By phenomenological analysis of warm compaction, it is found that, compared with the contribution of particle plastical deformation to densification of powder compact,the particle rearrangement is a dominant densifica...By phenomenological analysis of warm compaction, it is found that, compared with the contribution of particle plastical deformation to densification of powder compact,the particle rearrangement is a dominant densification mechanism for powder warm compaction, and the plastical deformation of particles plays an important role in offering accommodating deformation for particle rearrangement and densifying powder compact at the final stage of pressing.In order to attain density gain as high as possible during warm compaction, six rules for designing warm compacting powder mixtures were proposed in detail.展开更多
In order to achieve the functional requirements of multi-moving state, a new autonomous underwater vehicle(AUV) provided with the functions such as the submarine vectorial thrust, landing on the sea bottom, wheel driv...In order to achieve the functional requirements of multi-moving state, a new autonomous underwater vehicle(AUV) provided with the functions such as the submarine vectorial thrust, landing on the sea bottom, wheel driving on the ground and crawling on the ground was designed. Then five new theories and methods were proposed about the motion mechanism of the AUV such as vectorial thruster technology, design of a new wheel propeller, kinematics and dynamics, navigation control and the ambient flow field in complex sea conditions, which can all conquer conventional technique shortages and predict the multi-moving state performance under wave disturbance. The theoretical research can realize the results such as a vectorial transmission shaft with the characteristics of spatial deflexion and continual circumgyratetion, parameterized design of the new wheel propeller with preferable open-water performance and intensity characteristics satisfying multi-moving state requirements, motion computation and kinetic analysis of AUV's arbitrary postures under wave disturbance, a second-order sliding mode controller with double-loop structure based on dynamic boundary layer that ensures AUV's trajectory high-precision tracking performance under wave disturbance, fast and exact prediction of the ambient flow field characteristics and the interaction mechanism between AUV hull and wheel propellers. The elaborate data obtained from the theoretical research can provide an important theoretical guidance and technical support for the manufacture of experimental prototype.展开更多
In the printing industry,vacuum pumps play a critical role in sheet feeding and gripping processes.In order to improve the efficiency of vacuum pumps,By analyzing the internal flow field of the vane type vacuum pump,t...In the printing industry,vacuum pumps play a critical role in sheet feeding and gripping processes.In order to improve the efficiency of vacuum pumps,By analyzing the internal flow field of the vane type vacuum pump,the CFD method was used to simulate the internal flow field of the air pump,and it was found that a main vortex was formed near the rotor of the trailing blade.Based on this observation,a new rotor shape design was proposed in this study,which design places arc-shaped depressed on the circumference of the rotor where the main vortex forms.The existence of the depression facilitated forward motion of the main airflow and thus effectively restricting reverse flow.Simulation results demonstrated that the proposed design is able to decrease pressure-induced torque load on the pump,and the reduction increases for an increasing operating speed.For all three operating speeds tested,the reduction in pressure-induced torque ranges from 5%to up to 10%comparing to the original pump.展开更多
A novel hybrid algorithm named ABC-BBO, which integrates artificial bee colony(ABC) algorithm with biogeography-based optimization(BBO) algorithm, is proposed to solve constrained mechanical design problems. ABC-BBO c...A novel hybrid algorithm named ABC-BBO, which integrates artificial bee colony(ABC) algorithm with biogeography-based optimization(BBO) algorithm, is proposed to solve constrained mechanical design problems. ABC-BBO combined the exploration of ABC algorithm with the exploitation of BBO algorithm effectively, and hence it can generate the promising candidate individuals. The proposed hybrid algorithm speeds up the convergence and improves the algorithm's performance. Several benchmark test functions and mechanical design problems are applied to verifying the effects of these improvements and it is demonstrated that the performance of this proposed ABC-BBO is superior to or at least highly competitive with other population-based optimization approaches.展开更多
Minimizing the impact of the mixed uncertainties(i.e.,the aleatory uncertainty and the epistemic uncertainty) for a complex product of compliant mechanism(CPCM) quality improvement signifies a fascinating research top...Minimizing the impact of the mixed uncertainties(i.e.,the aleatory uncertainty and the epistemic uncertainty) for a complex product of compliant mechanism(CPCM) quality improvement signifies a fascinating research topic to enhance the robustness.However, most of the existing works in the CPCM robust design optimization neglect the mixed uncertainties, which might result in an unstable design or even an infeasible design. To solve this issue, a response surface methodology-based hybrid robust design optimization(RSM-based HRDO) approach is proposed to improve the robustness of the quality characteristic for the CPCM via considering the mixed uncertainties in the robust design optimization. A bridge-type amplification mechanism is used to manifest the effectiveness of the proposed approach. The comparison results prove that the proposed approach can not only keep its superiority in the robustness, but also provide a robust scheme for optimizing the design parameters.展开更多
Aimed at two typical composite floor systems of through steel bridges in high speed railway,design methods of headed studs were put forward for different composite members through comparing and analyzing the structure...Aimed at two typical composite floor systems of through steel bridges in high speed railway,design methods of headed studs were put forward for different composite members through comparing and analyzing the structure,mechanical characteristics and transmission routes of deck loads.The simplified calculation models were brought out for the stud design of the longitudinal girders and transverse girders in the composite floor system of Nanjing Dashengguan Yangtze River Bridge (NDB).Studs were designed and arranged by taking the middle panel of 336 m main span for example.The results show that under deck loads,the longitudinal girders in the composite floor system of through steel bridges are in tension-bending state,longitudinal shear force on the interface is caused by both longitudinal force of "The first mechanical system" and vertical bending of "The second mechanical system",and studs can be arranged with equal space in terms of the shear force in range of 0.2d (where d is the panel length) on the top ends.Transverse girders in steel longitudinal and transverse girders-concrete slab composite deck are in compound-bending state,and out-of-plane bending has to be taken into account in the stud design.In orthotropic integral steel deck-concrete slab composite deck,out-of-plane bending of transverse girders is very small so that it can be neglected,and studs on the orthotropic integral steel deck can be arranged according to the structural requirements.The above design methods and simplified calculation models have been applied in the stud design of NDB.展开更多
Plane wave generators(PWGs) are used to accelerate flyer plates to high velocities with their generated plane waves,which are widely used in the test of dynamic properties of materials.The traditional PWG is composed ...Plane wave generators(PWGs) are used to accelerate flyer plates to high velocities with their generated plane waves,which are widely used in the test of dynamic properties of materials.The traditional PWG is composed of two explosives with different detonation velocities.It is difficult to implement the related fabrication processes and control the generated waves due to its complicated structures.A simple plane wave generator is presented in this paper,which is composed of two identical cylindrical high explosive(HE) charges and an air-metal barrier.A theoretical model was established based on two different paths of the propagation of detonation waves,based on which the size of air-metal barrier was calculated for a given charge.The corresponding numerical simulations were also carried out by AUTODYN-2D based on the calculated results,which were used to compare with the theoretical calculations.A detonation wave with a flatness of 0.039 μs within the range of 70-percent diameter of the main charge was obtained through the simulations.展开更多
The kinematical equations of McPherson suspension and steering system were set up by using R-W method of multi-rigid body system dynamics.The incidence matrix,route matrix,hinge vector matrix and system constraint equ...The kinematical equations of McPherson suspension and steering system were set up by using R-W method of multi-rigid body system dynamics.The incidence matrix,route matrix,hinge vector matrix and system constraint equations were educed.The optimization model of McPherson suspension steering mechanism was founded by regarding the McPherson suspension and steering system as an integrated system.In order to gain the best optimization effect,a continuous weighting function was created according to the requirement of steering system performance.Taking example for TJ7136U,the optimization design of McPherson suspension steering system was conducted in this paper.展开更多
Feedback mechanism is a specific feature of control systems, however, the similarity has been found in decision support systems. Just because of this, the DSS can provide a flexible learning and thinking environment, ...Feedback mechanism is a specific feature of control systems, however, the similarity has been found in decision support systems. Just because of this, the DSS can provide a flexible learning and thinking environment, and help decision maker to solve semistructured and unstructured problems actively and creatively. In this paper, the role and type of the feedback in decision making are discussed from different point of view. This is also true in DSS because it supports decision making. The feedback design, especially the feedback interface design, is described through a case of practice DSS. Based on these points, the feedback mechanism is an important feature of DSS, and it is one of the differences between DSS and MIS.展开更多
Cylindrical Cam Mechanism which is one of the best eq uipments to accomplish an accurate motion transmission is widely used in the fie lds of industries, such as machine tool exchangers, textile machinery and automa t...Cylindrical Cam Mechanism which is one of the best eq uipments to accomplish an accurate motion transmission is widely used in the fie lds of industries, such as machine tool exchangers, textile machinery and automa tic transfer equipments. This paper proposes a new approach for the shape design and manufacturing of the cylindrical cam. The design approach uses the relative velocity concept and the manufacturing approach uses the inverse kinematics concept. For the shape desig n, the contact points between the cam and the follower roller are calculated bas ed on relative velocity of which the direction is on the common tangential line, and then the whole shape of cam is determined from transformation of the coordi nate system. For the manufacturing procedures, the location and the orientation of cutter path can be allocated corresponding to the designed shape data. The in tegral NC code for multi-axis CNC machining center is created using the inverse kinematics concept from the data of the location and the orientation of cutter path. As the advantages of the proposed approach, the machine tool is designed t o having an alternative size in fabricating the general cam, while the tool must be fitted to diameter size of the follower in the conventional approach. Finally, CAD/CAM program, "Cylindrical DAM", is developed on C++ lan guage. This program can perform shape design, manufacturing and kinematics simul ation, which can make integral NC code for multi-axis CNC machining center. The proposed method can be applied easily on fields of industries.展开更多
The technique of cutting slabstone with stone-sawi ng machine is analyzed completely. A new kind of cutting movement trajectory is gi ven whose actual cutting efficiency is near to 100%. It can reduce the energy w ear...The technique of cutting slabstone with stone-sawi ng machine is analyzed completely. A new kind of cutting movement trajectory is gi ven whose actual cutting efficiency is near to 100%. It can reduce the energy w earing greatly, and the surface quality of the product is improved to the utmost extent. The design mechanism of the optimal cutting movement trajectory system structure is analyzed incisively. At the same time, the principle of the complex movement of horizontal movement and swing is researched. The optimal design scheme of th e cutting movement trajectory system structure is set up. The choice method to g et the superior value of the movement system structure is found. The mathematics function formula is established which exhibits the relationship between the par ameter of the complex movement structure and that of the system movement structu re. By the formula, the precision value of the offset can be figured out. The r ule is adapted to different types of energy-saving stone-sawing machines. The complex movement structure of horizontal movement and swing is designed to f ulfill the cutting movement. It can make the saw frame move up with the hanging pod deviating from the vertical direction. At the same time, the saw frame have a down-movement. Then the sum of the two movements is near to zero, and the saw blade and the stone can keep in touch during the whole horizontal cutting. The result is that the actual cutting efficiency is 100%. Also, when the hanging pod moves to the limited position, the saw frame can keep the original inertia, and continue to swing up. It makes the back-cutting have high energy-storing. The optimal design of the eccentricity balance wheel is done. The mathematics fo rmula for expressing the movement system structure is deduced. The calculation m ethod and formula is set up which is used to get the value of important componen ts such as offset. The choice method and formula of elasticity distortion coeffi cient is set up when the saw frame moves smoothly. It is concluded that the offs et is the key dimension to actualize the optimal cutting movement trajectory. The resolving of the technical problems discussed above offers a theoretic and technical basis for optimal design of energy-saving stone-sawing machines.展开更多
航空光电装备平面光学窗口在确定构型尺寸和组合形式后,窗口厚度对装备成像性能影响至为关键。从设计变量、组合形式、作用载荷3个方面对窗口设计问题进行分析,确定了基于结构刚性和RMS(root mean square)波前误差的平面窗口厚度设计目...航空光电装备平面光学窗口在确定构型尺寸和组合形式后,窗口厚度对装备成像性能影响至为关键。从设计变量、组合形式、作用载荷3个方面对窗口设计问题进行分析,确定了基于结构刚性和RMS(root mean square)波前误差的平面窗口厚度设计目标;从光学窗口一阶结构谐振频率及其在温度和压力载荷作用下的RMS波前误差量化求解出窗口厚度尺寸范围11.9 mm~18.4 mm;提出针对光学窗口组合工况性能计算的集成分析流程,计算得到光学窗口一阶谐振频率为151 Hz,在飞行工作时各向组合工况-流场/重力/振动作用下光学窗口RMS波前误差不大于1/10参考波长。实验测试结果表明:光学窗口RMS波前误差小于0.07参考波长,实物样机振动和飞行条件下成像清晰、稳定,证明窗口厚度尺寸设计分析方法正确有效。展开更多
以基因、转录、蛋白质等生命组学为主体的生物大数据快速积累和以深度学习为代表的人工智能技术迅猛发展,催生出各种类别的生物大模型(biological large models)。复杂的深度学习架构、巨大的参数量和算力需求、以及海量的预训练数据等...以基因、转录、蛋白质等生命组学为主体的生物大数据快速积累和以深度学习为代表的人工智能技术迅猛发展,催生出各种类别的生物大模型(biological large models)。复杂的深度学习架构、巨大的参数量和算力需求、以及海量的预训练数据等是大模型技术的主要特征。预训练数据类别及参数量一定程度上决定了大模型所具备的能力强弱,而不同的模型架构则可支撑不同类别的下游任务。近两年,围绕DNA/RNA/蛋白质等生物序列与单细胞表达图谱等组学数据分析挖掘、大分子结构预测、新型药物设计和功能机制解析等多种应用场景,涌现了多种通用或专用大模型,展示出其在生物医学研究及转化应用等领域的巨大潜力。本文旨在结合不同类别的生物数据特点和研究应用需求,概述生物数据特征及其用于生物大模型训练的技术方法,并进一步综述现有大模型在生物医学研究及疾病诊疗中的应用进展,为提升生物大模型能力、拓展应用范围提供新的思路。展开更多
文摘By phenomenological analysis of warm compaction, it is found that, compared with the contribution of particle plastical deformation to densification of powder compact,the particle rearrangement is a dominant densification mechanism for powder warm compaction, and the plastical deformation of particles plays an important role in offering accommodating deformation for particle rearrangement and densifying powder compact at the final stage of pressing.In order to attain density gain as high as possible during warm compaction, six rules for designing warm compacting powder mixtures were proposed in detail.
基金Project(51505491)supported by the National Natural Science Foundation of ChinaProject(ZR2014EEP019)supported by the Natural Science Foundation of Shandong Province,China
文摘In order to achieve the functional requirements of multi-moving state, a new autonomous underwater vehicle(AUV) provided with the functions such as the submarine vectorial thrust, landing on the sea bottom, wheel driving on the ground and crawling on the ground was designed. Then five new theories and methods were proposed about the motion mechanism of the AUV such as vectorial thruster technology, design of a new wheel propeller, kinematics and dynamics, navigation control and the ambient flow field in complex sea conditions, which can all conquer conventional technique shortages and predict the multi-moving state performance under wave disturbance. The theoretical research can realize the results such as a vectorial transmission shaft with the characteristics of spatial deflexion and continual circumgyratetion, parameterized design of the new wheel propeller with preferable open-water performance and intensity characteristics satisfying multi-moving state requirements, motion computation and kinetic analysis of AUV's arbitrary postures under wave disturbance, a second-order sliding mode controller with double-loop structure based on dynamic boundary layer that ensures AUV's trajectory high-precision tracking performance under wave disturbance, fast and exact prediction of the ambient flow field characteristics and the interaction mechanism between AUV hull and wheel propellers. The elaborate data obtained from the theoretical research can provide an important theoretical guidance and technical support for the manufacture of experimental prototype.
文摘In the printing industry,vacuum pumps play a critical role in sheet feeding and gripping processes.In order to improve the efficiency of vacuum pumps,By analyzing the internal flow field of the vane type vacuum pump,the CFD method was used to simulate the internal flow field of the air pump,and it was found that a main vortex was formed near the rotor of the trailing blade.Based on this observation,a new rotor shape design was proposed in this study,which design places arc-shaped depressed on the circumference of the rotor where the main vortex forms.The existence of the depression facilitated forward motion of the main airflow and thus effectively restricting reverse flow.Simulation results demonstrated that the proposed design is able to decrease pressure-induced torque load on the pump,and the reduction increases for an increasing operating speed.For all three operating speeds tested,the reduction in pressure-induced torque ranges from 5%to up to 10%comparing to the original pump.
基金Projects(61463009,11264005,11361014)supported by the National Natural Science Foundation of ChinaProject([2013]2082)supported by the Science Technology Foundation of Guizhou Province,China
文摘A novel hybrid algorithm named ABC-BBO, which integrates artificial bee colony(ABC) algorithm with biogeography-based optimization(BBO) algorithm, is proposed to solve constrained mechanical design problems. ABC-BBO combined the exploration of ABC algorithm with the exploitation of BBO algorithm effectively, and hence it can generate the promising candidate individuals. The proposed hybrid algorithm speeds up the convergence and improves the algorithm's performance. Several benchmark test functions and mechanical design problems are applied to verifying the effects of these improvements and it is demonstrated that the performance of this proposed ABC-BBO is superior to or at least highly competitive with other population-based optimization approaches.
基金supported by the National Natural Science Foundation of China(71702072 71811540414+2 种基金 71573115)the Natural Science Foundation for Jiangsu Institutions(BK20170810)the Ministry of Education of Humanities and Social Science Planning Fund(18YJA630008)
文摘Minimizing the impact of the mixed uncertainties(i.e.,the aleatory uncertainty and the epistemic uncertainty) for a complex product of compliant mechanism(CPCM) quality improvement signifies a fascinating research topic to enhance the robustness.However, most of the existing works in the CPCM robust design optimization neglect the mixed uncertainties, which might result in an unstable design or even an infeasible design. To solve this issue, a response surface methodology-based hybrid robust design optimization(RSM-based HRDO) approach is proposed to improve the robustness of the quality characteristic for the CPCM via considering the mixed uncertainties in the robust design optimization. A bridge-type amplification mechanism is used to manifest the effectiveness of the proposed approach. The comparison results prove that the proposed approach can not only keep its superiority in the robustness, but also provide a robust scheme for optimizing the design parameters.
基金Project(2004G016-B) supported by the Science and Technology Development Program of Railways Department,China
文摘Aimed at two typical composite floor systems of through steel bridges in high speed railway,design methods of headed studs were put forward for different composite members through comparing and analyzing the structure,mechanical characteristics and transmission routes of deck loads.The simplified calculation models were brought out for the stud design of the longitudinal girders and transverse girders in the composite floor system of Nanjing Dashengguan Yangtze River Bridge (NDB).Studs were designed and arranged by taking the middle panel of 336 m main span for example.The results show that under deck loads,the longitudinal girders in the composite floor system of through steel bridges are in tension-bending state,longitudinal shear force on the interface is caused by both longitudinal force of "The first mechanical system" and vertical bending of "The second mechanical system",and studs can be arranged with equal space in terms of the shear force in range of 0.2d (where d is the panel length) on the top ends.Transverse girders in steel longitudinal and transverse girders-concrete slab composite deck are in compound-bending state,and out-of-plane bending has to be taken into account in the stud design.In orthotropic integral steel deck-concrete slab composite deck,out-of-plane bending of transverse girders is very small so that it can be neglected,and studs on the orthotropic integral steel deck can be arranged according to the structural requirements.The above design methods and simplified calculation models have been applied in the stud design of NDB.
基金sponsored by the National Natural Science Foundation of China(NSFC10902053)the Zijin Intelligent Program,Nanjing University of Science and Technology (2013_ZJ_0101)+1 种基金Qing Lan Project of Jiangsu province and the Fundamental Research Funds for the Central Universities (No.2012XQTR006)the State Key Laboratory of Explosion Science and Technology (Beijing Institute of Technology)(KFJJ15-07M) for their great support on the research work presented in this paper
文摘Plane wave generators(PWGs) are used to accelerate flyer plates to high velocities with their generated plane waves,which are widely used in the test of dynamic properties of materials.The traditional PWG is composed of two explosives with different detonation velocities.It is difficult to implement the related fabrication processes and control the generated waves due to its complicated structures.A simple plane wave generator is presented in this paper,which is composed of two identical cylindrical high explosive(HE) charges and an air-metal barrier.A theoretical model was established based on two different paths of the propagation of detonation waves,based on which the size of air-metal barrier was calculated for a given charge.The corresponding numerical simulations were also carried out by AUTODYN-2D based on the calculated results,which were used to compare with the theoretical calculations.A detonation wave with a flatness of 0.039 μs within the range of 70-percent diameter of the main charge was obtained through the simulations.
文摘The kinematical equations of McPherson suspension and steering system were set up by using R-W method of multi-rigid body system dynamics.The incidence matrix,route matrix,hinge vector matrix and system constraint equations were educed.The optimization model of McPherson suspension steering mechanism was founded by regarding the McPherson suspension and steering system as an integrated system.In order to gain the best optimization effect,a continuous weighting function was created according to the requirement of steering system performance.Taking example for TJ7136U,the optimization design of McPherson suspension steering system was conducted in this paper.
文摘Feedback mechanism is a specific feature of control systems, however, the similarity has been found in decision support systems. Just because of this, the DSS can provide a flexible learning and thinking environment, and help decision maker to solve semistructured and unstructured problems actively and creatively. In this paper, the role and type of the feedback in decision making are discussed from different point of view. This is also true in DSS because it supports decision making. The feedback design, especially the feedback interface design, is described through a case of practice DSS. Based on these points, the feedback mechanism is an important feature of DSS, and it is one of the differences between DSS and MIS.
文摘Cylindrical Cam Mechanism which is one of the best eq uipments to accomplish an accurate motion transmission is widely used in the fie lds of industries, such as machine tool exchangers, textile machinery and automa tic transfer equipments. This paper proposes a new approach for the shape design and manufacturing of the cylindrical cam. The design approach uses the relative velocity concept and the manufacturing approach uses the inverse kinematics concept. For the shape desig n, the contact points between the cam and the follower roller are calculated bas ed on relative velocity of which the direction is on the common tangential line, and then the whole shape of cam is determined from transformation of the coordi nate system. For the manufacturing procedures, the location and the orientation of cutter path can be allocated corresponding to the designed shape data. The in tegral NC code for multi-axis CNC machining center is created using the inverse kinematics concept from the data of the location and the orientation of cutter path. As the advantages of the proposed approach, the machine tool is designed t o having an alternative size in fabricating the general cam, while the tool must be fitted to diameter size of the follower in the conventional approach. Finally, CAD/CAM program, "Cylindrical DAM", is developed on C++ lan guage. This program can perform shape design, manufacturing and kinematics simul ation, which can make integral NC code for multi-axis CNC machining center. The proposed method can be applied easily on fields of industries.
文摘The technique of cutting slabstone with stone-sawi ng machine is analyzed completely. A new kind of cutting movement trajectory is gi ven whose actual cutting efficiency is near to 100%. It can reduce the energy w earing greatly, and the surface quality of the product is improved to the utmost extent. The design mechanism of the optimal cutting movement trajectory system structure is analyzed incisively. At the same time, the principle of the complex movement of horizontal movement and swing is researched. The optimal design scheme of th e cutting movement trajectory system structure is set up. The choice method to g et the superior value of the movement system structure is found. The mathematics function formula is established which exhibits the relationship between the par ameter of the complex movement structure and that of the system movement structu re. By the formula, the precision value of the offset can be figured out. The r ule is adapted to different types of energy-saving stone-sawing machines. The complex movement structure of horizontal movement and swing is designed to f ulfill the cutting movement. It can make the saw frame move up with the hanging pod deviating from the vertical direction. At the same time, the saw frame have a down-movement. Then the sum of the two movements is near to zero, and the saw blade and the stone can keep in touch during the whole horizontal cutting. The result is that the actual cutting efficiency is 100%. Also, when the hanging pod moves to the limited position, the saw frame can keep the original inertia, and continue to swing up. It makes the back-cutting have high energy-storing. The optimal design of the eccentricity balance wheel is done. The mathematics fo rmula for expressing the movement system structure is deduced. The calculation m ethod and formula is set up which is used to get the value of important componen ts such as offset. The choice method and formula of elasticity distortion coeffi cient is set up when the saw frame moves smoothly. It is concluded that the offs et is the key dimension to actualize the optimal cutting movement trajectory. The resolving of the technical problems discussed above offers a theoretic and technical basis for optimal design of energy-saving stone-sawing machines.
文摘以基因、转录、蛋白质等生命组学为主体的生物大数据快速积累和以深度学习为代表的人工智能技术迅猛发展,催生出各种类别的生物大模型(biological large models)。复杂的深度学习架构、巨大的参数量和算力需求、以及海量的预训练数据等是大模型技术的主要特征。预训练数据类别及参数量一定程度上决定了大模型所具备的能力强弱,而不同的模型架构则可支撑不同类别的下游任务。近两年,围绕DNA/RNA/蛋白质等生物序列与单细胞表达图谱等组学数据分析挖掘、大分子结构预测、新型药物设计和功能机制解析等多种应用场景,涌现了多种通用或专用大模型,展示出其在生物医学研究及转化应用等领域的巨大潜力。本文旨在结合不同类别的生物数据特点和研究应用需求,概述生物数据特征及其用于生物大模型训练的技术方法,并进一步综述现有大模型在生物医学研究及疾病诊疗中的应用进展,为提升生物大模型能力、拓展应用范围提供新的思路。
