Objective The aim of this study was to determine the effect of successful coronary revascularisation on left ventricular diastolic function.Methods We consecutively studied the diastolic function by Doppler echocardio...Objective The aim of this study was to determine the effect of successful coronary revascularisation on left ventricular diastolic function.Methods We consecutively studied the diastolic function by Doppler echocardiography in 125 patients with one vessel disease before and 48 hours after selective coronary angioplasty. The following parameters of left ventricular diastolic function were evaluated: peak early (VE, m/s) and peak late diastolic (VA, m/s) flow velocity, E/A ratio, acceleration time (AT, ms), deceleration time (DT, ms) and isovolumetric relaxation time (IVRT, ms). Ejection fraction (EF; %) was determined and used to characterise systolic left ventricular function. Results All of the patients were initially successful treated with coronary angioplasty (residual stenosis <40% ). In 98 patients( 78.4% ) stents were used to improve an inadequate result after coronary angioplasty. Both patient groups (27 patients with coronary angioplasty and 98 patients with combined coronary angioplasty and stent implantation) showed no relevant differences concerning sex, age, atherosclerotic risk factors, exercise capacity and results of exercise electrocardiography. All patients who underwent stent implantation showed an early improvement of left ventricular diastolic function 48 hours after revascularisation. Surprisingly there was no significant short term improvement (48 hours) of diastolic function in patients with initially successful angioplasty.Conclusions We suppose that stent implantation might normalize coronary blood flow faster than that of coronary balloon angioplasty.展开更多
Germplasm effect reflects the quantitative relation between production ability of germplasm elements and yield （quality） of a certain crop, which can be shown by mathematic function, namely, germplasm effect functio...Germplasm effect reflects the quantitative relation between production ability of germplasm elements and yield （quality） of a certain crop, which can be shown by mathematic function, namely, germplasm effect function. Germplasm effect of a crop variety is an aggregation of many effective factors, and is restrained by different effective factors; constant increase of any one effect of germplasm elements would lead to law of effect decline, therefore, possible modes of transgenic crops effect function were deduced according to the law of effect decline. The possible modes of single transgenic germplasm effect function and multi-transgenic germplasm effect regression equation were discussed, and the characteristics of germplasm effect regression equation were analyzed in this paper.展开更多
目的观察咳喘镇定汤在小儿咳嗽变异性哮喘治疗中的作用及对患儿嗜酸性粒细胞计数(eosinophil count,EOS)、白介素-23(interleukin-23,IL-23)/辅助性T细胞17(helper T cells17,Th17)轴的影响。方法选取2020年8月—2023年2月收治的小儿咳...目的观察咳喘镇定汤在小儿咳嗽变异性哮喘治疗中的作用及对患儿嗜酸性粒细胞计数(eosinophil count,EOS)、白介素-23(interleukin-23,IL-23)/辅助性T细胞17(helper T cells17,Th17)轴的影响。方法选取2020年8月—2023年2月收治的小儿咳嗽变异性哮喘患儿104例,将患儿采用简单随机法分为两组。常规组给予止咳化痰、抗炎、平喘等常规治疗,咳喘镇定汤组在常规组基础上采用咳喘镇定汤辅助治疗。检测组间及组内T淋巴亚群、EOS、巨噬细胞炎症蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)、Clara细胞分泌蛋白16(clara cell secreted protein 16,CC-16)、嗜酸细胞活化趋化因子(Eotaxin)、IL-23/Th17轴、小气道功能水平。评估组间及组内咳嗽症状评分、中医证候评分差异。统计组间疗效和不良反应。结果治疗前T淋巴亚群、CC-16、Eotaxin等差异无统计学意义(P>0.05)。两组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin降低,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)升高,咳喘镇定汤组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin低于常规组,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)高于常规组(P<0.05)。治疗前比较IL-23/Th17轴差异无统计学意义(P>0.05)。两组治疗后IL-23、Th17、白介素-17(interleukin-17,IL-17)降低,咳喘镇定汤组治疗后IL-23/Th17轴低于常规组(P<0.05)。治疗前相关评分无差异(P>0.05)。两组治疗后咳嗽症状评分、中医证候评分降低,咳喘镇定汤组治疗后咳嗽症状评分、中医症候评分低于常规组(P<0.05)。治疗前小气道功能无差异(P>0.05)。两组治疗后小气道功能升高,咳喘镇定汤组治疗后小气道功能高于常规组(P<0.05)。咳喘镇定汤组治愈13例,显效和有效共35例,总有效率92.31%高于常规组,差异有统计学意义(P<0.05)。结论咳喘镇定汤可通过调控小儿咳嗽变异性哮喘患儿IL-23/Th17轴,改善T淋巴亚群和小气道功能,减轻咳嗽症状,提高疗效。展开更多
目的观察培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效。方法纳入肾阳不足型膝关节退行性病变患者80例,采取随机数字表法分为对照组40例与观察组40例,对照组接受膝关节置换术治疗,观察组在对照组治疗基础上结合培元养心...目的观察培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效。方法纳入肾阳不足型膝关节退行性病变患者80例,采取随机数字表法分为对照组40例与观察组40例,对照组接受膝关节置换术治疗,观察组在对照组治疗基础上结合培元养心法(背俞穴温针灸)治疗,观察各组数据情况:疗效优良率、治疗前后中医证候积分变化、术后3 d及术后6 d、术后9 d患者的疼痛评分[视觉模拟疼痛评分法(Visual analogue scale,VAS)],治疗前后患者C反应蛋白(C-reactive protein,CRP)及肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)和白介素-6(Interleukin-6,IL-6)指标变化、治疗前后患者Lysholm膝关节量表评分变化、并发症发生率、治疗前、治疗2周及治疗4周身体健康评分(the MOS item short from health survey,SF-36)。结果观察组患者治疗效果优良率(95.00%,38/40)高于对照组(80.00%,32/40),差异有统计学意义(P<0.05);各组患者治疗后中医证候积分下降,炎症因子(CRP、TNF-α、IL-6)均显著下降,Lysholm膝关节量表总评分显著上升,观察组治疗后中医证候积分及炎症因子(CRP、TNF-α、IL-6)均低于对照组,Lysholm膝关节量表总评分高于对照组,差异有统计学意义(P<0.05);观察组患者术后3、6、9 d的VAS评分均比对照组更低,差异有统计学意义(P<0.05);对照组并发症率为20.00%(8/40),比观察组的5.00%(2/40)更低,差异有统计学意义(P<0.05);治疗2周及治疗4周后观察组患者的SF-36评分均高于对照组患者,差异有统计学意义(P<0.05)。结论培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效良好,患者症状改善,膝关节功能改善,并发症少,治疗安全可靠,且患者治疗后身体健康好转,值得应用。展开更多
文摘Objective The aim of this study was to determine the effect of successful coronary revascularisation on left ventricular diastolic function.Methods We consecutively studied the diastolic function by Doppler echocardiography in 125 patients with one vessel disease before and 48 hours after selective coronary angioplasty. The following parameters of left ventricular diastolic function were evaluated: peak early (VE, m/s) and peak late diastolic (VA, m/s) flow velocity, E/A ratio, acceleration time (AT, ms), deceleration time (DT, ms) and isovolumetric relaxation time (IVRT, ms). Ejection fraction (EF; %) was determined and used to characterise systolic left ventricular function. Results All of the patients were initially successful treated with coronary angioplasty (residual stenosis <40% ). In 98 patients( 78.4% ) stents were used to improve an inadequate result after coronary angioplasty. Both patient groups (27 patients with coronary angioplasty and 98 patients with combined coronary angioplasty and stent implantation) showed no relevant differences concerning sex, age, atherosclerotic risk factors, exercise capacity and results of exercise electrocardiography. All patients who underwent stent implantation showed an early improvement of left ventricular diastolic function 48 hours after revascularisation. Surprisingly there was no significant short term improvement (48 hours) of diastolic function in patients with initially successful angioplasty.Conclusions We suppose that stent implantation might normalize coronary blood flow faster than that of coronary balloon angioplasty.
文摘Germplasm effect reflects the quantitative relation between production ability of germplasm elements and yield （quality） of a certain crop, which can be shown by mathematic function, namely, germplasm effect function. Germplasm effect of a crop variety is an aggregation of many effective factors, and is restrained by different effective factors; constant increase of any one effect of germplasm elements would lead to law of effect decline, therefore, possible modes of transgenic crops effect function were deduced according to the law of effect decline. The possible modes of single transgenic germplasm effect function and multi-transgenic germplasm effect regression equation were discussed, and the characteristics of germplasm effect regression equation were analyzed in this paper.
文摘目的观察咳喘镇定汤在小儿咳嗽变异性哮喘治疗中的作用及对患儿嗜酸性粒细胞计数(eosinophil count,EOS)、白介素-23(interleukin-23,IL-23)/辅助性T细胞17(helper T cells17,Th17)轴的影响。方法选取2020年8月—2023年2月收治的小儿咳嗽变异性哮喘患儿104例,将患儿采用简单随机法分为两组。常规组给予止咳化痰、抗炎、平喘等常规治疗,咳喘镇定汤组在常规组基础上采用咳喘镇定汤辅助治疗。检测组间及组内T淋巴亚群、EOS、巨噬细胞炎症蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)、Clara细胞分泌蛋白16(clara cell secreted protein 16,CC-16)、嗜酸细胞活化趋化因子(Eotaxin)、IL-23/Th17轴、小气道功能水平。评估组间及组内咳嗽症状评分、中医证候评分差异。统计组间疗效和不良反应。结果治疗前T淋巴亚群、CC-16、Eotaxin等差异无统计学意义(P>0.05)。两组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin降低,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)升高,咳喘镇定汤组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin低于常规组,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)高于常规组(P<0.05)。治疗前比较IL-23/Th17轴差异无统计学意义(P>0.05)。两组治疗后IL-23、Th17、白介素-17(interleukin-17,IL-17)降低,咳喘镇定汤组治疗后IL-23/Th17轴低于常规组(P<0.05)。治疗前相关评分无差异(P>0.05)。两组治疗后咳嗽症状评分、中医证候评分降低,咳喘镇定汤组治疗后咳嗽症状评分、中医症候评分低于常规组(P<0.05)。治疗前小气道功能无差异(P>0.05)。两组治疗后小气道功能升高,咳喘镇定汤组治疗后小气道功能高于常规组(P<0.05)。咳喘镇定汤组治愈13例,显效和有效共35例,总有效率92.31%高于常规组,差异有统计学意义(P<0.05)。结论咳喘镇定汤可通过调控小儿咳嗽变异性哮喘患儿IL-23/Th17轴,改善T淋巴亚群和小气道功能,减轻咳嗽症状,提高疗效。
文摘目的观察培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效。方法纳入肾阳不足型膝关节退行性病变患者80例,采取随机数字表法分为对照组40例与观察组40例,对照组接受膝关节置换术治疗,观察组在对照组治疗基础上结合培元养心法(背俞穴温针灸)治疗,观察各组数据情况:疗效优良率、治疗前后中医证候积分变化、术后3 d及术后6 d、术后9 d患者的疼痛评分[视觉模拟疼痛评分法(Visual analogue scale,VAS)],治疗前后患者C反应蛋白(C-reactive protein,CRP)及肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)和白介素-6(Interleukin-6,IL-6)指标变化、治疗前后患者Lysholm膝关节量表评分变化、并发症发生率、治疗前、治疗2周及治疗4周身体健康评分(the MOS item short from health survey,SF-36)。结果观察组患者治疗效果优良率(95.00%,38/40)高于对照组(80.00%,32/40),差异有统计学意义(P<0.05);各组患者治疗后中医证候积分下降,炎症因子(CRP、TNF-α、IL-6)均显著下降,Lysholm膝关节量表总评分显著上升,观察组治疗后中医证候积分及炎症因子(CRP、TNF-α、IL-6)均低于对照组,Lysholm膝关节量表总评分高于对照组,差异有统计学意义(P<0.05);观察组患者术后3、6、9 d的VAS评分均比对照组更低,差异有统计学意义(P<0.05);对照组并发症率为20.00%(8/40),比观察组的5.00%(2/40)更低,差异有统计学意义(P<0.05);治疗2周及治疗4周后观察组患者的SF-36评分均高于对照组患者,差异有统计学意义(P<0.05)。结论培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效良好,患者症状改善,膝关节功能改善,并发症少,治疗安全可靠,且患者治疗后身体健康好转,值得应用。
