)。
文摘EV71-type virus is one of the main pathogens causing the occurrence of hand,foot and mouth disease(HFMD),and VP1 protein,a factor that directly determines the antigenicity of the virus,has been isolated.The tomato was selected as a bioreactor for the production of an edible EV71 vaccine designed for the VP1 capsid protein.Using molecular biology techniques,the fusion gene EV71-VP1 was cut from vector PGEX-4T-2,a vector containing the p2300-EV71 gene with CaMV35S promoter and TL regulatory elements was constructed,and the hypocotyl and cotyledons of tomato were transformed using Agrobacterium(EHA105)-mediated method,screened,elongated and rooted,and finally 20 resistant tomato plants were obtained.Five transgenic positive seedlings were obtained by digestion and PCR assay,among which three plants were detected by RT-PCR to be capable of transcriptional translation at the RNA level.The experimental results aimed to explore new material support for the preparation of transgenic plant oral vaccines against EV71 infection and provide a theoretical basis for accelerating the development of transgenic plant vaccines in the future.
基金National Natural Science Foundation #30801163,year2008,and#30640058
文摘Objectives: To investigate foot transverse arch biomechanical stability contributed by the second metatarsal and the three ligaments connecting medial cuneiform to the second metatarsal base.Methods: Six fresh-frozen cadaveric lower extremities were dissected to expose the
基金supported by the central facilities and internal funds of Interdisciplinary Biotechnology Unit,AMU,India which are highly acknowledged
文摘Objective:To assess potential risk factors for diabetic foot ulcers infected with multidrug-resistant-organisms(MDROs)and to investigate antibiotic susceptibility patterns and extended-spectrum-β-lactamase(ESBL)-production in bacteria isolated from these ulcers.Methods:Seventy-seven diabetic foot ulcer-patients were studied in a consecutive series.Forty-four study factors were recorded for each patient.Specimens were obtained by scraping the ulcer base or the deep portion of the wound edge with a sterile curette.The soft tissue specimens were quickly sent to the laboratory and processed for microbial pathogens.Gram-negative bacterial isolates were tested for ESBL production by double-disc-diffusion method.The association of study variables with MDRO and non-MDRO infection status of ulcers was tested by Student's t test or Fisher's exact test using SPSS(version 11.5,Chicago).Results:An alarming number of patients were MDRO-positive(72.7%).ESBL-positive strains constituted 19.8% of total isolates.Staphylococcal isolates identified as methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Staphylococcus aureus(VRSA),were 3.7%(n=8)and 0.5%(n=1)respectively.Twenty-two study factors were found to be significantly associated with MDRO infection status of ulcers in the univariate analysis.Multiple logistic regressions proved that MDRO status was the only significant,independent predictor of glycemic control(Odds ratio = 4.22,P<0.01).Conclusion:It is concluded that MDRO infected patients have poor glycemic control.Imipenem and linezolid can be suggested as the drugs of choice in the described setting.
文摘通过检索PubMed、Web of Science、中国知网和万方等数据库,对近年来发表的有关扁平足在生物力学上的成因和治疗方法的相关内容进行综述。其中,扁平足的形成原因包括先天性因素和后天性因素,而治疗方法主要有矫形鞋垫、物理疗法、手术治疗和运动疗法。这些方法在一定程度上能够纠正足部结构异常,优化生物力学性能,提高足部的稳定性和活动范围。对于未来的研究,将利用先进的影像和仿真技术进行精确的病情评估,新型材料和非手术疗法的应用将能够长期缓解症状,而基因研究将推动早期诊断和个性化治疗的发展,智能矫形器的使用将实现实时监测和动态调整,从而为扁平足的评估、干预和治疗提供更多更有效的方法和手段。
